NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine
Valerie, Nicholas C K, Hagenkort, Anna, Page, Brent D G, Masuyer, Geoffrey, Rehling, Daniel, Carter, Megan, Bevc, Luka, Herr, Patrick, Homan, Evert, Sheppard, Nina G, Stenmark, Pål, Jemth, Ann-Sofie, Helleday, Thomas
Published in Cancer research (Chicago, Ill.) (15.09.2016)
Published in Cancer research (Chicago, Ill.) (15.09.2016)
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Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
Herold, Nikolas, Rudd, Sean G, Ljungblad, Linda, Sanjiv, Kumar, Myrberg, Ida Hed, Paulin, Cynthia B J, Heshmati, Yaser, Hagenkort, Anna, Kutzner, Juliane, Page, Brent D G, Calderón-Montaño, José M, Loseva, Olga, Jemth, Ann-Sofie, Bulli, Lorenzo, Axelsson, Hanna, Tesi, Bianca, Valerie, Nicholas C K, Höglund, Andreas, Bladh, Julia, Wiita, Elisée, Sundin, Mikael, Uhlin, Michael, Rassidakis, Georgios, Heyman, Mats, Tamm, Katja Pokrovskaja, Warpman-Berglund, Ulrika, Walfridsson, Julian, Lehmann, Sören, Grandér, Dan, Lundbäck, Thomas, Kogner, Per, Henter, Jan-Inge, Helleday, Thomas, Schaller, Torsten
Published in Nature medicine (01.02.2017)
Published in Nature medicine (01.02.2017)
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Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2
Carter, Megan, Jemth, Ann-Sofie, Hagenkort, Anna, Page, Brent D. G., Gustafsson, Robert, Griese, Julia J., Gad, Helge, Valerie, Nicholas C. K., Desroses, Matthieu, Boström, Johan, Warpman Berglund, Ulrika, Helleday, Thomas, Stenmark, Pål
Published in Nature communications (04.08.2015)
Published in Nature communications (04.08.2015)
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Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
Page, Brent D. G., Valerie, Nicholas C. K., Wright, Roni H. G., Wallner, Olov, Isaksson, Rebecka, Carter, Megan, Rudd, Sean G., Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Font-Mateu, Jofre, Llona-Minguez, Sabin, Baranczewski, Pawel, Jeppsson, Fredrik, Homan, Evert, Almqvist, Helena, Axelsson, Hanna, Regmi, Shruti, Gustavsson, Anna-Lena, Lundbäck, Thomas, Scobie, Martin, Strömberg, Kia, Stenmark, Pål, Beato, Miguel, Helleday, Thomas
Published in Nature communications (2018)
Published in Nature communications (2018)
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NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
Zhang, Si Min, Rehling, Daniel, Jemth, Ann-Sofie, Throup, Adam, Landázuri, Natalia, Almlöf, Ingrid, Göttmann, Mona, Valerie, Nicholas C.K., Borhade, Sanjay R., Wakchaure, Prasad, Page, Brent D.G., Desroses, Matthieu, Homan, Evert J., Scobie, Martin, Rudd, Sean G., Berglund, Ulrika Warpman, Söderberg-Nauclér, Cecilia, Stenmark, Pål, Helleday, Thomas
Published in Cell chemical biology (16.12.2021)
Published in Cell chemical biology (16.12.2021)
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Development of a chemical probe against NUDT15
Zhang, Si Min, Desroses, Matthieu, Hagenkort, Anna, Valerie, Nicholas C. K., Rehling, Daniel, Carter, Megan, Wallner, Olov, Koolmeister, Tobias, Throup, Adam, Jemth, Ann-Sofie, Almlöf, Ingrid, Loseva, Olga, Lundbäck, Thomas, Axelsson, Hanna, Regmi, Shruti, Sarno, Antonio, Krämer, Andreas, Pudelko, Linda, Bräutigam, Lars, Rasti, Azita, Göttmann, Mona, Wiita, Elisée, Kutzner, Juliane, Schaller, Torsten, Kalderén, Christina, Cázares-Körner, Armando, Page, Brent D. G., Krimpenfort, Rosa, Eshtad, Saeed, Altun, Mikael, Rudd, Sean G., Knapp, Stefan, Scobie, Martin, Homan, Evert J., Berglund, Ulrika Warpman, Stenmark, Pål, Helleday, Thomas
Published in Nature chemical biology (01.10.2020)
Published in Nature chemical biology (01.10.2020)
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Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1
Llona-Minguez, Sabin, Höglund, Andreas, Jacques, Sylvain A, Johansson, Lars, Calderón-Montaño, José Manuel, Claesson, Magnus, Loseva, Olga, Valerie, Nicholas C. K, Lundbäck, Thomas, Piedrafita, Javier, Maga, Giovanni, Crespan, Emmanuele, Meijer, Laurent, Burgos Morón, Estefanía, Baranczewski, Pawel, Hagbjörk, Ann-Louise, Svensson, Richard, Wiita, Elisee, Almlöf, Ingrid, Visnes, Torkild, Jeppsson, Fredrik, Sigmundsson, Kristmundur, Jensen, Annika Jenmalm, Artursson, Per, Jemth, Ann-Sofie, Stenmark, Pål, Warpman Berglund, Ulrika, Scobie, Martin, Helleday, Thomas
Published in Journal of medicinal chemistry (11.02.2016)
Published in Journal of medicinal chemistry (11.02.2016)
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Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells (vol 9, 250, 2018)
Page, BDG, Valerie, NCK, Wright, RHG, Wallner, O, Isaksson, R, Carter, M, Rudd, SG, Loseva, O, Jemth, A-S, Almlof, I
Published in NATURE COMMUNICATIONS (01.11.2019)
Published in NATURE COMMUNICATIONS (01.11.2019)
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Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors
Llona-Minguez, Sabin, Höglund, Andreas, Ghassemian, Artin, Desroses, Matthieu, Calderón-Montaño, José Manuel, Burgos Morón, Estefanía, Valerie, Nicholas C. K, Wiita, Elisee, Almlöf, Ingrid, Koolmeister, Tobias, Mateus, André, Cazares-Körner, Cindy, Sanjiv, Kumar, Homan, Evert, Loseva, Olga, Baranczewski, Pawel, Darabi, Masoud, Mehdizadeh, Amir, Fayezi, Shabnam, Jemth, Ann-Sofie, Warpman Berglund, Ulrika, Sigmundsson, Kristmundur, Lundbäck, Thomas, Jenmalm Jensen, Annika, Artursson, Per, Scobie, Martin, Helleday, Thomas
Published in Journal of medicinal chemistry (25.05.2017)
Published in Journal of medicinal chemistry (25.05.2017)
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Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
Page, Brent D. G., Valerie, Nicholas C. K., Wright, Roni H. G., Wallner, Olov, Isaksson, Rebecka, Carter, Megan, Rudd, Sean G., Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Font-Mateu, Jofre, Llona-Minguez, Sabin, Baranczewski, Pawel, Jeppsson, Fredrik, Homan, Evert, Almqvist, Helena, Axelsson, Hanna, Regmi, Shruti, Gustavsson, Anna-Lena, Lundbäck, Thomas, Scobie, Martin, Strömberg, Kia, Stenmark, Pål, Beato, Miguel, Helleday, Thomas
Published in Nature communications (01.11.2019)
Published in Nature communications (01.11.2019)
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Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors (vol 60, pg 4279, 2017)
Llona-Minguez, S, Hoglund, A, Ghassemian, A, Desroses, M, Calderon-Montano, JM, Moron, EB, Valerie, NCK, Wiita, E, Almlof, I, Koolmeister, T
Published in JOURNAL OF MEDICINAL CHEMISTRY (14.09.2017)
Published in JOURNAL OF MEDICINAL CHEMISTRY (14.09.2017)
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Correction to Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors
Llona-Minguez, Sabin, Höglund, Andreas, Ghassemian, Artin, Desroses, Matthieu, Calderón-Montaño, José Manuel, Burgos Morón, Estefanía, Valerie, Nicholas C. K, Wiita, Elisee, Almlöf, Ingrid, Koolmeister, Tobias, Mateus, André, Cazares-Körner, Cindy, Sanjiv, Kumar, Homan, Evert, Loseva, Olga, Baranczewski, Pawel, Darabi, Masoud, Mehdizadeh, Amir, Fayezi, Shabnam, Jemth, Ann-Sofie, Warpman Berglund, Ulrika, Sigmundsson, Kristmundur, Lundbäck, Thomas, Jenmalm Jensen, Annika, Artursson, Per, Scobie, Martin, Helleday, Thomas
Published in Journal of medicinal chemistry (14.09.2017)
Published in Journal of medicinal chemistry (14.09.2017)
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