Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells
De Henau, Olivier, Rausch, Matthew, Winkler, David, Campesato, Luis Felipe, Liu, Cailian, Cymerman, Daniel Hirschhorn, Budhu, Sadna, Ghosh, Arnab, Pink, Melissa, Tchaicha, Jeremy, Douglas, Mark, Tibbitts, Thomas, Sharma, Sujata, Proctor, Jennifer, Kosmider, Nicole, White, Kerry, Stern, Howard, Soglia, John, Adams, Julian, Palombella, Vito J, McGovern, Karen, Kutok, Jeffery L, Wolchok, Jedd D, Merghoub, Taha
Published in Nature (London) (17.11.2016)
Published in Nature (London) (17.11.2016)
Get full text
Journal Article
Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer
Zadra, Giorgia, Ribeiro, Caroline F., Chetta, Paolo, Ho, Yeung, Cacciatore, Stefano, Gao, Xueliang, Syamala, Sudeepa, Bango, Clyde, Photopoulos, Cornelia, Huang, Ying, Tyekucheva, Svitlana, Bastos, Debora C., Tchaicha, Jeremy, Lawney, Brian, Uo, Takuma, D’Anello, Laura, Csibi, Alfredo, Kalekar, Radha, Larimer, Benjamin, Ellis, Leigh, Butler, Lisa M., Morrissey, Colm, McGovern, Karen, Palombella, Vito J., Kutok, Jeffery L., Mahmood, Umar, Bosari, Silvano, Adams, Julian, Peluso, Stephane, Dehm, Scott M., Plymate, Stephen R., Loda, Massimo
Published in Proceedings of the National Academy of Sciences - PNAS (08.01.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (08.01.2019)
Get full text
Journal Article
PI3Kγ is a molecular switch that controls immune suppression
Kaneda, Megan M, Messer, Karen S, Ralainirina, Natacha, Li, Hongying, Leem, Christopher J, Gorjestani, Sara, Woo, Gyunghwi, Nguyen, Abraham V, Figueiredo, Camila C, Foubert, Philippe, Schmid, Michael C, Pink, Melissa, Winkler, David G, Rausch, Matthew, Palombella, Vito J, Kutok, Jeffery, McGovern, Karen, Frazer, Kelly A, Wu, Xuefeng, Karin, Michael, Sasik, Roman, Cohen, Ezra E W, Varner, Judith A
Published in Nature (London) (17.11.2016)
Published in Nature (London) (17.11.2016)
Get full text
Journal Article
The Fully human anti-CD47 antibody SRF231 exerts dual-mechanism antitumor activity via engagement of the activating receptor CD32a
Peluso, Marisa O, Adam, Ammar, Armet, Caroline M, Zhang, Li, O’Connor, Rachel W, Lee, Benjamin H, Lake, Andrew C, Normant, Emmanuel, Chappel, Scott C, Hill, Jonathan A, Palombella, Vito J, Holland, Pamela M, Paterson, Alison M
Published in Journal for immunotherapy of cancer (01.04.2020)
Published in Journal for immunotherapy of cancer (01.04.2020)
Get full text
Journal Article
Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)‑γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate
Evans, Catherine A, Liu, Tao, Lescarbeau, André, Nair, Somarajan J, Grenier, Louis, Pradeilles, Johan A, Glenadel, Quentin, Tibbitts, Thomas, Rowley, Ann M, DiNitto, Jonathan P, Brophy, Erin E, O’Hearn, Erin L, Ali, Janid A, Winkler, David G, Goldstein, Stanley I, O’Hearn, Patrick, Martin, Christian M, Hoyt, Jennifer G, Soglia, John R, Cheung, Culver, Pink, Melissa M, Proctor, Jennifer L, Palombella, Vito J, Tremblay, Martin R, Castro, Alfredo C
Published in ACS medicinal chemistry letters (08.09.2016)
Published in ACS medicinal chemistry letters (08.09.2016)
Get full text
Journal Article
HSP90 inhibition enhances antimitotic drug-induced mitotic arrest and cell death in preclinical models of non-small cell lung cancer
O'Connell, Brenda C, O'Callaghan, Katie, Tillotson, Bonnie, Douglas, Mark, Hafeez, Nafeeza, West, Kip A, Stern, Howard, Ali, Janid A, Changelian, Paul, Fritz, Christian C, Palombella, Vito J, McGovern, Karen, Kutok, Jeffery L
Published in PloS one (26.12.2014)
Published in PloS one (26.12.2014)
Get full text
Journal Article
Development of 17-Allylamino-17-Demethoxygeldanamycin Hydroquinone Hydrochloride (IPI-504), an Anti-Cancer Agent Directed against Hsp90
Sydor, Jens R., Normant, Emmanuel, Pien, Christine S., Porter, James R., Ge, Jie, Grenier, Louis, Pak, Roger H., Ali, Janid A., Dembski, Marlene S., Hudak, Jebecka, Patterson, Jon, Penders, Courtney, Pink, Melissa, Read, Margaret A., Sang, Jim, Woodward, Caroline, Zhang, Yilong, Grayzel, David S., Wright, Jim, Barrett, John A., Palombella, Vito J., Adams, Julian, Tong, Jeffrey K.
Published in Proceedings of the National Academy of Sciences - PNAS (14.11.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (14.11.2006)
Get full text
Journal Article
The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
HIDESHIMA, Teru, RICHARDSON, Paul, CHAUHAN, Dharminder, PALOMBELLA, Vito J, ELLIOTT, Peter J, ADAMS, Julian, ANDERSON, Kenneth C
Published in Cancer research (Chicago, Ill.) (01.04.2001)
Get full text
Published in Cancer research (Chicago, Ill.) (01.04.2001)
Journal Article
Design, Synthesis, and Biological Evaluation of Hydroquinone Derivatives of 17-Amino-17-demethoxygeldanamycin as Potent, Water-Soluble Inhibitors of Hsp90
Ge, Jie, Normant, Emmanuel, Porter, James R, Ali, Janid A, Dembski, Marlene S, Gao, Yun, Georges, Asimina T, Grenier, Louis, Pak, Roger H, Patterson, Jon, Sydor, Jens R, Tibbitts, Thomas T, Tong, Jeffrey K, Adams, Julian, Palombella, Vito J
Published in Journal of medicinal chemistry (27.07.2006)
Published in Journal of medicinal chemistry (27.07.2006)
Get full text
Journal Article
Synthetic Silvestrol Analogues as Potent and Selective Protein Synthesis Inhibitors
Liu, Tao, Nair, Somarajan J, Lescarbeau, André, Belani, Jitendra, Peluso, Stéphane, Conley, James, Tillotson, Bonnie, O’Hearn, Patrick, Smith, Sherri, Slocum, Kelly, West, Kip, Helble, Joseph, Douglas, Mark, Bahadoor, Adilah, Ali, Janid, McGovern, Karen, Fritz, Christian, Palombella, Vito J, Wylie, Andrew, Castro, Alfredo C, Tremblay, Martin R
Published in Journal of medicinal chemistry (25.10.2012)
Published in Journal of medicinal chemistry (25.10.2012)
Get full text
Journal Article
Reduction of IgG in Nonhuman Primates by a Peptide Antagonist of the Neonatal Fc Receptor FcRn
Mezo, Adam R., McDonnell, Kevin A., Hehir, Cristina A. Tan, Low, Susan C., Palombella, Vito J., Stattel, James M., Kamphaus, George D., Fraley, Cara, Zhang, Yixia, Dumont, Jennifer A., Bitonti, Alan J.
Published in Proceedings of the National Academy of Sciences - PNAS (19.02.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (19.02.2008)
Get full text
Journal Article
Pulmonary Delivery of an Erythropoietin Fc Fusion Protein in Non-Human Primates through an Immunoglobulin Transport Pathway
Bitonti, Alan J., Dumont, Jennifer A., Low, Susan C., Peters, Robert T., Kropp, Keith E., Palombella, Vito J., Stattel, James M., Lu, Yichun, Tan, Cristina A., Song, Jeffrey J., Garcia, Ana Maria, Simister, Neil E., Spiekermann, Gerburg M., Lencer, Wayne I., Blumberg, Richard S., Bjorkman, Pamela J.
Published in Proceedings of the National Academy of Sciences - PNAS (29.06.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (29.06.2004)
Get full text
Journal Article
SRF617 Is a Potent Inhibitor of CD39 with Immunomodulatory and Antitumor Properties
Warren, Michael C, Matissek, Stephan, Rausch, Matthew, Panduro, Marisella, Hall, R J, Dulak, Austin, Brennan, David, Das Yekkirala, Sonia, Koseoglu, Secil, Masia, Ricard, Yang, Yu, Reddy, Navamallika, Prenovitz, Robert, Strand, Jamie, Zaidi, Tauqueer, Devereaux, Erik, Foissac, Célia Jacoberger, Stagg, John, Lee, Benjamin H, Holland, Pamela, Palombella, Vito J, Lake, Andrew C
Published in ImmunoHorizons (01.05.2023)
Published in ImmunoHorizons (01.05.2023)
Get full text
Journal Article
Semisynthetic Cyclopamine Analogues as Potent and Orally Bioavailable Hedgehog Pathway Antagonists
Tremblay, Martin R, Nevalainen, Marta, Nair, Somarajan J, Porter, James R, Castro, Alfredo C, Behnke, Mark L, Yu, Lin-Chen, Hagel, Margit, White, Kerry, Faia, Kerrie, Grenier, Louis, Campbell, Matthew J, Cushing, Jill, Woodward, Caroline N, Hoyt, Jennifer, Foley, Michael A, Read, Margaret A, Sydor, Jens R, Tong, Jeffrey K, Palombella, Vito J, McGovern, Karen, Adams, Julian
Published in Journal of medicinal chemistry (13.11.2008)
Published in Journal of medicinal chemistry (13.11.2008)
Get full text
Journal Article
Proteasome inhibitors : A novel class of potent and effective antitumor agents
ADAMS, J, PALOMBELLA, V. J, SAUSVILLE, E. A, JOHNSON, J, DESTREE, A, LAZARUS, D. D, MAAS, J, PIEN, C. S, PRAKASH, S, ELLIOTT, P. J
Published in Cancer research (Chicago, Ill.) (01.06.1999)
Get full text
Published in Cancer research (Chicago, Ill.) (01.06.1999)
Journal Article
Hsp90 (Heat Shock Protein 90) Inhibitor Occupancy Is a Direct Determinant of Client Protein Degradation and Tumor Growth Arrest in Vivo
Tillotson, Bonnie, Slocum, Kelly, Coco, John, Whitebread, Nigel, Thomas, Brian, West, Kip A., MacDougall, John, Ge, Jie, Ali, Janid A., Palombella, Vito J., Normant, Emmanuel, Adams, Julian, Fritz, Christian C.
Published in The Journal of biological chemistry (17.12.2010)
Published in The Journal of biological chemistry (17.12.2010)
Get full text
Journal Article
Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides
Manam, Rama Rao, McArthur, Katherine A, Chao, Ta-Hsiang, Weiss, Jeffrey, Ali, Janid A, Palombella, Vito J, Groll, Michael, Lloyd, G. Kenneth, Palladino, Michael A, Neuteboom, Saskia T. C, Macherla, Venkat R, Potts, Barbara C. M
Published in Journal of medicinal chemistry (13.11.2008)
Published in Journal of medicinal chemistry (13.11.2008)
Get full text
Journal Article
Corrigendum: PI3Kγ is a molecular switch that controls immune suppression
Kaneda, Megan M, Messer, Karen S, Ralainirina, Natacha, Li, Hongying, Leem, Christopher J, Gorjestani, Sara, Woo, Gyunghwi, Nguyen, Abraham V, Figueiredo, Camila C, Foubert, Philippe, Schmid, Michael C, Pink, Melissa, Winkler, David G, Rausch, Matthew, Palombella, Vito J, Kutok, Jeffery, McGovern, Karen, Frazer, Kelly A, Wu, Xuefeng, Karin, Michael, Sasik, Roman, Cohen, Ezra E W, Varner, Judith A
Published in Nature (London) (02.02.2017)
Published in Nature (London) (02.02.2017)
Get full text
Journal Article