Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia
Mansour, Mahmoud N, Seddon, Andrew P, Hoth, Lise R, Xia, Donghui, Geoghegan, Kieran F, Griffor, Matthew C, Subashi, Timothy A, Shenolikar, Shirish, Danley, Dennis E, Ammirati, Mark J, McGrath, Katherine M, Culp, Jeffrey S, Hawkins, Julie L, Varghese, Alison H, Qiu, Xiayang, Warren, Laurie C, Cunningham, David, Stutzman-Engwall, Kim J
Published in Nature structural & molecular biology (01.05.2007)
Published in Nature structural & molecular biology (01.05.2007)
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Pharmacologic Inhibition of Site 1 Protease Activity Inhibits Sterol Regulatory Element-Binding Protein Processing and Reduces Lipogenic Enzyme Gene Expression and Lipid Synthesis in Cultured Cells and Experimental Animals
Hawkins, Julie L, Robbins, Michael D, Warren, Laurie C, Xia, Donghui, Petras, Stephen F, Valentine, James J, Varghese, Alison H, Wang, Ing-Kae, Subashi, Timothy A, Shelly, Lorraine D, Hay, Bruce A, Landschulz, Katherine T, Geoghegan, Kieran F, Harwood, Jr, H James
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)
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Immunohistochemical localization of PDE10A in the rat brain
Seeger, Thomas F, Bartlett, Brenda, Coskran, Timothy M, Culp, Jeffrey S, James, Larry C, Krull, David L, Lanfear, Jerry, Ryan, Anne M, Schmidt, Christopher J, Strick, Christine A, Varghese, Alison H, Williams, Robert D, Wylie, Patricia G, Menniti, Frank S
Published in Brain research (26.09.2003)
Published in Brain research (26.09.2003)
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Discovery of Cytotoxic Dolastatin 10 Analogues with N‑Terminal Modifications
Maderna, Andreas, Doroski, Matthew, Subramanyam, Chakrapani, Porte, Alexander, Leverett, Carolyn A, Vetelino, Beth C, Chen, Zecheng, Risley, Hud, Parris, Kevin, Pandit, Jayvardhan, Varghese, Alison H, Shanker, Suman, Song, Cynthia, Sukuru, Sai Chetan K, Farley, Kathleen A, Wagenaar, Melissa M, Shapiro, Michael J, Musto, Sylvia, Lam, My-Hanh, Loganzo, Frank, O’Donnell, Christopher J
Published in Journal of medicinal chemistry (26.12.2014)
Published in Journal of medicinal chemistry (26.12.2014)
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Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design
Butler, Christopher R, Brodney, Michael A, Beck, Elizabeth M, Barreiro, Gabriela, Nolan, Charles E, Pan, Feng, Vajdos, Felix, Parris, Kevin, Varghese, Alison H, Helal, Christopher J, Lira, Ricardo, Doran, Shawn D, Riddell, David R, Buzon, Leanne M, Dutra, Jason K, Martinez-Alsina, Luis A, Ogilvie, Kevin, Murray, John C, Young, Joseph M, Atchison, Kevin, Robshaw, Ashley, Gonzales, Cathleen, Wang, Jinlong, Zhang, Yong, O’Neill, Brian T
Published in Journal of medicinal chemistry (26.03.2015)
Published in Journal of medicinal chemistry (26.03.2015)
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Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads
Leverett, Carolyn A, Sukuru, Sai Chetan K, Vetelino, Beth C, Musto, Sylvia, Parris, Kevin, Pandit, Jayvardhan, Loganzo, Frank, Varghese, Alison H, Bai, Guoyun, Liu, Bin, Liu, Dingguo, Hudson, Sarah, Doppalapudi, Venkata Ramana, Stock, Joseph, O’Donnell, Christopher J, Subramanyam, Chakrapani
Published in ACS medicinal chemistry letters (10.11.2016)
Published in ACS medicinal chemistry letters (10.11.2016)
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Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism
Ahn, Kay, Boehm, Markus, Brown, Matthew F, Calloway, Jessica, Che, Ye, Chen, Jinshan, Fennell, Kimberly F, Geoghegan, Kieran F, Gilbert, Adam M, Gutierrez, Jemy A, Kalgutkar, Amit S, Lanba, Adhiraj, Limberakis, Chris, Magee, Thomas V, O’Doherty, Inish, Oliver, Robert, Pabst, Brandon, Pandit, Jayvardhan, Parris, Kevin, Pfefferkorn, Jeffrey A, Rolph, Timothy P, Patel, Rushi, Schuff, Brandon, Shanmugasundaram, Veerabahu, Starr, Jeremy T, Varghese, Alison H, Vera, Nicholas B, Vernochet, Cecile, Yan, Jiangli
Published in ACS chemical biology (16.09.2016)
Published in ACS chemical biology (16.09.2016)
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Deconstruction of Activity-Dependent Covalent Modification of Heme in Human Neutrophil Myeloperoxidase by Multistage Mass Spectrometry (MS4)
Geoghegan, Kieran F, Varghese, Alison H, Feng, Xidong, Bessire, Andrew J, Conboy, James J, Ruggeri, Roger B, Ahn, Kay, Spath, Samantha N, Filippov, Sergey V, Conrad, Steven J, Carpino, Philip A, Guimarães, Cristiano R. W, Vajdos, Felix F
Published in Biochemistry (Easton) (13.03.2012)
Published in Biochemistry (Easton) (13.03.2012)
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Aminopyrrolidineamide inhibitors of site-1 protease
Hay, Bruce A., Abrams, Barbara, Zumbrunn, Allice Y., Valentine, James J., Warren, Laurie C., Petras, Stephen F., Shelly, Lorraine D., Xia, Angela, Varghese, Alison H., Hawkins, Julie L., Van Camp, Jennifer A., Robbins, Michael D., Landschulz, Katherine, Harwood, H. James
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
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Binding to the Low-Density Lipoprotein Receptor Accelerates Futile Catalytic Cycling in PCSK9 and Raises the Equilibrium Level of Intramolecular Acylenzyme
Geoghegan, Kieran F, Hoth, Lise R, Varghese, Alison H, Lin, Wen, Boyd, James G, Griffor, Matthew C
Published in Biochemistry (Easton) (07.04.2009)
Published in Biochemistry (Easton) (07.04.2009)
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Xenopus lipovitellin 1 is a Zn(2+)- and Cd(2+)-binding protein
Sunderman, Jr, F W, Antonijczuk, K, Antonijczuk, A, Grbac-Ivankovic, S, Varghese, A H, Korza, G, Ozols, J
Published in Molecular reproduction and development (01.10.1995)
Published in Molecular reproduction and development (01.10.1995)
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Characterization of pNiXa, a serpin of Xenopus laevis oocytes and embryos, and its histidine-rich, Ni(II)-binding domain
Sunderman Jr, F. William, Varghese, Alison H., Kroftova, Olga S., Grbacivankovic, Svetlana, Kotyza, Jaromir, Datta, Arun K., Davis, Milton, Bal, Wojciech, Kasprzak, Kazimierz S.
Published in Molecular reproduction and development (01.08.1996)
Published in Molecular reproduction and development (01.08.1996)
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Journal Article
Characterization of pNiXa, a serpin ofXenopus laevis oocytes and embryos, and its histidine-rich, Ni(II)-binding domain
Sunderman, F. William, Varghese, Alison H., Kroftova, Olga S., Grbacivankovic, Svetlana, Kotyza, Jaromir, Datta, Arun K., Davis, Milton, Bal, Wojciech, Kasprzak, Kazimierz S.
Published in Molecular reproduction and development (01.08.1996)
Published in Molecular reproduction and development (01.08.1996)
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Lipovitellin 2 beta is the 31 kD Ni(2+)-binding protein (pNiXb) in Xenopus oocytes and embryos
Grbac-Ivankovic, S, Antonijczuk, K, Varghese, A H, Plowman, M C, Antonijczuk, A, Korza, G, Ozols, J, Sunderman, Jr, F W
Published in Molecular reproduction and development (01.07.1994)
Published in Molecular reproduction and development (01.07.1994)
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Interactions of serine proteinases with pNiXa, a serpin of Xenopus oocytes and embryos
Kotyza, Jaromir, Varghese, Alison H, Korza, George, Sunderman, F.William
Published in Biochimica et biophysica acta (17.02.1998)
Published in Biochimica et biophysica acta (17.02.1998)
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The 40 kDa 63Ni2+-binding protein (pNiXc) on Western blots of Xenopus laevis oocytes and embryos is the monomer of fructose-1,6-bisphosphate aldolase A
Antonijczuk, Katarzyna, Kroftova, Olga S., Varghese, Alison H., Antonijczuk, Adam, Henjum, Daniel C., Korza, George, Ozols, Juris, William Sunderman, F.
Published in Biochimica et biophysica acta, Protein structure and molecular enzymology (01.02.1995)
Published in Biochimica et biophysica acta, Protein structure and molecular enzymology (01.02.1995)
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The 40 kDa 63Ni 2+-binding protein (pNiXc) on Western blots of Xenopus laevis oocytes and embryos is the monomer of fructose-1,6-bisphosphate aldolase A
Antonijczuk, Katarzyna, Kroftova, Olga S., Varghese, Alison H., Antonijczuk, Adam, Henjum, Daniel C., Korza, George, Ozols, Juris, William Sunderman, F.
Published in Biochimica et biophysica acta, Protein structure and molecular enzymology (1995)
Published in Biochimica et biophysica acta, Protein structure and molecular enzymology (1995)
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