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Published in PLoS pathogens (01.06.2020)
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Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801
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Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A‑Disulfide Reductase by Coenzyme A‑Mimetics: Mechanistic and Structural Insights
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Published in Biochemistry (Easton) (02.10.2012)
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Dose-fractionation studies of a Plasmodium phosphatidylinositol 4-kinase inhibitor in a humanized mouse model of malaria
Gibhard, Liezl, Njoroge, Mathew, Mulubwa, Mwila, Lawrence, Nina, Smith, Dennis, Duffy, James, Le Manach, Claire, Brunschwig, Christel, Taylor, Dale, van der Westhuyzen, Renier, Street, Leslie J, Basarab, Gregory S, Chibale, Kelly
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Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors
Yoo, Euna, Stokes, Barbara H, de Jong, Hanna, Vanaerschot, Manu, Kumar, TRS, Lawrence, Nina, Njoroge, Mathew, Garcia, Arnold, Van der Westhuyzen, Renier, Momper, Jeremiah D, Ng, Caroline L, Fidock, David A, Bogyo, Matthew
Published in Journal of the American Chemical Society (12.09.2018)
Published in Journal of the American Chemical Society (12.09.2018)
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Pyrrolo[3,4‑c]pyridine-1,3(2H)‑diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration
van der Westhuyzen, Renier, Winks, Susan, Wilson, Colin R, Boyle, Grant A, Gessner, Richard K, Soares de Melo, Candice, Taylor, Dale, de Kock, Carmen, Njoroge, Mathew, Brunschwig, Christel, Lawrence, Nina, Rao, Srinivasa P.S, Sirgel, Frederick, van Helden, Paul, Seldon, Ronnett, Moosa, Atica, Warner, Digby F, Arista, Luca, Manjunatha, Ujjini H, Smith, Paul W, Street, Leslie J, Chibale, Kelly
Published in Journal of medicinal chemistry (10.12.2015)
Published in Journal of medicinal chemistry (10.12.2015)
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Benzoheterocyclic Oxime Carbamates Active against Mycobacterium tuberculosis: Synthesis, Structure–Activity Relationship, Metabolism, and Biology Triaging
van der Westhuyzen, Renier, Mabhula, Amanda, Njaria, Paul M, Müller, Rudolf, Ngumbu Muhunga, Denis, Taylor, Dale, Lawrence, Nina, Njoroge, Mathew, Brunschwig, Christel, Moosa, Atica, Singh, Vinayak, Rao, Srinivasa P.S, Manjunatha, Ujjini H, Smith, Paul W, Warner, Digby F, Street, Leslie J, Chibale, Kelly
Published in Journal of medicinal chemistry (08.07.2021)
Published in Journal of medicinal chemistry (08.07.2021)
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Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization
Soares de Melo, Candice, Feng, Tzu-Shean, van der Westhuyzen, Renier, Gessner, Richard K., Street, Leslie J., Morgans, Garreth L., Warner, Digby F., Moosa, Atica, Naran, Krupa, Lawrence, Nina, Boshoff, Helena I.M., Barry, Clifton E., Harris, C. John, Gordon, Richard, Chibale, Kelly
Published in Bioorganic & medicinal chemistry (15.11.2015)
Published in Bioorganic & medicinal chemistry (15.11.2015)
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The Antibiotic CJ-15,801 Is an Antimetabolite that Hijacks and Then Inhibits CoA Biosynthesis
van der Westhuyzen, Renier, Hammons, Justin C., Meier, Jordan L., Dahesh, Samira, Moolman, Wessel J.A., Pelly, Stephen C., Nizet, Victor, Burkart, Michael D., Strauss, Erick
Published in Chemistry & biology (25.05.2012)
Published in Chemistry & biology (25.05.2012)
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Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801† †Electronic supplementary information (ESI) available: Additional experimental information and electronic copies of selected spectra. See DOI: 10.1039/c9md00312f
Domingo, Riyad, van der Westhuyzen, Renier, Hamann, Anton R., Mostert, Konrad J., Barnard, Leanne, Paquet, Tanya, Tjhin, Erick T., Saliba, Kevin J., van Otterlo, Willem A. L., Strauss, Erick
Published in MedChemComm (17.10.2019)
Published in MedChemComm (17.10.2019)
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Corrigendum to “Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization” [Bioorg. Med. Chem. 23 (2015) 7240–7250]
Soares de Melo, Candice, Feng, Tzu-Shean, van der Westhuyzen, Renier, Gessner, Richard K., Street, Leslie J., Morgans, Garreth L., Warner, Digby F., Moosa, Atica, Naran, Krupa, Lawrence, Nina, Boshoff, Helena I.M., Barry, Clifton E., Harris, C. John, Gordon, Richard, Chibale, Kelly
Published in Bioorganic & medicinal chemistry (15.01.2016)
Published in Bioorganic & medicinal chemistry (15.01.2016)
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Journal Article
The Antibiotic CJ-15,801 is an Antimetabolite which Hijacks and then Inhibits CoA Biosynthesis
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Published in Chemistry & biology (25.05.2012)
Published in Chemistry & biology (25.05.2012)
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