A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activity
Macuamule, Cristiano J, Tjhin, Erick T, Jana, Collins E, Barnard, Leanne, Koekemoer, Lizbé, de Villiers, Marianne, Saliba, Kevin J, Strauss, Erick
Published in Antimicrobial agents and chemotherapy (01.06.2015)
Published in Antimicrobial agents and chemotherapy (01.06.2015)
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Adsorption to the Surface of Hemozoin Crystals: Structure‐Based Design and Synthesis of Amino‐Phenoxazine β‐Hematin Inhibitors
Olivier, Tania, Loots, Leigh, Kok, Michélle, Villiers, Marianne, Reader, Janette, Birkholtz, Lyn‐Marié, Arnott, Gareth E., Villiers, Katherine A.
Published in ChemMedChem (18.05.2022)
Published in ChemMedChem (18.05.2022)
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Chemoenzymatic Synthesis of ortho-, meta-, and para-Substituted Derivatives of L-threo-3-Benzyloxyaspartate, An Important Glutamate Transporter Blocker
de Villiers, Jandré, de Villiers, Marianne, Geertsema, Edzard M., Raj, Hans, Poelarends, Gerrit J.
Published in ChemCatChem (03.07.2015)
Published in ChemCatChem (03.07.2015)
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Journal Article
Enantioselective Synthesis of N-Substituted Aspartic Acids Using an Engineered Variant of Methylaspartate Ammonia Lyase
Puthan Veetil, Vinod, Raj, Hans, de Villiers, Marianne, Tepper, Pieter G., Dekker, Frank J., Quax, Wim J., Poelarends, Gerrit J.
Published in ChemCatChem (01.06.2013)
Published in ChemCatChem (01.06.2013)
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Journal Article
Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids
Raj, Hans, Szymański, Wiktor, de Villiers, Jandré, Rozeboom, Henriëtte J., Veetil, Vinod Puthan, Reis, Carlos R., de Villiers, Marianne, Dekker, Frank J., de Wildeman, Stefaan, Quax, Wim J., Thunnissen, Andy-Mark W. H., Feringa, Ben L., Janssen, Dick B., Poelarends, Gerrit J.
Published in Nature chemistry (01.06.2012)
Published in Nature chemistry (01.06.2012)
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Inhibition of Plasmodium falciparum Hsp70-Hop partnership by 2-phenylthynesulfonamide
Muthelo, Tshifhiwa, Mulaudzi, Vhahangwele, Netshishivhe, Munei, Dongola, Tendamudzimu Harmfree, Kok, Michelle, Makumire, Stanley, de Villiers, Marianne, Burger, Adélle, Zininga, Tawanda, Shonhai, Addmore
Published in Frontiers in molecular biosciences (13.09.2022)
Published in Frontiers in molecular biosciences (13.09.2022)
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Journal Article
Structural Modification of Pantothenamides Counteracts Degradation by Pantetheinase and Improves Antiplasmodial Activity
de Villiers, Marianne, Macuamule, Cristiano, Spry, Christina, Hyun, Yoo-Min, Strauss, Erick, Saliba, Kevin J
Published in ACS medicinal chemistry letters (08.08.2013)
Published in ACS medicinal chemistry letters (08.08.2013)
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Journal Article
Adsorption to the surface of hemozoin crystals: Structure-based design and synthesis of new amino-phenoxazine β-hematin inhibitors
Olivier, Tania, Loots, Leigh, Kok, Michélle, de Villiers, Marianne, Reader, Janette, Birkholtz, Lyn-Marié, Arnott, Gareth E., de Villiers, Katherine A.
Published in ChemMedChem (26.04.2022)
Published in ChemMedChem (26.04.2022)
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Journal Article
Acetyl-4′-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency
Di Meo, Ivano, Colombelli, Cristina, Srinivasan, Balaji, de Villiers, Marianne, Hamada, Jeffrey, Jeong, Suh Y., Fox, Rachel, Woltjer, Randall L., Tepper, Pieter G., Lahaye, Liza L., Rizzetto, Emanuela, Harrs, Clara H., de Boer, Theo, van der Zwaag, Marianne, Jenko, Branko, Čusak, Alen, Pahor, Jerca, Kosec, Gregor, Grzeschik, Nicola A., Hayflick, Susan J., Tiranti, Valeria, Sibon, Ody C. M.
Published in Scientific reports (12.09.2017)
Published in Scientific reports (12.09.2017)
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Toward a Stable and Potent Coenzyme A‑Targeting Antiplasmodial Agent: Structure–Activity Relationship Studies of N‑Phenethyl-α-methyl-pantothenamide
Spry, Christina, Barnard, Leanne, Kok, Michélle, Powell, Andrew K, Mahesh, Darvina, Tjhin, Erick T, Saliba, Kevin J, Strauss, Erick, de Villiers, Marianne
Published in ACS infectious diseases (10.07.2020)
Published in ACS infectious diseases (10.07.2020)
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Journal Article
Antiplasmodial Mode of Action of Pantothenamides: Pantothenate Kinase Serves as a Metabolic Activator Not as a Target
de Villiers, Marianne, Spry, Christina, Macuamule, Cristiano J, Barnard, Leanne, Wells, Gordon, Saliba, Kevin J, Strauss, Erick
Published in ACS infectious diseases (14.07.2017)
Published in ACS infectious diseases (14.07.2017)
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Inside Cover: Chemoenzymatic Synthesis of ortho-, meta-, and para-Substituted Derivatives of L-threo-3-Benzyloxyaspartate, An Important Glutamate Transporter Blocker (ChemCatChem 13/2015)
de Villiers, Jandré, de Villiers, Marianne, Geertsema, Edzard M., Raj, Hans, Poelarends, Gerrit J.
Published in ChemCatChem (03.07.2015)
Published in ChemCatChem (03.07.2015)
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