Preclinical activity of the type II CD20 antibody GA101 (obinutuzumab) compared with rituximab and ofatumumab in vitro and in xenograft models
Herter, Sylvia, Herting, Frank, Mundigl, Olaf, Waldhauer, Inja, Weinzierl, Tina, Fauti, Tanja, Muth, Gunter, Ziegler-Landesberger, Doris, Van Puijenbroek, Erwin, Lang, Sabine, Duong, Minh Ngoc, Reslan, Lina, Gerdes, Christian A, Friess, Thomas, Baer, Ute, Burtscher, Helmut, Weidner, Michael, Dumontet, Charles, Umana, Pablo, Niederfellner, Gerhard, Bacac, Marina, Klein, Christian
Published in Molecular cancer therapeutics (01.10.2013)
Published in Molecular cancer therapeutics (01.10.2013)
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Journal Article
High-affinity CD16-polymorphism and Fc-engineered antibodies enable activity of CD16-chimeric antigen receptor-modified T cells for cancer therapy
Rataj, Felicitas, Jacobi, Severin J., Stoiber, Stefan, Asang, Florian, Ogonek, Justyna, Tokarew, Nicholas, Cadilha, Bruno L., van Puijenbroek, Erwin, Heise, Constanze, Duewell, Peter, Endres, Stefan, Klein, Christian, Kobold, Sebastian
Published in British journal of cancer (08.01.2019)
Published in British journal of cancer (08.01.2019)
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Journal Article
The Type II Anti‐CD20 Antibody Obinutuzumab (GA101) Is More Effective Than Rituximab at Depleting B Cells and Treating Disease in a Murine Lupus Model
Marinov, Anthony D., Wang, Haowei, Bastacky, Sheldon I., Puijenbroek, Erwin, Schindler, Thomas, Speziale, Dario, Perro, Mario, Klein, Christian, Nickerson, Kevin M., Shlomchik, Mark J.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.05.2021)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.05.2021)
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Journal Article
GA201 (RG7160): A Novel, Humanized, Glycoengineered Anti-EGFR Antibody with Enhanced ADCC and Superior In Vivo Efficacy Compared with Cetuximab
GERDES, Christian A, NICOLINI, Valeria Gonzalez, BOSSENMAIER, Birgit, MUELLER, Hans Joachim, UMANA, Pablo, HERTER, Sylvia, PUIJENBROEK, Erwin Van, LANG, Sabine, ROEMMELE, Michaela, MOESSNER, Ekkehard, FREYTAG, Olivier, FRIESS, Thomas, RIES, Carola H
Published in Clinical cancer research (01.03.2013)
Published in Clinical cancer research (01.03.2013)
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Journal Article
Simlukafusp alfa (FAP-IL2v) immunocytokine is a versatile combination partner for cancer immunotherapy
Waldhauer, Inja, Gonzalez-Nicolini, Valeria, Freimoser-Grundschober, Anne, Nayak, Tapan K, Fahrni, Linda, Hosse, Ralf J, Gerrits, Danny, Geven, Edwin J W, Sam, Johannes, Lang, Sabine, Bommer, Esther, Steinhart, Virginie, Husar, Elisabeth, Colombetti, Sara, Van Puijenbroek, Erwin, Neubauer, Markus, Cline, J Mark, Garg, Pradeep K, Dugan, Gregory, Cavallo, Federica, Acuna, Gonzalo, Charo, Jehad, Teichgräber, Volker, Evers, Stefan, Boerman, Otto C, Bacac, Marina, Moessner, Ekkehard, Umaña, Pablo, Klein, Christian
Published in mAbs (01.01.2021)
Published in mAbs (01.01.2021)
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Journal Article
GA101 P329GLALA, a variant of obinutuzumab with abolished ADCC, ADCP and CDC function but retained cell death induction, is as efficient as rituximab in B-cell depletion and antitumor activity
Herter, Sylvia, Herting, Frank, Muth, Gunter, van Puijenbroek, Erwin, Schlothauer, Tilman, Ferrara, Claudia, Brady, Kevin, Lang, Sabine, Bacac, Marina, Mössner, Ekkehard, Umana, Pablo, Klein, Christian
Published in Haematologica (Roma) (01.02.2018)
Published in Haematologica (Roma) (01.02.2018)
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Journal Article
Fc gamma receptor IIIb binding of individual antibody proteoforms resolved by affinity chromatography-mass spectrometry
Lippold, Steffen, Knaupp, Alexander, de Ru, Arnoud H, Tjokrodirijo, Rayman T N, van Veelen, Peter A, van Puijenbroek, Erwin, de Taeye, Steven W, Reusch, Dietmar, Vidarsson, Gestur, Wuhrer, Manfred, Schlothauer, Tilman, Falck, David
Published in mAbs (01.01.2021)
Published in mAbs (01.01.2021)
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Journal Article
Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines
Klein, Christian, Waldhauer, Inja, Nicolini, Valeria G., Freimoser-Grundschober, Anne, Nayak, Tapan, Vugts, Danielle J., Dunn, Claire, Bolijn, Marije, Benz, Jörg, Stihle, Martine, Lang, Sabine, Roemmele, Michaele, Hofer, Thomas, van Puijenbroek, Erwin, Wittig, David, Moser, Samuel, Ast, Oliver, Brünker, Peter, Gorr, Ingo H., Neumann, Sebastian, de Vera Mudry, Maria Cristina, Hinton, Heather, Crameri, Flavio, Saro, Jose, Evers, Stefan, Gerdes, Christian, Bacac, Marina, van Dongen, Guus, Moessner, Ekkehard, Umaña, Pablo
Published in Oncoimmunology (04.03.2017)
Published in Oncoimmunology (04.03.2017)
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Journal Article
Novel Tumor-Targeted, Engineered IL-2 Variant (IL2v)-Based Immunocytokines For Immunotherapy Of Cancer
Klein, Christian, Waldhauer, Inja, Nicolini, Valeria, Dunn, Claire, Freimoser-Grundschober, Anne, Danny, Gerrits, Boerman, Otto, Nayak, Tapan, Herter, Sylvia, Van Puijenbroek, Erwin, Ast, Oliver, Hofer, Thomas, Hosse, Ralf, Lang, Sabine, Neumann, Sebastian, Kettenberger, Hubert, Neubauer, Markus, Gorr, Ingo, Tuerck, Dietrich, Evers, Stefan, Gerdes, Christian, Levitsky, Victor, Bacac, Marina, Moessner, Ekkehard, Umana, Pablo
Published in Blood (15.11.2013)
Published in Blood (15.11.2013)
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Journal Article
항-HBV 항체 및 사용 방법
PELLETIER NADEGE, DRIESSEN WOUTER, BERETTA MAXIME, POL STANISLAS, FISCHER JENS, SCHLOTHAUER TILMAN, BOURGINE MARYLINE, STRICK MARCHAND HELENE, MOUQUET HUGO, VAN PUIJENBROEK ERWIN, HEHLE VERENA, AIT GOUGHOULTE MALIKA, GEORGES GUY
Year of Publication 13.02.2023
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Year of Publication 13.02.2023
Patent
Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell–mediated B-cell cytotoxicity
Mössner, Ekkehard, Brünker, Peter, Moser, Samuel, Püntener, Ursula, Schmidt, Carla, Herter, Sylvia, Grau, Roger, Gerdes, Christian, Nopora, Adam, van Puijenbroek, Erwin, Ferrara, Claudia, Sondermann, Peter, Jäger, Christiane, Strein, Pamela, Fertig, Georg, Friess, Thomas, Schüll, Christine, Bauer, Sabine, Dal Porto, Joseph, Del Nagro, Christopher, Dabbagh, Karim, Dyer, Martin J.S., Poppema, Sibrand, Klein, Christian, Umaña, Pablo
Published in Blood (03.06.2010)
Published in Blood (03.06.2010)
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Journal Article
B cell depletion with anti-CD20 promotes neuroprotection in a BAFF-dependent manner in mice and humans
Wang, Angela A, Luessi, Felix, Neziraj, Tradite, Pössnecker, Elisabeth, Zuo, Michelle, Engel, Sinah, Hanuscheck, Nicholas, Florescu, Alexandra, Bugbee, Eryn, Ma, Xianjie I, Rana, Fatima, Lee, Dennis, Ward, Lesley A, Kuhle, Jens, Himbert, Johannes, Schraad, Muriel, van Puijenbroek, Erwin, Klein, Christian, Urich, Eduard, Ramaglia, Valeria, Pröbstel, Anne-Katrin, Zipp, Frauke, Gommerman, Jennifer L
Published in Science translational medicine (06.03.2024)
Published in Science translational medicine (06.03.2024)
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Journal Article
Premedication and Chemotherapy Agents do not Impair Imgatuzumab (GA201)-Mediated Antibody-Dependent Cellular Cytotoxicity and Combination Therapies Enhance Efficacy
Gonzalez-Nicolini, Valeria, Herter, Sylvia, Lang, Sabine, Waldhauer, Inja, Bacac, Marina, Roemmele, Michaela, Bommer, Esther, Freytag, Olivier, van Puijenbroek, Erwin, Umaña, Pablo, Gerdes, Christian A
Published in Clinical cancer research (15.05.2016)
Published in Clinical cancer research (15.05.2016)
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Journal Article
Abstract 2460: Dissecting the in vitro and in vivo mechanism of action of obinutuzumab (GA101) in preclinical models using an immune effector-dead version of obinutuzumab
Herter, Sylvia, Herting, Frank, Muth, Gunter, van Puijenbroek, Erwin, Ferrara, Claudia, Lang, Sabine, Bacac, Marina, Moessner, Ekkehard, Umana, Pablo, Klein, Christian
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Abstract 3629: Engineering a novel asymmetric head-to-tail 2+1 T-cell bispecific (2+1 TCB) IgG antibody platform with superior T-cell killing compared to 1+1 asymmetric TCBs
Klein, Christian, Neumann, Christiane, Fauti, Tanja, Weinzierl, Tina, Freimoser-Grundschober, Anne, Waldhauer, Inja, Fahrni, Linda, Herter, Sylvia, Puijenbroek, Erwin van, Colombetti, Sara, Sam, Johannes, Lang, Sabine, Dudal, Sherri, Schäfer, Wolfgang, Regula, Jörg T., Moser, Samuel, Ast, Oliver, Hosse, Ralf, Mössner, Ekkehard, Brünker, Peter, Bacac, Marina, Umana, Pablo
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
A New Class of T-Cell Bispecific Antibodies for the Treatment of Multiple Myeloma, Binding to B Cell Maturation Antigen and CD3 and Showing Potent, Specific Antitumor Activity in Myeloma Cells and Long Duration of Action in Cynomolgus Monkeys
Vu, Minh Diem, Moser, Samuel, Delon, Camille, Latzko, Melanie, Gianotti, Reto, Lüoend, Remo, Friang, Chloé, Murr, Ramona, Duerner, Lydia Jasmin, Weinzierl, Tina, Fauti, Tanja, Bacac, Marina, Ast, Oliver, Freimoser-Grundschober, Anne, Rodriguez Diaz, Tea, Zielonka, Jörg, van Puijenbroek, Erwin, Hosse, Ralf, Bruenker, Peter, Mössner, Ekkehard, Klein, Christian, Umaña, Pablo, Strein, Klaus
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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Journal Article
Abstract A156: GA201 (RG7160) pretreatments and combination therapies improve efficacy without negatively affecting antitumoral ADCC
Nicolini, Valeria, Herter, Sylvia, Lang, Sabine, Walhauer, Inja, van Puijenbroek, Erwin, Dunn, Claire, Umana, Pablo, Gerdes, Christian A.
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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Journal Article
Abstract 486: Tumor-targeted, engineered IL-2 variant (IL-2v)-based immunocytokines for the immunotherapy of cancer
Klein, Christian, Waldhauer, Inja, Nicolini, Valeria, Dunn, Claire, Freimoser-Grundschober, Anne, Herter, Sylvia, Geven, Edwin, Boerman, Otto, Nayak, Tapan, van Puijenbroek, Erwin, Wittig, David, Moser, Samuel, Ast, Oliver, Bruenker, Peter, Hosse, Ralf, Lang, Sabine, Neumann, Sebastian, Kettenberger, Hubert, Grossmann, Adelbert, Gorr, Ingo, Evers, Stefan, Pisa, Pavel, Fretland, Jennifer, Levitsky, Victor, Gerdes, Christian, Bacac, Marina, Moessner, Ekkehard, Umaña, Pablo
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Journal Article
Abstract PR8: Novel tumor-targeted, engineered IL-2 variant (IL-2v)-based immunocytokines for immunotherapy of cancer
Klein, Christian, Inja, Waldhauer, Nicolini, Valeria, Claire, Dunn, Freimoser, Anne, Herter, Sylvia, Geven, Edwin, Boerman, Otto, Puijenbroek, Erwin van, Wittig, David, Moser, Samuel, Ast, Oliver, Hosse, Ralf, Lang, Sabine, Neumann, Sebastian, Grossmann, Adelbert, Gorr, Ingo, Evers, Stefan, Pisa, Pavel, Fretland, Jennifer, Levitsky, Victor, Gerdes, Christian, Bacac, Marina, Moessner, Ekkehard, Umaña, Pablo
Published in Cancer research (Chicago, Ill.) (01.01.2013)
Published in Cancer research (Chicago, Ill.) (01.01.2013)
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Journal Article
Abstract LB-236: M4-3-ML2, a novel glycoengineered humanized IgG1 antibody, targeting a membrane-proximal epitope of MCSP/CSPG4 exhibits potent ADCC induction in vitro and in vivo anti-tumoral efficacy in disseminated melanoma models
Mössner, Ekkehard, Tuffin, Gerald, Colombetti, Sara, Freytag, Olivier, Moser, Samuel, Dunn, Claire, Bacac, Marina, Herter, Sylvia, Otz, Tina, Waldhauer, Inja, Fauti, Tanja, van Puijenbroek, Erwin, Nicolini, Valeria, Freimoser, Anne, Jäger, Christiane, Mundigl, Olaf, Georges, Guy, Culton, Lisa, Manigold, Tobias, Gerdes, Christian, Umana, Pablo, Klein, Christian
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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