Methanesulfonamide group at position-4 of the C-5-phenyl ring of 1,5-diarylpyrazole affords a potent class of cyclooxygenase-2 (COX-2) inhibitors
Singh, Sunil Kumar, Vobbalareddy, Saibaba, Shivaramakrishna, Samala, Krishnamraju, A., Rajjak, Shaikh Abdul, Casturi, Seshagiri Rao, Akhila, Vangoori, Rao, Yeleswarapu Koteswar
Published in Bioorganic & medicinal chemistry letters (05.04.2004)
Published in Bioorganic & medicinal chemistry letters (05.04.2004)
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Journal Article
2-hydroxymethyl-4-[5-(4-methoxyphenyl)-3-trifluoromethyl-1H-1-pyrazolyl]-1-benzenesulfonamide (DRF-4367): an orally active COX-2 inhibitor identified through pharmacophoric modulation
Singh, SK, Vobbalareddy, S, Kalleda, Rajjak, SA, Casturi, Datla, Mamidi, RNVS, Mullangi, R, Bhamidipati, R, Ramanujam, R, Akella, Yeleswarapu, KR
Published in Organic & biomolecular chemistry (07.09.2004)
Published in Organic & biomolecular chemistry (07.09.2004)
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