Imaging early changes in proliferation at 1 week post chemotherapy: a pilot study in breast cancer patients with 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography
Kenny, Laura, Coombes, R Charles, Vigushin, David M, Al-Nahhas, Adil, Shousha, Sami, Aboagye, Eric O
Published in European journal of nuclear medicine and molecular imaging (01.09.2007)
Published in European journal of nuclear medicine and molecular imaging (01.09.2007)
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Journal Article
Quantification of cellular proliferation in tumor and normal tissues of patients with breast cancer by [18F]fluorothymidine -positron emission tomography imaging : Evaluation of analytical methods
KENNY, Laura M, VIGUSHIN, David M, AL-NAHHAS, Adil, OSMAN, Safiye, LUTHRA, Sajinder K, SHOUSHA, Sami, COOMBES, R. Charles, ABOAGYE, Eric O
Published in Cancer research (Chicago, Ill.) (01.11.2005)
Published in Cancer research (Chicago, Ill.) (01.11.2005)
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Journal Article
Phase I Study of STX 64 (667 Coumate) in Breast Cancer Patients: The First Study of a Steroid Sulfatase Inhibitor
STANWAY, Susannah J, PUROHIT, Atul, ELLIOTT, Moira, POTTER, Barry V. L, REED, Michael J, COOMBES, R. Charles, WOO, L. W. Lawrence, SUFI, Saulat, VIGUSHIN, David, WARD, Rebecca, WILSON, Richard H, STANCZYK, Frank Z, DOBBS, Nicola, KULINSKAYA, Elena
Published in Clinical cancer research (01.03.2006)
Published in Clinical cancer research (01.03.2006)
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Journal Article
Histone Deacetylase Inhibitor Trichostatin A Represses Estrogen Receptor α-Dependent Transcription and Promotes Proteasomal Degradation of Cyclin D1 in Human Breast Carcinoma Cell Lines
ALAO, John Patrick, LAM, Eric W.-F, ALI, Simak, BULUWELA, Laki, BORDOGNA, Walter, LOCKEY, Peter, VARSHOCHI, Rana, STAVROPOULOU, Alexandra V, COOMBES, R. Charles, VIGUSHIN, David M
Published in Clinical cancer research (01.12.2004)
Published in Clinical cancer research (01.12.2004)
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Journal Article
In vivo biological activity of the histone deacetylase inhibitor LAQ824 is detectable with 3' -deoxy-3'-[18F]fluorothymidine positron emission tomography
LEYTON, Julius, ALAO, John P, WORKMAN, Paul, VIGUSHIN, David M, ABOAGYE, Eric O, DA COSTA, Marco, STAVROPOULOU, Alexandra V, LATIGO, John R, PERUMAL, Meg, FILIAL, Radhakrishna, QIMIN HE, ATADJA, Peter, LAM, Eric W.-F
Published in Cancer research (Chicago, Ill.) (01.08.2006)
Published in Cancer research (Chicago, Ill.) (01.08.2006)
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Ring-Closing Metathesis in the Synthesis of Biologically Active Peptidomimetics of Apicidin A
Deshmukh, Prashant H., Schulz-Fademrecht, Carsten, Procopiou, Panayiotis A., Vigushin, David A., Coombes, R. Charles, Barrett, Anthony G. M.
Published in Advanced synthesis & catalysis (08.01.2007)
Published in Advanced synthesis & catalysis (08.01.2007)
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Journal Article
Structure–activity relationships of aryloxyalkanoic acid hydroxyamides as potent inhibitors of histone deacetylase
Marson, Charles M., Mahadevan, Thevaki, Dines, Jon, Sengmany, Stéphane, Morrell, James M., Alao, John P., Joel, Simon P., Vigushin, David M., Charles Coombes, R.
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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Journal Article
Trichostatin A Is a Histone Deacetylase Inhibitor with Potent Antitumor Activity against Breast Cancer in Vivo
VIGUSHIN, David M, ALI, Simak, PACE, Paul E, MIRSAIDI, Nina, ITO, Kazuhiro, ADCOCK, Ian, COOMBES, R. Charles
Published in Clinical cancer research (01.04.2001)
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Published in Clinical cancer research (01.04.2001)
Journal Article
FR-901228 Fujisawa/National Cancer Institute
Vigushin, David M
Published in Current opinion in investigational drugs (London, England : 2000) (01.09.2002)
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Published in Current opinion in investigational drugs (London, England : 2000) (01.09.2002)
Journal Article
Pyrazino[1,2-a]indole-1,4-diones, simple analogues of gliotoxin, as selective inhibitors of geranylgeranyltransferase I
VIGUSHIN, David M, BROOKE, Greg, WILLOWS, David, COOMBES, R. Charles, MOODY, Christopher J
Published in Bioorganic & medicinal chemistry letters (03.11.2003)
Published in Bioorganic & medicinal chemistry letters (03.11.2003)
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Journal Article
Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2 E,4 E)-5-arylpenta-2,4-dienoic acid hydroxyamides
Marson, Charles M., Serradji, Nawal, Rioja, Alphonso S., Gastaud, Sebastien P., Alao, John P., Coombes, R.Charles, Vigushin, David M.
Published in Bioorganic & medicinal chemistry letters (17.05.2004)
Published in Bioorganic & medicinal chemistry letters (17.05.2004)
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Journal Article
Targeted histone deacetylase inhibition for cancer prevention and therapy
Palmieri, Carlo, Coombes, R Charles, Vigushin, David M
Published in Progress in drug research (2005)
Published in Progress in drug research (2005)
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Increased gestational age at evacuation of a complete hydatidiform mole: does it correlate with increased risk of requiring chemotherapy?
Seckl, Michael J, Dhillon, Tony, Dancey, Gairin, Foskett, Marianne, Paradinas, Fernando J, Rees, Helene C, Sebire, Neil, Vigushin, David M, Newlands, Edward S
Published in Journal of reproductive medicine (01.07.2004)
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Published in Journal of reproductive medicine (01.07.2004)
Journal Article
ICI182,780 Induces p21Waf1 Gene Transcription through Releasing Histone Deacetylase 1 and Estrogen Receptor α from Sp1 Sites to Induce Cell Cycle Arrest in MCF-7 Breast Cancer Cell Line
Varshochi, Rana, Halim, Faezah, Sunters, Andrew, Alao, John P., Madureira, Patricia A., Hart, Stephen M., Ali, Simak, Vigushin, David M., Coombes, R. Charles, Lam, Eric W.-F.
Published in The Journal of biological chemistry (04.02.2005)
Published in The Journal of biological chemistry (04.02.2005)
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Journal Article
Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferase
Marson, Charles M., Rioja, Alphonso S., Brooke, Greg, Coombes, R.Charles, Vigushin, David M.
Published in Bioorganic & medicinal chemistry letters (21.01.2002)
Published in Bioorganic & medicinal chemistry letters (21.01.2002)
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Bilateral chylothorax due to retrosternal goiter in a patient with non-Hodgkin's lymphoma
Simmgen, M, Newlands, E S, Southcott, B M, Vigushin, D M
Published in Medical oncology (Northwood, London, England) (01.01.2001)
Published in Medical oncology (Northwood, London, England) (01.01.2001)
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