Pre-clinical studies of EC2629, a highly potent folate- receptor-targeted DNA crosslinking agent
Reddy, Joseph A., Nelson, Melissa, Dircksen, Christina, Vetzel, Marilynn, Johnson, Theresa, Cross, Vicky, Westrick, Elaine, Qi, LongWu, Hahn, Spencer, Santhapuram, Hari Krishna, Parham, Garth, Wang, Kevin, Vaughn, Jeremy F., Felten, Albert, Pugh, Michael, Lu, June, Klein, Patrick, Vlahov, Iontcho R., Leamon, Christopher P.
Published in Scientific reports (29.07.2020)
Published in Scientific reports (29.07.2020)
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Folate–Vinca Alkaloid Conjugates for Cancer Therapy: A Structure–Activity Relationship
Leamon, Christopher P, Vlahov, Iontcho R, Reddy, Joseph A, Vetzel, Marilynn, Santhapuram, Hari Krishna R, You, Fei, Bloomfield, Alicia, Dorton, Ryan, Nelson, Melissa, Kleindl, Paul, Vaughn, Jeremy F, Westrick, Elaine
Published in Bioconjugate chemistry (19.03.2014)
Published in Bioconjugate chemistry (19.03.2014)
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Design and synthesis of a folate-receptor targeted diazepine-ring-opened pyrrolobenzodiazepine prodrug conjugate
Vlahov, Iontcho R., Qi, Longwu, Santhapuram, Hari Krishna R., Felten, Albert, Parham, Garth L., Zou, Ning, Wang, Kevin, You, Fei, Vaughn, Jeremy F., Hahn, Spencer J., Klein, Hanna F., Kleindl, Paul J., Reddy, Joe, Reno, Dan, Nicoson, Jeff, Leamon, Christopher P.
Published in Bioorganic & medicinal chemistry letters (01.04.2020)
Published in Bioorganic & medicinal chemistry letters (01.04.2020)
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Detecting Functional and Accessible Folate Receptor Expression in Cancer and Polycystic Kidneys
Chu, Haiyan, Shillingford, Jonathan M, Reddy, Joseph A, Westrick, Elaine, Nelson, Melissa, Wang, Emilia Z, Parker, Nikki, Felten, Albert E, Vaughn, Jeremy F, Xu, Le-Cun, Lu, Yingjuan J, Vlahov, Iontcho R, Leamon, Christopher P
Published in Molecular pharmaceutics (03.09.2019)
Published in Molecular pharmaceutics (03.09.2019)
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Latent Warheads for Targeted Cancer Therapy: Design and Synthesis of pro-Pyrrolobenzodiazepines and Conjugates
Vlahov, Iontcho R, Qi, Longwu, Kleindl, Paul J, Santhapuram, Hari K, Felten, Albert, Parham, Garth L, Wang, Kevin, You, Fei, Vaughn, Jeremy F, Hahn, Spencer J, Klein, Hanna F, Vetzel, Marilynn, Reddy, Joseph A, Nelson, Melissa, Nicoson, Jeff, Leamon, Christopher P
Published in Bioconjugate chemistry (20.12.2017)
Published in Bioconjugate chemistry (20.12.2017)
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Antiinflammatory Activity of a Novel Folic Acid Targeted Conjugate of the mTOR Inhibitor Everolimus
Lu, Yingjuan, Parker, Nikki, Kleindl, Paul J, Cross, Vicky A, Wollak, Kristin, Westrick, Elaine, Stinnette, Torian W, Gehrke, Mark A, Wang, Kevin, Santhapuram, Hari Krishna R, You, Fei, Hahn, Spencer J, Vaughn, Jeremy F, Klein, Patrick J, Vlahov, Iontcho R, Low, Philip S, Leamon, Christopher P
Published in Molecular medicine (Cambridge, Mass.) (08.07.2015)
Published in Molecular medicine (Cambridge, Mass.) (08.07.2015)
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Journal Article
Carbohydrate-Based Synthetic Approach to Control Toxicity Profiles of Folate−Drug Conjugates
Vlahov, Iontcho R, Santhapuram, Hari Krishna R, You, Fei, Wang, Yu, Kleindl, Paul J, Hahn, Spencer J, Vaughn, Jeremy F, Reno, Daniel S, Leamon, Christopher P
Published in Journal of organic chemistry (04.06.2010)
Published in Journal of organic chemistry (04.06.2010)
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Folate receptor-targeted aminopterin therapy is highly effective and specific in experimental models of autoimmune uveitis and autoimmune encephalomyelitis
Lu, Yingjuan, Wollak, Kristin N, Cross, Vicky A, Westrick, Elaine, Wheeler, Leroy W, Stinnette, Torian W, Vaughn, Jeremy F, Hahn, Spencer J, Xu, Le-Cun, Vlahov, Iontcho R, Leamon, Christopher P
Published in Clinical immunology (Orlando, Fla.) (01.01.2014)
Published in Clinical immunology (Orlando, Fla.) (01.01.2014)
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Journal Article
Design and regioselective synthesis of a new generation of targeted therapeutics. Part 3: Folate conjugates of aminopterin hydrazide for the treatment of inflammation
Vlahov, Iontcho R., You, Fei, Santhapuram, Hari Krishna R., Wang, Yu, Vaughn, Jeremy F., Hahn, Spencer J., Kleindl, Paul J., Fan, Mingjin, Leamon, Christopher P.
Published in Bioorganic & medicinal chemistry letters (15.02.2011)
Published in Bioorganic & medicinal chemistry letters (15.02.2011)
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Intramolecular Chiral Relay at Stereogenic Nitrogen. Synthesis and Application of a New Chiral Auxiliary Derived from (1R,2S)-Norephedrine and Acetone
Hitchcock, Shawn R, Casper, David M, Vaughn, Jeremy F, Finefield, Jennifer M, Ferrence, Gregory M, Esken, Joel M
Published in Journal of organic chemistry (06.02.2004)
Published in Journal of organic chemistry (06.02.2004)
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Abstract 216: pro -Pyrrolobenzodiazepine ( pro -PBD) bioconjugates, the legacy: Design and synthesis of pro -PBD conjugates containing self-immolative substituted disulfide linkers
Vlahov, Iontcho, Qi, Longwu, Santhapuram, Hari K., Parham, Garth, Wang, Kevin, Vaughn, Jeremy F., Hahn, Spencer J., Vetzel, Marilynn, Nelson, Melissa, Reddy, Joseph A., Leamon, Christopher P.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract 4017: Development and application of an immunohistochemistry-based assay for evaluating functional and accessible folate receptor expression in vivo
Chu, Haiyan, Shillingford, Jonathan M., Parker, Nikki, Nelson, Melissa, Vaughn, Jeremy F., Felten, Albert, Lu, Yingjuan, Reddy, Joseph A., Vlahov, Iontcho R., Leamon, Christopher P.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Abstract 5515: Design and synthesis of releasable folate-drug conjugates possessing optimized carbohydrate-based spacer units
Vlahov, Iontcho R., Santhapuram, Hari Krishna R., Wang, Yu, You, Fei, Kleindl, Paul J., Fan, Mingjin, Vaughn, Jeremy F., Han, Spencer J., Leamon, Christopher P.
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Synthesis, asymmetric aldol reactions, and X-ray crystallography of some oxadiazinanone derivatives
Hitchcock, Shawn R., Davis, Ryan A., Richmond, Daniel M., Dore, Delvis D., Kuschel, Stephanie L., Vaughn, Jeremy F., Wolfe, Jesse A., Hamaker, Christopher G., Casper, David M., Dingle, Jarvis
Published in Journal of heterocyclic chemistry (01.09.2008)
Published in Journal of heterocyclic chemistry (01.09.2008)
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ChemInform Abstract: Synthesis, Asymmetric Aldol Reactions, and X-Ray Crystallography of Some Oxadiazinanone Derivatives
Hitchcock, Shawn R., Davis, Ryan A., Richmond, Daniel M., Dore, Delvis D., Kuschel, Stephanie L., Vaughn, Jeremy F., Wolfe, Jesse A., Hamaker, Christopher G., Casper, David M., Dingle, Jarvis
Published in ChemInform (10.02.2009)
Published in ChemInform (10.02.2009)
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