CRISPR screen in regulatory T cells reveals modulators of Foxp3
Cortez, Jessica T, Montauti, Elena, Shifrut, Eric, Gatchalian, Jovylyn, Zhang, Yusi, Shaked, Oren, Xu, Yuanming, Roth, Theodore L, Simeonov, Dimitre R, Zhang, Yana, Chen, Siqi, Li, Zhongmei, Woo, Jonathan M, Ho, Josephine, Vogel, Ian A, Prator, Grace Y, Zhang, Bin, Lee, Youjin, Sun, Zhaolin, Ifergan, Igal, Van Gool, Frédéric, Hargreaves, Diana C, Bluestone, Jeffrey A, Marson, Alexander, Fang, Deyu
Published in Nature (London) (18.06.2020)
Published in Nature (London) (18.06.2020)
Get full text
Journal Article
Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity
Wang, David, Quiros, Jason, Mahuron, Kelly, Pai, Chien-Chun, Ranzani, Valeria, Young, Arabella, Silveria, Stephanie, Harwin, Tory, Abnousian, Arbi, Pagani, Massimiliano, Rosenblum, Michael D., Van Gool, Frederic, Fong, Lawrence, Bluestone, Jeffrey A., DuPage, Michel
Published in Cell reports (Cambridge) (12.06.2018)
Published in Cell reports (Cambridge) (12.06.2018)
Get full text
Journal Article
Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation
Molofsky, Ari B., Van Gool, Frédéric, Liang, Hong-Erh, Van Dyken, Steven J., Nussbaum, Jesse C., Lee, Jinwoo, Bluestone, Jeffrey A., Locksley, Richard M.
Published in Immunity (Cambridge, Mass.) (21.07.2015)
Published in Immunity (Cambridge, Mass.) (21.07.2015)
Get full text
Journal Article
Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner
Leo, Oberdan, Van Gool, Frédéric, Gallí, Mara, Gueydan, Cyril, Kruys, Véronique, Prevot, Pierre-Paul, Bedalov, Antonio, Mostoslavsky, Raul, Alt, Frederick W, De Smedt, Thibaut
Published in Nature medicine (01.02.2009)
Published in Nature medicine (01.02.2009)
Get full text
Journal Article
The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28
Muller, Yannick D, Nguyen, Duy P, Ferreira, Leonardo M R, Ho, Patrick, Raffin, Caroline, Valencia, Roxxana Valeria Beltran, Congrave-Wilson, Zion, Roth, Theodore L, Eyquem, Justin, Van Gool, Frederic, Marson, Alexander, Perez, Laurent, Wells, James A, Bluestone, Jeffrey A, Tang, Qizhi
Published in Frontiers in immunology (23.03.2021)
Published in Frontiers in immunology (23.03.2021)
Get full text
Journal Article
A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells
Van Gool, Frédéric, Nguyen, Michelle L.T., Mumbach, Maxwell R., Satpathy, Ansuman T., Rosenthal, Wendy L., Giacometti, Simone, Le, Duy T., Liu, Weihong, Brusko, Todd M., Anderson, Mark S., Rudensky, Alexander Y., Marson, Alexander, Chang, Howard Y., Bluestone, Jeffrey A.
Published in Immunity (Cambridge, Mass.) (19.02.2019)
Published in Immunity (Cambridge, Mass.) (19.02.2019)
Get full text
Journal Article
Interleukin-5–producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy
Van Gool, Frédéric, Molofsky, Ari B., Morar, Malika M., Rosenzwajg, Michelle, Liang, Hong-Erh, Klatzmann, David, Locksley, Richard M., Bluestone, Jeffrey A.
Published in Blood (04.12.2014)
Published in Blood (04.12.2014)
Get full text
Journal Article
Nicotinamide Phosphoribosyl Transferase/Pre-B Cell Colony-Enhancing Factor/Visfatin Is Required for Lymphocyte Development and Cellular Resistance to Genotoxic Stress
Rongvaux, Anthony, Galli, Mara, Denanglaire, Sebastien, Van Gool, Frederic, Dreze, Pierre L, Szpirer, Claude, Bureau, Fabrice, Andris, Fabienne, Leo, Oberdan
Published in The Journal of immunology (1950) (01.10.2008)
Published in The Journal of immunology (1950) (01.10.2008)
Get full text
Journal Article
Web Resource
Pharmacological inhibition of nicotinamide phosphoribosyltransferase/visfatin enzymatic activity identifies a new inflammatory pathway linked to NAD
Busso, Nathalie, Karababa, Mahir, Nobile, Massimo, Rolaz, Aline, Van Gool, Frédéric, Galli, Mara, Leo, Oberdan, So, Alexander, De Smedt, Thibaut
Published in PloS one (21.05.2008)
Published in PloS one (21.05.2008)
Get full text
Journal Article
ChemR23 dampens lung inflammation and enhances anti-viral immunity in a mouse model of acute viral pneumonia
Bondue, Benjamin, Vosters, Olivier, de Nadai, Patricia, Glineur, Stéphanie, De Henau, Olivier, Luangsay, Souphalone, Van Gool, Frédéric, Communi, David, De Vuyst, Paul, Desmecht, Daniel, Parmentier, Marc
Published in PLoS pathogens (01.11.2011)
Published in PLoS pathogens (01.11.2011)
Get full text
Journal Article
Web Resource
The autoimmune targets in IPEX are dominated by gut epithelial proteins
Eriksson, Daniel, Bacchetta, Rosa, Gunnarsson, Hörður Ingi, Chan, Alice, Barzaghi, Federica, Ehl, Stephan, Hallgren, Åsa, van Gool, Frederic, Sardh, Fabian, Lundqvist, Christina, Laakso, Saila M., Rönnblom, Anders, Ekwall, Olov, Mäkitie, Outi, Bensing, Sophie, Husebye, Eystein S., Anderson, Mark, Kämpe, Olle, Landegren, Nils
Published in Journal of allergy and clinical immunology (01.07.2019)
Published in Journal of allergy and clinical immunology (01.07.2019)
Get full text
Journal Article
Multiple Environmental Signaling Pathways Control the Differentiation of RORγt-Expressing Regulatory T Cells
Hussein, Hind, Denanglaire, Sébastien, Van Gool, Frédéric, Azouz, Abdulkader, Ajouaou, Yousra, El-Khatib, Hana, Oldenhove, Guillaume, Leo, Oberdan, Andris, Fabienne
Published in Frontiers in immunology (08.01.2020)
Published in Frontiers in immunology (08.01.2020)
Get full text
Journal Article
Nicotinamide inhibits B lymphocyte activation by disrupting MAPK signal transduction
Daniel, Julien, Marechal, Yoann, Van Gool, Frédéric, Andris, Fabienne, Leo, Oberdan
Published in Biochemical pharmacology (15.03.2007)
Published in Biochemical pharmacology (15.03.2007)
Get full text
Journal Article
Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes
Thompson, Peter J., Shah, Ajit, Ntranos, Vasilis, Van Gool, Frederic, Atkinson, Mark, Bhushan, Anil
Published in Cell metabolism (07.05.2019)
Published in Cell metabolism (07.05.2019)
Get full text
Journal Article
Discovery of stimulation-responsive immune enhancers with CRISPR activation
Simeonov, Dimitre R, Gowen, Benjamin G, Boontanrart, Mandy, Roth, Theodore L, Gagnon, John D, Mumbach, Maxwell R, Satpathy, Ansuman T, Lee, Youjin, Bray, Nicolas L, Chan, Alice Y, Lituiev, Dmytro S, Nguyen, Michelle L, Gate, Rachel E, Subramaniam, Meena, Li, Zhongmei, Woo, Jonathan M, Mitros, Therese, Ray, Graham J, Curie, Gemma L, Naddaf, Nicki, Chu, Julia S, Ma, Hong, Boyer, Eric, Van Gool, Frederic, Huang, Hailiang, Liu, Ruize, Tobin, Victoria R, Schumann, Kathrin, Daly, Mark J, Farh, Kyle K, Ansel, K Mark, Ye, Chun J, Greenleaf, William J, Anderson, Mark S, Bluestone, Jeffrey A, Chang, Howard Y, Corn, Jacob E, Marson, Alexander
Published in Nature (London) (07.09.2017)
Published in Nature (London) (07.09.2017)
Get full text
Journal Article
A new inflammatory pathway linked to NAD
Van Gool, Frédéric, Galli, Mara, Rongvaux, Anthony, Andris, Fabienne, Leo, Oberdan
Published in M.S. Médecine sciences (01.06.2009)
Published in M.S. Médecine sciences (01.06.2009)
Get full text
Journal Article
Generation of a mouse model of extrathymically-derived regulatory T cells in type 1 diabetes
Holohan, Daniel R., Dong, Shen, Porter, Caroline, Rozenblatt-Rosen, Orit, Regev, Aviv, Van Gool, Frederic, Bluestone, Jeffrey A.
Published in The Journal of immunology (1950) (01.05.2018)
Published in The Journal of immunology (1950) (01.05.2018)
Get full text
Journal Article