Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712
Breinlinger, Eric, Van Epps, Stacy, Friedman, Michael, Argiriadi, Maria, Chien, Ellen, Chhor, Gekleng, Cowart, Marlon, Dunstan, Theresa, Graff, Candace, Hardee, David, Herold, J. Martin, Little, Andrew, McCarthy, Richard, Parmentier, Julie, Perham, Matthew, Qiu, Wei, Schrimpf, Michael, Vargo, Thomas, Webster, Matthew P., Wu, Fei, Bennett, Dawn, Edmunds, Jeremy
Published in Journal of medicinal chemistry (26.10.2023)
Published in Journal of medicinal chemistry (26.10.2023)
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PRIMARY CARBOXAMIDES AS BTK INHIBITORS
FRANK KRISTINE E, HOEMANN MICHAEL Z, WILSON NOEL S, OSUMA AUGUSTINE, SHEPPARD GEORGE, BONAFOUX DOMINIQUE, VAN CAMP JENNIFER, VAN EPPS STACY A, HUNTLEY RAYMOND, SOMAL GAGANDEEP K, XU XIANGDONG, WALLACE GRIER A, WANG LU, DAVIS HEATHER M, FRIEDMAN MICHAEL M, VASUDEVAN ANIL, HEROLD J. MARTIN, WANG ZHI
Year of Publication 08.03.2016
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Year of Publication 08.03.2016
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Structure activity optimization of 6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazines as Jak1 kinase inhibitors
Friedman, Michael, Frank, Kristine E., Aguirre, Ana, Argiriadi, Maria A., Davis, Heather, Edmunds, Jeremy J., George, Dawn M., George, Jonathan S., Goedken, Eric, Fiamengo, Bryan, Hyland, Deborah, Li, Bin, Murtaza, Anwar, Morytko, Michael, Somal, Gagandeep, Stewart, Kent, Tarcsa, Edit, Van Epps, Stacy, Voss, Jeffrey, Wang, Lu, Woller, Kevin, Wishart, Neil
Published in Bioorganic & medicinal chemistry letters (15.10.2015)
Published in Bioorganic & medicinal chemistry letters (15.10.2015)
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Journal Article
Design and synthesis of tricyclic cores for kinase inhibition
Van Epps, Stacy, Fiamengo, Bryan, Edmunds, Jeremy, Ericsson, Anna, Frank, Kristine, Friedman, Michael, George, Dawn, George, Jonathan, Goedken, Eric, Kotecki, Brian, Martinez, Gloria, Merta, Philip, Morytko, Michael, Shekhar, Shashank, Skinner, Barbara, Stewart, Kent, Voss, Jeffrey, Wallace, Grier, Wang, Lu, Wishart, Neil
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
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Journal Article
PRIMARY CARBOXAMIDES AS BTK INHIBITORS
BONAFOUX, Dominique, OSUMA, Augustine, HUNTLEY, Raymond, SOMAL, Gagandeep, K, WALLACE, Grier, A, FRIEDMAN, Michael, M, VASUDEVAN, Anil, HOEMANN, Michael, Z, HEROLD, J. Martin, VAN CAMP, Jennifer, VAN EPPS, Stacy, A, SHEPPARD, George, FRANK, Kristine, E, XU, Xiangdong, DAVIS, Heather, M, WANG, Lu, WANG, Zhi, WILSON, Noel, S
Year of Publication 08.06.2022
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Year of Publication 08.06.2022
Patent
Primary carboxamides as btk inhibitors
Osuma, Augustine, Wang, Zhi, Bonafoux, Dominique, Herold, J, Huntley, Raymond, Sheppard, George, Van Camp, Jennifer, Wallace, Grier, Davis, Heather, Somal, Gagandeep, Xu, Xiangdong, Friedman, Michael M, Vasudevan, Anil, Wilson, Noel, Van Epps, Stacy, Frank, Kristine, Wang, Lu, Hoemann, Michael
Year of Publication 25.06.2021
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Year of Publication 25.06.2021
Patent
Primary carboxamides as btk inhibitors
Osuma, Augustine, Wang, Zhi, Bonafoux, Dominique, Herold, J, Huntley, Raymond, Sheppard, George, Van Camp, Jennifer, Wallace, Grier, Davis, Heather, Somal, Gagandeep, Xu, Xiangdong, Friedman, Michael M, Vasudevan, Anil, Wilson, Noel, Van Epps, Stacy, Frank, Kristine, Wang, Lu, Hoemann, Michael
Year of Publication 25.06.2021
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Year of Publication 25.06.2021
Patent
PRIMARY CARBOXAMIDES AS BTK INHIBITORS
VAN EPPS, STACY A, HUNTLEY, RAYMOND, WALLACE, GRIER A, DAVIS, HEATHER M, SOMAL, GAGANDEEP K, WANG, ZHI, SHEPPARD, GEORGE, VAN CAMP, JENNIFER, WANG, LU, OSUMA, AUGUSTINE, FRIEDMAN, MICHAEL M, VASUDEVAN, ANIL, FRANK, KRISTINE E, BONAFOUX, DOMINIQUE, XU, XIANGDONG, HEROLD, J. MARTIN, WILSON, NOEL S, HOEMANN, MICHAEL Z
Year of Publication 12.10.2021
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Year of Publication 12.10.2021
Patent
PRIMARY CARBOXAMIDES AS BTK INHIBITORS
Frank, Kristine E, Osuma, Augustine, Van Epps, Stacy Anne, Wang, Zhi, Bonafoux, Dominique, Huntley, Raymond, Sheppard, George, Van Camp, Jennifer, Xu, Xiangdong, Friedman, Michael M, Wallace, Grier Allan, Somal, Gagandeep Kaur, Vasudevan, Anil, Hoemann, Michael Z, Davis, Heather Michele, Wilson, Noel S, Wang, Lu, Herold, J. Martin
Year of Publication 17.06.2021
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Year of Publication 17.06.2021
Patent
Primary carboxamides as BTK inhibitors
FRANK, Kristine E, BONAFOUX, Dominique, OSUMA, Augustine, HUNTLEY, Raymond, VASUDEVAN, Anil, WANG Zhi, DAVIS, Heather M, HEROLD, J. Martin, HOEMANN, Michael Z, VAN CAMP, Jennifer, WILSON, Noel S, FRIEDMAN, Michael M, SHEPPARD, George, VAN EPPS, Stacy A, SOMAL, Gagandeep K, XU, Xiangdong, WALLACE, Grier A, WANG, Lu
Year of Publication 25.03.2021
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Year of Publication 25.03.2021
Patent
INHIBITORS OF TYROSINE KINASE 2 MEDIATED SIGNALING
Argiriadi, Maria A, Frank, Kristine E, Van Epps, Stacy A, Schrimpf, Michael R, Chien, Ellen Yulin Tsai, Cowart, Marlon D, Katcher, Matthew H, Hardee, David J, Webster, Matthew P, Dunstan, Theresa A, Vargo, Thomas R, Breinlinger, Eric C, Friedman, Michael M, Schiedler, David A, Scanio, Marc J, Qiu, Wei, Liu, Huaqing, Little, Andrew J, Herold, J. Martin
Year of Publication 13.08.2020
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Year of Publication 13.08.2020
Patent
PRIMARY CARBOXAMIDES AS BTK INHIBITORS
FRANK, Kristine E, BONAFOUX, Dominique, OSUMA, Augustine, HUNTLEY, Raymond, VASUDEVAN, Anil, DAVIS, Heather M, HEROLD, J. Martin, HOEMANN, Michael Z, VAN CAMP, Jennifer, WILSON, Noel S, FRIEDMAN, Michael M, SHEPPARD, George, VAN EPPS, Stacy A, SOMAL, Gagandeep K, XU, Xiangdong, WALLACE, Grier A, WANG, Lu, WANG, Zhi
Year of Publication 27.05.2020
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Year of Publication 27.05.2020
Patent
PRIMARY CARBOXAMIDES AS BTK INHIBITORS
HEROLD, J, BONAFOUX, Dominique, OSUMA, Augustine, HOEMANN, Michael, VAN EPPS, Stacy, WILSON, Noel, HUNTLEY, Raymond, VASUDEVAN, Anil, SOMAL, Gagandeep, DAVIS, Heather, VAN CAMP, Jennifer, SHEPPARD, George, WALLACE, Grier, XU, Xiangdong, FRIEDMAN, Michael, FRANK, Kristine, WANG, Lu, WANG, Zhi
Year of Publication 28.03.2019
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Year of Publication 28.03.2019
Patent
PRIMARY CARBOXAMIDES AS BTK INHIBITORS
HEROLD, J, BONAFOUX, Dominique, OSUMA, Augustine, HOEMANN, Michael, VAN EPPS, Stacy, WILSON, Noel, HUNTLEY, Raymond, VASUDEVAN, Anil, SOMAL, Gagandeep, DAVIS, Heather, VAN CAMP, Jennifer, SHEPPARD, George, WALLACE, Grier, XU, Xiangdong, FRIEDMAN, Michael, FRANK, Kristine, WANG, Lu, WANG, Zhi
Year of Publication 10.01.2019
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Year of Publication 10.01.2019
Patent
PRIMARY CARBOXAMIDES AS BTK INHIBITORS
FRANK, Kristine E, BONAFOUX, Dominique, OSUMA, Augustine, HUNTLEY, Raymond, VASUDEVAN, Anil, DAVIS, Heather M, HEROLD, J. Martin, HOEMANN, Michael Z, VAN CAMP, Jennifer, WILSON, Noel S, FRIEDMAN, Michael M, SHEPPARD, George, VAN EPPS, Stacy A, SOMAL, Gagandeep K, XU, Xiangdong, WALLACE, Grier A, WANG, Lu, WANG, Zhi
Year of Publication 20.10.2019
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Year of Publication 20.10.2019
Patent
PRIMARY CARBOXAMIDES AS BTK INHIBITORS
Frank, Kristine E, Osuma, Augustine, Van Epps, Stacy Anne, Wang, Zhi, Bonafoux, Dominique, Huntley, Raymond, Sheppard, George, Van Camp, Jennifer, Xu, Xiangdong, Friedman, Michael M, Wallace, Grier Allan, Somal, Gagandeep Kaur, Vasudevan, Anil, Hoemann, Michael Z, Davis, Heather Michele, Wilson, Noel S, Wang, Lu, Herold, J. Martin
Year of Publication 19.09.2019
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Year of Publication 19.09.2019
Patent
INHIBITORS OF TYROSINE KINASE 2 MEDIATED SIGNALING
LITTLE, ANDREW J, VAN EPPS, STACY A, SCHRIMPF, MICHAEL R, CHIEN, ELLEN YULIN TSAI, SCHIEDLER, DAVID A, BREINLINGER, ERIC C, WEBSTER, MATTHEW P, VARGO, THOMAS R, KATCHER, MATTHEW H, FRIEDMAN, MICHAEL M, FRANK, KRISTINE E, DUNSTAN, THERESA A, COWART, MARLON D, QIU, WEI, SCANIO, MARC J, HARDEE, DAVID J, HEROLD, J. MARTIN, ARGIRIADI, MARIA A, LIU, HUAQING
Year of Publication 19.09.2019
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Year of Publication 19.09.2019
Patent
INHIBITORS OF TYROSINE KINASE 2 MEDIATED SIGNALING
VARGO, Thomas R, FRANK, Kristine E, KATCHER, Matthew H, ARGIRIADI, Maria A, QIU, Wei, WEBSTER, Matthew P, LITTLE, Andrew J, HARDEE, David J, SCHIEDLER, David A, SCANIO, Marc J, COWART, Marlon D, HEROLD, J. Martin, LIU, Huaqing, BREINLINGER, Eric C, CHIEN, Ellen Yulin Tsai, FRIEDMAN, Michael M, DUNSTAN, Theresa A, VAN EPPS, Stacy A, SCHRIMPF, Michael R
Year of Publication 19.09.2019
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Year of Publication 19.09.2019
Patent