Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’
Goodridge, Helen S., Reyes, Christopher N., Becker, Courtney A., Katsumoto, Tamiko R., Ma, Jun, Wolf, Andrea J., Bose, Nandita, Chan, Anissa S. H., Magee, Andrew S., Danielson, Michael E., Weiss, Arthur, Vasilakos, John P., Underhill, David M.
Published in Nature (London) (28.04.2011)
Published in Nature (London) (28.04.2011)
Get full text
Journal Article
Effective innate and adaptive antimelanoma immunity through localized TLR7/8 activation
Singh, Manisha, Khong, Hiep, Dai, Zhimin, Huang, Xue-Fei, Wargo, Jennifer A, Cooper, Zachary A, Vasilakos, John P, Hwu, Patrick, Overwijk, Willem W
Published in The Journal of immunology (1950) (01.11.2014)
Published in The Journal of immunology (1950) (01.11.2014)
Get full text
Journal Article
Intratumoral immunotherapy with TLR7/8 agonist MEDI9197 modulates the tumor microenvironment leading to enhanced activity when combined with other immunotherapies
Mullins, Stefanie R., Vasilakos, John P., Deschler, Katharina, Grigsby, Iwen, Gillis, Pete, John, Julius, Elder, Matthew J., Swales, John, Timosenko, Elina, Cooper, Zachary, Dovedi, Simon J., Leishman, Andrew J., Luheshi, Nadia, Elvecrog, James, Tilahun, Ashenafi, Goodwin, Richard, Herbst, Ronald, Tomai, Mark A., Wilkinson, Robert W.
Published in Journal for immunotherapy of cancer (11.09.2019)
Published in Journal for immunotherapy of cancer (11.09.2019)
Get full text
Journal Article
Synthetic TLR Agonists Reveal Functional Differences between Human TLR7 and TLR8
Gorden, Keith B, Gorski, Kevin S, Gibson, Sheila J, Kedl, Ross M, Kieper, William C, Qiu, Xiaohong, Tomai, Mark A, Alkan, Sefik S, Vasilakos, John P
Published in The Journal of immunology (1950) (01.02.2005)
Published in The Journal of immunology (1950) (01.02.2005)
Get full text
Journal Article
Cutting Edge: Activation of Murine TLR8 by a Combination of Imidazoquinoline Immune Response Modifiers and PolyT Oligodeoxynucleotides
Gorden, Keith K. B, Qiu, Xiaohong X, Binsfeld, Christine C. A, Vasilakos, John P, Alkan, Sefik S
Published in The Journal of immunology (1950) (15.11.2006)
Published in The Journal of immunology (1950) (15.11.2006)
Get full text
Journal Article
First in Human Phase I Trial of 852A, a Novel Systemic Toll-like Receptor 7 Agonist, to Activate Innate Immune Responses in Patients with Advanced Cancer
Dudek, Arkadiusz Z, Yunis, Carla, Harrison, Lester I, Kumar, Sandeep, Hawkinson, Ronald, Cooley, Sarah, Vasilakos, John P, Gorski, Kevin S, Miller, Jeffrey S
Published in Clinical cancer research (01.12.2007)
Published in Clinical cancer research (01.12.2007)
Get full text
Journal Article
TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth
Dowling, David J, van Haren, Simon D, Scheid, Annette, Bergelson, Ilana, Kim, Dhohyung, Mancuso, Christy J, Foppen, Willemina, Ozonoff, Al, Fresh, Lynn, Theriot, Terese B, Lackner, Andrew A, Fichorova, Raina N, Smirnov, Dmitri, Vasilakos, John P, Beaurline, Joe M, Tomai, Mark A, Midkiff, Cecily C, Alvarez, Xavier, Blanchard, James L, Gilbert, Margaret H, Aye, Pyone Pyone, Levy, Ofer
Published in JCI insight (23.03.2017)
Published in JCI insight (23.03.2017)
Get full text
Journal Article
Comparison of human B cell activation by TLR7 and TLR9 agonists
Hanten, John A, Vasilakos, John P, Riter, Christie L, Neys, Lori, Lipson, Kenneth E, Alkan, Sefik S, Birmachu, Woubalem
Published in BMC immunology (24.07.2008)
Published in BMC immunology (24.07.2008)
Get full text
Journal Article
Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists
Gorski, Kevin S., Waller, Emily L., Bjornton-Severson, Jacqueline, Hanten, John A., Riter, Christie L., Kieper, William C., Gorden, Keith B., Miller, Jeffrey S., Vasilakos, John P., Tomai, Mark A., Alkan, Sefik S.
Published in International immunology (01.07.2006)
Published in International immunology (01.07.2006)
Get full text
Journal Article
Combined TLR and CD40 triggering induces potent CD8+ T cell expansion with variable dependence on type I IFN
Ahonen, Cory L, Doxsee, Christie L, McGurran, Sean M, Riter, Tony R, Wade, William F, Barth, Richard J, Vasilakos, John P, Noelle, Randolph J, Kedl, Ross M
Published in The Journal of experimental medicine (15.03.2004)
Published in The Journal of experimental medicine (15.03.2004)
Get full text
Journal Article
Binding of Soluble Yeast β-Glucan to Human Neutrophils and Monocytes is Complement-Dependent
Bose, Nandita, Chan, Anissa S H, Guerrero, Faimola, Maristany, Carolyn M, Qiu, Xiaohong, Walsh, Richard M, Ertelt, Kathleen E, Jonas, Adria Bykowski, Gorden, Keith B, Dudney, Christine M, Wurst, Lindsay R, Danielson, Michael E, Elmasry, Natalie, Magee, Andrew S, Patchen, Myra L, Vasilakos, John P
Published in Frontiers in immunology (2013)
Published in Frontiers in immunology (2013)
Get full text
Journal Article
Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats
Hammerbeck, David M., Burleson, Gary R., Schuller, Craig J., Vasilakos, John P., Tomai, Mark, Egging, Elaine, Cochran, Felicia R., Woulfe, Susan, Miller, Richard L.
Published in Antiviral research (01.01.2007)
Published in Antiviral research (01.01.2007)
Get full text
Journal Article
TLR7 agonist 852A inhibition of tumor cell proliferation is dependent on plasmacytoid dendritic cells and type I IFN
Inglefield, Jon R, Dumitru, Calin Dan, Alkan, Sefik S, Gibson, Sheila J, Lipson, Kenneth E, Tomai, Mark A, Larson, Chris J, Vasilakos, John P
Published in Journal of interferon & cytokine research (01.04.2008)
Published in Journal of interferon & cytokine research (01.04.2008)
Get full text
Journal Article
Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists
Birmachu, Woubalem, Gleason, Raymond M, Bulbulian, Barbara J, Riter, Christie L, Vasilakos, John P, Lipson, Kenneth E, Nikolsky, Yuri
Published in BMC immunology (12.10.2007)
Published in BMC immunology (12.10.2007)
Get full text
Journal Article
Toll-like receptor activation enhances cell-mediated immunity induced by an antibody vaccine targeting human dendritic cells
Ramakrishna, Venky, Vasilakos, John P, Tario, Jr, Joseph D, Berger, Marc A, Wallace, Paul K, Keler, Tibor
Published in Journal of translational medicine (25.01.2007)
Published in Journal of translational medicine (25.01.2007)
Get full text
Journal Article