Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications
Vatine, Gad D., Barrile, Riccardo, Workman, Michael J., Sances, Samuel, Barriga, Bianca K., Rahnama, Matthew, Barthakur, Sonalee, Kasendra, Magdalena, Lucchesi, Carolina, Kerns, Jordan, Wen, Norman, Spivia, Weston R., Chen, Zhaohui, Van Eyk, Jennifer, Svendsen, Clive N.
Published in Cell stem cell (06.06.2019)
Published in Cell stem cell (06.06.2019)
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Journal Article
An isogenic blood–brain barrier model comprising brain endothelial cells, astrocytes, and neurons derived from human induced pluripotent stem cells
Canfield, Scott G., Stebbins, Matthew J., Morales, Bethsymarie Soto, Asai, Shusaku W., Vatine, Gad D., Svendsen, Clive N., Palecek, Sean P., Shusta, Eric V.
Published in Journal of neurochemistry (01.03.2017)
Published in Journal of neurochemistry (01.03.2017)
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Journal Article
Modeling Psychomotor Retardation using iPSCs from MCT8-Deficient Patients Indicates a Prominent Role for the Blood-Brain Barrier
Vatine, Gad D., Al-Ahmad, Abraham, Barriga, Bianca K., Svendsen, Soshana, Salim, Ariel, Garcia, Leslie, Garcia, Veronica J., Ho, Ritchie, Yucer, Nur, Qian, Tongcheng, Lim, Ryan G., Wu, Jie, Thompson, Leslie M., Spivia, Weston R., Chen, Zhaohui, Van Eyk, Jennifer, Palecek, Sean P., Refetoff, Samuel, Shusta, Eric V., Svendsen, Clive N.
Published in Cell stem cell (01.06.2017)
Published in Cell stem cell (01.06.2017)
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Journal Article
Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits
Lim, Ryan G., Quan, Chris, Reyes-Ortiz, Andrea M., Lutz, Sarah E., Kedaigle, Amanda J., Gipson, Theresa A., Wu, Jie, Vatine, Gad D., Stocksdale, Jennifer, Casale, Malcolm S., Svendsen, Clive N., Fraenkel, Ernest, Housman, David E., Agalliu, Dritan, Thompson, Leslie M.
Published in Cell reports (Cambridge) (16.05.2017)
Published in Cell reports (Cambridge) (16.05.2017)
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Journal Article
Impedance Characteristics of Microfluidic Channels and Integrated Coplanar Parallel Electrodes as Design Parameters for Whole-Channel Analysis in Organ-on-Chip Micro-Systems
Rapier, Crystal E, Jagadeesan, Srikanth, Vatine, Gad D, Ben-Yoav, Hadar
Published in Biosensors (Basel) (01.08.2024)
Published in Biosensors (Basel) (01.08.2024)
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Journal Article
The light-induced transcriptome of the zebrafish pineal gland reveals complex regulation of the circadian clockwork by light
Ben-Moshe, Zohar, Alon, Shahar, Mracek, Philipp, Faigenbloom, Lior, Tovin, Adi, Vatine, Gad D, Eisenberg, Eli, Foulkes, Nicholas S, Gothilf, Yoav
Published in Nucleic acids research (01.04.2014)
Published in Nucleic acids research (01.04.2014)
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Journal Article
Generation of iPSC lines from two (BGUi002-A and BGUi003-A) homozygous p450 oxidoreductase-deficient patients and from one (BGUi001-A) heterozygous healthy family relative
Zlotnik, Dor, Rabinski, Tatiana, Ofir, Rivka, Hershkovitz, Eli, Vatine, Gad D.
Published in Stem cell research (01.10.2020)
Published in Stem cell research (01.10.2020)
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Journal Article
Induced pluripotent stem cell (iPSC) lines from two individuals carrying a homozygous (BGUi007-A) and a heterozygous (BGUi006-A) mutation in ELP1 for in vitro modeling of familial dysautonomia
Dor, Lior, Rabinski, Tatiana, Zlotnik, Dor, Shilian, Michal, Weil, Miguel, Vatine, Gad D.
Published in Stem cell research (01.08.2021)
Published in Stem cell research (01.08.2021)
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Journal Article
Generation and characterization of iPSC lines (BGUi004-A, BGUi005-A) from two identical twins with polyalanine expansion in the paired-like homeobox 2B (PHOX2B) gene
Falik, Daniel, Rabinski, Tatiana, Zlotnik, Dor, Eshel, Reut, Zorsky, Meshi, Garin-Shkolnik, Tali, Ofir, Rivka, Adato, Avital, Ashkenazi, Avraham, Vatine, Gad D.
Published in Stem cell research (01.10.2020)
Published in Stem cell research (01.10.2020)
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Journal Article
Reprogramming of two induced pluripotent stem cell lines from a heterozygous GRIN2D developmental and epileptic encephalopathy (DEE) patient (BGUi011-A) and from a healthy family relative (BGUi012-A)
Rabinski, Tatiana, Sagiv, Sivan T., Hausman-Kedem, Moran, Fattal-Valevski, Aviva, Rubinstein, Moran, Avraham, Karen B., Vatine, Gad D.
Published in Stem cell research (01.03.2021)
Published in Stem cell research (01.03.2021)
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Journal Article
SnapShot: Autonomic nervous system disorders
Sharabi, Yehonatan, Vatine, Gad D., Ashkenazi, Avraham
Published in Neuron (Cambridge, Mass.) (20.04.2022)
Published in Neuron (Cambridge, Mass.) (20.04.2022)
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Journal Article
Proteomic analysis of human iPSC-derived sympathetic neurons identifies proteostasis collapse as a molecular signature following subtoxic rotenone exposure
Gordon, Tamar, Saleh, Mahmood Ali, Pasmanik-Chor, Metsada, Vatine, Gad D, Ashkenazi, Avraham
Published in Toxicology (Amsterdam) (25.11.2024)
Published in Toxicology (Amsterdam) (25.11.2024)
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Journal Article
Sodium Phenylbutyrate Rescues Thyroid Hormone Transport in Brain Endothelial-Like Cells
Braun, Doreen, Bohleber, Simon, Vatine, Gad D, Svendsen, Clive N, Schweizer, Ulrich
Published in Thyroid (New York, N.Y.) (01.07.2022)
Published in Thyroid (New York, N.Y.) (01.07.2022)
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Journal Article
Chronic and acute exposure to rotenone reveals distinct Parkinson's disease-related phenotypes in human iPSC-derived peripheral neurons
Saleh, Mahmood Ali, Amer-Sarsour, Fatima, Berant, Asaf, Pasmanik-Chor, Metsada, Kobo, Hila, Sharabi, Yehonatan, Vatine, Gad D., Ashkenazi, Avraham
Published in Free radical biology & medicine (01.03.2024)
Published in Free radical biology & medicine (01.03.2024)
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Journal Article
Introducing ADNP and SIRT1 as new partners regulating microtubules and histone methylation
Hadar, Adva, Kapitansky, Oxana, Ganaiem, Maram, Sragovich, Shlomo, Lobyntseva, Alexandra, Giladi, Eliezer, Yeheskel, Adva, Avitan, Aliza, Vatine, Gad D., Gurwitz, David, Ivashko-Pachima, Yanina, Gozes, Illana
Published in Molecular psychiatry (01.11.2021)
Published in Molecular psychiatry (01.11.2021)
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Journal Article
Disease-associated polyalanine expansion mutations impair UBA6-dependent ubiquitination
Amer-Sarsour, Fatima, Falik, Daniel, Berdichevsky, Yevgeny, Kordonsky, Alina, Eid, Sharbel, Rabinski, Tatiana, Ishtayeh, Hasan, Cohen-Adiv, Stav, Braverman, Itzhak, Blumen, Sergiu C, Laviv, Tal, Prag, Gali, Vatine, Gad D, Ashkenazi, Avraham
Published in The EMBO journal (16.01.2024)
Published in The EMBO journal (16.01.2024)
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Journal Article
Oligodendrocyte progenitor cell maturation is dependent on dual function of MCT8 in the transport of thyroid hormone across brain barriers and the plasma membrane
Vatine, Gad D., Shelest, Oksana, Barriga, Bianca K., Ofan, Raz, Rabinski, Tatyana, Mattis, Virginia B., Heuer, Heike, Svendsen, Clive N.
Published in Glia (01.09.2021)
Published in Glia (01.09.2021)
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Journal Article
AAV9-MCT8 Delivery at Juvenile Stage Ameliorates Neurological and Behavioral Deficits in a Mouse Model of MCT8-Deficiency
Liao, Xiao-Hui, Avalos, Pablo, Shelest, Oksana, Ofan, Raz, Shilo, Michael, Bresee, Catherine, Likhite, Shibi, Vit, Jean-Philippe, Heuer, Heike, Kaspar, Brian, Meyer, Kathrin, Dumitrescu, Alexandra M, Refetoff, Samuel, Svendsen, Clive N, Vatine, Gad D
Published in Thyroid (New York, N.Y.) (01.07.2022)
Published in Thyroid (New York, N.Y.) (01.07.2022)
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