The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation
Vijayaraj, Swarna L., Feltham, Rebecca, Rashidi, Maryam, Frank, Daniel, Liu, Zhengyang, Simpson, Daniel S., Ebert, Gregor, Vince, Angelina, Herold, Marco J., Kueh, Andrew, Pearson, Jaclyn S., Dagley, Laura F., Murphy, James M., Webb, Andrew I., Lawlor, Kate E., Vince, James E.
Published in Nature communications (11.05.2021)
Published in Nature communications (11.05.2021)
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The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation
Vince, James E., De Nardo, Dominic, Gao, Wenqing, Vince, Angelina J., Hall, Cathrine, McArthur, Kate, Simpson, Daniel, Vijayaraj, Swarna, Lindqvist, Lisa M., Bouillet, Philippe, Rizzacasa, Mark A., Man, Si Ming, Silke, John, Masters, Seth L., Lessene, Guillaume, Huang, David C.S., Gray, Daniel H.D., Kile, Benjamin T., Shao, Feng, Lawlor, Kate E.
Published in Cell reports (Cambridge) (27.11.2018)
Published in Cell reports (Cambridge) (27.11.2018)
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XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation
Lawlor, Kate E., Feltham, Rebecca, Yabal, Monica, Conos, Stephanie A., Chen, Kaiwen W., Ziehe, Stephanie, Graß, Carina, Zhan, Yifan, Nguyen, Tan A., Hall, Cathrine, Vince, Angelina J., Chatfield, Simon M., D’Silva, Damian B., Pang, Kenneth C., Schroder, Kate, Silke, John, Vaux, David L., Jost, Philipp J., Vince, James E.
Published in Cell reports (Cambridge) (18.07.2017)
Published in Cell reports (Cambridge) (18.07.2017)
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Divergent roles of RIPK3 and MLKL in high-fat diet-induced obesity and MAFLD in mice
Tye, Hazel, Conos, Stephanie A, Djajawi, Tirta M, Gottschalk, Timothy A, Abdoulkader, Nasteho, Kong, Isabella Y, Kammoun, Helene L, Narayana, Vinod K, Kratina, Tobias, Speir, Mary, Emery, Jack, Simpson, Daniel S, Hall, Cathrine, Vince, Angelina J, Russo, Sophia, Crawley, Rhiannan, Rashidi, Maryam, Hildebrand, Joanne M, Murphy, James M, Whitehead, Lachlan, De Souza, David P, Masters, Seth L, Samson, Andre L, Lalaoui, Najoua, Hawkins, Edwin D, Murphy, Andrew J, Vince, James E, Lawlor, Kate E
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Published in Life science alliance (01.01.2025)
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The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release
Rashidi, Maryam, Simpson, Daniel S, Hempel, Anne, Frank, Daniel, Petrie, Emma, Vince, Angelina, Feltham, Rebecca, Murphy, Jane, Chatfield, Simon M, Salvesen, Guy S, Murphy, James M, Wicks, Ian P, Vince, James E
Published in The Journal of immunology (1950) (01.08.2019)
Published in The Journal of immunology (1950) (01.08.2019)
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The inflammasome-activated cytokine IL-1β is targeted for ubiquitylation and proteasomal degradation to limit its inflammatory potential
Vijayaraj, Swarna L, Feltham, Rebecca, Rashidi, Maryam, Frank, Daniel, Liu, Zhengyang, Simpson, Daniel S, Ebert, Gregor, Vince, Angelina, Herold, Marco J, Kueh, Andrew, Pearson, Jaclyn S, Dagley, Laura F, Murphy, James M, Webb, Andrew I, Lawlor, Kate E, Vince, James E
Published in bioRxiv (16.03.2021)
Published in bioRxiv (16.03.2021)
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