Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer
Burger, Matthew T, Pecchi, Sabina, Wagman, Allan, Ni, Zhi-Jie, Knapp, Mark, Hendrickson, Thomas, Atallah, Gordana, Pfister, Keith, Zhang, Yanchen, Bartulis, Sarah, Frazier, Kelly, Ng, Simon, Smith, Aaron, Verhagen, Joelle, Haznedar, Joshua, Huh, Kay, Iwanowicz, Ed, Xin, Xiaohua, Menezes, Daniel, Merritt, Hanne, Lee, Isabelle, Wiesmann, Marion, Kaufman, Susan, Crawford, Kenneth, Chin, Michael, Bussiere, Dirksen, Shoemaker, Kevin, Zaror, Isabel, Maira, Sauveur-Michel, Voliva, Charles F
Published in ACS medicinal chemistry letters (13.10.2011)
Published in ACS medicinal chemistry letters (13.10.2011)
Get full text
Journal Article
Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma
Williams, Teresa E, Subramanian, Sharadha, Verhagen, Joelle, McBride, Christopher M, Costales, Abran, Sung, Leonard, Antonios-McCrea, William, McKenna, Maureen, Louie, Alicia K, Ramurthy, Savithri, Levine, Barry, Shafer, Cynthia M, Machajewski, Timothy, Renhowe, Paul A, Appleton, Brent A, Amiri, Payman, Chou, James, Stuart, Darrin, Aardalen, Kimberly, Poon, Daniel
Published in ACS medicinal chemistry letters (10.09.2015)
Published in ACS medicinal chemistry letters (10.09.2015)
Get full text
Journal Article
Synthesis and in Vitro and in Vivo Evaluation of Phosphoinositide-3-kinase Inhibitors
Burger, Matthew T, Knapp, Mark, Wagman, Allan, Ni, Zhi-Jie, Hendrickson, Thomas, Atallah, Gordana, Zhang, Yanchen, Frazier, Kelly, Verhagen, Joelle, Pfister, Keith, Ng, Simon, Smith, Aaron, Bartulis, Sarah, Merrit, Hanne, Weismann, Marion, Xin, Xiaohua, Haznedar, Joshua, Voliva, Charles F, Iwanowicz, Ed, Pecchi, Sabina
Published in ACS medicinal chemistry letters (13.01.2011)
Published in ACS medicinal chemistry letters (13.01.2011)
Get full text
Journal Article
Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model
Han, Wooseok, Menezes, Daniel L., Xu, Yongjin, Knapp, Mark S., Elling, Robert, Burger, Matthew T., Ni, Zhi-Jie, Smith, Aaron, Lan, Jiong, Williams, Teresa E., Verhagen, Joelle, Huh, Kay, Merritt, Hanne, Chan, John, Kaufman, Susan, Voliva, Charles F., Pecchi, Sabina
Published in Bioorganic & medicinal chemistry letters (01.02.2016)
Published in Bioorganic & medicinal chemistry letters (01.02.2016)
Get full text
Journal Article
Design and synthesis of 5,6-fused heterocyclic amides as Raf kinase inhibitors
Ramurthy, Savithri, Aikawa, Mina, Amiri, Payman, Costales, Abran, Hashash, Ahmad, Jansen, Johanna M., Lin, Song, Ma, Sylvia, Renhowe, Paul A., Shafer, Cynthia M., Subramanian, Sharadha, Sung, Leonard, Verhagen, Joelle
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
Get full text
Journal Article
Design and Synthesis of Orally Bioavailable Benzimidazole Reverse Amides as Pan RAF Kinase Inhibitors
Subramanian, Sharadha, Costales, Abran, Williams, Teresa E, Levine, Barry, McBride, Christopher M, Poon, Daniel, Amiri, Payman, Renhowe, Paul A, Shafer, Cynthia M, Stuart, Darrin, Verhagen, Joelle, Ramurthy, Savithri
Published in ACS medicinal chemistry letters (11.09.2014)
Published in ACS medicinal chemistry letters (11.09.2014)
Get full text
Journal Article
Correction to Design and Synthesis of Orally Bioavailable Benzimidazole Reverse Amides as Pan RAF Kinase Inhibitors
Subramanian, Sharadha, Costales, Abran, Williams, Teresa E, Levine, Barry, McBride, Christopher M, Poon, Daniel, Amiri, Payman, Renhowe, Paul A, Shafer, Cynthia M, Stuart, Darrin, Verhagen, Joelle, Ramurthy, Savithri
Published in ACS medicinal chemistry letters (11.12.2014)
Published in ACS medicinal chemistry letters (11.12.2014)
Get full text
Journal Article
Derivados de pirimidina, sua composição e seu uso
Louie Alicia, Burger Matthew, Smith Aaron, HENDRICKSON TOM, Zhang Yanchen, NG Simon, KNAPP MARK, Bartulis Sarah, Teresa E. Pick, Pfister Keith, Iwanowicz Edwin, Poon Daniel, Pecchi Sabina, VOLIVA CHARLES, MERITT HANNE, Frazier Kelly, Ni Zhi-Jie, Barsanti Paul, Xin Xiahua, Atallah Gordana, Verhagen Joelle, WIESMANN MARION, Wagman Allan, FANTL WENDY
Year of Publication 21.12.2021
Get full text
Year of Publication 21.12.2021
Patent
INHIBIDORES DE PI-3 QUINASA
SMITH, AARON, ATALLAH, GORDANA, PECCHI, SABINA, ZHANG, YANCHEN, FRAZIER, KELLY, VERHAGEN, JOELLE, NI, ZHI, BARTULLIS, SARAH, JIE - BURGER, MATTHEW
Year of Publication 25.09.2019
Get full text
Year of Publication 25.09.2019
Patent
SUBSTITUTED BENZAZOLES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE
HANSEN TERESA, MCBRIDE CHRISTOPHER, VERHAGEN JOELLE, LEVINE BARRY H, RAMURTHY SAVITHRI, SHAFER CYNTHIA M, SUBRAMANIAN SHARADHA, COSTALES ABRAN, POON DANIEL J, RENHOWE PAUL A
Year of Publication 29.08.2013
Get full text
Year of Publication 29.08.2013
Patent
Substituted benzazoles and methods of their use as inhibitors of RAF Kinase
HANSEN TERESA, MCBRIDE CHRISTOPHER, VERHAGEN JOELLE, LEVINE BARRY H, RAMURTHY SAVITHRI, SHAFER CYNTHIA M, SUBRAMANIAN SHARADHA, COSTALES ABRAN, POON DANIEL J, RENHOWE PAUL A
Year of Publication 09.04.2013
Get full text
Year of Publication 09.04.2013
Patent
PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE
PECCHI, SABINA, KNAPP, MARK, ZHANG, YANCHEN, PFISTER, KEITH, BURGER, MATTHEW, BARTULIS, SARAH, XIN, XIAHUA, WIESMANN, MARION, MERITT, HANNE, WAGMAN, ALLAN, POON, DANIEL, NI, ZHI-JIE, ATALLAH, GORDANA, SMITH, AARON, FANTL, WENDY, LOUIE, ALICIA, FRAZIER, KELLY, VERHAGEN, JOELLE, IWANOWICZ, EDWIN, BARSANTI, PAUL, PICK, TERESA, HENDRICKSON, THOMAS, VOLIVA, CHARLES, NG, SIMON
Year of Publication 28.02.2014
Get full text
Year of Publication 28.02.2014
Patent
PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS
PECCHI, SABINA, KNAPP, MARK, ZHANG, YANCHEN, PFISTER, KEITH, BURGER, MATTHEW, BARTULIS, SARAH, XIN, XIAHUA, WIESMANN, MARION, WAGMAN, ALLAN, POON, DANIEL, NI, ZHI-JIE, ATALLAH, GORDANA, SMITH, AARON, FANTL, WENDY, LOUIE, ALICIA, FRAZIER, KELLY, VERHAGEN, JOELLE, IWANOWICZ, EDWIN, BARSANTI, PAUL, PICK, TERESA, HENDRICKSON, THOMAS, MERRITT, HANNE, VOLIVA, CHARLES, NG, SIMON
Year of Publication 25.02.2014
Get full text
Year of Publication 25.02.2014
Patent
Pyrimidine derivatives used as pi-3 kinase inhibitors
PECCHI, SABINA, KNAPP, MARK, ZHANG, YANCHEN, PFISTER, KEITH, BURGER, MATTHEW, BARTULIS, SARAH, XIN, XIAHUA, WIESMANN, MARION, MERITT, HANNE, WAGMAN, ALLAN, POON, DANIEL, NI, ZHI-JIE, ATALLAH, GORDANA, SMITH, AARON, FANTL, WENDY, LOUIE, ALICIA, FRAZIER, KELLY, VERHAGEN, JOELLE, IWANOWICZ, EDWIN, BARSANTI, PAUL, PICK, TERESA, HENDRICKSON, THOMAS, VOLIVA, CHARLES, NG, SIMON
Year of Publication 31.12.2013
Get full text
Year of Publication 31.12.2013
Patent
Pyrimidine derivatives used as pi-3 kinase inhibitors
BURGER MATTHEW, FRAZIER KELLY, KNAPP MARK, XIN XIAHUA, LOUIE ALICIA, POON DANIEL, IWANOWICZ EDWIN, SMITH AARON, NG SIMON, VOLIVA CHARLES, HENDRICKSON THOMAS, MERITT HANNE, PICK TERESA, WAGMAN ALLAN, BARTULIS SARAH, VERHAGEN JOELLE, NI ZHI-JIE, PECCHI SABINA, BARSANTI PAUL, PFISTER KEITH, WIESMANN MARION, FANTL WENDY, ATALLAH GORDANA, ZHANG YANCHEN
Year of Publication 30.10.2013
Get full text
Year of Publication 30.10.2013
Patent
Pyrimidine derivatives used as PI-3 kinase inhibitors
BURGER MATTHEW, ATALIAH GORDANA, FRAZIER KELLY, KNAPP MARK, XIN XIAHUA, LOUIE ALICIA, IWANOWICZ EDWIN, SMITH AARON, NG SIMON, VOLIVA CHARLES, HENDRICKSON THOMAS, MERITT HANNE, PICK TERESA, WAGMAN ALLAN, BARTULIS SARAH, VERHAGEN JOELLE, NI ZHI-JIE, PECCHI SABINA, BARSANTI PAUL, PFISTER KEITH, POON DANIEL J, WIESMANN MARION, FANTL WENDY, ZHANG YANCHEN
Year of Publication 22.10.2013
Get full text
Year of Publication 22.10.2013
Patent
PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS
PECCHI, SABINA, KNAPP, MARK, ZHANG, YANCHEN, PFISTER, KEITH, BURGER, MATTHEW, BARTULIS, SARAH, XIN, XIAHUA, WIESMANN, MARION, MERITT, HANNE, WAGMAN, ALLAN, POON, DANIEL, NI, ZHI-JIE, ATALLAH, GORDANA, SMITH, AARON, FANTL, WENDY, LOUIE, ALICIA, FRAZIER, KELLY, VERHAGEN, JOELLE, IWANOWICZ, EDWIN, BARSANTI, PAUL, PICK, TERESA, HENDRICKSON, THOMAS, VOLIVA, CHARLES, NG, SIMON
Year of Publication 30.09.2013
Get full text
Year of Publication 30.09.2013
Patent
Pyrimidinderivater anvendt som PI-3-kinasehæmmere
PECCHI, SABINA, KNAPP, MARK, ZHANG, YANCHEN, PFISTER, KEITH, BURGER, MATTHEW, BARTULIS, SARAH, XIN, XIAHUA, WIESMANN, MARION, MERITT, HANNE, WAGMAN, ALLAN, POON, DANIEL, NI, ZHI-JIE, ATALLAH, GORDANA, SMITH, AARON, FANTL, WENDY, LOUIE, ALICIA, FRAZIER, KELLY, VERHAGEN, JOELLE, IWANOWICZ, EDWIN, BARSANTI, PAUL, PICK, TERESA, HENDRICKSON, THOMAS, VOLIVA, CHARLES, NG, SIMON
Year of Publication 23.09.2013
Get full text
Year of Publication 23.09.2013
Patent
PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS
EDWIN IWANOWICZ, XIAHUA XIN, DANIEL POON, ALICIA LOUIE, WENDY FANTL, AARON SMITH, THOMAS HENDRICKSON, ZHI-JIE NI, YANCHEN ZHANG, SIMON NG, ALLAN WAGMAN, KEITH PFISTER, HANNE MERITT, CHARLES VOLIVA, MATTHEW BURGER, MARK KNAPP, SABINA PECCHI, TERESA PICK, MARION WIESMANN, SARAH BARTULIS, GORDANA ATALLAH, JOELLE VERHAGEN, PAUL BARSANTI, KELLY FRAZIER
Year of Publication 16.09.2013
Get full text
Year of Publication 16.09.2013
Patent