Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs
Ferruz, Noelia, Doerr, Stefan, Vanase-Frawley, Michelle A., Zou, Yaozhong, Chen, Xiaomin, Marr, Eric S., Nelson, Robin T., Kormos, Bethany L., Wager, Travis T., Hou, Xinjun, Villalobos, Anabella, Sciabola, Simone, De Fabritiis, Gianni
Published in Scientific reports (17.01.2018)
Published in Scientific reports (17.01.2018)
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Systematic N-methylation of oxytocin: Impact on pharmacology and intramolecular hydrogen bonding network
Sciabola, Simone, Goetz, Gilles H., Bai, Guoyun, Rogers, Bruce N., Gray, David L., Duplantier, Allen, Fonseca, Kari R., Vanase-Frawley, Michelle A., Kablaoui, Natasha M.
Published in Bioorganic & medicinal chemistry (15.08.2016)
Published in Bioorganic & medicinal chemistry (15.08.2016)
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Identification of Multiple 5‑HT4 Partial Agonist Clinical Candidates for the Treatment of Alzheimer’s Disease
Brodney, Michael A, Johnson, David E, Sawant-Basak, Aarti, Coffman, Karen J, Drummond, Elena M, Hudson, Emily L, Fisher, Katherine E, Noguchi, Hirohide, Waizumi, Nobuaki, McDowell, Laura L, Papanikolaou, Alexandros, Pettersen, Betty A, Schmidt, Anne W, Tseng, Elaine, Stutzman-Engwall, Kim, Rubitski, David M, Vanase-Frawley, Michelle A, Grimwood, Sarah
Published in Journal of medicinal chemistry (08.11.2012)
Published in Journal of medicinal chemistry (08.11.2012)
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Metabolism of a Serotonin-4 Receptor Partial Agonist 4-{4-[4-Tetrahydrofuran-3-yloxy)-Benzo[d]Isoxazol-3-yloxymethyl]-Piperidin-1-ylmethyl}-Tetrahydropyran-4-ol (TBPT): Identification of an Unusual Pharmacologically Active Cyclized Oxazolidine Metabolite in Human
Sawant-Basak, Aarti, Coffman, Karen J., Walker, Gregory S., Ryder, Tim F., Tseng, Elaine, Miller, Emily, Lee, Carlos, Vanase-Frawley, Michelle A., Wong, John W., Brodney, Michael A., Rapp, Tracey, Obach, R. Scott
Published in Journal of pharmaceutical sciences (01.09.2013)
Published in Journal of pharmaceutical sciences (01.09.2013)
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Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy
Diggle, Christine P., Sukoff Rizzo, Stacey J., Popiolek, Michael, Hinttala, Reetta, Schülke, Jan-Philip, Kurian, Manju A., Carr, Ian M., Markham, Alexander F., Bonthron, David T., Watson, Christopher, Sharif, Saghira Malik, Reinhart, Veronica, James, Larry C., Vanase-Frawley, Michelle A., Charych, Erik, Allen, Melanie, Harms, John, Schmidt, Christopher J., Ng, Joanne, Pysden, Karen, Strick, Christine, Vieira, Päivi, Mankinen, Katariina, Kokkonen, Hannaleena, Kallioinen, Matti, Sormunen, Raija, Rinne, Juha O., Johansson, Jarkko, Alakurtti, Kati, Huilaja, Laura, Hurskainen, Tiina, Tasanen, Kaisa, Anttila, Eija, Marques, Tiago Reis, Howes, Oliver, Politis, Marius, Fahiminiya, Somayyeh, Nguyen, Khanh Q., Majewski, Jacek, Uusimaa, Johanna, Sheridan, Eamonn, Brandon, Nicholas J.
Published in American journal of human genetics (07.04.2016)
Published in American journal of human genetics (07.04.2016)
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Author Correction: Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs
Ferruz, Noelia, Doerr, Stefan, Vanase-Frawley, Michelle A., Zou, Yaozhong, Chen, Xiaomin, Marr, Eric S., Nelson, Robin T., Kormos, Bethany L., Wager, Travis T., Hou, Xinjun, Villalobos, Anabella, Sciabola, Simone, De Fabritiis, Gianni
Published in Scientific reports (10.04.2019)
Published in Scientific reports (10.04.2019)
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Design, synthesis and evaluation of [3H]PF-7191, a highly specific nociceptin opioid peptide (NOP) receptor radiotracer for in vivo receptor occupancy (RO) studies
Zhang, Lei, Drummond, Elena, Brodney, Michael A., Cianfrogna, Julie, Drozda, Susan E., Grimwood, Sarah, Vanase-Frawley, Michelle A., Villalobos, Anabella
Published in Bioorganic & medicinal chemistry letters (15.11.2014)
Published in Bioorganic & medicinal chemistry letters (15.11.2014)
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Dopamine D3/D2 Receptor Antagonist PF-4363467 Attenuates Opioid Drug-Seeking Behavior without Concomitant D2 Side Effects
Wager, Travis T, Chappie, Thomas, Horton, David, Chandrasekaran, Ramalakshmi Y, Samas, Brian, Dunn-Sims, Elizabeth R, Hsu, Cathleen, Nawreen, Nawshaba, Vanase-Frawley, Michelle A, O’Connor, Rebecca E, Schmidt, Christopher J, Dlugolenski, Keith, Stratman, Nancy C, Majchrzak, Mark J, Kormos, Bethany L, Nguyen, David P, Sawant-Basak, Aarti, Mead, Andy N
Published in ACS chemical neuroscience (18.01.2017)
Published in ACS chemical neuroscience (18.01.2017)
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The 5-Hydroxytryptamine 4 Receptor Agonists Prucalopride and PRX-03140 Increase Acetylcholine and Histamine Levels in the Rat Prefrontal Cortex and the Power of Stimulated Hippocampal θ Oscillations
Johnson, David E., Drummond, Elena, Grimwood, Sarah, Sawant-Basak, Aarti, Miller, Emily, Tseng, Elaine, McDowell, Laura L., Vanase-Frawley, Michelle A., Fisher, Katherine E., Rubitski, David M., Stutzman-Engwall, Kim J., Nelson, Robin T., Horner, Weldon E., Gorczyca, Roxanne R., Hajos, Mihaly, Siok, Chester J.
Published in The Journal of pharmacology and experimental therapeutics (01.06.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2012)
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Journal Article
Dopamine D3/D2 Receptor Antagonist PF-4363467 Attenuates Opioid Drug-Seeking Behavior without Concomitant D2 Side Effects
Wager, Travis T., Chappie, Thomas, Horton, David, Chandrasekaran, Ramalakshmi Y., Samas, Brian, Dunn-Sims, Elizabeth R., Hsu, Cathleen, Nawreen, Nawshaba, Vanase-Frawley, Michelle A., O’Connor, Rebecca E., Schmidt, Christopher J., Dlugolenski, Keith, Stratman, Nancy C., Majchrzak, Mark J., Kormos, Bethany L., Nguyen, David P., Sawant-Basak, Aarti, Mead, Andy N.
Published in ACS chemical neuroscience (10.10.2016)
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Published in ACS chemical neuroscience (10.10.2016)
Journal Article
Identification of Multiple 5-HT 4 Partial Agonist Clinical Candidates for the Treatment of Alzheimer’s Disease
Brodney, Michael A., Johnson, David E., Sawant-Basak, Aarti, Coffman, Karen J., Drummond, Elena M., Hudson, Emily L., Fisher, Katherine E., Noguchi, Hirohide, Waizumi, Nobuaki, McDowell, Laura L., Papanikolaou, Alexandros, Pettersen, Betty A., Schmidt, Anne W., Tseng, Elaine, Stutzman-Engwall, Kim, Rubitski, David M., Vanase-Frawley, Michelle A., Grimwood, Sarah
Published in Journal of medicinal chemistry (08.11.2012)
Published in Journal of medicinal chemistry (08.11.2012)
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Journal Article
The 5-hydroxytryptamine4 receptor agonists prucalopride and PRX-03140 increase acetylcholine and histamine levels in the rat prefrontal cortex and the power of stimulated hippocampal θ oscillations
Johnson, David E, Drummond, Elena, Grimwood, Sarah, Sawant-Basak, Aarti, Miller, Emily, Tseng, Elaine, McDowell, Laura L, Vanase-Frawley, Michelle A, Fisher, Katherine E, Rubitski, David M, Stutzman-Engwall, Kim J, Nelson, Robin T, Horner, Weldon E, Gorczyca, Roxanne R, Hajos, Mihaly, Siok, Chester J
Published in The Journal of pharmacology and experimental therapeutics (01.06.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2012)
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