The rapid generation of recombinant functional monoclonal antibodies from individual, antigen-specific bone marrow-derived plasma cells isolated using a novel fluorescence-based method
Clargo, Alison M, Hudson, Ashley R, Ndlovu, Welcome, Wootton, Rebecca J, Cremin, Louise A, O'Dowd, Victoria L, Nowosad, Carla R, Starkie, Dale O, Shaw, Sophie P, Compson, Joanne E, White, Dominic P, MacKenzie, Brendon, Snowden, James R, Newnham, Laura E, Wright, Michael, Stephens, Paul E, Griffiths, Meryn R, Lawson, Alastair DG, Lightwood, Daniel J
Published in mAbs (01.01.2014)
Published in mAbs (01.01.2014)
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A Mixture of Functionally Oligoclonal Humanized Monoclonal Antibodies That Neutralize Clostridium difficile TcdA and TcdB with High Levels of In Vitro Potency Shows In Vivo Protection in a Hamster Infection Model
Davies, Nicola L, Compson, Joanne E, Mackenzie, Brendon, O'Dowd, Victoria L, Oxbrow, Amanda K F, Heads, James T, Turner, Alison, Sarkar, Kaushik, Dugdale, Sarah L, Jairaj, Mark, Christodoulou, Louis, Knight, David E O, Cross, Amanda S, Hervé, Karine J M, Tyson, Kerry L, Hailu, Hanna, Doyle, Carl B, Ellis, Mark, Kriek, Marco, Cox, Matthew, Page, Matthew J T, Moore, Adrian R, Lightwood, Daniel J, Humphreys, David P
Published in Clinical and Vaccine Immunology (01.03.2013)
Published in Clinical and Vaccine Immunology (01.03.2013)
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CD1a promotes systemic manifestations of skin inflammation
Hardman, Clare S, Chen, Yi-Ling, Wegrecki, Marcin, Ng, Soo Weei, Murren, Robert, Mangat, Davinderpreet, Silva, John-Paul, Munro, Rebecca, Chan, Win Yan, O'Dowd, Victoria, Doyle, Carl, Mori, Prashant, Popplewell, Andy, Rossjohn, Jamie, Lightwood, Daniel, Ogg, Graham S
Published in Nature communications (07.12.2022)
Published in Nature communications (07.12.2022)
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Therapeutic Monoclonal Antibodies for Ebola Virus Infection Derived from Vaccinated Humans
Rijal, Pramila, Elias, Sean C., Machado, Samara Rosendo, Xiao, Julie, Schimanski, Lisa, O’Dowd, Victoria, Baker, Terry, Barry, Emily, Mendelsohn, Simon C., Cherry, Catherine J., Jin, Jing, Labbé, Geneviève M., Donnellan, Francesca R., Rampling, Tommy, Dowall, Stuart, Rayner, Emma, Findlay-Wilson, Stephen, Carroll, Miles, Guo, Jia, Xu, Xiao-Ning, Huang, Kuan-Ying A., Takada, Ayato, Burgess, Gillian, McMillan, David, Popplewell, Andy, Lightwood, Daniel J., Draper, Simon J., Townsend, Alain R.
Published in Cell reports (Cambridge) (02.04.2019)
Published in Cell reports (Cambridge) (02.04.2019)
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Recognition of Amino Acid Motifs, Rather Than Specific Proteins, by Human Plasma Cell–Derived Monoclonal Antibodies to Posttranslationally Modified Proteins in Rheumatoid Arthritis
Steen, Johanna, Forsström, Björn, Sahlström, Peter, Odowd, Victoria, Israelsson, Lena, Krishnamurthy, Akilan, Badreh, Sara, Mathsson Alm, Linda, Compson, Joanne, Ramsköld, Daniel, Ndlovu, Welcome, Rapecki, Stephen, Hansson, Monika, Titcombe, Philip J., Bang, Holger, Mueller, Daniel L., Catrina, Anca I., Grönwall, Caroline, Skriner, Karl, Nilsson, Peter, Lightwood, Daniel, Klareskog, Lars, Malmström, Vivianne
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.02.2019)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.02.2019)
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Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms
Ramberger, Melanie, Berretta, Antonio, Tan, Jeanne M M, Sun, Bo, Michael, Sophia, Yeo, Tianrong, Theorell, Jakob, Bashford-Rogers, Rachael, Paneva, Sofija, O'Dowd, Victoria, Dedi, Neesha, Topia, Sarfaraj, Griffin, Robert, Ramirez-Franco, Jorge, El Far, Oussama, Baulac, Stéphanie, Leite, Maria I, Sen, Arjune, Jeans, Alexander, McMillan, David, Marshall, Diane, Anthony, Daniel, Lightwood, Daniel, Waters, Patrick, Irani, Sarosh R
Published in Brain (London, England : 1878) (01.06.2020)
Published in Brain (London, England : 1878) (01.06.2020)
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A fully automated primary screening system for the discovery of therapeutic antibodies directly from B cells
Tickle, Simon, Howells, Louise, O'Dowd, Victoria, Starkie, Dale, Whale, Kevin, Saunders, Mark, Lee, David, Lightwood, Daniel
Published in Journal of biomolecular screening (01.04.2015)
Published in Journal of biomolecular screening (01.04.2015)
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Journal Article
The Discovery, Engineering and Characterisation of a Highly Potent Anti-Human IL-13 Fab Fragment Designed for Administration by Inhalation
Lightwood, Daniel, O'Dowd, Victoria, Carrington, Bruce, Veverka, Vaclav, Carr, Mark D., Tservistas, Markus, Henry, Alistair J., Smith, Bryan, Tyson, Kerry, Lamour, Sabrina, Sarkar, Kaushik, Turner, Alison, Lawson, Alastair D., Bourne, Tim, Gozzard, Neil, Palframan, Roger
Published in Journal of molecular biology (08.02.2013)
Published in Journal of molecular biology (08.02.2013)
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A broadly-neutralizing antibody against Ebolavirus glycoprotein that potentiates the breadth and neutralization potency of other antibodies
Donnellan, Francesca R, Rayaprolu, Vamseedhar, Rijal, Pramila, O'Dowd, Victoria, Parvate, Amar, Callaway, Heather, Hariharan, Chitra, Parekh, Dipti, Hui, Sean, Shaffer, Kelly, Avalos, Ruben Diaz, Hastie, Kathryn, Schimanski, Lisa, Müller-Kräuter, Helena, Strecker, Thomas, Balaram, Ariane, Halfmann, Peter, Saphire, Erica Ollmann, Lightwood, Daniel J, Townsend, Alain R, Draper, Simon J
Published in bioRxiv (25.06.2024)
Published in bioRxiv (25.06.2024)
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Journal Article
Corrigendum to “The Discovery, Engineering and Characterisation of a Highly Potent Anti-Human IL-13 Fab Fragment Designed for Administration by Inhalation” [J. Mol. Biol. 425 (2013), 577–593]
Lightwood, Daniel, O'Dowd, Victoria, Carrington, Bruce, Veverka, Vaclav, Carr, Mark D., Tservistas, Markus, Henry, Alistair J., Smith, Bryan, Tyson, Kerry, Lamour, Sabrina, Bracher, Marguerite, Sarkar, Kaushik, Turner, Alison, Lawson, Alastair D., Bourne, Tim, Gozzard, Neil, Palframan, Roger
Published in Journal of molecular biology (12.06.2013)
Published in Journal of molecular biology (12.06.2013)
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Journal Article
Synaptic autoimmunity: new insights into LGI1 antibody-mediated neuronal dysfunction
Ramberger, Melanie, Berretta, Antonio, Tan, Jeanne, Sun, Bo, Michael, Sophia, Yeo, Tianrong, Theorell, Jakob, Bashford-Rogers, Rachael, Paneva, Sofija, O’dowd, Victoria, Dedi, Neesha, Topia, Sarfaraj, Griffin, Robert, Ramirez-Franco, Jorge, El Far, Oussama, Baulac, Stéphanie, Leite, Maria, Sen, Arjune, Jeans, Alexander, Mcmillan, David, Marshall, Diane, Anthony, Daniel, Lightwood, Daniel, Waters, Patrick, Irani, Sarosh
Published in Brain (London, England : 1878) (2020)
Published in Brain (London, England : 1878) (2020)
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Journal Article
08.24Monoclonal acpa antibodies recognising a common citrulline motif are mainly dependent on light chain hypermutations for antigen recognition
Steen, Johanna, sstrom, Bjorn, Israelsson, Lena, Krishnamurthy, Akilan, Hansson, Monika, Sahlstrom, Peter, Stalesen, Ragnhild, Odowd, Victoria, Rapecki, Stephen, Klareskog, Lars, Catrina, Anca, Nilsson, Peter, Lightwood, Daniel, Malmstrom, Vivianne
Published in Annals of the rheumatic diseases (01.03.2017)
Published in Annals of the rheumatic diseases (01.03.2017)
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Journal Article
08.24 Monoclonal acpa antibodies recognising a common citrulline motif are mainly dependent on light chain hypermutations for antigen recognition
Steen, Johanna, Forsström, Björn, Israelsson, Lena, Krishnamurthy, Akilan, Hansson, Monika, Sahlström, Peter, Stålesen, Ragnhild, Odowd, Victoria, Rapecki, Stephen, Klareskog, Lars, Catrina, Anca, Nilsson, Peter, Lightwood, Daniel, Malmström, Vivianne
Published in Annals of the rheumatic diseases (01.03.2017)
Published in Annals of the rheumatic diseases (01.03.2017)
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Journal Article
ANTI-HLA-G ANTIBODIES
DOYLE, Carl Brendan, TYSON, Kerry Louise, HUMPHREYS, David Paul, COLLEY, Thomas, WHITE, Ann Louise, BERTEAU, Caroline, O'DOWD, Victoria, DEDI, Neesha, THOMPSON, Clare, LE FRIEC, Gaelle, MCELHONE, Ruth
Year of Publication 26.06.2024
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Year of Publication 26.06.2024
Patent
MONOCLONAL ACPA ANTIBODIES RECOGNISING A COMMON CITRULLINE MOTIF ARE MAINLY DEPENDENT ON LIGHT CHAIN HYPERMUTATIONS FOR ANTIGEN RECOGNITION
Steen, Johanna, Forsstrom, Bjorn, Israelsson, Lena, Krishnamurthy, Akilan, Hansson, Monika, Sahlstrom, Peter, Stalesen, Ragnhild, Odowd, Victoria, Rapecki, Stephen, Klareskog, Lars, Catrina, Anca, Nilsson, Peter, Lightwood, Daniel, Malmstrom, Vivianne
Published in ANNALS OF THE RHEUMATIC DISEASES (2017)
Published in ANNALS OF THE RHEUMATIC DISEASES (2017)
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Journal Article
Conference Proceeding
ANTIBODIES
LIGHTWOOD, Daniel John, DONNELLAN, Francesca Rose, TYSON, Kerry Louise, DRAPER, Simon John, REDGRAVE-O'DOWD, Victoria Louise
Year of Publication 03.06.2021
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Year of Publication 03.06.2021
Patent
ANTI-HLA-G ANTIBODIES
DOYLE, Carl Brendan, TYSON, Kerry Louise, HUMPHREYS, David Paul, COLLEY, Thomas, WHITE, Ann Louise, BERTEAU, Caroline, O'DOWD, Victoria, DEDI, Neesha, THOMPSON, Clare, LE FRIEC, Gaelle, MCELHONE, Ruth
Year of Publication 01.02.2024
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Year of Publication 01.02.2024
Patent
ANTIBODIES TO EBOLA VIRUS GLYCOPROTEIN
LIGHTWOOD, Daniel John, SMITH, Lisa Marie, RIJAL, Pramila, REDGRAVE-O'DOWD, Victoria, Louise, ELIAS, Sean Christopher, TOWNSEND, Alain, DRAPER, Simon John
Year of Publication 24.11.2021
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Year of Publication 24.11.2021
Patent
ANTI-HLA-G ANTIBODIES
DOYLE, Carl Brendan, TYSON, Kerry Louise, HUMPHREYS, David Paul, COLLEY, Thomas, WHITE, Ann Louise, BERTEAU, Caroline, O'DOWD, Victoria, DEDI, Neesha, THOMPSON, Clare, LE FRIEC, Gaelle, MCELHONE, Ruth
Year of Publication 23.02.2023
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Year of Publication 23.02.2023
Patent
ANTI-HLA-G ANTIBODIES
THOMPSON, CLARE, MCELHONE, RUTH, BERTEAU, CAROLINE, DEDI, NEESHA, DOYLE, CARL BRENDAN, TYSON, KERRY LOUISE, LE FRIEC, GAELLE, HUMPHREYS, DAVID PAUL, O'DOWD, VICTORIA, WHITE, ANN LOUISE, COLLEY, THOMAS
Year of Publication 23.02.2023
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Year of Publication 23.02.2023
Patent