Synthesis and in vitro antitumor activity of new deaza analogues of the nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (PT523)
Vaidya, Chitra M, Wright, Joel E, Rosowsky, Andre
Published in Journal of medicinal chemistry (11.04.2002)
Published in Journal of medicinal chemistry (11.04.2002)
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Journal Article
Synthesis and In Vitro Antitumor Activity of New Deaza Analogues of the Nonpolyglutamatable Antifolate N α-(4-Amino-4-deoxypteroyl)-N δ-hemiphthaloyl-l-ornithine (PT523)
Vaidya, Chitra M, Wright, Joel E, Rosowsky, Andre
Published in Journal of medicinal chemistry (11.04.2002)
Published in Journal of medicinal chemistry (11.04.2002)
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Journal Article
Analogues of the Potent Nonpolyglutamatable Antifolate N α-(4-Amino-4-deoxypteroyl)-N δ-hemiphthaloyl-l-ornithine (PT523) with Modifications in the Side Chain, p-Aminobenzoyl Moiety, or 9,10-Bridge: Synthesis and in Vitro Antitumor Activity
Rosowsky, Andre, Wright, Joel E, Vaidya, Chitra M, Forsch, Ronald A, Bader, Henry
Published in Journal of medicinal chemistry (20.04.2000)
Published in Journal of medicinal chemistry (20.04.2000)
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Journal Article
Synthesis and Potent Antifolate Activity and Cytotoxicity of B-Ring Deaza Analogues of the Nonpolyglutamatable Dihydrofolate Reductase Inhibitor N α-(4-Amino-4-deoxypteroyl)-N δ-hemiphthaloyl-l-ornithine (PT523)
Rosowsky, Andre, Wright, Joel E, Vaidya, Chitra M, Bader, Henry, Forsch, Ronald A, Mota, Clara E, Pardo, Jorge, Chen, Cindy S, Chen, Ying-Nan
Published in Journal of medicinal chemistry (17.12.1998)
Published in Journal of medicinal chemistry (17.12.1998)
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Journal Article
Analogues of N α-(4-Amino-4-deoxypteroyl)-N δ-hemiphthaloyl-l-ornithine (PT523) Modified in the Side Chain: Synthesis and Biological Evaluation
Rosowsky, Andre, Vaidya, Chitra M, Bader, Henry, Wright, Joel E, Teicher, Beverly A
Published in Journal of medicinal chemistry (31.01.1997)
Published in Journal of medicinal chemistry (31.01.1997)
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Journal Article
The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate Nα-(4-amino-4-deoxypteroyl)- Nδ-hemiphthaloyl- l-ornithine
Rosowsky, Andre, Wright, Joel E., Vaidya, Chitra M., Forsch, Ronald A.
Published in Pharmacology & therapeutics (Oxford) (01.03.2000)
Published in Pharmacology & therapeutics (Oxford) (01.03.2000)
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Journal Article
The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine
Rosowsky, A, Wright, J E, Vaidya, C M, Forsch, R A
Published in Pharmacology & therapeutics (Oxford) (01.03.2000)
Published in Pharmacology & therapeutics (Oxford) (01.03.2000)
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Journal Article
Analogues of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (PT523) with modifications in the side chain, p-aminobenzoyl moiety, or 9,10-bridge: synthesis and in vitro antitumor activity
Rosowsky, A, Wright, J E, Vaidya, C M, Forsch, R A, Bader, H
Published in Journal of medicinal chemistry (20.04.2000)
Published in Journal of medicinal chemistry (20.04.2000)
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Journal Article
Efficient utilization of the reduced folate carrier in CCRF-CEM human leukemic lymphoblasts by the potent antifolate Nα-(4-amino-4-deoxypteroyl)- Nδ-hemiphthaloyl- l-ornithine (PT523) and its B-ring analogues
Wright, Joel E, Vaidya, Chitra M, Chen, Ying-Nan, Rosowsky, Andre
Published in Biochemical pharmacology (01.07.2000)
Published in Biochemical pharmacology (01.07.2000)
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Journal Article