A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys
Kumar, S, Dare, L, Vasko-Moser, J.A, James, I.E, Blake, S.M, Rickard, D.J, Hwang, S.-M, Tomaszek, T, Yamashita, D.S, Marquis, R.W, Oh, H, Jeong, J.U, Veber, D.F, Gowen, M, Lark, M.W, Stroup, G
Published in Bone (New York, N.Y.) (01.01.2007)
Published in Bone (New York, N.Y.) (01.01.2007)
Get full text
Journal Article
Physical Map and Characterization of Transcripts in the Candidate Interval for Familial Chondrocalcinosis at Chromosome 5p15.1
Rojas, K., Serrano de la Peña, L., Gallardo, T., Simmons, A., Nyce, K., McGrath, R., Considine, E., Vasko, A.J., Peterson, E., Grady, D., Cox, R., Andrew, L.J., Lovett, M., Overhauser, J., Williams, C.J.
Published in Genomics (San Diego, Calif.) (01.12.1999)
Published in Genomics (San Diego, Calif.) (01.12.1999)
Get full text
Journal Article
Changes in bone turnover following gonadotropin-releasing hormone (GnRH) agonist administration and estrogen treatment in cynomolgus monkeys: a short-term model for evaluation of antiresorptive therapy
Stroup, G.B, Hoffman, S.J, Vasko-Moser, J.A, Lechowska, B.A, Jenkins, E.L, Dare, L.C, Gowen, M
Published in Bone (New York, N.Y.) (01.05.2001)
Published in Bone (New York, N.Y.) (01.05.2001)
Get full text
Journal Article
Reduction in myocardial ischemic/reperfusion injury and neutrophil accumulation after therapeutic administration of streptokinase
Smith, 3rd, E F, Nichols, A J, Sellers, T S, O'Brien, S R, Griswold, D E, Egan, J W, Hillegass, L M, Vasko, J A, Slivjak, M J, Davis, P A
Published in Journal of cardiovascular pharmacology (01.11.1991)
Published in Journal of cardiovascular pharmacology (01.11.1991)
Get more information
Journal Article
Potent and Selective Inhibition of Human Cathepsin K Leads to Inhibition of Bone Resorption In Vivo in a Nonhuman Primate
Stroup, George B., Lark, Michael W., Veber, Daniel F., Bhattacharyya, Amit, Blake, Simon, Dare, Lauren C., Erhard, Karl F., Hoffman, Sandra J., James, Ian E., Marquis, Robert W., Ru, Yu, Vasko‐Moser, Janice A., Smith, Brian R., Tomaszek, Thadeus, Gowen, Maxine
Published in Journal of bone and mineral research (01.10.2001)
Published in Journal of bone and mineral research (01.10.2001)
Get full text
Journal Article
Investigation of conformational specificity at GPIIb/IIIa: evaluation of conformationally constrained RGD peptides
Peishoff, Catherine E, Ali, Fadia E, Bean, John W, Calvo, Raul, D'Ambrosio, Cynthia A, Eggleston, Drake S, Kline, Tammy Page, Koster, Paul F, Hwang, S. M
Published in Journal of medicinal chemistry (01.10.1992)
Published in Journal of medicinal chemistry (01.10.1992)
Get full text
Journal Article
Conformationally Constrained Peptides and Semipeptides Derived from RGD as Potent Inhibitors of the Platelet Fibrinogen Receptor and Platelet Aggregation
Ali, Fadia E, Bennett, Donald B, Calvo, Raul R, Elliott, John D, Hwang, Shing-Mei, Ku, Thomas W, Lago, M. Amparo, Nichols, Andrew J, Romoff, Todd T
Published in Journal of medicinal chemistry (01.03.1994)
Published in Journal of medicinal chemistry (01.03.1994)
Get full text
Journal Article
The in vivo pharmacological profile of the novel glycoprotein IIb/IIIa antagonist, SK&F 106760
Nichols, A J, Vasko, J A, Koster, P F, Valocik, R E, Rhodes, G R, Miller-Stein, C, Boppana, V, Samanen, J M
Published in The Journal of pharmacology and experimental therapeutics (01.08.1994)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.08.1994)
Journal Article
Conformational Preferences in a Benzodiazepine Series of Potent Nonpeptide Fibrinogen Receptor Antagonists
Keenan, Richard M, Callahan, James F, Samanen, James M, Bondinell, William E, Calvo, Raul R, Chen, Lichong, DeBrosse, Charles, Eggleston, Drake S, Haltiwanger, R. Curtis, Hwang, Shing Mei, Jakas, Dalia R, Ku, Thomas W, Miller, William H, Newlander, Kenneth A, Nichols, Andrew, Parker, Michael F, Southhall, Linda S, Uzinskas, Irene, Vasko-Moser, Janice A, Venslavsky, Joseph W, Wong, Angela S, Huffman, William F
Published in Journal of medicinal chemistry (25.02.1999)
Published in Journal of medicinal chemistry (25.02.1999)
Get full text
Journal Article
The in vitro pharmacological profile of SK&F 106760, a novel GPIIB/IIIA antagonist
Nichols, Andrew J., Vasko, Janice A., Valocik, Richard E., Kopaciewicz, Linda J., Storer, Barbara L., Ali, Fadia E., Romoff, Todd, Calvo, Raul, Samanen, James M.
Published in Thrombosis research (15.07.1994)
Published in Thrombosis research (15.07.1994)
Get full text
Journal Article
Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model
Miller, William H., Bondinell, William E., Cousins, Russell D., Erhard, Karl F., Jakas, Dalia R., Keenan, Richard M., Ku, Thomas W., Newlander, Kenneth A., Ross, Stephen T., Haltiwanger, R.Curtis, Bradbeer, Jeremy, Drake, Fred H., Gowen, Maxine, Hoffman, Sandra J., Hwang, Shing-Mei, James, Ian E., Lark, Michael W., Lechowska, Beata, Rieman, David J., Stroup, George B., Vasko-Moser, Janice A., Zembryki, Denise L., Azzarano, Leonard M., Adams, Paula C., Salyers, Kevin L., Smith, Brian R., Ward, Keith W., Johanson, Kyung O., Huffaman, William F.
Published in Bioorganic & medicinal chemistry letters (05.07.1999)
Published in Bioorganic & medicinal chemistry letters (05.07.1999)
Get full text
Journal Article
Design and synthesis of a C7 mimetic for the predicted .gamma.-turn conformation found in several constrained RGD antagonists
Callahan, James F, Bean, John W, Burgess, Joelle L, Eggleston, Drake S, Hwang, Shing Mei, Kopple, Kenneth D, Koster, Paul F, Nichols, Andrew, Peishoff, Catherine E
Published in Journal of medicinal chemistry (01.10.1992)
Published in Journal of medicinal chemistry (01.10.1992)
Get full text
Journal Article
DESIGN AND SYNTHESIS OF A C-7 MIMETIC FOR THE PREDICTED GAMMA-TURN CONFORMATION FOUND IN SEVERAL CONSTRAINED RGD ANTAGONISTS
CALLAHAN, JF, BEAN, JW, BURGESS, JL, EGGLESTON, DS, HWANG, SM, KOPPLE, KD, KOSTER, PF, NICHOLS, A, PEISHOFF, CE, SAMANEN, JM, VASKO, JA, WONG, A, HUFFMAN, WF
Published in Journal of medicinal chemistry (16.10.1992)
Published in Journal of medicinal chemistry (16.10.1992)
Get full text
Journal Article