Pharmacologic Inhibitor of DNA-PK, M3814, Potentiates Radiotherapy and Regresses Human Tumors in Mouse Models
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Published in Molecular cancer therapeutics (01.05.2020)
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Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2 -amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study
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Published in Journal of medicinal chemistry (25.07.2013)
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Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
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Published in Proceedings of the National Academy of Sciences - PNAS (03.09.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.2013)
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MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models
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Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Therapeutic Implications of p53 Status on Cancer Cell Fate Following Exposure to Ionizing Radiation and the DNA-PK Inhibitor M3814
Sun, Qing, Guo, Yige, Liu, Xiaohong, Czauderna, Frank, Carr, Michael I, Zenke, Frank T, Blaukat, Andree, Vassilev, Lyubomir T
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Published in Molecular cancer research (01.12.2019)
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Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized α‑Helical Peptide in Clinical Development
Guerlavais, Vincent, Sawyer, Tomi K., Carvajal, Luis, Chang, Yong S., Graves, Bradford, Ren, Jian-Guo, Sutton, David, Olson, Karen A., Packman, Kathryn, Darlak, Krzysztof, Elkin, Carl, Feyfant, Eric, Kesavan, Kamala, Gangurde, Pranoti, Vassilev, Lyubomir T., Nash, Huw M., Vukovic, Vojislav, Aivado, Manuel, Annis, D. Allen
Published in Journal of medicinal chemistry (27.07.2023)
Published in Journal of medicinal chemistry (27.07.2023)
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A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies
Zimmermann, Astrid, Zenke, Frank T, Chiu, Li-Ya, Dahmen, Heike, Pehl, Ulrich, Fuchss, Thomas, Grombacher, Thomas, Blume, Beatrix, Vassilev, Lyubomir T, Blaukat, Andree
Published in Molecular cancer therapeutics (01.06.2022)
Published in Molecular cancer therapeutics (01.06.2022)
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Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization
Graves, Bradford, Thompson, Thelma, Xia, Mingxuan, Janson, Cheryl, Lukacs, Christine, Deo, Dayanand, Di Lello, Paola, Fry, David, Garvie, Colin, Huang, Kuo-Sen, Gao, Lin, Tovar, Christian, Lovey, Allen, Wanner, Jutta, Vassilev, Lyubomir T
Published in Proceedings of the National Academy of Sciences - PNAS (17.07.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (17.07.2012)
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Selective Inhibition of ATM-dependent Double-strand Break Repair and Checkpoint Control Synergistically Enhances the Efficacy of ATR Inhibitors
Turchick, Audrey, Zimmermann, Astrid, Chiu, Li-Ya, Dahmen, Heike, Elenbaas, Brian, Zenke, Frank T, Blaukat, Andree, Vassilev, Lyubomir T
Published in Molecular cancer therapeutics (05.07.2023)
Published in Molecular cancer therapeutics (05.07.2023)
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Selective Small-Molecule Inhibitor Reveals Critical Mitotic Functions of Human CDK1
Vassilev, Lyubomir T., Tovar, Christian, Chen, Shaoqing, Knezevic, Dejan, Zhao, Xiaolan, Sun, Hongmao, Heimbrook, David C., Chen, Li
Published in Proceedings of the National Academy of Sciences - PNAS (11.07.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (11.07.2006)
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Selective ATM inhibition augments radiation-induced inflammatory signaling and cancer cell death
Chiu, Li-Ya, Sun, Qing, Zenke, Frank T, Blaukat, Andree, Vassilev, Lyubomir T
Published in Aging (Albany, NY.) (17.01.2023)
Published in Aging (Albany, NY.) (17.01.2023)
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DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia
Haines, Eric, Nishida, Yuki, Carr, Michael I., Montoya, Rafael Heinz, Ostermann, Lauren B., Zhang, Weiguo, Zenke, Frank T., Blaukat, Andree, Andreeff, Michael, Vassilev, Lyubomir T.
Published in Scientific reports (09.06.2021)
Published in Scientific reports (09.06.2021)
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Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development
Vu, Binh, Wovkulich, Peter, Pizzolato, Giacomo, Lovey, Allen, Ding, Qingjie, Jiang, Nan, Liu, Jin-Jun, Zhao, Chunlin, Glenn, Kelli, Wen, Yang, Tovar, Christian, Packman, Kathryn, Vassilev, Lyubomir, Graves, Bradford
Published in ACS medicinal chemistry letters (09.05.2013)
Published in ACS medicinal chemistry letters (09.05.2013)
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Small-Molecule MDM2 Antagonists Reveal Aberrant P53 Signaling in Cancer: Implications for Therapy
Tovar, Christian, Rosinski, James, Filipovic, Zoran, Higgins, Brian, Kolinsky, Kenneth, Hilton, Holly, Zhao, Xiaolan, Vu, Binh T., Qing, Weiguo, Packman, Kathryn, Myklebost, Ola, Heimbrook, David C., Vassilev, Lyubomir T.
Published in Proceedings of the National Academy of Sciences - PNAS (07.02.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (07.02.2006)
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In vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
Vassilev, Lyubomir T., Vu, Binh T., Graves, Bradford, Carvajal, Daisy, Podlaski, Frank, Filipovic, Zoran, Kong, Norman, Kammlott, Ursula, Lukacs, Christine, Klein, Christian, Fotouhi, Nader, Liu, Emily A.
Published in Science (American Association for the Advancement of Science) (06.02.2004)
Published in Science (American Association for the Advancement of Science) (06.02.2004)
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