Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons
Virdi, Gurvir S., Choi, Minee L., Evans, James R., Yao, Zhi, Athauda, Dilan, Strohbuecker, Stephanie, Nirujogi, Raja S., Wernick, Anna I., Pelegrina-Hidalgo, Noelia, Leighton, Craig, Saleeb, Rebecca S., Kopach, Olga, Alrashidi, Haya, Melandri, Daniela, Perez-Lloret, Jimena, Angelova, Plamena R., Sylantyev, Sergiy, Eaton, Simon, Heales, Simon, Rusakov, Dmitri A., Alessi, Dario R., Kunath, Tilo, Horrocks, Mathew H., Abramov, Andrey Y., Patani, Rickie, Gandhi, Sonia
Published in NPJ Parkinson's Disease (24.11.2022)
Published in NPJ Parkinson's Disease (24.11.2022)
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Journal Article
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Choi, Minee L., Chappard, Alexandre, Singh, Bhanu P., Maclachlan, Catherine, Rodrigues, Margarida, Fedotova, Evgeniya I., Berezhnov, Alexey V., De, Suman, Peddie, Christopher J., Athauda, Dilan, Virdi, Gurvir S., Zhang, Weijia, Evans, James R., Wernick, Anna I., Zanjani, Zeinab Shadman, Angelova, Plamena R., Esteras, Noemi, Vinokurov, Andrey Y., Morris, Katie, Jeacock, Kiani, Tosatto, Laura, Little, Daniel, Gissen, Paul, Clarke, David J., Kunath, Tilo, Collinson, Lucy, Klenerman, David, Abramov, Andrey Y., Horrocks, Mathew H., Gandhi, Sonia
Published in Nature neuroscience (01.09.2022)
Published in Nature neuroscience (01.09.2022)
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Journal Article
MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration
Simone, Roberto, Javad, Faiza, Emmett, Warren, Wilkins, Oscar G., Almeida, Filipa Lourenço, Barahona-Torres, Natalia, Zareba-Paslawska, Justyna, Ehteramyan, Mazdak, Zuccotti, Paola, Modelska, Angelika, Siva, Kavitha, Virdi, Gurvir S., Mitchell, Jamie S., Harley, Jasmine, Kay, Victoria A., Hondhamuni, Geshanthi, Trabzuni, Daniah, Ryten, Mina, Wray, Selina, Preza, Elisavet, Kia, Demis A., Pittman, Alan, Ferrari, Raffaele, Manzoni, Claudia, Lees, Andrew, Hardy, John A., Denti, Michela A., Quattrone, Alessandro, Patani, Rickie, Svenningsson, Per, Warner, Thomas T., Plagnol, Vincent, Ule, Jernej, de Silva, Rohan
Published in Nature (London) (03.06.2021)
Published in Nature (London) (03.06.2021)
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Journal Article
Author Correction: Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Choi, Minee L., Chappard, Alexandre, Singh, Bhanu P., Maclachlan, Catherine, Rodrigues, Margarida, Fedotova, Evgeniya I., Berezhnov, Alexey V., De, Suman, Peddie, Christopher J., Athauda, Dilan, Virdi, Gurvir S., Zhang, Weijia, Evans, James R., Wernick, Anna I., Zanjani, Zeinab Shadman, Angelova, Plamena R., Esteras, Noemi, Vinokurov, Andrey Y., Morris, Katie, Jeacock, Kiani, Tosatto, Laura, Little, Daniel, Gissen, Paul, Clarke, David J., Kunath, Tilo, Collinson, Lucy, Klenerman, David, Abramov, Andrey Y., Horrocks, Mathew H., Gandhi, Sonia
Published in Nature neuroscience (01.11.2022)
Published in Nature neuroscience (01.11.2022)
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Journal Article
Prediction of mechanistic subtypes of Parkinson’s using patient-derived stem cell models
D’Sa, Karishma, Evans, James R., Virdi, Gurvir S., Vecchi, Giulia, Adam, Alexander, Bertolli, Ottavia, Fleming, James, Chang, Hojong, Leighton, Craig, Horrocks, Mathew H., Athauda, Dilan, Choi, Minee L., Gandhi, Sonia
Published in Nature machine intelligence (2023)
Published in Nature machine intelligence (2023)
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Journal Article
Deep learning in human neurons predicts mechanistic subtypes of Parkinson's
D'sa, Karishma, Evans, James R, Virdi, Gurvir S, Vecchi, Giulia, Adam, Alex, Bertolli, Ottavia, Fleming, James, Chang, Hojong, Athauda, Dilan, Choi, Minee L, Gandhi, Sonia
Published in bioRxiv (12.03.2022)
Published in bioRxiv (12.03.2022)
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Highly enriched hiPSC-derived midbrain dopaminergic neurons robustly models Parkinson’s disease
Virdi, Gurvir S, Choi, Minee L, Yao, Zhi, Evans, James R, Athauda, Dilan, Melandri, Daniela, Sylantyev, Sergiy, Abramov, Andrey Y, Patani, Rickie, Gandhi, Sonia
Published in bioRxiv (08.09.2020)
Published in bioRxiv (08.09.2020)
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