Deubiquitylating enzymes in receptor endocytosis and trafficking
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Published in Biochemical journal (15.12.2016)
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ADAM17-Dependent c-MET-STAT3 Signaling Mediates Resistance to MEK Inhibitors in KRAS Mutant Colorectal Cancer
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Published in Cell reports (Cambridge) (26.06.2014)
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Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells
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Published in Cell death & disease (29.10.2020)
Published in Cell death & disease (29.10.2020)
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Identification of Galanin and Its Receptor GalR1 as Novel Determinants of Resistance to Chemotherapy and Potential Biomarkers in Colorectal Cancer
STEVENSON, Leanne, ALLEN, Wendy L, TURKINGTON, Richard, JITHESH, Puthen V, PROUTSKI, Irina, STEWART, Gail, LENZ, Heinz-Josef, VAN SCHAEYBROECK, Sandra, LONGLEY, Daniel B, JOHNSTON, Patrick G
Published in Clinical cancer research (01.10.2012)
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Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges
Bradley, Conor A, Salto-Tellez, Manuel, Laurent-Puig, Pierre, Bardelli, Alberto, Rolfo, Christian, Tabernero, Josep, Khawaja, Hajrah A, Lawler, Mark, Johnston, Patrick G, Van Schaeybroeck, Sandra
Published in Nature reviews. Clinical oncology (01.09.2017)
Published in Nature reviews. Clinical oncology (01.09.2017)
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USP17 is required for clathrin mediated endocytosis of epidermal growth factor receptor
Jaworski, Jakub, de la Vega, Michelle, Fletcher, Sarah J, McFarlane, Cheryl, Greene, Michelle K, Smyth, Andrew W, Van Schaeybroeck, Sandra, Johnston, James A, Scott, Christopher J, Rappoport, Joshua Z, Burrows, James F
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Repurposing of Cetuximab in antibody-directed chemotherapy-loaded nanoparticles in EGFR therapy-resistant pancreatic tumours
McDaid, William J, Greene, Michelle K, Johnston, Michael C, Pollheimer, Ellen, Smyth, Peter, McLaughlin, Kirsty, Van Schaeybroeck, Sandra, Straubinger, Robert M, Longley, Daniel B, Scott, Christopher J
Published in Nanoscale (14.11.2019)
Published in Nanoscale (14.11.2019)
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EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer
Dunne, Philip D, Dasgupta, Sonali, Blayney, Jaine K, McArt, Darragh G, Redmond, Keara L, Weir, Jessica-Anne, Bradley, Conor A, Sasazuki, Takehiko, Shirasawa, Senji, Wang, Tingting, Srivastava, Supriya, Ong, Chee Wee, Arthur, Ken, Salto-Tellez, Manuel, Wilson, Richard H, Johnston, Patrick G, Van Schaeybroeck, Sandra
Published in Clinical cancer research (01.01.2016)
Published in Clinical cancer research (01.01.2016)
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An atlas of inter- and intra-tumor heterogeneity of apoptosis competency in colorectal cancer tissue at single-cell resolution
Lindner, Andreas Ulrich, Salvucci, Manuela, McDonough, Elizabeth, Cho, Sanghee, Stachtea, Xanthi, O'Connell, Emer P, Corwin, Alex D, Santamaria-Pang, Alberto, Carberry, Steven, Fichtner, Michael, Van Schaeybroeck, Sandra, Laurent-Puig, Pierre, Burke, John P, McNamara, Deborah A, Lawler, Mark, Sood, Anup, Graf, John F, Rehm, Markus, Dunne, Philip D, Longley, Daniel B, Ginty, Fiona, Prehn, Jochen H M
Published in Cell death and differentiation (01.04.2022)
Published in Cell death and differentiation (01.04.2022)
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Development of a protein signature to enable clinical positioning of IAP inhibitors in colorectal cancer
McCann, Christopher, Matveeva, Anna, McAllister, Katherine, Van Schaeybroeck, Sandra, Sessler, Tamas, Fichtner, Michael, Carberry, Steven, Rehm, Markus, Prehn, Jochen H.M., Longley, Daniel B.
Published in The FEBS journal (01.09.2021)
Published in The FEBS journal (01.09.2021)
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USP17 is required for peripheral trafficking of lysosomes
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Published in EMBO reports (05.04.2022)
Published in EMBO reports (05.04.2022)
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Stratification of chemotherapy-treated stage III colorectal cancer patients using multiplexed imaging and single-cell analysis of T-cell populations
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Published in Modern pathology (01.04.2022)
Published in Modern pathology (01.04.2022)
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Controlled coupling of an ultrapotent auristatin warhead to cetuximab yields a next-generation antibody-drug conjugate for EGFR-targeted therapy of KRAS mutant pancreatic cancer
Greene, Michelle K, Chen, Ting, Robinson, Eifion, Straubinger, Ninfa L, Minx, Charlene, Chan, Darren K W, Wang, Jun, Burrows, James F, Van Schaeybroeck, Sandra, Baker, James R, Caddick, Stephen, Longley, Daniel B, Mager, Donald E, Straubinger, Robert M, Chudasama, Vijay, Scott, Christopher J
Published in British journal of cancer (10.11.2020)
Published in British journal of cancer (10.11.2020)
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AXL Is a Key Regulator of Inherent and Chemotherapy-Induced Invasion and Predicts a Poor Clinical Outcome in Early-Stage Colon Cancer
DUNNE, Philip D, MCART, Darragh G, REDMOND, Keara, LONGLEY, Daniel B, SALTO-TELLEZ, Manuel, JOHNSTON, Patrick G, VAN SCHAEYBROECK, Sandra, BLAYNEY, Jaine K, KALIMUTHO, Murugan, GREER, Samanda, TINGTING WANG, SRIVASTAVA, Supriya, CHEE WEE ONG, ARTHUR, Ken, LOUGHREY, Maurice
Published in Clinical cancer research (01.01.2014)
Published in Clinical cancer research (01.01.2014)
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Fundamental control of grade‐specific colorectal cancer morphology by Src regulation of ezrin–centrosome engagement
Rainey, Lisa, Deevi, Ravi K, McClements, Jane, Khawaja, Hajrah, Watson, Chris J, Roudier, Martine, Van Schaeybroeck, Sandra, Campbell, Frederick C
Published in The Journal of pathology (01.07.2020)
Published in The Journal of pathology (01.07.2020)
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The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic BRAF Mutant Colorectal Cancer
Forsythe, Nicholas, Refaat, Alaa, Javadi, Arman, Khawaja, Hajrah, Weir, Jessica-Anne, Emam, Heba, Allen, Wendy L, Burkamp, Frank, Popovici, Vlad, Jithesh, Puthen V, Isella, Claudio, Labonte, Melissa J, Mills, Ian G, Johnston, Patrick G, Van Schaeybroeck, Sandra
Published in Molecular cancer therapeutics (01.06.2018)
Published in Molecular cancer therapeutics (01.06.2018)
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Chemotherapy-Induced Activation of ADAM-17: A Novel Mechanism of Drug Resistance in Colorectal Cancer
KYULA, Joan N, VAN SCHAEYBROECK, Sandra, DOHERTY, Joanne, FENNING, Catherine S, LONGLEY, Daniel B, JOHNSTON, Patrick G
Published in Clinical cancer research (01.07.2010)
Published in Clinical cancer research (01.07.2010)
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Orthogonal MET analysis in a population‐representative stage II–III colon cancer cohort: prognostic and potential therapeutic implications
Craig, Stephanie G., Mende, Svenja, Humphries, Matthew P., Bingham, Victoria, Viratham Pulsawatdi, Amélie, Loughrey, Maurice B., Coleman, Helen G., McQuaid, Stephen, Wilson, Richard H., Van Schaeybroeck, Sandra, James, Jacqueline A., Salto‐Tellez, Manuel
Published in Molecular oncology (01.12.2021)
Published in Molecular oncology (01.12.2021)
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USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells
McCann, Aidan P, Smyth, Peter, Cogo, Francesco, McDaid, William J, Jiang, Lai, Lin, Jia, Evergren, Emma, Burden, Roberta E, Van Schaeybroeck, Sandra, Scott, Christopher J, Burrows, James F
Published in Cell communication and signaling (08.11.2018)
Published in Cell communication and signaling (08.11.2018)
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