Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination
Varma, Manthena V. S, Obach, R. Scott, Rotter, Charles, Miller, Howard R, Chang, George, Steyn, Stefanus J, El-Kattan, Ayman, Troutman, Matthew D
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
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Functional Role of P-Glycoprotein in Limiting Intestinal Absorption of Drugs: Contribution of Passive Permeability to P-Glycoprotein Mediated Efflux Transport
Varma, Manthena V. S, Sateesh, Khandavilli, Panchagnula, Ramesh
Published in Molecular pharmaceutics (01.01.2005)
Published in Molecular pharmaceutics (01.01.2005)
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Journal Article
Membrane transporters in drug development and as determinants of precision medicine
Galetin, Aleksandra, Brouwer, Kim L. R., Tweedie, Donald, Yoshida, Kenta, Sjöstedt, Noora, Aleksunes, Lauren, Chu, Xiaoyan, Evers, Raymond, Hafey, Michael J., Lai, Yurong, Matsson, Pär, Riselli, Andrew, Shen, Hong, Sparreboom, Alex, Varma, Manthena V. S., Yang, Jia, Yang, Xinning, Yee, Sook Wah, Zamek-Gliszczynski, Maciej J., Zhang, Lei, Giacomini, Kathleen M.
Published in Nature reviews. Drug discovery (01.04.2024)
Published in Nature reviews. Drug discovery (01.04.2024)
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Journal Article
Transporters in drug development: International transporter consortium update on emerging transporters of clinical importance
Zamek-Gliszczynski, Maciej J, Sangha, Vishal, Shen, Hong, Feng, Bo, Wittwer, Matthias B, Varma, Manthena V S, Liang, Xiaomin, Sugiyama, Yuichi, Zhang, Lei, Bendayan, Reina
Published in Clinical pharmacology and therapeutics (01.09.2022)
Published in Clinical pharmacology and therapeutics (01.09.2022)
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Journal Article
Biomarker-Informed Model-Based Risk Assessment of Organic Anion Transporting Polypeptide 1B Mediated Drug-Drug Interactions
Kimoto, Emi, Costales, Chester, West, Mark A, Bi, Yi-An, Vourvahis, Manoli, David Rodrigues, A, Varma, Manthena V S
Published in Clinical pharmacology and therapeutics (01.02.2022)
Published in Clinical pharmacology and therapeutics (01.02.2022)
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Journal Article
Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: "SLC-Phenotyping" Using Primary Human Hepatocytes
Bi, Yi-An, Costales, Chester, Mathialagan, Sumathy, West, Mark, Eatemadpour, Soraya, Lazzaro, Sarah, Tylaska, Laurie, Scialis, Renato, Zhang, Hui, Umland, John, Kimoto, Emi, Tess, David A, Feng, Bo, Tremaine, Larry M, Varma, Manthena V S, Rodrigues, A David
Published in The Journal of pharmacology and experimental therapeutics (01.07.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2019)
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Journal Article
Organic Anion Transporter 2–Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability–Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs
Kimoto, Emi, Mathialagan, Sumathy, Tylaska, Laurie, Niosi, Mark, Lin, Jian, Carlo, Anthony A., Tess, David A., Varma, Manthena V. S.
Published in The Journal of pharmacology and experimental therapeutics (01.11.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2018)
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Journal Article
Role of Hepatic Organic Anion Transporter 2 in the Pharmacokinetics of R- and S‑Warfarin: In Vitro Studies and Mechanistic Evaluation
Bi, Yi-an, Lin, Jian, Mathialagan, Sumathy, Tylaska, Laurie, Callegari, Ernesto, Rodrigues, A. David, Varma, Manthena V. S
Published in Molecular pharmaceutics (05.03.2018)
Published in Molecular pharmaceutics (05.03.2018)
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Journal Article
Effect of Human Plasma on Hepatic Uptake of Organic Anion-Transporting Polypeptide 1B Substrates: Studies Using Transfected Cells and Primary Human Hepatocytes
Bi, Yi-An, Ryu, Sangwoo, Tess, David A, Rodrigues, A David, Varma, Manthena V S
Published in Drug metabolism and disposition (01.01.2021)
Published in Drug metabolism and disposition (01.01.2021)
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Journal Article
Organic Anion Transporter 2 Mediates Hepatic Uptake of Tolbutamide, a CYP2C9 Probe Drug
Bi, Yi-An, Mathialagan, Sumathy, Tylaska, Laurie, Fu, Myra, Keefer, Julie, Vildhede, Anna, Costales, Chester, Rodrigues, A David, Varma, Manthena V S
Published in The Journal of pharmacology and experimental therapeutics (01.03.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2018)
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Journal Article
Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro-In Vivo Scaling of Hepatic Uptake Clearance
De Bruyn, Tom, Ufuk, Ayşe, Cantrill, Carina, Kosa, Rachel E, Bi, Yi-An, Niosi, Mark, Modi, Sweta, Rodrigues, A David, Tremaine, Larry M, Varma, Manthena V S, Galetin, Aleksandra, Houston, J Brian
Published in Drug metabolism and disposition (01.07.2018)
Published in Drug metabolism and disposition (01.07.2018)
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Journal Article
Hepatic Disposition of Gemfibrozil and Its Major Metabolite Gemfibrozil 1‑O‑β-Glucuronide
Kimoto, Emi, Li, Rui, Scialis, Renato J, Lai, Yurong, Varma, Manthena V. S
Published in Molecular pharmaceutics (02.11.2015)
Published in Molecular pharmaceutics (02.11.2015)
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Journal Article
Mechanistic Evaluation of the Complex Drug-Drug Interactions of Maraviroc: Contribution of Cytochrome P450 3A, P-Glycoprotein and Organic Anion Transporting Polypeptide 1B1
Kimoto, Emi, Vourvahis, Manoli, Scialis, Renato J, Eng, Heather, Rodrigues, A David, Varma, Manthena V S
Published in Drug metabolism and disposition (01.05.2019)
Published in Drug metabolism and disposition (01.05.2019)
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