Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents
Engers, Julie L, Rodriguez, Alice L, Konkol, Leah C, Morrison, Ryan D, Thompson, Analisa D, Byers, Frank W, Blobaum, Anna L, Chang, Sichen, Venable, Daryl F, Loch, Matthew T, Niswender, Colleen M, Daniels, J. Scott, Jones, Carrie K, Conn, P. Jeffrey, Lindsley, Craig W, Emmitte, Kyle A
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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Journal Article
Design of 4‑Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2
Felts, Andrew S, Rodriguez, Alice L, Smith, Katrina A, Engers, Julie L, Morrison, Ryan D, Byers, Frank W, Blobaum, Anna L, Locuson, Charles W, Chang, Sichen, Venable, Daryl F, Niswender, Colleen M, Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W, Emmitte, Kyle A
Published in Journal of medicinal chemistry (25.11.2015)
Published in Journal of medicinal chemistry (25.11.2015)
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Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety
Felts, Andrew S., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Manka, Jason T., Bates, Brittney S., Blobaum, Anna L., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
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Journal Article
Chemical Modulation of Mutant mGlu1 Receptors Derived from Deleterious GRM1 Mutations Found in Schizophrenics
Cho, Hyekyung P, Garcia-Barrantes, Pedro M, Brogan, John T, Hopkins, Corey R, Niswender, Colleen M, Rodriguez, Alice L, Venable, Daryl F, Morrison, Ryan D, Bubser, Michael, Daniels, J. Scott, Jones, Carrie K, Conn, P. Jeffrey, Lindsley, Craig W
Published in ACS chemical biology (17.10.2014)
Published in ACS chemical biology (17.10.2014)
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Journal Article
Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5
Felts, Andrew S., Rodriguez, Alice L., Morrison, Ryan D., Bollinger, Katrina A., Venable, Daryl F., Blobaum, Anna L., Byers, Frank W., Thompson Gray, Analisa, Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
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Journal Article
A Novel Class of Succinimide-Derived Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 1 Provides Insight into a Disconnect in Activity between the Rat and Human Receptors
Cho, Hyekyung P, Engers, Darren W, Venable, Daryl F, Niswender, Colleen M, Lindsley, Craig W, Conn, P. Jeffrey, Emmitte, Kyle A, Rodriguez, Alice L
Published in ACS chemical neuroscience (16.07.2014)
Published in ACS chemical neuroscience (16.07.2014)
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Journal Article
The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5
Morrison, Ryan D, Blobaum, Anna L, Byers, Frank W, Santomango, Tammy S, Bridges, Thomas M, Stec, Donald, Brewer, Katrina A, Sanchez-Ponce, Raymundo, Corlew, Melany M, Rush, Roger, Felts, Andrew S, Manka, Jason, Bates, Brittney S, Venable, Daryl F, Rodriguez, Alice L, Jones, Carrie K, Niswender, Colleen M, Conn, P Jeffrey, Lindsley, Craig W, Emmitte, Kyle A, Daniels, J Scott
Published in Drug metabolism and disposition (01.09.2012)
Published in Drug metabolism and disposition (01.09.2012)
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Journal Article
N-Alkylpyrido[1′,2′:1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu1/5 with CNS exposure in rodents
Felts, Andrew S., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Blobaum, Anna L., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Published in Bioorganic & medicinal chemistry letters (15.04.2016)
Published in Bioorganic & medicinal chemistry letters (15.04.2016)
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Journal Article
Discovery of molecular switches within the ADX-47273 mGlu₅ PAM scaffold that modulate modes of pharmacology to afford potent mGlu₅ NAMs, PAMs and partial antagonists
Lamb, Jeffrey P, Engers, Darren W, Niswender, Colleen M, Rodriguez, Alice L, Venable, Daryl F, Conn, P. Jeffrey, Lindsley, Craig W
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
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Journal Article
Discovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety
Bates, Brittney S, Rodriguez, Alice L, Felts, Andrew S, Morrison, Ryan D, Venable, Daryl F, Blobaum, Anna L, Byers, Frank W, Lawson, Kera P, Daniels, J Scott, Niswender, Colleen M, Jones, Carrie K, Conn, P Jeffrey, Lindsley, Craig W, Emmitte, Kyle A
Published in Bioorganic & medicinal chemistry letters (01.08.2014)
Published in Bioorganic & medicinal chemistry letters (01.08.2014)
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Journal Article
Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1
Manka, Jason T., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Cho, Hyekyung P., Blobaum, Anna L., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Published in Bioorganic & medicinal chemistry letters (15.09.2013)
Published in Bioorganic & medicinal chemistry letters (15.09.2013)
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Journal Article
N-Acyl-N′-arylpiperazines as negative allosteric modulators of mGlu1: Identification of VU0469650, a potent and selective tool compound with CNS exposure in rats
Lovell, Kimberly M., Felts, Andrew S., Rodriguez, Alice L., Venable, Daryl F., Cho, Hyekyung P., Morrison, Ryan D., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
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Journal Article
Discovery of N‑(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation
Felts, Andrew S, Rodriguez, Alice L, Blobaum, Anna L, Morrison, Ryan D, Bates, Brittney S, Thompson Gray, Analisa, Rook, Jerri M, Tantawy, Mohammed N, Byers, Frank W, Chang, Sichen, Venable, Daryl F, Luscombe, Vincent B, Tamagnan, Gilles D, Niswender, Colleen M, Daniels, J. Scott, Jones, Carrie K, Conn, P. Jeffrey, Lindsley, Craig W, Emmitte, Kyle A
Published in Journal of medicinal chemistry (22.06.2017)
Published in Journal of medicinal chemistry (22.06.2017)
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Journal Article
Substituted 1‑Phenyl-3-(pyridin-2-yl)urea Negative Allosteric Modulators of mGlu5: Discovery of a New Tool Compound VU0463841 with Activity in Rat Models of Cocaine Addiction
Amato, Russell J, Felts, Andrew S, Rodriguez, Alice L, Venable, Daryl F, Morrison, Ryan D, Byers, Frank W, Daniels, J. Scott, Niswender, Colleen M, Conn, P. Jeffrey, Lindsley, Craig W, Jones, Carrie K, Emmitte, Kyle A
Published in ACS chemical neuroscience (21.08.2013)
Published in ACS chemical neuroscience (21.08.2013)
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Journal Article
Synergistic antiviral activity of human interferon combinations in the hepatitis C virus replicon system
Larkin, Jonathan, Jin, Ling, Farmen, Mark, Venable, Daryl, Huang, Ying, Tan, Seng-Lai, Glass, John I
Published in Journal of interferon & cytokine research (01.05.2003)
Published in Journal of interferon & cytokine research (01.05.2003)
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Journal Article
Cytoskeletal Requirements for Hepatitis C Virus (HCV) RNA Synthesis in the HCV Replicon Cell Culture System
Bost, Anne G, Venable, Daryl, Liu, Lifei, Heinz, Beverly A
Published in Journal of Virology (01.04.2003)
Published in Journal of Virology (01.04.2003)
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Journal Article
N-Alkylpyrido[1 ',2 ':1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu(1/5) with CNS exposure in rodents
Felts, Andrew S., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Blobaum, Anna L., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Published in Bioorganic & medicinal chemistry letters (15.04.2016)
Published in Bioorganic & medicinal chemistry letters (15.04.2016)
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Journal Article
Discovery of a selective M-4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: Development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia
Le, Uyen, Melancon, Bruce J., Bridges, Thomas M., Vinson, Paige N., Utley, Thomas J., Lamsal, Atin, Rodriguez, Alice L., Venable, Daryl, Sheffler, Douglas J., Jones, Carrie K., Blobaum, Anna L., Wood, Michael R., Daniels, J. Scott, Conn, P. Jeffrey, Niswender, Colleen M., Lindsley, Craig W., Hopkins, Corey R.
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
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Journal Article
Discovery of VU0409106: A negative allosteric modulator of mGlu(5) with activity in a mouse model of anxiety
Felts, Andrew S., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Manka, Jason T., Bates, Brittney S., Blobaum, Anna L., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
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Journal Article
Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: Development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia
Le, Uyen, Melancon, Bruce J., Bridges, Thomas M., Vinson, Paige N., Utley, Thomas J., Lamsal, Atin, Rodriguez, Alice L., Venable, Daryl, Sheffler, Douglas J., Jones, Carrie K., Blobaum, Anna L., Wood, Michael R., Daniels, J. Scott, Conn, P. Jeffrey, Niswender, Colleen M., Lindsley, Craig W., Hopkins, Corey R.
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
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