Evaluation of metabolite profiles as biomarkers for the pharmacological effects of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers
Van Doorn, Martijn, Vogels, Jack, Tas, Albert, Van Hoogdalem, Ewoud Jan, Burggraaf, Jacobus, Cohen, Adam, Van Der Greef, Jan
Published in British journal of clinical pharmacology (01.05.2007)
Published in British journal of clinical pharmacology (01.05.2007)
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Safety and Pharmacokinetics of Intravenous and Oral Fosmanogepix, a First-in-Class Antifungal Agent, in Healthy Volunteers
Hodges, Michael R, Ople, Eric, Wedel, Pamela, Shaw, Karen J, Jakate, Abhijeet, Kramer, William G, Marle, Sjoerd van, van Hoogdalem, Ewoud-Jan, Tawadrous, Margaret
Published in Antimicrobial agents and chemotherapy (18.04.2023)
Published in Antimicrobial agents and chemotherapy (18.04.2023)
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Journal Article
Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion
He, Shenghui, Roberts, Patrick J, Sorrentino, Jessica A, Bisi, John E, Storrie-White, Hannah, Tiessen, Renger G, Makhuli, Karenann M, Wargin, William A, Tadema, Henko, van Hoogdalem, Ewoud-Jan, Strum, Jay C, Malik, Rajesh, Sharpless, Norman E
Published in Science translational medicine (26.04.2017)
Published in Science translational medicine (26.04.2017)
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Pharmacokinetics, safety, and tolerability of fosmanogepix IV to oral switch and multiple IV doses in healthy participants
Hodges, Michael R, Hazel, Susan, Kramer, William G, van Hoogdalem, Ewoud-Jan, van Marle, Sjoerd, Tawadrous, Margaret, Jakate, Abhijeet
Published in Antimicrobial agents and chemotherapy (02.05.2024)
Published in Antimicrobial agents and chemotherapy (02.05.2024)
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Journal Article
Predictability of Elimination and Excretion of Small Molecules in Animals and Humans, and its Impact on Dosimetry for human ADME Studies with Radiolabeled Drugs
Roffel, Ad, Lier, Jan Jaap van, Rozema, Gerk, van Hoogdalem, Ewoud-Jan
Published in Current reviews in clinical and experimental pharmacology (2022)
Published in Current reviews in clinical and experimental pharmacology (2022)
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Journal Article
Renal glucose excretion as a function of blood glucose concentration in subjects with type 2 diabetes—results of a hyperglycaemic glucose clamp study
Rave, Klaus, Nosek, Leszek, Posner, John, Heise, Tim, Roggen, Kerstin, van Hoogdalem, Ewoud-Jan
Published in Nephrology, dialysis, transplantation (01.08.2006)
Published in Nephrology, dialysis, transplantation (01.08.2006)
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Journal Article
First-in-Human Study of the Safety, Tolerability, Pharmacokinetics and - Preliminary Dynamics of Neuroprotectant 2-Iminobiotin in Healthy Subjects
van Hoogdalem, Ewoud-Jan, Peeters-Scholte, Cacha M P C D, Leufkens, Paul W T J, Hartstra, Jan, van Lier, Jan J, de Leede, Leo G J
Published in Current clinical pharmacology (01.01.2020)
Published in Current clinical pharmacology (01.01.2020)
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Journal Article
First-in-human Phase 1 safety, PK, and PD study of the CDK4/6 inhibitor G1T28
Tiessen, Renger G., Roberts, Patrick J., Sorrentino, Jessica A., White, Hannah S., Makhuli, Karenann M., Bisi, John E., Strum, Jay C., Hoogdalem, Ewoud-Jan van, Malik, Rajesh K.
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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Journal Article
Evaluation of targeted bone marrow arrest by G1T28, a CDK4/6 inhibitor in clinical development to reduce chemotherapy-induced myelosuppression
Roberts, Patrick J., White, Hannah S., Sorrentino, Jessica A., Tadema, Henko, Sale, Mark, Tiessen, Renger G., Bisi, John E., Makhuli, Karenann M., Hoogdalem, Ewoud-Jan van, Malik, Rajesh K., Strum, Jay C.
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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Journal Article
Phase 1 Study to Assess Safety, Tolerability and Pharmacokinetics of Single and Multiple Oral Doses of APX001 and to Investigate the Effect of Food on APX001 Bioavailability
Hodges, Michael R, Ople, Eric, Shaw, Karen J, Mansbach, Robert, Van Marle, Sjoerd P, Van Hoogdalem, Ewoud-Jan, Kramer, William, Wedel, Pamela
Published in Open forum infectious diseases (01.10.2017)
Published in Open forum infectious diseases (01.10.2017)
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Journal Article
First-in-Human Study to Assess Safety, Tolerability and Pharmacokinetics of APX001 Administered by Intravenous Infusion to Healthy Subjects
Hodges, Michael R, Ople, Eric, Shaw, Karen J, Mansbach, Robert, Van Marle, Sjoerd J, Van Hoogdalem, Ewoud-Jan, Wedel, Pamela, Kramer, William
Published in Open forum infectious diseases (01.10.2017)
Published in Open forum infectious diseases (01.10.2017)
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