Pharmacologic Inhibitor of DNA-PK, M3814, Potentiates Radiotherapy and Regresses Human Tumors in Mouse Models
Zenke, Frank T, Zimmermann, Astrid, Sirrenberg, Christian, Dahmen, Heike, Kirkin, Vladimir, Pehl, Ulrich, Grombacher, Thomas, Wilm, Claudia, Fuchss, Thomas, Amendt, Christiane, Vassilev, Lyubomir T, Blaukat, Andree
Published in Molecular cancer therapeutics (01.05.2020)
Published in Molecular cancer therapeutics (01.05.2020)
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Discovery of RG7388, a Potent and Selective p53–MDM2 Inhibitor in Clinical Development
Ding, Qingjie, Zhang, Zhuming, Liu, Jin-Jun, Jiang, Nan, Zhang, Jing, Ross, Tina M, Chu, Xin-Jie, Bartkovitz, David, Podlaski, Frank, Janson, Cheryl, Tovar, Christian, Filipovic, Zoran M, Higgins, Brian, Glenn, Kelli, Packman, Kathryn, Vassilev, Lyubomir T, Graves, Bradford
Published in Journal of medicinal chemistry (25.07.2013)
Published in Journal of medicinal chemistry (25.07.2013)
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Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
Chang, Yong S, Graves, Bradford, Guerlavais, Vincent, Tovar, Christian, Packman, Kathryn, To, Kwong-Him, Olson, Karen A, Kesavan, Kamala, Gangurde, Pranoti, Mukherjee, Aditi, Baker, Theresa, Darlak, Krzysztof, Elkin, Carl, Filipovic, Zoran, Qureshi, Farooq Z, Cai, Hongliang, Berry, Pamela, Feyfant, Eric, Shi, Xiangguo E, Horstick, James, Annis, D Allen, Manning, Anthony M, Fotouhi, Nader, Nash, Huw, Vassilev, Lyubomir T, Sawyer, Tomi K
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.2013)
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MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models
TOVAR, Christian, GRAVES, Bradford, LINN, Michael, PODLASKI, Frank, WOVKULICH, Peter, VU, Binh, VASSILEV, Lyubomir T, PACKMAN, Kathryn, FILIPOVIC, Zoran, HIGGINS MINGXUAN XIA, Brian, TARDELL, Christine, GARRIDO, Rosario, LEE, Edmund, KOLINSKY, Kenneth, TO, Kwong-Him
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Therapeutic Implications of p53 Status on Cancer Cell Fate Following Exposure to Ionizing Radiation and the DNA-PK Inhibitor M3814
Sun, Qing, Guo, Yige, Liu, Xiaohong, Czauderna, Frank, Carr, Michael I, Zenke, Frank T, Blaukat, Andree, Vassilev, Lyubomir T
Published in Molecular cancer research (01.12.2019)
Published in Molecular cancer research (01.12.2019)
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Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2 -amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study
Ray-Coquard, Isabelle, Dr, Blay, Jean-Yves, Prof, Italiano, Antoine, MD, Le Cesne, Axel, MD, Penel, Nicolas, MD, Zhi, Jianguo, PhD, Heil, Florian, PhD, Rueger, Ruediger, MD, Graves, Bradford, PhD, Ding, Meichun, PhD, Geho, David, MD, Middleton, Steven A, PhD, Vassilev, Lyubomir T, PhD, Nichols, Gwen L, MD, Bui, Binh Nguyen, MD
Published in The lancet oncology (01.11.2012)
Published in The lancet oncology (01.11.2012)
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A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies
Zimmermann, Astrid, Zenke, Frank T, Chiu, Li-Ya, Dahmen, Heike, Pehl, Ulrich, Fuchss, Thomas, Grombacher, Thomas, Blume, Beatrix, Vassilev, Lyubomir T, Blaukat, Andree
Published in Molecular cancer therapeutics (01.06.2022)
Published in Molecular cancer therapeutics (01.06.2022)
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Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization
Graves, Bradford, Thompson, Thelma, Xia, Mingxuan, Janson, Cheryl, Lukacs, Christine, Deo, Dayanand, Di Lello, Paola, Fry, David, Garvie, Colin, Huang, Kuo-Sen, Gao, Lin, Tovar, Christian, Lovey, Allen, Wanner, Jutta, Vassilev, Lyubomir T
Published in Proceedings of the National Academy of Sciences - PNAS (17.07.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (17.07.2012)
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Selective Small-Molecule Inhibitor Reveals Critical Mitotic Functions of Human CDK1
Vassilev, Lyubomir T., Tovar, Christian, Chen, Shaoqing, Knezevic, Dejan, Zhao, Xiaolan, Sun, Hongmao, Heimbrook, David C., Chen, Li
Published in Proceedings of the National Academy of Sciences - PNAS (11.07.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (11.07.2006)
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DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia
Haines, Eric, Nishida, Yuki, Carr, Michael I, Montoya, Rafael Heinz, Ostermann, Lauren B, Zhang, Weiguo, Zenke, Frank T, Blaukat, Andree, Andreeff, Michael, Vassilev, Lyubomir T
Published in Scientific reports (09.06.2021)
Published in Scientific reports (09.06.2021)
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Small-Molecule MDM2 Antagonists Reveal Aberrant P53 Signaling in Cancer: Implications for Therapy
Tovar, Christian, Rosinski, James, Filipovic, Zoran, Higgins, Brian, Kolinsky, Kenneth, Hilton, Holly, Zhao, Xiaolan, Vu, Binh T., Qing, Weiguo, Packman, Kathryn, Myklebost, Ola, Heimbrook, David C., Vassilev, Lyubomir T.
Published in Proceedings of the National Academy of Sciences - PNAS (07.02.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (07.02.2006)
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In vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
Vassilev, Lyubomir T., Vu, Binh T., Graves, Bradford, Carvajal, Daisy, Podlaski, Frank, Filipovic, Zoran, Kong, Norman, Kammlott, Ursula, Lukacs, Christine, Klein, Christian, Fotouhi, Nader, Liu, Emily A.
Published in Science (American Association for the Advancement of Science) (06.02.2004)
Published in Science (American Association for the Advancement of Science) (06.02.2004)
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Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells
Valente, Liz J., Aubrey, Brandon J., Herold, Marco J., Kelly, Gemma L., Happo, Lina, Scott, Clare L., Newbold, Andrea, Johnstone, Ricky W., Huang, David C.S., Vassilev, Lyubomir T., Strasser, Andreas
Published in Cell reports (Cambridge) (01.03.2016)
Published in Cell reports (Cambridge) (01.03.2016)
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MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy
Kojima, Kensuke, Konopleva, Marina, Samudio, Ismael J., Shikami, Masato, Cabreira-Hansen, Maria, McQueen, Teresa, Ruvolo, Vivian, Tsao, Twee, Zeng, Zhihong, Vassilev, Lyubomir T., Andreeff, Michael
Published in Blood (01.11.2005)
Published in Blood (01.11.2005)
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Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin
EFEYAN, Alejo, ORTEGA-MOLINA, Ana, VELASCO-MIGUEL, Susana, HERRANZ, Daniel, VASSILEV, Lyubomir T, SERRANO, Manuel
Published in Cancer research (Chicago, Ill.) (01.08.2007)
Published in Cancer research (Chicago, Ill.) (01.08.2007)
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Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5
Carter, Bing Z., Mak, Duncan H., Schober, Wendy D., Dietrich, Martin F., Pinilla, Clemencia, Vassilev, Lyubomir T., Reed, John C., Andreeff, Michael
Published in Blood (01.04.2008)
Published in Blood (01.04.2008)
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