Combined administration of an mGlu2/3 receptor agonist and a 5-HT2A receptor antagonist markedly attenuate the psychomotor-activating and neurochemical effects of psychostimulants
Uslaner, Jason M., Smith, Sean M., Huszar, Sarah L., Pachmerhiwala, Rashida, Hinchliffe, Richard M., Vardigan, Joshua D., Hutson, Pete H.
Published in Psychopharmacologia (01.11.2009)
Published in Psychopharmacologia (01.11.2009)
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Effects of a novel M4 muscarinic positive allosteric modulator on behavior and cognitive deficits relevant to Alzheimer's disease and schizophrenia in rhesus monkey
Lange, Henry S., Vardigan, Joshua D., Cannon, Christopher E., Puri, Vanita, Henze, Darrell A., Uslaner, Jason M.
Published in Neuropharmacology (01.10.2021)
Published in Neuropharmacology (01.10.2021)
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The selective positive allosteric M1 muscarinic receptor modulator PQCA attenuates learning and memory deficits in the Tg2576 Alzheimer's disease mouse model
Puri, Vanita, Wang, Xiaohai, Vardigan, Joshua D., Kuduk, Scott D., Uslaner, Jason M.
Published in Behavioural brain research (01.07.2015)
Published in Behavioural brain research (01.07.2015)
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Pharmacological Characterization of the Novel and Selective α7 Nicotinic Acetylcholine Receptor-Positive Allosteric Modulator BNC375
Wang, Xiaohai, Daley, Christopher, Gakhar, Vanita, Lange, Henry S, Vardigan, Joshua D, Pearson, Michelle, Zhou, Xiaoping, Warren, Lee, Miller, Corin O, Belden, Michelle, Harvey, Andrew J, Grishin, Anton A, Coles, Carolyn J, O'Connor, Susan M, Thomson, Fiona, Duffy, Joseph L, Bell, Ian M, Uslaner, Jason M
Published in The Journal of pharmacology and experimental therapeutics (01.05.2020)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2020)
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2‑Aminopyridines as Potent and Selective Nav1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model
Breslin, Michael J., Schubert, Jeffrey W., Wang, Deping, Huang, Chienjung, Clements, Michelle K., Li, Yuxing, Zhou, Xiaoping, Vardigan, Joshua D., Kraus, Richard L., Santarelli, Vincent P., Uslaner, Jason M., Coleman, Paul J., Stachel, Shawn J.
Published in ACS medicinal chemistry letters (13.06.2024)
Published in ACS medicinal chemistry letters (13.06.2024)
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The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey
Smith, Sean M., Uslaner, Jason M., Cox, Christopher D., Huszar, Sarah L., Cannon, Christopher E., Vardigan, Joshua D., Eddins, Donnie, Toolan, Dawn M., Kandebo, Monika, Yao, Lihang, Raheem, Izzat T., Schreier, John D., Breslin, Michael J., Coleman, Paul J., Renger, John J.
Published in Neuropharmacology (01.01.2013)
Published in Neuropharmacology (01.01.2013)
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Pharmacological Characterization of the Novel and Selective α 7 Nicotinic Acetylcholine Receptor-Positive Allosteric Modulator BNC375
Wang, Xiaohai, Daley, Christopher, Gakhar, Vanita, Lange, Henry S, Vardigan, Joshua D, Pearson, Michelle, Zhou, Xiaoping, Warren, Lee, Miller, Corin O, Belden, Michelle, Harvey, Andrew J, Grishin, Anton A, Coles, Carolyn J, O'Connor, Susan M, Thomson, Fiona, Duffy, Joseph L, Bell, Ian M, Uslaner, Jason M
Published in The Journal of pharmacology and experimental therapeutics (01.05.2020)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2020)
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Na v 1.7 target modulation and efficacy can be measured in nonhuman primate assays
Kraus, Richard L, Zhao, Fuqiang, Pall, Parul S, Zhou, Dan, Vardigan, Joshua D, Danziger, Andrew, Li, Yuxing, Daley, Christopher, Ballard, Jeanine E, Clements, Michelle K, Klein, Rebecca M, Holahan, Marie A, Greshock, Thomas J, Kim, Ronald M, Layton, Mark E, Burgey, Christopher S, Serra, Jordi, Henze, Darrell A, Houghton, Andrea K
Published in Science translational medicine (19.05.2021)
Published in Science translational medicine (19.05.2021)
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MK-801 produces a deficit in sucrose preference that is reversed by clozapine, d-serine, and the metabotropic glutamate 5 receptor positive allosteric modulator CDPPB: Relevance to negative symptoms associated with schizophrenia?
Vardigan, Joshua D., Huszar, Sarah L., McNaughton, Caitlyn H., Hutson, Peter H., Uslaner, Jason M.
Published in Pharmacology, biochemistry and behavior (01.04.2010)
Published in Pharmacology, biochemistry and behavior (01.04.2010)
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Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator
Rudd, Michael T., Manley, Peter J., Hanney, Barbara, Meng, Zhaoyang, Shu, Youheng, de Leon, Pablo, Frie, Jessica L., Han, Yongxin, Wai, Jenny Miu-Chun, Yang, Zhi-Qiang, Perkins, James J., Hurzy, Danielle M., Manikowski, Jesse J., Zhu, Hong, Bungard, Christopher J., Converso, Antonella, Meissner, Robert S., Cosden, Mali L., Hayashi, Ikuo, Ma, Lei, O’Brien, Julie, Uebele, Victor N., Schachter, Joel B., Bhandari, Neetesh, Ward, Gwendolyn J., Fillgrove, Kerry L., Lu, Bing, Liang, Yuexia, Dubost, David C., Puri, Vanita, Eddins, Donnie M., Vardigan, Joshua D., Drolet, Robert E., Kern, Jonathan T., Uslaner, Jason M.
Published in ACS medicinal chemistry letters (10.08.2023)
Published in ACS medicinal chemistry letters (10.08.2023)
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Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson’s Disease
Roecker, Anthony J., Schirripa, Kathy M., Loughran, H. Marie, Tong, Ling, Liang, Tao, Fillgrove, Kerry L., Kuo, Yuhsin, Bleasby, Kelly, Collier, Hannah, Altman, Michael D., Ford, Melissa C., Drolet, Robert E., Cosden, Mali, Jinn, Sarah, Hatcher, Nathan G., Yao, Lihang, Kandebo, Monika, Vardigan, Joshua D., Flick, Rosemarie B., Liu, Xiaomei, Minnick, Christina, Price, Laura A., Watt, Marla L., Lemaire, Wei, Burlein, Christine, Adam, Gregory C., Austin, Lauren A., Marcus, Jacob N., Smith, Sean M., Fraley, Mark E.
Published in ACS medicinal chemistry letters (09.02.2023)
Published in ACS medicinal chemistry letters (09.02.2023)
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T-type calcium channel antagonism produces antipsychotic-like effects and reduces stimulant-induced glutamate release in the nucleus accumbens of rats
Uslaner, Jason M., Smith, Sean M., Huszar, Sarah L., Pachmerhiwala, Rashida, Hinchliffe, Richard M., Vardigan, Joshua D., Nguyen, Shannon J., Surles, Nathan O., Yao, Lihang, Barrow, James C., Uebele, Victor N., Renger, John J., Clark, Janet, Hutson, Pete H.
Published in Neuropharmacology (01.03.2012)
Published in Neuropharmacology (01.03.2012)
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Pharmacological validation of a novel nonhuman primate measure of thermal responsivity with utility for predicting analgesic effects
Vardigan, Joshua D, Houghton, Andrea K, Lange, Henry S, Adarayan, Emily D, Pall, Parul S, Ballard, Jeanine E, Henze, Darrell A, Uslaner, Jason M
Published in Journal of pain research (01.01.2018)
Published in Journal of pain research (01.01.2018)
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Journal Article
Combined administration of an mGlu2/3 receptor agonist and a 5-HT 2A receptor antagonist markedly attenuate the psychomotor-activating and neurochemical effects of psychostimulants
Uslaner, Jason M, Smith, Sean M, Huszar, Sarah L, Pachmerhiwala, Rashida, Hinchliffe, Richard M, Vardigan, Joshua D, Hutson, Pete H
Published in Psychopharmacology (Berlin, Germany) (01.11.2009)
Published in Psychopharmacology (Berlin, Germany) (01.11.2009)
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T-Type Calcium Channel Antagonism Decreases Motivation for Nicotine and Blocks Nicotine- and Cue-Induced Reinstatement for a Response Previously Reinforced with Nicotine
Uslaner, Jason M, Vardigan, Joshua D, Drott, Jason M, Uebele, Victor N, Renger, John J, Lee, Ariel, Li, Zhaoxia, Lê, A.D, Hutson, Pete H
Published in Biological psychiatry (1969) (15.10.2010)
Published in Biological psychiatry (1969) (15.10.2010)
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Journal Article
2-Aminopyridines as Potent and Selective Na v 1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model
Breslin, Michael J., Schubert, Jeffrey W., Wang, Deping, Huang, Chienjung, Clements, Michelle K., Li, Yuxing, Zhou, Xiaoping, Vardigan, Joshua D., Kraus, Richard L., Santarelli, Vincent P., Uslaner, Jason M., Coleman, Paul J., Stachel, Shawn J.
Published in ACS medicinal chemistry letters (24.05.2024)
Published in ACS medicinal chemistry letters (24.05.2024)
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Combined administration of an mGlu2/3 receptor agonist and a 5-HT sub(2A) receptor antagonist markedly attenuate the psychomotor-activating and neurochemical effects of psychostimulants
Uslaner, Jason M, Smith, Sean M, Huszar, Sarah L, Pachmerhiwala, Rashida, Hinchliffe, Richard M, Vardigan, Joshua D, Hutson, Pete H
Published in Psychopharmacology (01.11.2009)
Published in Psychopharmacology (01.11.2009)
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