Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease
Meredith, Jr, Jere E, Sankaranarayanan, Sethu, Guss, Valerie, Lanzetti, Anthony J, Berisha, Flora, Neely, Robert J, Slemmon, J Randall, Portelius, Erik, Zetterberg, Henrik, Blennow, Kaj, Soares, Holly, Ahlijanian, Michael, Albright, Charles F
Published in PloS one (07.10.2013)
Published in PloS one (07.10.2013)
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Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies
Easton, Amy, Jensen, Marianne L., Wang, Congwei, Hagedorn, Peter H., Li, Yuwen, Weed, Michael, Meredith, Jere E., Guss, Valerie, Jones, Kelli, Gill, Martin, Krause, Carol, Brown, Jeffrey M., Hunihan, Lisa, Natale, Joanne, Fernandes, Alda, Lu, Yifeng, Polino, Joe, Bookbinder, Mark, Cadelina, Greg, Benitex, Yulia, Sane, Ramola, Morrison, John, Drexler, Dieter, Mercer, Stephen E., Bon, Charlotte, Pandya, Nikhil J., Jagasia, Ravi, Ou Yang, Tai-Hsien, Distler, Tania, Grüninger, Fiona, Meldgaard, Michael, Terrigno, Marco, Macor, John E., Albright, Charles F., Loy, James, Hoeg, Anja M., Olson, Richard E., Cacace, Angela M.
Published in Molecular therapy. Nucleic acids (13.09.2022)
Published in Molecular therapy. Nucleic acids (13.09.2022)
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Tau Transgenic Mice as Models for Cerebrospinal Fluid Tau Biomarkers
Barten, Donna M., Cadelina, Gregory W., Hoque, Nina, DeCarr, Lynn B., Guss, Valerie L., Yang, Ling, Sankaranarayanan, Sethu, Wes, Paul D., Flynn, Marianne E., Meredith, Jere E., Ahlijanian, Michael K., Albright, Charles F.
Published in Journal of Alzheimer's disease (01.01.2011)
Published in Journal of Alzheimer's disease (01.01.2011)
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An Assessment of the Effects of Serotonin 6 (5-HT6) Receptor Antagonists in Rodent Models of Learning
Lindner, Mark D, Hodges, Jr, Donald B, Hogan, John B, Orie, Anitra F, Corsa, Jason A, Barten, Donna M, Polson, Craig, Robertson, Barbara J, Guss, Valerie L, Gillman, Kevin W, Starrett, Jr, John E, Gribkoff, Valentin K
Published in The Journal of pharmacology and experimental therapeutics (01.11.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2003)
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Journal Article
2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as γ-secretase inhibitors
Parker, Michael F., Barten, Donna M., Bergstrom, Carl P., Bronson, Joanne J., Corsa, Jason A., Dee, Michael F., Gai, Yonghua, Guss, Valerie L., Higgins, Mendi A., Keavy, Daniel J., Loo, Alice, Mate, Robert A., Marcin, Larry R., McElhone, Katharine E., Polson, Craig T., Roberts, Susan B., Macor, John E.
Published in Bioorganic & medicinal chemistry letters (15.11.2012)
Published in Bioorganic & medicinal chemistry letters (15.11.2012)
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Discovery of (S) -2 -( (S) -2 -(3,5 -difluorophenyl ) -2-hydroxyacetamido ) -N-( (S,Z) -3 -methyl -4 -oxo -4,5 -dihydro -3H-benzo[d|[1,2 ]diazepin -5 -yl )propanamide (BMS -433796 ) : A γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's disease
PRASAD, C. V. C, MING ZHENG, LOO, Alice, JIAN WANG, SLECZKA, Bogdan G, DANGLER, Charles, ROBERTSON, Barbara J, HENDRICK, Joseph P, ROBERTS, Susan B, BARTEN, Donna M, VIG, Shikha, BERGSTROM, Carl, SMITH, David W, QI GAO, YEOLA, Suresh, POLSON, Craig T, CORSA, Jason A, GUSS, Valerie L
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
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Journal Article
Viable mouse gene ablations that robustly alter brain Aβ levels are rare
Toyn, Jeremy H, Lin, Xu-Alan, Thompson, Mark W, Guss, Valerie, Meredith, Jr, Jere E, Sankaranarayanan, Sethu, Barrezueta, Nestor, Corradi, John, Majumdar, Antara, Small, Daniel L, Hansard, Melissa, Lanthorn, Thomas, Westphal, Ryan S, Albright, Charles F
Published in BMC neuroscience (05.11.2010)
Published in BMC neuroscience (05.11.2010)
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Journal Article
Amino-caprolactam derivatives as γ-secretase inhibitors
Parker, Michael F., Bronson, Joanne J., Barten, Donna M., Corsa, Jason A., Du, Wengsheng, Felsenstein, Kevin M., Guss, Valerie L., Izzarelli, Darcy, Loo, Alice, McElhone, Kate E., Marcin, Larry R., Padmanabha, Ramesh, Pak, Roger, Polson, Craig T., Toyn, Jeremy H., Varma, Sam, Wang, Jian, Wong, Victoria, Zheng, Ming, Roberts, Susan B.
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
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Journal Article
2,3-Benzodiazepin-1,4-diones as peptidomimetic inhibitors of γ-secretase
Prasad, C.V.C., Vig, Shikha, Smith, David W., Gao, Qi, Polson, Craig T., Corsa, Jason A., Guss, Valerie L., Loo, Alice, Barten, Donna M., Zheng, Ming, Felsenstein, Kevin M., Roberts, Susan B.
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
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Journal Article
Nitrogen-appended N-alkylsulfonamides as inhibitors of γ-secretase
Bergstrom, Carl P., Sloan, Charles P., Wang, Henry H., Parker, Michael F., Smith, David W., Zheng, Ming, Hansel, Steven B., Polson, Craig T., Barber, Lauren E., Bursuker, Isia, Guss, Valerie L., Corsa, Jason A., Barten, Donna M., Felsenstein, Kevin M., Roberts, Susan B.
Published in Bioorganic & medicinal chemistry (2008)
Published in Bioorganic & medicinal chemistry (2008)
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Journal Article
N-(5-Chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as γ-secretase inhibitors
Parker, Michael F., Barten, Donna M., Bergstrom, Carl P., Bronson, Joanne J., Corsa, Jason A., Deshpande, Milind S., Felsenstein, Kevin M., Guss, Valerie L., Hansel, Steven B., Johnson, Graham, Keavy, Daniel J., Lau, Wai Y., Mock, Jeremy, Prasad, C.V.C., Polson, Craig T., Sloan, Charles P., Smith, David W., Wallace, Owen B., Wang, Henry H., Williams, Andrew, Zheng, Ming
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
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Journal Article
Divergent CSF τ alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy
Wagshal, Dana, Sankaranarayanan, Sethu, Guss, Valerie, Hall, Tracey, Berisha, Flora, Lobach, Iryna, Karydas, Anna, Voltarelli, Lisa, Scherling, Carole, Heuer, Hilary, Tartaglia, Maria Carmela, Miller, Zachary, Coppola, Giovanni, Ahlijanian, Michael, Soares, Holly, Kramer, Joel H, Rabinovici, Gil D, Rosen, Howard J, Miller, Bruce L, Meredith, Jere, Boxer, Adam L
Published in Journal of neurology, neurosurgery and psychiatry (01.03.2015)
Published in Journal of neurology, neurosurgery and psychiatry (01.03.2015)
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Journal Article
Measurement of Aβ1-42 in cerebrospinal fluid is influenced by matrix effects
Slemmon, J. Randall, Meredith, Jere, Guss, Valerie, Andreasson, Ulf, Andreasen, Niels, Zetterberg, Henrik, Blennow, Kaj
Published in Journal of neurochemistry (01.01.2012)
Published in Journal of neurochemistry (01.01.2012)
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Journal Article
Pharmacodynamics of selective inhibition of γ-secretase by avagacestat
Albright, Charles F, Dockens, Randy C, Meredith, Jr, Jere E, Olson, Richard E, Slemmon, Randy, Lentz, Kimberley A, Wang, Jun-Sheng, Denton, R Rex, Pilcher, Gary, Rhyne, Paul W, Raybon, Joseph J, Barten, Donna M, Burton, Catherine, Toyn, Jeremy H, Sankaranarayanan, Sethu, Polson, Craig, Guss, Valerie, White, Randy, Simutis, Frank, Sanderson, Thomas, Gillman, Kevin W, Starrett, Jr, John E, Bronson, Joanne, Sverdlov, Oleksandr, Huang, Shu-Pang, Castaneda, Lorna, Feldman, Howard, Coric, Vlad, Zaczek, Robert, Macor, John E, Houston, John, Berman, Robert M, Tong, Gary
Published in The Journal of pharmacology and experimental therapeutics (01.03.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2013)
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Journal Article
Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects
Toyn, Jeremy H, Boy, Kenneth M, Raybon, Joseph, Meredith, Jr, Jere E, Robertson, Alan S, Guss, Valerie, Hoque, Nina, Sweeney, Francis, Zhuo, Xiaoliang, Clarke, Wendy, Snow, Kimberly, Denton, R Rex, Zuev, Dmitry, Thompson, Lorin A, Morrison, John, Grace, James, Berisha, Flora, Furlong, Michael, Wang, Jun-Sheng, Lentz, Kimberly A, Padmanabha, Ramesh, Cook, Lynda, Wei, Cong, Drexler, Dieter M, Macor, John E, Albright, Charlie F, Gasior, Maciej, Olson, Richard E, Hong, Quan, Soares, Holly D, AbuTarif, Malaz, Ahlijanian, Michael K
Published in The Journal of pharmacology and experimental therapeutics (01.07.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2016)
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Utility of high resolution accurate mass spectrometry (HRMS) in the mass isotopomer distribution analysis (MIDA) of CSF proteins modified by stable isotope labeling in mammals (SILAM) methodology applied to neurodegenerative diseasesElectronic supplementary information (ESI) available: To establish analytical figures of merit such as sensitivity, specificity, accuracy, precision, and reproducibility for the MIDA by LC-HRMS approach, the following studies were performed. See DOI: 10.1039/c7ay0086
Cantone, Joseph L, Polson, Craig, Wei, Cong, Guss, Valerie, Ahlijanian, Michael K, Meredith, Jere E, Drexler, Dieter M
Year of Publication 15.06.2017
Year of Publication 15.06.2017
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Journal Article
Measurement of A beta 1-42 in cerebrospinal fluid is influenced by matrix effects
Slemmon, JRandall, Meredith, Jere, Guss, Valerie, Andreasson, Ulf, Andreasen, Niels, Zetterberg, Henrik, Blennow, Kaj
Published in Journal of neurochemistry (01.01.2012)
Published in Journal of neurochemistry (01.01.2012)
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Journal Article
Utility of high resolution accurate mass spectrometry (HRMS) in the mass isotopomer distribution analysis (MIDA) of CSF proteins modified by stable isotope labeling in mammals (SILAM) methodology applied to neurodegenerative diseases
Cantone, Joseph L., Polson, Craig, Wei, Cong, Guss, Valerie, Ahlijanian, Michael K., Meredith, Jere E., Drexler, Dieter M.
Published in Analytical methods (21.06.2017)
Published in Analytical methods (21.06.2017)
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Journal Article
P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice
Meredith, Jr, Jere E, Thompson, Lorin A, Toyn, Jeremy H, Marcin, Lawrence, Barten, Donna M, Marcinkeviciene, Jovita, Kopcho, Lisa, Kim, Young, Lin, Alan, Guss, Valerie, Burton, Catherine, Iben, Lawrence, Polson, Craig, Cantone, Joe, Ford, Michael, Drexler, Dieter, Fiedler, Tracey, Lentz, Kimberley A, Grace, Jr, James E, Kolb, Janet, Corsa, Jason, Pierdomenico, Maria, Jones, Kelli, Olson, Richard E, Macor, John E, Albright, Charles F
Published in The Journal of pharmacology and experimental therapeutics (01.08.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2008)
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