Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes
Wager, Travis T, Chandrasekaran, Ramalakshmi Y, Hou, Xinjun, Troutman, Matthew D, Verhoest, Patrick R, Villalobos, Anabella, Will, Yvonne
Published in ACS chemical neuroscience (16.06.2010)
Published in ACS chemical neuroscience (16.06.2010)
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PET imaging of beta-secretase 1 in the human brain: radiation dosimetry, quantification, and test-retest examination of [18F]PF-06684511
Arakawa, Ryosuke, Takano, Akihiro, Stenkrona, Per, Stepanov, Vladimir, Nag, Sangram, Jahan, Mahabuba, Grybäck, Per, Bolin, Martin, Chen, Laigao, Zhang, Lei, He, Ping, Villalobos, Anabella, McCarthy, Timothy J., Halldin, Christer, Varrone, Andrea
Published in European journal of nuclear medicine and molecular imaging (01.09.2020)
Published in European journal of nuclear medicine and molecular imaging (01.09.2020)
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The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging
Zhang, Lei, Chen, Laigao, Beck, Elizabeth M, Chappie, Thomas A, Coelho, Richard V, Doran, Shawn D, Fan, Kuo-Hsien, Helal, Christopher J, Humphrey, John M, Hughes, Zoe, Kuszpit, Kyle, Lachapelle, Erik A, Lazzaro, John T, Lee, Chewah, Mather, Robert J, Patel, Nandini C, Skaddan, Marc B, Sciabola, Simone, Verhoest, Patrick R, Young, Joseph M, Zasadny, Kenneth, Villalobos, Anabella
Published in Journal of medicinal chemistry (26.10.2017)
Published in Journal of medicinal chemistry (26.10.2017)
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Borrelidin B: Isolation, Biological Activity, and Implications for Nitrile Biosynthesis
Schulze, Christopher J, Bray, Walter M, Loganzo, Frank, Lam, My-Hanh, Szal, Teresa, Villalobos, Anabella, Koehn, Frank E, Linington, Roger G
Published in Journal of natural products (Washington, D.C.) (26.11.2014)
Published in Journal of natural products (Washington, D.C.) (26.11.2014)
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Author Correction: Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs
Ferruz, Noelia, Doerr, Stefan, Vanase-Frawley, Michelle A, Zou, Yaozhong, Chen, Xiaomin, Marr, Eric S, Nelson, Robin T, Kormos, Bethany L, Wager, Travis T, Hou, Xinjun, Villalobos, Anabella, Sciabola, Simone, De Fabritiis, Gianni
Published in Scientific reports (10.04.2019)
Published in Scientific reports (10.04.2019)
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Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease
Liston, Dane R., Nielsen, Jann A., Villalobos, Anabella, Chapin, Douglas, Jones, Shawn B., Hubbard, Sean T., Shalaby, Ismail A., Ramirez, Andres, Nason, Deane, White, W.Frost
Published in European journal of pharmacology (13.02.2004)
Published in European journal of pharmacology (13.02.2004)
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Moving beyond rules: the development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike properties
Wager, Travis T, Hou, Xinjun, Verhoest, Patrick R, Villalobos, Anabella
Published in ACS chemical neuroscience (16.06.2010)
Published in ACS chemical neuroscience (16.06.2010)
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Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery
Wager, Travis T, Hou, Xinjun, Verhoest, Patrick R, Villalobos, Anabella
Published in ACS chemical neuroscience (15.06.2016)
Published in ACS chemical neuroscience (15.06.2016)
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Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides
Genna, Vito, Iglesias-Fernández, Javier, Reyes-Fraile, Laura, Villegas, Nuria, Guckian, Kevin, Seth, Punit, Wan, Brad, Cabrero, Cristina, Terrazas, Montserrat, Brun-Heath, Isabelle, González, Carlos, Sciabola, Simone, Villalobos, Anabella, Orozco, Modesto
Published in Nucleic acids research (09.06.2023)
Published in Nucleic acids research (09.06.2023)
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Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodiesterase 2A PET Ligand
Zhang, Lei, Villalobos, Anabella, Beck, Elizabeth M, Bocan, Thomas, Chappie, Thomas A, Chen, Laigao, Grimwood, Sarah, Heck, Steven D, Helal, Christopher J, Hou, Xinjun, Humphrey, John M, Lu, Jiemin, Skaddan, Marc B, McCarthy, Timothy J, Verhoest, Patrick R, Wager, Travis T, Zasadny, Kenneth
Published in Journal of medicinal chemistry (13.06.2013)
Published in Journal of medicinal chemistry (13.06.2013)
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Journal Article
Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties
Wager, Travis T, Hou, Xinjun, Verhoest, Patrick R, Villalobos, Anabella
Published in ACS chemical neuroscience (25.03.2010)
Published in ACS chemical neuroscience (25.03.2010)
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Journal Article
Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs
Ferruz, Noelia, Doerr, Stefan, Vanase-Frawley, Michelle A, Zou, Yaozhong, Chen, Xiaomin, Marr, Eric S, Nelson, Robin T, Kormos, Bethany L, Wager, Travis T, Hou, Xinjun, Villalobos, Anabella, Sciabola, Simone, De Fabritiis, Gianni
Published in Scientific reports (17.01.2018)
Published in Scientific reports (17.01.2018)
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Dopamine D 1 Receptor Agonist PET Tracer Development: Assessment in Nonhuman Primates
Barret, Olivier, Zhang, Lei, Alagille, David, Constantinescu, Cristian C, Sandiego, Christine, Papin, Caroline, Sullivan, Jenna M, Morley, Thomas, Carroll, Vincent M, Seibyl, John, Chen, Jianqing, Lee, Chewah, Villalobos, Anabella, Gray, David, McCarthy, Timothy J, Tamagnan, Gilles
Published in Journal of Nuclear Medicine (01.09.2021)
Published in Journal of Nuclear Medicine (01.09.2021)
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Journal Article
Dopamine D1 Receptor Agonist PET Tracer Development: Assessment in Nonhuman Primates
Barret, Olivier, Zhang, Lei, Alagille, David, Constantinescu, Cristian C, Sandiego, Christine, Papin, Caroline, Sullivan, Jenna M, Morley, Thomas, Carroll, Vincent M, Seibyl, John, Chen, Jianqing, Lee, Chewah, Villalobos, Anabella, Gray, David, McCarthy, Timothy J, Tamagnan, Gilles
Published in The Journal of nuclear medicine (1978) (01.09.2021)
Published in The Journal of nuclear medicine (1978) (01.09.2021)
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Identification and Development of an Irreversible Monoacylglycerol Lipase (MAGL) Positron Emission Tomography (PET) Radioligand with High Specificity
Zhang, Lei, Butler, Christopher R, Maresca, Kevin P, Takano, Akihiro, Nag, Sangram, Jia, Zhisheng, Arakawa, Ryosuke, Piro, Justin R, Samad, Tarek, Smith, Deborah L, Nason, Deane M, O’Neil, Steven, McAllister, Laura, Schildknegt, Klaas, Trapa, Patrick, McCarthy, Timothy J, Villalobos, Anabella, Halldin, Christer
Published in Journal of medicinal chemistry (26.09.2019)
Published in Journal of medicinal chemistry (26.09.2019)
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Dihedral Angle-Based Sampling of Natural Product Polyketide Conformations: Application to Permeability Prediction
Wang, Qin, Sciabola, Simone, Barreiro, Gabriela, Hou, Xinjun, Bai, Guoyun, Shapiro, Michael J, Koehn, Frank, Villalobos, Anabella, Jacobson, Matthew P
Published in Journal of chemical information and modeling (28.11.2016)
Published in Journal of chemical information and modeling (28.11.2016)
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Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation
O’Neill, Brian T, Beck, Elizabeth M, Butler, Christopher R, Nolan, Charles E, Gonzales, Cathleen, Zhang, Lei, Doran, Shawn D, Lapham, Kimberly, Buzon, Leanne M, Dutra, Jason K, Barreiro, Gabriela, Hou, Xinjun, Martinez-Alsina, Luis A, Rogers, Bruce N, Villalobos, Anabella, Murray, John C, Ogilvie, Kevin, LaChapelle, Erik A, Chang, Cheng, Lanyon, Lorraine F, Steppan, Claire M, Robshaw, Ashley, Hales, Katherine, Boucher, Germaine G, Pandher, Karamjeet, Houle, Christopher, Ambroise, Claude W, Karanian, David, Riddell, David, Bales, Kelly R, Brodney, Michael A
Published in Journal of medicinal chemistry (24.05.2018)
Published in Journal of medicinal chemistry (24.05.2018)
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