Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells
Eskew, Jeffery D, Sadikot, Takrima, Morales, Pedro, Duren, Alicia, Dunwiddie, Irene, Swink, Megan, Zhang, Xiaoying, Hembruff, Stacey, Donnelly, Alison, Rajewski, Roger A, Blagg, Brian S J, Manjarrez, Jacob R, Matts, Robert L, Holzbeierlein, Jeffrey M, Vielhauer, George A
Published in BMC cancer (31.10.2011)
Published in BMC cancer (31.10.2011)
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Engineering an Antibiotic to Fight Cancer: Optimization of the Novobiocin Scaffold to Produce Anti-proliferative Agents
Zhao, Huiping, Donnelly, Alison C, Kusuma, Bhaskar R, Brandt, Gary E. L, Brown, Douglas, Rajewski, Roger A, Vielhauer, George, Holzbeierlein, Jeffrey, Cohen, Mark S, Blagg, Brian S. J
Published in Journal of medicinal chemistry (09.06.2011)
Published in Journal of medicinal chemistry (09.06.2011)
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KU675, a Concomitant Heat-Shock Protein Inhibitor of Hsp90 and Hsc70 that Manifests Isoform Selectivity for Hsp90α in Prostate Cancer Cells
Liu, Weiya, Vielhauer, George A, Holzbeierlein, Jeffrey M, Zhao, Huiping, Ghosh, Suman, Brown, Douglas, Lee, Eugene, Blagg, Brian S J
Published in Molecular pharmacology (01.07.2015)
Published in Molecular pharmacology (01.07.2015)
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KU135, a Novel Novobiocin-Derived C-Terminal Inhibitor of the 90-kDa Heat Shock Protein, Exerts Potent Antiproliferative Effects in Human Leukemic Cells
Shelton, Shary N, Shawgo, Mary E, Matthews, Shawna B, Lu, Yuanming, Donnelly, Alison C, Szabla, Kristen, Tanol, Mehmet, Vielhauer, George A, Rajewski, Roger A, Matts, Robert L, Blagg, Brian S J, Robertson, John D
Published in Molecular pharmacology (01.12.2009)
Published in Molecular pharmacology (01.12.2009)
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Hsp90 C‑Terminal Inhibitors Exhibit Antimigratory Activity by Disrupting the Hsp90α/Aha1 Complex in PC3-MM2 Cells
Ghosh, Suman, Shinogle, Heather E, Garg, Gaurav, Vielhauer, George A, Holzbeierlein, Jeffrey M, Dobrowsky, Rick T, Blagg, Brian S. J
Published in ACS chemical biology (20.02.2015)
Published in ACS chemical biology (20.02.2015)
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The hERG Channel Is Dependent upon the Hsp90α Isoform for Maturation and Trafficking
Peterson, Laura B, Eskew, Jeffrey D, Vielhauer, George A, Blagg, Brian S. J
Published in Molecular pharmaceutics (04.06.2012)
Published in Molecular pharmaceutics (04.06.2012)
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Design, Synthesis, and Evaluation of Duocarmycin O-Amino Phenol Prodrugs Subject to Tunable Reductive Activation
Lajiness, James P, Robertson, William M, Dunwiddie, Irene, Broward, Melinda A, Vielhauer, George A, Weir, Scott J, Boger, Dale L
Published in Journal of medicinal chemistry (11.11.2010)
Published in Journal of medicinal chemistry (11.11.2010)
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Efficacious Cyclic N‑Acyl O‑Amino Phenol Duocarmycin Prodrugs
Wolfe, Amanda L, Duncan, Katharine K, Parelkar, Nikhil K, Brown, Douglas, Vielhauer, George A, Boger, Dale L
Published in Journal of medicinal chemistry (23.05.2013)
Published in Journal of medicinal chemistry (23.05.2013)
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Human cancer xenografts in outbred nude mice can be confounded by polymorphisms in a modifier of tumorigenesis
Zeineldin, Maged, Jensen, Derek, Paranjape, Smita R, Parelkar, Nikhil K, Jokar, Iman, Vielhauer, George A, Neufeld, Kristi L
Published in Genetics (Austin) (01.08.2014)
Published in Genetics (Austin) (01.08.2014)
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Characterization of a novel novobiocin analogue as a putative C-terminal inhibitor of heat shock protein 90 in prostate cancer cells
Matthews, Shawna B., Vielhauer, George A., Manthe, Craig A., Chaguturu, Vamsee K., Szabla, Kristen, Matts, Robert L., Donnelly, Alison C., Blagg, Brian S. J., Holzbeierlein, Jeffrey M.
Published in The Prostate (01.01.2010)
Published in The Prostate (01.01.2010)
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A Unique Class of Duocarmycin and CC-1065 Analogues Subject to Reductive Activation
Jin, Wei, Trzupek, John D, Rayl, Thomas J, Broward, Melinda A, Vielhauer, George A, Weir, Scott J, Hwang, Inkyu, Boger, Dale L
Published in Journal of the American Chemical Society (12.12.2007)
Published in Journal of the American Chemical Society (12.12.2007)
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Expression of the C-C Chemokine Receptor 7 Mediates Metastasis of Breast Cancer to the Lymph Nodes in Mice
Cunningham, Heather D., Shannon, Laura A., Calloway, Psachal A., Fassold, Brian C., Dunwiddie, Irene, Vielhauer, George, Zhang, Ming, Vines, Charlotte M.
Published in Translational oncology (01.12.2010)
Published in Translational oncology (01.12.2010)
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Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors
Sadikot, Takrima, Swink, Megan, Eskew, Jeffery D, Brown, Douglas, Zhao, Huiping, Kusuma, Bhaskar R, Rajewski, Roger A, Blagg, Brian S J, Matts, Robert L, Holzbeierlein, Jeffrey M, Vielhauer, George A
Published in Assay and drug development technologies (01.10.2013)
Published in Assay and drug development technologies (01.10.2013)
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Biological characterization of preclinical Bioluminescent Osteosarcoma Orthotopic Mouse (BOOM) model: A multi-modality approach
Garimella, Rama, Eskew, Jeff, Bhamidi, Priyanka, Vielhauer, George, Hong, Yan, Anderson, H. Clarke, Tawfik, Ossama, Rowe, Peter
Published in Journal of bone oncology (01.02.2013)
Published in Journal of bone oncology (01.02.2013)
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Hsp90: A Drug Target?
Holzbeierlein, Jeffrey M., Windsperger, Andrew, Vielhauer, George
Published in Current oncology reports (01.03.2010)
Published in Current oncology reports (01.03.2010)
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Synthesis and biological evaluation of coumarin replacements of novobiocin as Hsp90 inhibitors
Kusuma, Bhaskar Reddy, Khandelwal, Anuj, Gu, Wen, Brown, Douglas, Liu, Weiya, Vielhauer, George, Holzbeierlein, Jeffrey, Blagg, Brian S.J.
Published in Bioorganic & medicinal chemistry (15.02.2014)
Published in Bioorganic & medicinal chemistry (15.02.2014)
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