An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells
Vinogradova, Maia, Gehling, Victor S, Gustafson, Amy, Arora, Shilpi, Tindell, Charles A, Wilson, Catherine, Williamson, Kaylyn E, Guler, Gulfem D, Gangurde, Pranoti, Manieri, Wanda, Busby, Jennifer, Flynn, E Megan, Lan, Fei, Kim, Hyo-jin, Odate, Shobu, Cochran, Andrea G, Liu, Yichin, Wongchenko, Matthew, Yang, Yibin, Cheung, Tommy K, Maile, Tobias M, Lau, Ted, Costa, Michael, Hegde, Ganapati V, Jackson, Erica, Pitti, Robert, Arnott, David, Bailey, Christopher, Bellon, Steve, Cummings, Richard T, Albrecht, Brian K, Harmange, Jean-Christophe, Kiefer, James R, Trojer, Patrick, Classon, Marie
Published in Nature chemical biology (01.07.2016)
Published in Nature chemical biology (01.07.2016)
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Journal Article
Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation
Benod, Cindy, Vinogradova, Maia V., Jouravel, Natalia, Kim, Grace E., Fletterick, Robert J., Sablin, Elena P.
Published in Proceedings of the National Academy of Sciences - PNAS (11.10.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (11.10.2011)
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Journal Article
COBRA™: a highly potent conditionally active T cell engager engineered for the treatment of solid tumors
Panchal, Anand, Seto, Pui, Wall, Russell, Hillier, Brian J, Zhu, Ying, Krakow, Jessica, Datt, Aakash, Pongo, Elizabeth, Bagheri, Andisheh, Chen, Tseng-Hui T, Degenhardt, Jeremiah D, Culp, Patricia A, Dettling, Danielle E, Vinogradova, Maia V, May, Chad, DuBridge, Robert B
Published in mAbs (01.01.2020)
Published in mAbs (01.01.2020)
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Journal Article
Ca2+-Regulated Structural Changes in Troponin
Vinogradova, Maia V., Stone, Deborah B., Malanina, Galina G., Karatzaferi, Christina, Cooke, Roger, Mendelson, Robert A., Fletterick, Robert J., Cohen, Carolyn
Published in Proceedings of the National Academy of Sciences - PNAS (05.04.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (05.04.2005)
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Journal Article
Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies
Liang, Jun, Zhang, Birong, Labadie, Sharada, Ortwine, Daniel F., Vinogradova, Maia, Kiefer, James R., Gehling, Victor S., Harmange, Jean-Christophe, Cummings, Richard, Lai, Tommy, Liao, Jiangpeng, Zheng, Xiaoping, Liu, Yichin, Gustafson, Amy, Van der Porten, Erica, Mao, Weifeng, Liederer, Bianca M., Deshmukh, Gauri, Classon, Marie, Trojer, Patrick, Dragovich, Peter S., Murray, Lesley
Published in Bioorganic & medicinal chemistry letters (15.08.2016)
Published in Bioorganic & medicinal chemistry letters (15.08.2016)
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Journal Article
Plant Kinesin-Like Calmodulin Binding Protein Employs Its Regulatory Domain for Dimerization
Vinogradova, Maia V, Malanina, Galina G, Waitzman, Joshua S, Rice, Sarah E, Fletterick, Robert J
Published in PloS one (21.06.2013)
Published in PloS one (21.06.2013)
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Journal Article
An atomic model of the thin filament in the relaxed and Ca2+-activated states
Pirani, Alnoor, Vinogradova, Maia V, Curmi, Paul M G, King, William A, Fletterick, Robert J, Craig, Roger, Tobacman, Larry S, Xu, Chen, Hatch, Victoria, Lehman, William
Published in Journal of molecular biology (31.03.2006)
Published in Journal of molecular biology (31.03.2006)
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Journal Article
Regression of EGFR positive established solid tumors in mice with the conditionally active T cell engager TAK-186
Dettling, Danielle E, Kwok, Eilene, Quach, Lucy, Datt, Aakash, Degenhardt, Jeremiah D, Panchal, Anand, Seto, Pui, Krakow, Jessica L, Wall, Russell, Hillier, Brian J, Zhu, Ying, Vinogradova, Maia, DuBridge, Robert B, May, Chad
Published in Journal for immunotherapy of cancer (01.06.2022)
Published in Journal for immunotherapy of cancer (01.06.2022)
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Journal Article
Structural dynamics of the microtubule binding and regulatory elements in the kinesin-like calmodulin binding protein
Vinogradova, Maia V., Malanina, Galina G., Reddy, Vaka S., Reddy, Anireddy S.N., Fletterick, Robert J.
Published in Journal of structural biology (01.07.2008)
Published in Journal of structural biology (01.07.2008)
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Journal Article
Crystal structure of kinesin regulated by Ca(2+)-calmodulin
Vinogradova, Maia V, Reddy, Vaka S, Reddy, Anireddy S N, Sablin, Elena P, Fletterick, Robert J
Published in The Journal of biological chemistry (28.05.2004)
Published in The Journal of biological chemistry (28.05.2004)
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Journal Article
Crystal Structure of Kinesin Regulated by Ca2+-Calmodulin
Vinogradova, Maia V., Reddy, Vaka S., Reddy, Anireddy S.N., Sablin, Elena P., Fletterick, Robert J.
Published in The Journal of biological chemistry (01.05.2004)
Published in The Journal of biological chemistry (01.05.2004)
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Journal Article
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER plus Breast Cancer
Liang, Jun, Zbieg, Jason R., Blake, Robert A., Chang, Jae H., Daly, Stephen, DiPasquale, Antonio G., Friedman, Lori S., Gelzleichter, Thomas, Gill, Matthew, Giltnane, Jennifer M., Goodacre, Simon, Guan, Jane, Hartman, Steven J., Ingalla, Ellen Rei, Kategaya, Lorn, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada S., Lai, Tommy, Li, Jun, Liao, Jiangpeng, Liu, Zhiguo, Mody, Vidhi, McLean, Neville, Metcalfe, Ciara, Nannini, Michelle A., Oeh, Jason, O'Rourke, Martin G., Ortwine, Daniel F., Ran, Yingqing, Ray, Nicholas C., Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Schutt, Leah K., Vinogradova, Maia, Wai, John, Wang, Tao, Wertz, Ingrid E., White, Jonathan R., Yeap, Siew Kuen, Young, Amy, Zhang, Birong, Zheng, Xiaoping, Zhou, Wei, Zhong, Yu, Wang, Xiaojing
Published in Journal of medicinal chemistry (26.08.2021)
Published in Journal of medicinal chemistry (26.08.2021)
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Journal Article
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer
Liang, Jun, Zbieg, Jason R., Blake, Robert A., Chang, Jae H., Daly, Stephen, DiPasquale, Antonio G., Friedman, Lori S., Gelzleichter, Thomas, Gill, Matthew, Giltnane, Jennifer M., Goodacre, Simon, Guan, Jane, Hartman, Steven J., Ingalla, Ellen Rei, Kategaya, Lorn, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada S., Lai, Tommy, Li, Jun, Liao, Jiangpeng, Liu, Zhiguo, Mody, Vidhi, McLean, Neville, Metcalfe, Ciara, Nannini, Michelle A., Oeh, Jason, O’Rourke, Martin G., Ortwine, Daniel F., Ran, Yingqing, Ray, Nicholas C., Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Schutt, Leah K., Vinogradova, Maia, Wai, John, Wang, Tao, Wertz, Ingrid E., White, Jonathan R., Yeap, Siew Kuen, Young, Amy, Zhang, Birong, Zheng, Xiaoping, Zhou, Wei, Zhong, Yu, Wang, Xiaojing
Published in Journal of medicinal chemistry (26.08.2021)
Published in Journal of medicinal chemistry (26.08.2021)
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Journal Article
From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors
Liang, Jun, Labadie, Sharada, Zhang, Birong, Ortwine, Daniel F., Patel, Snahel, Vinogradova, Maia, Kiefer, James R., Mauer, Till, Gehling, Victor S., Harmange, Jean-Christophe, Cummings, Richard, Lai, Tommy, Liao, Jiangpeng, Zheng, Xiaoping, Liu, Yichin, Gustafson, Amy, Van der Porten, Erica, Mao, Weifeng, Liederer, Bianca M., Deshmukh, Gauri, An, Le, Ran, Yingqing, Classon, Marie, Trojer, Patrick, Dragovich, Peter S., Murray, Lesley
Published in Bioorganic & medicinal chemistry letters (01.07.2017)
Published in Bioorganic & medicinal chemistry letters (01.07.2017)
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Journal Article
Lead optimization of apyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies
Liang, Jun, Zhang, Birong, Labadie, Sharada, Ortwine, Daniel F., Vinogradova, Maia, Kiefer, James R., Gehling, Victor S., Harmange, Jean-Christophe, Cummings, Richard, Lai, Tommy, Liao, Jiangpeng, Zheng, Xiaoping, Liu, Yichin, Gustafson, Amy, Van der Porten, Erica, Mao, Weifeng, Liederer, Bianca M., Deshmukh, Gauri, Classon, Marie, Trojer, Patrick, Dragovich, Peter S., Murray, Lesley
Published in Bioorganic & medicinal chemistry letters (15.08.2016)
Published in Bioorganic & medicinal chemistry letters (15.08.2016)
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Journal Article
INDUCIBLE BINDING PROTEINS AND METHODS OF USE
GUENOT JEANMARIE, PANCHAL ANAND, WESCHE HOLGER, DUBRIDGE ROBERT B, BAEUERLE PATRICK, EVNIN LUKE, VINOGRADOVA MAIA
Year of Publication 24.03.2023
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Year of Publication 24.03.2023
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