Discovery of a Pharmacologically Active Antagonist of the Two-Pore-Domain Potassium Channel K2P9.1 (TASK-3)
Coburn, Craig A., Luo, Yunfu, Cui, Mingxiang, Wang, Jiabing, Soll, Richard, Dong, Jingchao, Hu, Bin, Lyon, Michael A., Santarelli, Vincent P., Kraus, Richard L., Gregan, Yun, Wang, Yi, Fox, Steven V., Binns, Jacquelyn, Doran, Scott M., Reiss, Duane R., Tannenbaum, Pamela L., Gotter, Anthony L., Meinke, Peter T., Renger, John J.
Published in ChemMedChem (02.01.2012)
Published in ChemMedChem (02.01.2012)
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Identification, structural, and biophysical characterization of a positive modulator of human Kv3.1 channels
Chen, Yun-Ting, Hong, Mee Ra, Zhang, Xin-Jun, Kostas, James, Li, Yuxing, Kraus, Richard L, Santarelli, Vincent P, Wang, Deping, Gomez-Llorente, Yacob, Brooun, Alexei, Strickland, Corey, Soisson, Stephen M, Klein, Daniel J, Ginnetti, Anthony T, Marino, Michael J, Stachel, Shawn J, Ishchenko, Andrii
Published in Proceedings of the National Academy of Sciences - PNAS (17.10.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (17.10.2023)
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Analgesia and peripheral c-fiber modulation by selective Nav1.8 inhibition in rhesus
Vardigan, Joshua D, Pall, Parul S, McDevitt, Dillon S, Huang, ChienJung, Clements, Michelle K, Li, Yuxing, Kraus, Richard L, Breslin, Michael J, Bungard, Christopher J, Nemenov, Mikhail I, Klukinov, Mikhail, Burgey, Chritopher S, Layton, Mark E, Stachel, Shawn J, Lange, Henry S, Savitz, Alan T, Santarelli, Vincent P, Henze, Darrell A, Uslaner, Jason M
Published in Pain (Amsterdam) (08.10.2024)
Published in Pain (Amsterdam) (08.10.2024)
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Journal Article
Functional TASK-3–Like Channels in Mitochondria of Aldosterone-Producing Zona Glomerulosa Cells
Yao, Junlan, McHedlishvili, David, McIntire, William E, Guagliardo, Nick A, Erisir, Alev, Coburn, Craig A, Santarelli, Vincent P, Bayliss, Douglas A, Barrett, Paula Q
Published in Hypertension (Dallas, Tex. 1979) (01.08.2017)
Published in Hypertension (Dallas, Tex. 1979) (01.08.2017)
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2‑Aminopyridines as Potent and Selective Nav1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model
Breslin, Michael J., Schubert, Jeffrey W., Wang, Deping, Huang, Chienjung, Clements, Michelle K., Li, Yuxing, Zhou, Xiaoping, Vardigan, Joshua D., Kraus, Richard L., Santarelli, Vincent P., Uslaner, Jason M., Coleman, Paul J., Stachel, Shawn J.
Published in ACS medicinal chemistry letters (13.06.2024)
Published in ACS medicinal chemistry letters (13.06.2024)
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Journal Article
2-Aminopyridines as Potent and Selective Na v 1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model
Breslin, Michael J, Schubert, Jeffrey W, Wang, Deping, Huang, Chienjung, Clements, Michelle K, Li, Yuxing, Zhou, Xiaoping, Vardigan, Joshua D, Kraus, Richard L, Santarelli, Vincent P, Uslaner, Jason M, Coleman, Paul J, Stachel, Shawn J
Published in ACS medicinal chemistry letters (13.06.2024)
Published in ACS medicinal chemistry letters (13.06.2024)
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Journal Article
A Cation-π Interaction Discriminates among Sodium Channels That Are Either Sensitive or Resistant to Tetrodotoxin Block
Santarelli, Vincent P., Eastwood, Amy L., Dougherty, Dennis A., Horn, Richard, Ahern, Christopher A.
Published in The Journal of biological chemistry (16.03.2007)
Published in The Journal of biological chemistry (16.03.2007)
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Journal Article
TASK-3 as a potential antidepressant target
Gotter, Anthony L, Santarelli, Vincent P, Doran, Scott M, Tannenbaum, Pamela L, Kraus, Richard L, Rosahl, Thomas W, Meziane, Hamid, Montial, Marina, Reiss, Duane R, Wessner, Keith, McCampbell, Alexander, Stevens, Joanne, Brunner, Joseph I, Fox, Steven V, Uebele, Victor N, Bayliss, Douglas A, Winrow, Christopher J, Renger, John J
Published in Brain research (06.10.2011)
Published in Brain research (06.10.2011)
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Journal Article
Calcium Block of Single Sodium Channels: Role of a Pore-Lining Aromatic Residue
Santarelli, Vincent P., Eastwood, Amy L., Dougherty, Dennis A., Ahern, Christopher A., Horn, Richard
Published in Biophysical journal (01.10.2007)
Published in Biophysical journal (01.10.2007)
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Journal Article
Positive Allosteric Interaction of Structurally Diverse T-Type Calcium Channel Antagonists
Uebele, Victor N, Nuss, Cindy E, Fox, Steven V, Garson, Susan L, Cristescu, Razvan, Doran, Scott M, Kraus, Richard L, Santarelli, Vincent P, Li, Yuxing, Barrow, James C, Yang, Zhi-Qiang, Schlegel, Kelly-Ann S, Rittle, Kenneth E, Reger, Thomas S, Bednar, Rodney A, Lemaire, Wei, Mullen, Faith A, Ballard, Jeanine E, Tang, Cuyue, Dai, Ge, McManus, Owen B, Koblan, Kenneth S, Renger, John J
Published in Cell biochemistry and biophysics (01.11.2009)
Published in Cell biochemistry and biophysics (01.11.2009)
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Journal Article
T-type calcium channels regulate cortical plasticity in-vivo. [corrected]
Uebele, Victor N, Nuss, Cindy E, Santarelli, Vincent P, Garson, Susan L, Kraus, Richard L, Barrow, James C, Stauffer, Shaun R, Koblan, Kenneth S, Renger, John J, Aton, Sara, Seibt, Julie, Dumoulin, Michelle, Jha, Sushil K, Coleman, Tammi, Frank, Marcos G
Published in Neuroreport (18.02.2009)
Published in Neuroreport (18.02.2009)
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A Cation-Ï Interaction Discriminates among Sodium Channels That Are Either Sensitive or Resistant to Tetrodotoxin Block
Vincent P. Santarelli, Amy L. Eastwood, Dennis A. Dougherty, Richard Horn, Christopher A. Ahern
Published in The Journal of biological chemistry (16.03.2007)
Published in The Journal of biological chemistry (16.03.2007)
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Journal Article
Discovery of a Pharmacologically Active Antagonist of the Two‐Pore‐Domain Potassium Channel K 2P 9.1 (TASK‐3)
Coburn, Craig A., Luo, Yunfu, Cui, Mingxiang, Wang, Jiabing, Soll, Richard, Dong, Jingchao, Hu, Bin, Lyon, Michael A., Santarelli, Vincent P., Kraus, Richard L., Gregan, Yun, Wang, Yi, Fox, Steven V., Binns, Jacquelyn, Doran, Scott M., Reiss, Duane R., Tannenbaum, Pamela L., Gotter, Anthony L., Meinke, Peter T., Renger, John J.
Published in ChemMedChem (02.01.2012)
Published in ChemMedChem (02.01.2012)
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Journal Article
Generation and characterization of a cell line with inducible expression of Ca(v)3.2 (T-type) channels
Xia, Menghang, Imredy, John P, Santarelli, Vincent P, Liang, Hongyu Annie, Condra, Cindra L, Bennett, Paul, Koblan, Kenneth S, Connolly, Thomas M
Published in Assay and drug development technologies (01.10.2003)
Published in Assay and drug development technologies (01.10.2003)
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