A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia
Tzelepis, Konstantinos, Koike-Yusa, Hiroko, De Braekeleer, Etienne, Li, Yilong, Metzakopian, Emmanouil, Dovey, Oliver M., Mupo, Annalisa, Grinkevich, Vera, Li, Meng, Mazan, Milena, Gozdecka, Malgorzata, Ohnishi, Shuhei, Cooper, Jonathan, Patel, Miten, McKerrell, Thomas, Chen, Bin, Domingues, Ana Filipa, Gallipoli, Paolo, Teichmann, Sarah, Ponstingl, Hannes, McDermott, Ultan, Saez-Rodriguez, Julio, Huntly, Brian J.P., Iorio, Francesco, Pina, Cristina, Vassiliou, George S., Yusa, Kosuke
Published in Cell reports (Cambridge) (18.10.2016)
Published in Cell reports (Cambridge) (18.10.2016)
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Leukemia-Associated Somatic Mutations Drive Distinct Patterns of Age-Related Clonal Hemopoiesis
McKerrell, Thomas, Park, Naomi, Moreno, Thaidy, Grove, Carolyn S., Ponstingl, Hannes, Stephens, Jonathan, Crawley, Charles, Craig, Jenny, Scott, Mike A., Hodkinson, Clare, Baxter, Joanna, Rad, Roland, Forsyth, Duncan R., Quail, Michael A., Zeggini, Eleftheria, Ouwehand, Willem, Varela, Ignacio, Vassiliou, George S.
Published in Cell reports (Cambridge) (03.03.2015)
Published in Cell reports (Cambridge) (03.03.2015)
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Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia
Yankova, Eliza, Blackaby, Wesley, Albertella, Mark, Rak, Justyna, De Braekeleer, Etienne, Tsagkogeorga, Georgia, Pilka, Ewa S., Aspris, Demetrios, Leggate, Dan, Hendrick, Alan G., Webster, Natalie A., Andrews, Byron, Fosbeary, Richard, Guest, Patrick, Irigoyen, Nerea, Eleftheriou, Maria, Gozdecka, Malgorzata, Dias, Joao M. L., Bannister, Andrew J., Vick, Binje, Jeremias, Irmela, Vassiliou, George S., Rausch, Oliver, Tzelepis, Konstantinos, Kouzarides, Tony
Published in Nature (London) (27.05.2021)
Published in Nature (London) (27.05.2021)
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Clonal dynamics of haematopoiesis across the human lifespan
Mitchell, Emily, Spencer Chapman, Michael, Williams, Nicholas, Dawson, Kevin J., Mende, Nicole, Calderbank, Emily F., Jung, Hyunchul, Mitchell, Thomas, Coorens, Tim H. H., Spencer, David H., Machado, Heather, Lee-Six, Henry, Davies, Megan, Hayler, Daniel, Fabre, Margarete A., Mahbubani, Krishnaa, Abascal, Federico, Cagan, Alex, Vassiliou, George S., Baxter, Joanna, Martincorena, Inigo, Stratton, Michael R., Kent, David G., Chatterjee, Krishna, Parsy, Kourosh Saeb, Green, Anthony R., Nangalia, Jyoti, Laurenti, Elisa, Campbell, Peter J.
Published in Nature (London) (09.06.2022)
Published in Nature (London) (09.06.2022)
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The longitudinal dynamics and natural history of clonal haematopoiesis
Fabre, Margarete A., de Almeida, José Guilherme, Fiorillo, Edoardo, Mitchell, Emily, Damaskou, Aristi, Rak, Justyna, Orrù, Valeria, Marongiu, Michele, Chapman, Michael Spencer, Vijayabaskar, M. S., Baxter, Joanna, Hardy, Claire, Abascal, Federico, Williams, Nicholas, Nangalia, Jyoti, Martincorena, Iñigo, Campbell, Peter J., McKinney, Eoin F., Cucca, Francesco, Gerstung, Moritz, Vassiliou, George S.
Published in Nature (London) (09.06.2022)
Published in Nature (London) (09.06.2022)
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Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis
Kar, Siddhartha P., Quiros, Pedro M., Gu, Muxin, Jiang, Tao, Mitchell, Jonathan, Langdon, Ryan, Iyer, Vivek, Barcena, Clea, Vijayabaskar, M. S., Fabre, Margarete A., Carter, Paul, Petrovski, Slavé, Burgess, Stephen, Vassiliou, George S.
Published in Nature genetics (01.08.2022)
Published in Nature genetics (01.08.2022)
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METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation
Orellana, Esteban A., Liu, Qi, Yankova, Eliza, Pirouz, Mehdi, De Braekeleer, Etienne, Zhang, Wencai, Lim, Jihoon, Aspris, Demetrios, Sendinc, Erdem, Garyfallos, Dimitrios A., Gu, Muxin, Ali, Raja, Gutierrez, Alejandro, Mikutis, Sigitas, Bernardes, Gonçalo J.L., Fischer, Eric S., Bradley, Allan, Vassiliou, George S., Slack, Frank J., Tzelepis, Konstantinos, Gregory, Richard I.
Published in Molecular cell (19.08.2021)
Published in Molecular cell (19.08.2021)
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Effect of Mutation Order on Myeloproliferative Neoplasms
Ortmann, Christina A, Kent, David G, Nangalia, Jyoti, Silber, Yvonne, Wedge, David C, Grinfeld, Jacob, Baxter, E. Joanna, Massie, Charles E, Papaemmanuil, Elli, Menon, Suraj, Godfrey, Anna L, Dimitropoulou, Danai, Guglielmelli, Paola, Bellosillo, Beatriz, Besses, Carles, Döhner, Konstanze, Harrison, Claire N, Vassiliou, George S, Vannucchi, Alessandro, Campbell, Peter J, Green, Anthony R
Published in The New England journal of medicine (12.02.2015)
Published in The New England journal of medicine (12.02.2015)
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Clonal hematopoiesis and hematological malignancy
Dunn, William G, McLoughlin, Matthew A, Vassiliou, George S
Published in The Journal of clinical investigation (01.10.2024)
Published in The Journal of clinical investigation (01.10.2024)
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Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia
Uckelmann, Hannah J, Kim, Stephanie M, Wong, Eric M, Hatton, Charles, Giovinazzo, Hugh, Gadrey, Jayant Y, Krivtsov, Andrei V, Rücker, Frank G, Döhner, Konstanze, McGeehan, Gerard M, Levine, Ross L, Bullinger, Lars, Vassiliou, George S, Armstrong, Scott A
Published in Science (American Association for the Advancement of Science) (31.01.2020)
Published in Science (American Association for the Advancement of Science) (31.01.2020)
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Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML
Basheer, Faisal, Giotopoulos, George, Meduri, Eshwar, Yun, Haiyang, Mazan, Milena, Sasca, Daniel, Gallipoli, Paolo, Marando, Ludovica, Gozdecka, Malgorzata, Asby, Ryan, Sheppard, Olivia, Dudek, Monika, Bullinger, Lars, Döhner, Hartmut, Dillon, Richard, Freeman, Sylvie, Ottmann, Oliver, Burnett, Alan, Russell, Nigel, Papaemmanuil, Elli, Hills, Robert, Campbell, Peter, Vassiliou, George S, Huntly, Brian J P
Published in The Journal of experimental medicine (01.04.2019)
Published in The Journal of experimental medicine (01.04.2019)
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TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells
Rasmussen, Kasper D, Berest, Ivan, Keβler, Sandra, Nishimura, Koutarou, Simón-Carrasco, Lucía, Vassiliou, George S, Pedersen, Marianne T, Christensen, Jesper, Zaugg, Judith B, Helin, Kristian
Published in Genome research (01.04.2019)
Published in Genome research (01.04.2019)
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