Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
Menon, Suchithra, Dibble, Christian C., Talbott, George, Hoxhaj, Gerta, Valvezan, Alexander J., Takahashi, Hidenori, Cantley, Lewis C., Manning, Brendan D.
Published in Cell (13.02.2014)
Published in Cell (13.02.2014)
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The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
Torrence, Margaret E, MacArthur, Michael R, Hosios, Aaron M, Valvezan, Alexander J, Asara, John M, Mitchell, James R, Manning, Brendan D
Published in eLife (01.03.2021)
Published in eLife (01.03.2021)
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mTORC1 activity oscillates throughout the cell cycle, promoting mitotic entry and differentially influencing autophagy induction
Joshi, Jay N., Lerner, Ariel D., Scallo, Frank, Grumet, Alexandra N., Matteson, Paul, Millonig, James H., Valvezan, Alexander J.
Published in Cell reports (Cambridge) (27.08.2024)
Published in Cell reports (Cambridge) (27.08.2024)
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The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish
Liu, Xiaolei, Jones, William D, Quesnel-Vallières, Mathieu, Devadiga, Sudhish A, Lorent, Kristin, Valvezan, Alexander J, Myers, Rebecca L, Li, Ning, Lengner, Christopher J, Barash, Yoseph, Pack, Michael, Klein, Peter S
Published in Journal of developmental biology (29.06.2023)
Published in Journal of developmental biology (29.06.2023)
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Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish
Valvezan, Alexander J, Huang, Jian, Lengner, Christopher J, Pack, Michael, Klein, Peter S
Published in Disease models & mechanisms (01.01.2014)
Published in Disease models & mechanisms (01.01.2014)
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Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
McNamara, Molly C., Hosios, Aaron M., Torrence, Margaret E., Zhao, Ting, Fraser, Cameron, Wilkinson, Meghan, Kwiatkowski, David J., Henske, Elizabeth P., Wu, Chin-Lee, Sarosiek, Kristopher A., Valvezan, Alexander J., Manning, Brendan D.
Published in iScience (18.11.2022)
Published in iScience (18.11.2022)
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mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability
Valvezan, Alexander J., Turner, Marc, Belaid, Amine, Lam, Hilaire C., Miller, Spencer K., McNamara, Molly C., Baglini, Christian, Housden, Benjamin E., Perrimon, Norbert, Kwiatkowski, David J., Asara, John M., Henske, Elizabeth P., Manning, Brendan D.
Published in Cancer cell (13.11.2017)
Published in Cancer cell (13.11.2017)
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Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi
Housden, Benjamin E, Valvezan, Alexander J, Kelley, Colleen, Sopko, Richelle, Hu, Yanhui, Roesel, Charles, Lin, Shuailiang, Buckner, Michael, Tao, Rong, Yilmazel, Bahar, Mohr, Stephanie E, Manning, Brendan D, Perrimon, Norbert
Published in Science signaling (08.09.2015)
Published in Science signaling (08.09.2015)
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A review of trilaciclib, a first-in-class cyclin-dependent kinase 4/6 inhibitor, for the management of metastatic small-cell lung cancer
Patel, Twinkle I., Joshi, Jay N., Valvezan, Alexander J., Moschitto, Matthew J.
Published in Medicinal chemistry research (01.10.2024)
Published in Medicinal chemistry research (01.10.2024)
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Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice
O'Brien, W Timothy, Huang, Jian, Buccafusca, Roberto, Garskof, Julie, Valvezan, Alexander J, Berry, Gerard T, Klein, Peter S
Published in The Journal of clinical investigation (01.09.2011)
Published in The Journal of clinical investigation (01.09.2011)
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Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA)
Housden, Benjamin E., Li, Zhongchi, Kelley, Colleen, Wang, Yuanli, Hu, Yanhui, Valvezan, Alexander J., Manning, Brendan D., Perrimon, Norbert
Published in Proceedings of the National Academy of Sciences - PNAS (12.12.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (12.12.2017)
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Lysosomal regulation of cholesterol homeostasis in tuberous sclerosis complex is mediated via NPC1 and LDL-R
Filippakis, Harilaos, Alesi, Nicola, Ogorek, Barbara, Nijmeh, Julie, Khabibullin, Damir, Gutierrez, Catherine, Valvezan, Alexander J, Cunningham, James, Priolo, Carmen, Henske, Elizabeth P
Published in Oncotarget (13.06.2017)
Published in Oncotarget (13.06.2017)
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IMPDH inhibitors for antitumor therapy in tuberous sclerosis complex
Valvezan, Alexander J, McNamara, Molly C, Miller, Spencer K, Torrence, Margaret E, Asara, John M, Henske, Elizabeth P, Manning, Brendan D
Published in JCI insight (09.04.2020)
Published in JCI insight (09.04.2020)
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The Tumor Suppressor IAdenomatous Polyposis Coli /I Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish
Liu, Xiaolei, Jones, William D, Quesnel-Vallières, Mathieu, Devadiga, Sudhish A, Lorent, Kristin, Valvezan, Alexander J, Myers, Rebecca L, Li, Ning, Lengner, Christopher J, Barash, Yoseph, Pack, Michael, Klein, Peter S
Published in Journal of developmental biology (01.06.2023)
Published in Journal of developmental biology (01.06.2023)
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Glycogen synthase kinase-3 is essential for [Beta]-arrestin-2 complex formation and lithium-sensitive behaviors in mice
O'Brien, W Timothy, Huang, Jian, Buccafusca, Roberto, Garskof, Julie, Valvezan, Alexander J, Berry, Gerard T, Klein, Peter S
Published in The Journal of clinical investigation (01.09.2011)
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Published in The Journal of clinical investigation (01.09.2011)
Journal Article
mTORC1 activity oscillates throughout the cell cycle promoting mitotic entry and differentially influencing autophagy induction
Joshi, Jay N, Lerner, Ariel D, Scallo, Frank, Grumet, Alexandra N, Matteson, Paul, Millonig, James H, Valvezan, Alexander J
Published in bioRxiv (07.02.2024)
Published in bioRxiv (07.02.2024)
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The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
Torrence, Margaret E, Macarthur, Michael R, Hosios, Aaron M, Valvezan, Alexander J, Asara, John M, Mitchell, James R, Manning, Brendan D
Published in bioRxiv (24.02.2021)
Published in bioRxiv (24.02.2021)
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