Adsorption to the Surface of Hemozoin Crystals: Structure‐Based Design and Synthesis of Amino‐Phenoxazine β‐Hematin Inhibitors
Olivier, Tania, Loots, Leigh, Kok, Michélle, Villiers, Marianne, Reader, Janette, Birkholtz, Lyn‐Marié, Arnott, Gareth E., Villiers, Katherine A.
Published in ChemMedChem (18.05.2022)
Published in ChemMedChem (18.05.2022)
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Recent advances in the discovery of haem-targeting drugs for malaria and schistosomiasis
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Book Review
Haemozoin (β-haematin) biomineralization occurs by self-assembly near the lipid/water interface
Egan, Timothy J., Chen, Jeff Y-J., de Villiers, Katherine A., Mabotha, Tebogo E., Naidoo, Kevin J., Ncokazi, Kanyile K., Langford, Steven J., McNaughton, Don, Pandiancherri, Shveta, Wood, Bayden R.
Published in FEBS letters (18.09.2006)
Published in FEBS letters (18.09.2006)
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Journal Article
Design, Synthesis, and Evaluation of Novel Ferroquine and Phenylequine Analogues as Potential Antiplasmodial Agents
Jacobs, Leon, de Kock, Carmen, de Villiers, Katherine A., Smith, Peter J., Smith, Vincent J., van Otterlo, Willem A. L., Blackie, Margaret A. L.
Published in ChemMedChem (01.12.2015)
Published in ChemMedChem (01.12.2015)
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Journal Article
Hemozoin inhibiting 2-phenylbenzimidazoles active against malaria parasites
L'abbate, Fabrizio P., Müller, Ronel, Openshaw, Roxanne, Combrinck, Jill M., de Villiers, Katherine A., Hunter, Roger, Egan, Timothy J.
Published in European journal of medicinal chemistry (05.11.2018)
Published in European journal of medicinal chemistry (05.11.2018)
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Journal Article
The Single Crystal X‑ray Structure of β‑Hematin DMSO Solvate Grown in the Presence of Chloroquine, a β‑Hematin Growth-Rate Inhibitor
Gildenhuys, Johandie, Roex, Tanya le, Egan, Timothy J, de Villiers, Katherine A
Published in Journal of the American Chemical Society (23.01.2013)
Published in Journal of the American Chemical Society (23.01.2013)
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Journal Article
Iron(III) Protoporphyrin IX Complexes of the Antimalarial Cinchona Alkaloids Quinine and Quinidine
de Villiers, Katherine A, Gildenhuys, Johandie, le Roex, Tanya
Published in ACS chemical biology (20.04.2012)
Published in ACS chemical biology (20.04.2012)
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Journal Article
Speciation and structure of ferriprotoporphyrin IX in aqueous solution: spectroscopic and diffusion measurements demonstrate dimerization, but not mu-oxo dimer formation
de Villiers, Katherine A, Kaschula, Catherine H, Egan, Timothy J, Marques, Helder M
Published in Journal of biological inorganic chemistry (01.01.2007)
Published in Journal of biological inorganic chemistry (01.01.2007)
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Journal Article
Alkoxide coordination of iron(III) protoporphyrin IX by antimalarial quinoline methanols: a key interaction observed in the solid-state and solution
Gildenhuys, Johandie, Sammy, Chandre J, Müller, Ronel, Streltsov, Victor A, le Roex, Tanya, Kuter, David, de Villiers, Katherine A
Published in Dalton transactions : an international journal of inorganic chemistry (14.10.2015)
Published in Dalton transactions : an international journal of inorganic chemistry (14.10.2015)
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Journal Article
Crystallization of synthetic haemozoin (beta-haematin) nucleated at the surface of lipid particles
Hoang, Anh N, Ncokazi, Kanyile K, de Villiers, Katherine A, Wright, David W, Egan, Timothy J
Published in Dalton transactions : an international journal of inorganic chemistry (01.01.2010)
Published in Dalton transactions : an international journal of inorganic chemistry (01.01.2010)
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Quinoline-benzofuran and quinoline-benzothiophene derivatives as antiplasmodium agents
Hay, Jonathan B., de Villiers, Katherine A., Taylor, Dale, Olivier, Tania, Van Otterlo, Willem A.L., Blackie, Margaret A.L.
Published in South African journal of chemistry (01.01.2023)
Published in South African journal of chemistry (01.01.2023)
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Journal Article
Insights into the initial stages of lipid-mediated haemozoin nucleation
Kuter, David, Mohunlal, Roxanne, Fitzroy, Sharné-Maré, Asher, Constance, Smith, Peter J., Egan, Timothy J., de Villiers, Katherine A.
Published in CrystEngComm (01.01.2016)
Published in CrystEngComm (01.01.2016)
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Insights into structural and physicochemical properties required for β-hematin inhibition of privileged triarylimidazoles
Veale, Clinton G. L, Jayram, Janeeka, Naidoo, Shivani, Laming, Dustin, Swart, Tarryn, Olivier, Tania, Akerman, Matthew P, de Villiers, Katherine A, Hoppe, Heinrich C, Jeena, Vineet
Published in MedChemComm (01.01.2020)
Published in MedChemComm (01.01.2020)
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Discriminating the Intraerythrocytic Lifecycle Stages of the Malaria Parasite Using Synchrotron FT-IR Microspectroscopy and an Artificial Neural Network
Webster, Grant T, de Villiers, Katherine A, Egan, Timothy J, Deed, Samantha, Tilley, Leann, Tobin, Mark J, Bambery, Keith R, McNaughton, Don, Wood, Bayden R
Published in Analytical chemistry (Washington) (01.04.2009)
Published in Analytical chemistry (Washington) (01.04.2009)
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Oriented Nucleation of β-Hematin Crystals Induced at Various Interfaces: Relevance to Hemozoin Formation
de Villiers, Katherine A, Osipova, Maria, Mabotha, Tebogo E, Solomonov, Inna, Feldman, Yishay, Kjaer, Kristian, Weissbuch, Isabelle, Egan, Timothy J, Leiserowitz, Leslie
Published in Crystal growth & design (07.01.2009)
Published in Crystal growth & design (07.01.2009)
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Journal Article
Adsorption to the surface of hemozoin crystals: Structure-based design and synthesis of new amino-phenoxazine β-hematin inhibitors
Olivier, Tania, Loots, Leigh, Kok, Michélle, de Villiers, Marianne, Reader, Janette, Birkholtz, Lyn-Marié, Arnott, Gareth E., de Villiers, Katherine A.
Published in ChemMedChem (26.04.2022)
Published in ChemMedChem (26.04.2022)
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