Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol
Kaan, Hung Yi Kristal, Ulaganathan, Venkatasubramanian, Rath, Oliver, Prokopcová, Hana, Dallinger, Doris, Kappe, C. Oliver, Kozielski, Frank
Published in Journal of medicinal chemistry (12.08.2010)
Published in Journal of medicinal chemistry (12.08.2010)
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Crystal structure of [2-({[2-(dimethylamino-κ N )ethyl]imino-κ N }methyl)phenolato-κ O ](1,10-phen-anthroline-κ 2 N , N ')copper(II) perchlorate
Mamindla, Anjaneyulu, Varadhan, Manikandan, Velusamy, Marappan, Ulaganathan, Venkatasubramanian, Rajendiran, Venugopal
Published in Acta crystallographica. Section E, Crystallographic communications (01.04.2023)
Published in Acta crystallographica. Section E, Crystallographic communications (01.04.2023)
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Lead Generation for Human Mitotic Kinesin Eg5 Using Structure-based Virtual Screening and Validation by In-vitro and Cell-based Assays
Makala, Himesh, Alexandar, Soundarya Priya, Nagarajan, Devipriya, Mahapatra, Santanu Kar, Ulaganathan, Venkatasubramanian
Published in Current computer-aided drug design (01.01.2021)
Published in Current computer-aided drug design (01.01.2021)
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Molecular dynamics and coarse-grained dynamics studies of wild type and mutants to understand conformational changes in human transglutaminase 2
Srikanth, Srimari, Sridhar, Dharineesh K., Doppalapudi, Karthikeya, Sen, Taner Z., Ulaganathan, Venkatasubramanian, Yennamalli, Ragothaman M.
Published in Biophysical journal (08.02.2024)
Published in Biophysical journal (08.02.2024)
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Journal Article
Targeting the Bottlenecks in Levan Biosynthesis Pathway in Bacillus subtilis and Strain Optimization by Computational Modeling and Omics Integration
Immanuel, Aruldoss, Yennamalli, Ragothaman M, Ulaganathan, Venkatasubramanian
Published in Omics (Larchmont, N.Y.) (01.02.2024)
Published in Omics (Larchmont, N.Y.) (01.02.2024)
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Journal Article
Crystal structure of 2-({2-(dimethylamino-κN)ethylimino-κN}methyl)phenolato-κO(1,10-phen-anthroline-κ2 N,N')copper(II) perchlorate
Mamindla, Anjaneyulu, Varadhan, Manikandan, Velusamy, Marappan, Ulaganathan, Venkatasubramanian, Rajendiran, Venugopal
Published in Acta crystallographica. Section E, Crystallographic communications (01.03.2023)
Published in Acta crystallographica. Section E, Crystallographic communications (01.03.2023)
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Journal Article
Coarse grained modelling highlights the binding differences in the two different allosteric sites of the Human Kinesin EG5 and its implications in inhibitor design
Alexandar, Soundarya Priya, Yennamalli, Ragothaman M., Ulaganathan, Venkatasubramanian
Published in Computational biology and chemistry (01.08.2022)
Published in Computational biology and chemistry (01.08.2022)
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Journal Article
Structural Insights into a Unique Inhibitor Binding Pocket in Kinesin Spindle Protein
Ulaganathan, Venkatasubramanian, Talapatra, Sandeep K, Rath, Oliver, Pannifer, Andrew, Hackney, David D, Kozielski, Frank
Published in Journal of the American Chemical Society (13.02.2013)
Published in Journal of the American Chemical Society (13.02.2013)
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Ferulic acid derivative inhibits NorA efflux and in combination with ciprofloxacin curtails growth of MRSA in vitro and in vivo
Sundaramoorthy, Niranjana Sri, Mitra, Kartik, Ganesh, Jayasankari Senthil, Makala, Himesh, Lotha, Robert, Bhanuvalli, Shamprasad R., Ulaganathan, Venkatasubramanian, Tiru, Vaidehi, Sivasubramanian, Aravind, Nagarajan, Saisubramanian
Published in Microbial pathogenesis (01.11.2018)
Published in Microbial pathogenesis (01.11.2018)
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Dithiazole thione derivative as competitive NorA efflux pump inhibitor to curtail multi drug resistant clinical isolate of MRSA in a zebrafish infection model
Lowrence, Rene Christena, Raman, Thiagarajan, Makala, Himesh V., Ulaganathan, Venkatasubramanian, Subramaniapillai, Selva Ganesan, Kuppuswamy, Ashok Ayyappa, Mani, Anisha, Chittoor Neelakantan, Sundaresan, Nagarajan, Saisubramanian
Published in Applied microbiology and biotechnology (01.11.2016)
Published in Applied microbiology and biotechnology (01.11.2016)
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The crystal structure and biochemical characterization of Kif15: a bifunctional molecular motor involved in bipolar spindle formation and neuronal development
Klejnot, Marta, Falnikar, Aditi, Ulaganathan, Venkatasubramanian, Cross, Robert A., Baas, Peter W., Kozielski, Frank
Published in Acta crystallographica. Section D, Biological crystallography. (01.01.2014)
Published in Acta crystallographica. Section D, Biological crystallography. (01.01.2014)
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Convenient method for the synthesis of some novel chiral methyl 2‐(2‐oxo‐2H‐benzo[e][1,3]oxazin‐3(4H)‐yl)propanoate derivatives and biological evaluation of their antioxidant, cytotoxic, and molecular docking properties
Matam, Sivakumar, Kaliyan, Prabakaran, Selvaraj, Loganathan, Muthu, Seenivasa Perumal, Lohanathan, Bharathi Priya, Viswanadhan, Vijaya Padma, Makala, Himesh, Venkatasubramanian, Ulaganathan
Published in Journal of heterocyclic chemistry (01.02.2021)
Published in Journal of heterocyclic chemistry (01.02.2021)
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Journal Article
Structure−Activity Relationship and Multidrug Resistance Study of New S-trityl-l-Cysteine Derivatives As Inhibitors of Eg5
Kaan, Hung Yi Kristal, Weiss, Johanna, Menger, Dominik, Ulaganathan, Venkatasubramanian, Tkocz, Katarzyna, Laggner, Christian, Popowycz, Florence, Joseph, Benoît, Kozielski, Frank
Published in Journal of medicinal chemistry (24.03.2011)
Published in Journal of medicinal chemistry (24.03.2011)
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Identification of benzochromene derivatives as a highly specific NorA efflux pump inhibitor to mitigate the drug resistant strains of S. aureus
Ganesan, Asaithampi, Christena, Lowrence Rene, Venkata Subbarao, Himesh Makala, Venkatasubramanian, Ulaganathan, Thiagarajan, Raman, Sivaramakrishnan, Venkatabalasubramanian, Kasilingam, Kabilan, Saisubramanian, Nagarajan, Selva Ganesan, Subramaniapillai
Published in RSC advances (01.01.2016)
Published in RSC advances (01.01.2016)
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Journal Article
Structure-Activity Relationships and Molecular Docking of Novel Dihydropyrimidine-Based Mitotic Eg5 Inhibitors
Prokopcová, Hana, Dallinger, Doris, Uray, Georg, Kaan, Hung Yi Kristal, Ulaganathan, Venkatasubramanian, Kozielski, Frank, Laggner, Christian, Kappe, C. Oliver
Published in ChemMedChem (04.10.2010)
Published in ChemMedChem (04.10.2010)
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