Screening for AMPA receptor auxiliary subunit specific modulators
Azumaya, Caleigh M, Days, Emily L, Vinson, Paige N, Stauffer, Shaun, Sulikowski, Gary, Weaver, C David, Nakagawa, Terunaga
Published in PloS one (30.03.2017)
Published in PloS one (30.03.2017)
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Structure based virtual screening identifies small molecule effectors for the sialoglycan binding protein Hsa
Agarwal, Rupesh, Bensing, Barbara A, Mi, Dehui, Vinson, Paige N, Baudry, Jerome, Iverson, Tina M, Smith, Jeremy C
Published in Biochemical journal (16.10.2020)
Published in Biochemical journal (16.10.2020)
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Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M5 Muscarinic Acetylcholine Receptor
Li, Jinming, Orsi, Douglas L., Engers, Julie L., Long, Madeline F., Capstick, Rory A., Maurer, Mallory A., Presley, Christopher C., Vinson, Paige N., Rodriguez, Alice L., Han, Allie, Cho, Hyekyung P., Chang, Sichen, Jackson, Megan, Bubser, Michael, Blobaum, Anna L., Boutaud, Olivier, Nader, Michael A., Niswender, Colleen M., Conn, P. Jeffrey, Jones, Carrie K., Lindsley, Craig W., Han, Changho
Published in Journal of medicinal chemistry (22.08.2024)
Published in Journal of medicinal chemistry (22.08.2024)
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Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M 5 Muscarinic Acetylcholine Receptor
Li, Jinming, Orsi, Douglas L, Engers, Julie L, Long, Madeline F, Capstick, Rory A, Maurer, Mallory A, Presley, Christopher C, Vinson, Paige N, Rodriguez, Alice L, Han, Allie, Cho, Hyekyung P, Chang, Sichen, Jackson, Megan, Bubser, Michael, Blobaum, Anna L, Boutaud, Olivier, Nader, Michael A, Niswender, Colleen M, Conn, P Jeffrey, Jones, Carrie K, Lindsley, Craig W, Han, Changho
Published in Journal of medicinal chemistry (22.08.2024)
Published in Journal of medicinal chemistry (22.08.2024)
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Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992
Kharade, Sujay V, Kurata, Haruto, Bender, Aaron M, Blobaum, Anna L, Figueroa, Eric E, Duran, Amanda, Kramer, Meghan, Days, Emily, Vinson, Paige, Flores, Daniel, Satlin, Lisa M, Meiler, Jens, Weaver, C David, Lindsley, Craig W, Hopkins, Corey R, Denton, Jerod S
Published in Molecular pharmacology (01.08.2018)
Published in Molecular pharmacology (01.08.2018)
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Discovery of a potent M5 antagonist with improved clearance profile. Part 2: Pyrrolidine amide-based antagonists
Orsi, Douglas L., Felts, Andrew S., Rodriguez, Alice L., Vinson, Paige N., Cho, Hyekyung P., Chang, Sichen, Blobaum, Anna L., Niswender, Colleen M., Conn, P. Jeffrey, Jones, Carrie K., Lindsley, Craig W., Han, Changho
Published in Bioorganic & medicinal chemistry letters (15.12.2022)
Published in Bioorganic & medicinal chemistry letters (15.12.2022)
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Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity
Rodriguez, Alice L, Grier, Mark D, Jones, Carrie K, Herman, Elizabeth J, Kane, Alexander S, Smith, Randy L, Williams, Richard, Zhou, Ya, Marlo, Joy E, Days, Emily L, Blatt, Tasha N, Jadhav, Satyawan, Menon, Usha N, Vinson, Paige N, Rook, Jerri M, Stauffer, Shaun R, Niswender, Colleen M, Lindsley, Craig W, Weaver, C David, Conn, P Jeffrey
Published in Molecular pharmacology (01.12.2010)
Published in Molecular pharmacology (01.12.2010)
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A Novel Approach To Identify Inhibitors of Iron Acquisition Systems of Pseudomonas aeruginosa
Kannon, Mamie, Nebane, N Miranda, Ruiz, Pedro, McKellip, Sara, Vinson, Paige N, Mitra, Avishek
Published in Microbiology spectrum (26.10.2022)
Published in Microbiology spectrum (26.10.2022)
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Unique Signaling Profiles of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Determine Differences in In Vivo Activity
Rook, Jerri M, Noetzel, Meredith J, Pouliot, Wendy A, Bridges, Thomas M, Vinson, Paige N, Cho, Hyekyung P, Zhou, Ya, Gogliotti, Rocco D, Manka, Jason T, Gregory, Karen J, Stauffer, Shaun R, Dudek, F. Edward, Xiang, Zixiu, Niswender, Colleen M, Daniels, J. Scott, Jones, Carrie K, Lindsley, Craig W, Conn, P. Jeffrey
Published in Biological psychiatry (1969) (15.03.2013)
Published in Biological psychiatry (1969) (15.03.2013)
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Selective Small Molecule Activators of TREK‑2 Channels Stimulate Dorsal Root Ganglion c‑Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx
Dadi, Prasanna K, Vierra, Nicholas C, Days, Emily, Dickerson, Matthew T, Vinson, Paige N, Weaver, C. David, Jacobson, David A
Published in ACS chemical neuroscience (15.03.2017)
Published in ACS chemical neuroscience (15.03.2017)
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Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships
Gregory, Karen J, Noetzel, Meredith J, Rook, Jerri M, Vinson, Paige N, Stauffer, Shaun R, Rodriguez, Alice L, Emmitte, Kyle A, Zhou, Ya, Chun, Aspen C, Felts, Andrew S, Chauder, Brian A, Lindsley, Craig W, Niswender, Colleen M, Conn, P Jeffrey
Published in Molecular pharmacology (01.11.2012)
Published in Molecular pharmacology (01.11.2012)
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Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function
Noetzel, Meredith J, Rook, Jerri M, Vinson, Paige N, Cho, Hyekyung P, Days, Emily, Zhou, Y, Rodriguez, Alice L, Lavreysen, Hilde, Stauffer, Shaun R, Niswender, Colleen M, Xiang, Zixiu, Daniels, J Scott, Jones, Carrie K, Lindsley, Craig W, Weaver, C David, Conn, P Jeffrey
Published in Molecular pharmacology (01.02.2012)
Published in Molecular pharmacology (01.02.2012)
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Development of VU6019650 : A Potent, Highly Selective, and Systemically Active Orthosteric Antagonist of the M 5 Muscarinic Acetylcholine Receptor for the Treatment of Opioid Use Disorder
Garrison, Aaron T, Orsi, Douglas L, Capstick, Rory A, Whomble, David, Li, Jinming, Carter, Trever R, Felts, Andrew S, Vinson, Paige N, Rodriguez, Alice L, Han, Allie, Hajari, Krishma, Cho, Hyekyung P, Teal, Laura B, Ragland, Madeline G, Ghamari-Langroudi, Masoud, Bubser, Michael, Chang, Sichen, Schnetz-Boutaud, Nathalie C, Boutaud, Olivier, Blobaum, Anna L, Foster, Daniel J, Niswender, Colleen M, Conn, P Jeffrey, Lindsley, Craig W, Jones, Carrie K, Han, Changho
Published in Journal of medicinal chemistry (28.04.2022)
Published in Journal of medicinal chemistry (28.04.2022)
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A high-throughput response to the SARS-CoV-2 pandemic
Rasmussen, Lynn, Sanders, Shalisa, Sosa, Melinda, McKellip, Sara, Nebane, N. Miranda, Martinez-Gzegozewska, Yohanka, Reece, Andrew, Ruiz, Pedro, Manuvakhova, Anna, Zhai, Ling, Warren, Brooke, Curry, Aliyah, Zeng, Qinghua, Bostwick, J. Robert, Vinson, Paige N.
Published in SLAS discovery (01.07.2024)
Published in SLAS discovery (01.07.2024)
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Delayed treatment with PTBA analogs reduces postinjury renal fibrosis after kidney injury
Skrypnyk, Nataliya I, Sanker, Subramaniam, Skvarca, Lauren Brilli, Novitskaya, Tatiana, Woods, Clara, Chiba, Takuto, Patel, Kevin, Goldberg, Natasha D, McDermott, Lee, Vinson, Paige N, Calcutt, M Wade, Huryn, Donna M, Vernetti, Lawrence A, Vogt, Andreas, Hukriede, Neil A, de Caestecker, Mark P
Published in American journal of physiology. Renal physiology (15.04.2016)
Published in American journal of physiology. Renal physiology (15.04.2016)
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Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanism
Bridges, Thomas M, Rook, Jerri M, Noetzel, Meredith J, Morrison, Ryan D, Zhou, Ya, Gogliotti, Rocco D, Vinson, Paige N, Xiang, Zixiu, Jones, Carrie K, Niswender, Colleen M, Lindsley, Craig W, Stauffer, Shaun R, Conn, P Jeffrey, Daniels, J Scott
Published in Drug metabolism and disposition (01.09.2013)
Published in Drug metabolism and disposition (01.09.2013)
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Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor
Salovich, James M., Vinson, Paige N., Sheffler, Douglas J., Lamsal, Atin, Utley, Thomas J., Blobaum, Anna L., Bridges, Thomas M., Le, Uyen, Jones, Carrie K., Wood, Michael R., Scott Daniels, J., Jeffrey Conn, P., Niswender, Colleen M., Lindsley, Craig W., Hopkins, Corey R.
Published in Bioorganic & medicinal chemistry letters (01.08.2012)
Published in Bioorganic & medicinal chemistry letters (01.08.2012)
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Exploration of Allosteric Agonism Structure–Activity Relationships within an Acetylene Series of Metabotropic Glutamate Receptor 5 (mGlu5) Positive Allosteric Modulators (PAMs): Discovery of 5‑((3-Fluorophenyl)ethynyl)‑N‑(3-methyloxetan-3-yl)picolinamide (ML254)
Turlington, Mark, Noetzel, Meredith J, Chun, Aspen, Zhou, Ya, Gogliotti, Rocco D, Nguyen, Elizabeth D, Gregory, Karen J, Vinson, Paige N, Rook, Jerri M, Gogi, Kiran K, Xiang, Zixiu, Bridges, Thomas M, Daniels, J. Scott, Jones, Carrie, Niswender, Colleen M, Meiler, Jens, Conn, P. Jeffrey, Lindsley, Craig W, Stauffer, Shaun R
Published in Journal of medicinal chemistry (24.10.2013)
Published in Journal of medicinal chemistry (24.10.2013)
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