Ultrasmall Folate Receptor Alpha Targeted Enzymatically Cleavable Silica Nanoparticle Drug Conjugates Augment Penetration and Therapeutic Efficacy in Models of Cancer
Wu, Fei, Chen, Pei-Ming, Gardinier, Thomas C., Turker, Melik Z., Venkatesan, Aranapakam M., Patel, Vaibhav, Khor, Tin, Bradbury, Michelle S., Wiesner, Ulrich B., Adams, Gregory P., Germano, Geno, Chen, Feng, Ma, Kai
Published in ACS nano (27.12.2022)
Published in ACS nano (27.12.2022)
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Bis(morpholino-1,3,5-triazine) Derivatives: Potent Adenosine 5′-Triphosphate Competitive Phosphatidylinositol-3-kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of Compound 26 (PKI-587), a Highly Efficacious Dual Inhibitor
Venkatesan, Aranapakam M, Dehnhardt, Christoph M, Delos Santos, Efren, Chen, Zecheng, Dos Santos, Osvaldo, Ayral-Kaloustian, Semiramis, Khafizova, Gulnaz, Brooijmans, Natasja, Mallon, Robert, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Yu, Ker, Gibbons, James, Abraham, Robert T, Chaudhary, Inder, Mansour, Tarek S
Published in Journal of medicinal chemistry (25.03.2010)
Published in Journal of medicinal chemistry (25.03.2010)
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Antitumor Efficacy of PKI-587, a Highly Potent Dual PI3K/mTOR Kinase Inhibitor
MALLON, Robert, FELDBERG, Larry R, HOLLANDER, Irwin, LUCAS, Judy, CHAUDHARY, Inder, DEHNHARDT, Christoph, DELOS SANTOS, Efren, ZECHENG CHEN, DOS SANTOS, Osvaldo, AYRAL-KALOUSTIAN, Semiramis, VENKATESAN, Aranapakam
Published in Clinical cancer research (15.05.2011)
Published in Clinical cancer research (15.05.2011)
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Synthetic Study toward Total Synthesis of (±)-Germine: Synthesis of (±)-4-Methylenegermine
Stork, Gilbert, Yamashita, Ayako, Hanson, Robert M, Phan, Ly, Phillips, Eifion, Dubé, Daniel, Bos, Pieter H, Clark, Andrew J, Gough, Maxwell, Greenlee, Mark L, Jiang, Yimin, Jones, Keith, Kitamura, Masato, Leonard, John, Liu, Tongzhu, Parsons, Philip J, Venkatesan, Aranapakam M
Published in Organic letters (06.10.2017)
Published in Organic letters (06.10.2017)
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Journal Article
Synthesis and SAR of Novel 4-Morpholinopyrrolopyrimidine Derivatives as Potent Phosphatidylinositol 3-Kinase Inhibitors
Chen, Zecheng, Venkatesan, Aranapakam M, Dehnhardt, Christoph M, Ayral-Kaloustian, Semiramis, Brooijmans, Natasja, Mallon, Robert, Feldberg, Larry, Hollander, Irwin, Lucas, Judy, Yu, Ker, Kong, Fangming, Mansour, Tarek S
Published in Journal of medicinal chemistry (22.04.2010)
Published in Journal of medicinal chemistry (22.04.2010)
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Journal Article
Lead Optimization of N-3-Substituted 7-Morpholinotriazolopyrimidines as Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of PKI-402
Dehnhardt, Christoph M, Venkatesan, Aranapakam M, Delos Santos, Efren, Chen, Zecheng, Santos, Osvaldo, Ayral-Kaloustian, Semiramis, Brooijmans, Natasja, Mallon, Robert, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Chaudhary, Inder, Yu, Ker, Gibbons, Jay, Abraham, Robert, Mansour, Tarek S
Published in Journal of medicinal chemistry (28.01.2010)
Published in Journal of medicinal chemistry (28.01.2010)
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PKI-179: An orally efficacious dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor
Venkatesan, Aranapakam M., Chen, Zecheng, Santos, Osvaldo Dos, Dehnhardt, Christoph, Santos, Efren Delos, Ayral-Kaloustian, Semiramis, Mallon, Robert, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Yu, Ker, Chaudhary, Inder, Mansour, Tarek S.
Published in Bioorganic & medicinal chemistry letters (01.10.2010)
Published in Bioorganic & medicinal chemistry letters (01.10.2010)
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Journal Article
2,4-Diamino-quinazolines as inhibitors of β-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer
Chen, Zecheng, Venkatesan, Aranapakam M., Dehnhardt, Christoph M., Santos, Osvaldo Dos, Santos, Efren Delos, Ayral-Kaloustian, Semiramis, Chen, Lei, Geng, Yi, Arndt, Kim T., Lucas, Judy, Chaudhary, Inder, Mansour, Tarek S.
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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Journal Article
Identification of 2-oxatriazines as highly potent pan-PI3K/mTOR dual inhibitors
Dehnhardt, Christoph M., Venkatesan, Aranapakam M., Chen, Zecheng, Delos-Santos, Efren, Ayral-Kaloustian, Semiramis, Brooijmans, Natasja, Yu, Ker, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Mallon, Robert
Published in Bioorganic & medicinal chemistry letters (15.08.2011)
Published in Bioorganic & medicinal chemistry letters (15.08.2011)
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Journal Article
5-Ureidobenzofuranone indoles as potent and efficacious inhibitors of PI3 kinase-α and mTOR for the treatment of breast cancer
Zhang, Nan, Ayral-Kaloustian, Semiramis, Anderson, James T., Nguyen, Thai, Das, Sasmita, Venkatesan, Aranapakam M., Brooijmans, Natasja, Lucas, Judy, Yu, Ker, Hollander, Irwin, Mallon, Robert
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Journal Article
5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of β-lactamases
Venkatesan, Aranapakam M., Agarwal, Atul, Abe, Takao, Ushirogochi, Hideki, Ado, Mihira, Tsuyoshi, Takasaki, Dos Santos, Osvaldo, Li, Zhong, Francisco, Gerry, Lin, Yang I., Petersen, Peter J., Yang, Youjun, Weiss, William J., Shlaes, David M., Mansour, Tarek S.
Published in Bioorganic & medicinal chemistry (15.02.2008)
Published in Bioorganic & medicinal chemistry (15.02.2008)
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Novel purine and pyrazolo[3,4- d]pyrimidine inhibitors of PI3 kinase-α: Hit to lead studies
Gilbert, Adam M., Nowak, Pawel, Brooijmans, Natasja, Bursavich, Matthew G., Dehnhardt, Christoph, Santos, Efren Delos, Feldberg, Larry R., Hollander, Irwin, Kim, Stephen, Lombardi, Sabrina, Park, Kaapjoo, Venkatesan, Aranapakam M., Mallon, Robert
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Journal Article
Stereoselective Synthesis of an Active Metabolite of the Potent PI3 Kinase Inhibitor PKI-179
Chen, Zecheng, Venkatesan, Aranapakam M, Dos Santos, Osvaldo, Delos Santos, Efren, Dehnhardt, Christoph M, Ayral-Kaloustian, Semiramis, Ashcroft, Joseph, McDonald, Leonard A, Mansour, Tarek S
Published in Journal of organic chemistry (05.03.2010)
Published in Journal of organic chemistry (05.03.2010)
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Journal Article
Design and Synthesis of Novel Diaminoquinazolines with in Vivo Efficacy for β-Catenin/T-Cell Transcriptional Factor 4 Pathway Inhibition
Dehnhardt, Christoph M, Venkatesan, Aranapakam M, Chen, Zecheng, Ayral-Kaloustian, Semiramis, Dos Santos, Osvaldo, Delos Santos, Efren, Curran, Kevin, Follettie, Max T, Diesl, Veronica, Lucas, Judy, Geng, Yi, DeJoy, Susan Quinn, Petersen, Rosanne, Chaudhary, Inder, Brooijmans, Natasja, Mansour, Tarek S, Arndt, Kim, Chen, Lei
Published in Journal of medicinal chemistry (28.01.2010)
Published in Journal of medicinal chemistry (28.01.2010)
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Journal Article
Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors
Venkatesan, Aranapakam M., Dehnhardt, Christoph M., Chen, Zecheng, Santos, Efren Delos, Dos Santos, Osvaldo, Bursavich, Matthew, Gilbert, Adam M., Ellingboe, John W., Ayral-Kaloustian, Semiramis, Khafizova, Gulnaz, Brooijmans, Natasja, Mallon, Robert, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Yu, Ker, Gibbons, Jay, Abraham, Robert, Mansour, Tarek S.
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Journal Article
Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity
Venkatesan, Aranapakam M, Dos Santos, O, Ellingboe, John, Evrard, Deborah A, Harrison, Boyd L, Smith, Deborah L, Scerni, Rosemary, Hornby, Geoffrey A, Schechter, Lee E, Andree, Terrence H
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Journal Article
Establishment of In Vitro Susceptibility Testing Methodologies and Comparative Activities of Piperacillin in Combination with the Penem β-Lactamase Inhibitor BLI-489
PETERSEN, Peter J, HAL JONES, C, VENKATESAN, Aranapakam M, MANSOUR, Tarek S, PROJAN, Steven J, BRADFORD, Patricia A
Published in Antimicrobial Agents and Chemotherapy (01.02.2009)
Published in Antimicrobial Agents and Chemotherapy (01.02.2009)
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Journal Article
Inhibition of OXA-1 β-Lactamase by Penems
BETHEL, Christopher R, DISTLER, Anne M, ANDERSON, Vernon E, LEONARD, David A, HUJER, Kristine M, ABE, Takao, VENKATESAN, Aranapakam M, MANSOUR, Tarek S, BONOMO, Robert A, RUSZCZYCKY, Mark W, CAREY, Marianne P, CAREY, Paul R, HUJER, Andrea M, TARACILA, Magda, HELFAND, Marion S, THOMSON, Jodi M, KALP, Matthew
Published in Antimicrobial Agents and Chemotherapy (01.09.2008)
Published in Antimicrobial Agents and Chemotherapy (01.09.2008)
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Journal Article
Structure−Activity Relationship of 6-Methylidene Penems Bearing Tricyclic Heterocycles as Broad-Spectrum β-Lactamase Inhibitors: Crystallographic Structures Show Unexpected Binding of 1,4-Thiazepine Intermediates
Venkatesan, Aranapakam M, Gu, Yansong, Santos, Osvaldo Dos, Abe, Takao, Agarwal, Atul, Yang, Youjun, Petersen, Peter J, Weiss, William J, Mansour, Tarek S, Nukaga, Michiyoshi, Hujer, Andrea M, Bonomo, Robert A, Knox, James R
Published in Journal of medicinal chemistry (16.12.2004)
Published in Journal of medicinal chemistry (16.12.2004)
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