Tissue-specific mutation accumulation in human adult stem cells during life
Blokzijl, Francis, de Ligt, Joep, Jager, Myrthe, Sasselli, Valentina, Roerink, Sophie, Sasaki, Nobuo, Huch, Meritxell, Boymans, Sander, Kuijk, Ewart, Prins, Pjotr, Nijman, Isaac J., Martincorena, Inigo, Mokry, Michal, Wiegerinck, Caroline L., Middendorp, Sabine, Sato, Toshiro, Schwank, Gerald, Nieuwenhuis, Edward E. S., Verstegen, Monique M. A., van der Laan, Luc J. W., de Jonge, Jeroen, IJzermans, Jan N. M., Vries, Robert G., van de Wetering, Marc, Stratton, Michael R., Clevers, Hans, Cuppen, Edwin, van Boxtel, Ruben
Published in Nature (London) (13.10.2016)
Published in Nature (London) (13.10.2016)
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Prime editing for functional repair in patient-derived disease models
Schene, Imre F., Joore, Indi P., Oka, Rurika, Mokry, Michal, van Vugt, Anke H. M., van Boxtel, Ruben, van der Doef, Hubert P. J., van der Laan, Luc J. W., Verstegen, Monique M. A., van Hasselt, Peter M., Nieuwenhuis, Edward E. S., Fuchs, Sabine A.
Published in Nature communications (23.10.2020)
Published in Nature communications (23.10.2020)
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LGR5 marks targetable tumor-initiating cells in mouse liver cancer
Cao, Wanlu, Li, Meng, Liu, Jiaye, Zhang, Shaoshi, Noordam, Lisanne, Verstegen, Monique M. A., Wang, Ling, Ma, Buyun, Li, Shan, Wang, Wenshi, Bolkestein, Michiel, Doukas, Michael, Chen, Kan, Ma, Zhongren, Bruno, Marco, Sprengers, Dave, Kwekkeboom, Jaap, van der Laan, Luc J. W., Smits, Ron, Peppelenbosch, Maikel P., Pan, Qiuwei
Published in Nature communications (23.04.2020)
Published in Nature communications (23.04.2020)
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Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease
Verstegen, Monique M. A., Roos, Floris J. M., Burka, Ksenia, Gehart, Helmuth, Jager, Myrthe, de Wolf, Maaike, Bijvelds, Marcel J. C., de Jonge, Hugo R., Ardisasmita, Arif I., van Huizen, Nick A., Roest, Henk P., de Jonge, Jeroen, Koch, Michael, Pampaloni, Francesco, Fuchs, Sabine A., Schene, Imre F., Luider, Theo M., van der Doef, Hubert P. J., Bodewes, Frank A. J. A., de Kleine, Ruben H. J., Spee, Bart, Kremers, Gert-Jan, Clevers, Hans, IJzermans, Jan N. M., Cuppen, Edwin, van der Laan, Luc J. W.
Published in Scientific reports (14.12.2020)
Published in Scientific reports (14.12.2020)
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Kinome profiling of cholangiocarcinoma organoids reveals potential druggable targets that hold promise for treatment stratification
Lieshout, Ruby, Faria, Alessandra V. S., Peppelenbosch, Maikel P., van der Laan, Luc J. W., Verstegen, Monique M. A., Fuhler, Gwenny M.
Published in Molecular medicine (Cambridge, Mass.) (28.06.2022)
Published in Molecular medicine (Cambridge, Mass.) (28.06.2022)
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Cholangiocyte organoids to study drug-induced injury
Wang, Zhenguo, Xing, Chen, van der Laan, Luc J W, Verstegen, Monique M A, Spee, Bart, Masereeuw, Rosalinde
Published in Stem cell research & therapy (13.03.2024)
Published in Stem cell research & therapy (13.03.2024)
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Label-Free Imaging Analysis of Patient-Derived Cholangiocarcinoma Organoids after Sorafenib Treatment
Koch, Michael, Nickel, Sandra, Lieshout, Ruby, Lissek, Susanna M, Leskova, Martina, van der Laan, Luc J W, Verstegen, Monique M A, Christ, Bruno, Pampaloni, Francesco
Published in Cells (Basel, Switzerland) (01.11.2022)
Published in Cells (Basel, Switzerland) (01.11.2022)
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Recombination-activating gene 1 ( Rag1 )–deficient mice with severe combined immunodeficiency treated with lentiviral gene therapy demonstrate autoimmune Omenn-like syndrome
van Til, Niek P., PhD, Sarwari, Roya, MSc, Visser, Trudi P., BSc, Hauer, Julia, MD, Lagresle-Peyrou, Chantal, PhD, van der Velden, Guus, BSc, Malshetty, Vidyasagar, PhD, Cortes, Patricia, PhD, Jollet, Arnaud, PhD, Danos, Olivier, PhD, Cassani, Barbara, PhD, Zhang, Fang, PhD, Thrasher, Adrian J., MD, PhD, Fontana, Elena, PhD, Poliani, Pietro L., MD, PhD, Cavazzana, Marina, MD, PhD, Verstegen, Monique M.A., PhD, Villa, Anna, MD, PhD, Wagemaker, Gerard, PhD
Published in Journal of allergy and clinical immunology (01.04.2014)
Published in Journal of allergy and clinical immunology (01.04.2014)
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Scalable Production of Size-Controlled Cholangiocyte and Cholangiocarcinoma Organoids within Liver Extracellular Matrix-Containing Microcapsules
van Tienderen, Gilles S, Willemse, Jorke, van Loo, Bas, van Hengel, Eline V A, de Jonge, Jeroen, van der Laan, Luc J W, Leijten, Jeroen, Verstegen, Monique M A
Published in Cells (Basel, Switzerland) (01.11.2022)
Published in Cells (Basel, Switzerland) (01.11.2022)
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Cholangiocyte organoids from human bile retain a local phenotype and can repopulate bile ducts in vitro
Roos, Floris J. M., Wu, Haoyu, Willemse, Jorke, Lieshout, Ruby, Albarinos, Laura A. Muñoz, Kan, Yik‐Yang, Poley, Jan‐Werner, Bruno, Marco J., Jonge, Jeroen, Bártfai, Richard, Marks, Hendrik, IJzermans, Jan N. M., Verstegen, Monique M. A., Laan, Luc J. W.
Published in Clinical and translational medicine (01.12.2021)
Published in Clinical and translational medicine (01.12.2021)
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Precancerous liver diseases do not cause increased mutagenesis in liver stem cells
Nguyen, Luan, Jager, Myrthe, Lieshout, Ruby, de Ruiter, Petra E., Locati, Mauro D., Besselink, Nicolle, van der Roest, Bastiaan, Janssen, Roel, Boymans, Sander, de Jonge, Jeroen, IJzermans, Jan N. M., Doukas, Michail, Verstegen, Monique M. A., van Boxtel, Ruben, van der Laan, Luc J. W., Cuppen, Edwin, Kuijk, Ewart
Published in Communications biology (18.11.2021)
Published in Communications biology (18.11.2021)
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Modelling immune cytotoxicity for cholangiocarcinoma with tumour-derived organoids and effector T cells
Zhou, Guoying, Lieshout, Ruby, van Tienderen, Gilles S., de Ruiter, Valeska, van Royen, Martin E., Boor, Patrick P. C., Magré, Luc, Desai, Jyaysi, Köten, Kübra, Kan, Yik Yang, Ge, Zhouhong, Campos Carrascosa, Lucia, Geuijen, Cecile, Sprengers, Dave, van der Laan, Luc J. W., Verstegen, Monique M. A., Kwekkeboom, Jaap
Published in British journal of cancer (01.09.2022)
Published in British journal of cancer (01.09.2022)
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Long-term live imaging and multiscale analysis identify heterogeneity and core principles of epithelial organoid morphogenesis
Hof, Lotta, Moreth, Till, Koch, Michael, Liebisch, Tim, Kurtz, Marina, Tarnick, Julia, Lissek, Susanna M, Verstegen, Monique M A, van der Laan, Luc J W, Huch, Meritxell, Matthäus, Franziska, Stelzer, Ernst H K, Pampaloni, Francesco
Published in BMC biology (24.02.2021)
Published in BMC biology (24.02.2021)
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Emerging organoid-immune co-culture models for cancer research: from oncoimmunology to personalized immunotherapies
Magré, Luc, Verstegen, Monique M A, Buschow, Sonja, van der Laan, Luc J W, Peppelenbosch, Maikel, Desai, Jyaysi
Published in Journal for immunotherapy of cancer (01.05.2023)
Published in Journal for immunotherapy of cancer (01.05.2023)
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Large‐Scale Production of LGR5‐Positive Bipotential Human Liver Stem Cells
Schneeberger, Kerstin, Sánchez‐Romero, Natalia, Ye, Shicheng, Steenbeek, Frank G., Oosterhoff, Loes A., Pla Palacin, Iris, Chen, Chen, Wolferen, Monique E., Tienderen, Gilles, Lieshout, Ruby, Colemonts‐Vroninks, Haaike, Schene, Imre, Hoekstra, Ruurdtje, Verstegen, Monique M.A., Laan, Luc J.W., Penning, Louis C., Fuchs, Sabine A., Clevers, Hans, De Kock, Joery, Baptista, Pedro M., Spee, Bart
Published in Hepatology (Baltimore, Md.) (01.07.2020)
Published in Hepatology (Baltimore, Md.) (01.07.2020)
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Recapitulating lipid accumulation and related metabolic dysregulation in human liver-derived organoids
Wang, Ling, Li, Meng, Yu, Bingting, Shi, Shaojun, Liu, Jiaye, Zhang, Ruyi, Ayada, Ibrahim, Verstegen, Monique M. A., van der Laan, Luc J. W., Peppelenbosch, Maikel P., Cao, Wanlu, Pan, Qiuwei
Published in Journal of molecular medicine (Berlin, Germany) (01.03.2022)
Published in Journal of molecular medicine (Berlin, Germany) (01.03.2022)
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Modeling liver cancer and therapy responsiveness using organoids derived from primary mouse liver tumors
Cao, Wanlu, Liu, Jiaye, Wang, Ling, Li, Meng, Verstegen, Monique M A, Yin, Yuebang, Ma, Buyun, Chen, Kan, Bolkestein, Michiel, Sprengers, Dave, van der Laan, Luc J W, Doukas, Michael, Kwekkeboom, Jaap, Smits, Ron, Peppelenbosch, Maikel P, Pan, Qiuwei
Published in Carcinogenesis (New York) (12.03.2019)
Published in Carcinogenesis (New York) (12.03.2019)
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Human primary liver cancer–derived organoid cultures for disease modeling and drug screening
Broutier, Laura, Mastrogiovanni, Gianmarco, Verstegen, Monique MA, Francies, Hayley E, Gavarró, Lena Morrill, Bradshaw, Charles R, Allen, George E, Arnes-Benito, Robert, Sidorova, Olga, Gaspersz, Marcia P, Georgakopoulos, Nikitas, Koo, Bon-Kyoung, Dietmann, Sabine, Davies, Susan E, Praseedom, Raaj K, Lieshout, Ruby, IJzermans, Jan N M, Wigmore, Stephen J, Saeb-Parsy, Kourosh, Garnett, Mathew J, van der Laan, Luc JW, Huch, Meritxell
Published in Nature Medicine (01.12.2017)
Published in Nature Medicine (01.12.2017)
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Lipid-mediated Wnt protein stabilization enables serum-free culture of human organ stem cells
Tüysüz, Nesrin, van Bloois, Louis, van den Brink, Stieneke, Begthel, Harry, Verstegen, Monique M. A., Cruz, Luis J., Hui, Lijian, van der Laan, Luc J. W., de Jonge, Jeroen, Vries, Robert, Braakman, Eric, Mastrobattista, Enrico, Cornelissen, Jan J., Clevers, Hans, ten Berge, Derk
Published in Nature communications (06.03.2017)
Published in Nature communications (06.03.2017)
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Scaffolds obtained from decellularized human extrahepatic bile ducts support organoids to establish functional biliary tissue in a dish
Willemse, Jorke, Roos, Floris J. M., Voogt, Iris J., Schurink, Ivo J., Bijvelds, Marcel, Jonge, Hugo R., Laan, Luc J. W., Jonge, Jeroen, Verstegen, Monique M. A.
Published in Biotechnology and bioengineering (01.02.2021)
Published in Biotechnology and bioengineering (01.02.2021)
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