IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan
Metz, Richard, Rust, Sonja, DuHadaway, James B., Mautino, Mario R., Munn, David H., Vahanian, Nicholas N., Link, Charles J., Prendergast, George C.
Published in Oncoimmunology (01.12.2012)
Published in Oncoimmunology (01.12.2012)
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Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors
Nayak-Kapoor, Asha, Hao, Zhonglin, Sadek, Ramses, Dobbins, Robin, Marshall, Lisa, Vahanian, Nicholas N, Jay Ramsey, W, Kennedy, Eugene, Mautino, Mario R, Link, Charles J, Lin, Ray S, Royer-Joo, Stephanie, Liang, Xiaorong, Salphati, Laurent, Morrissey, Kari M, Mahrus, Sami, McCall, Bruce, Pirzkall, Andrea, Munn, David H, Janik, John E, Khleif, Samir N
Published in Journal for immunotherapy of cancer (20.06.2018)
Published in Journal for immunotherapy of cancer (20.06.2018)
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Phase II trial of the IDO pathway inhibitor indoximod plus pembrolizumab for the treatment of patients with advanced melanoma
Zakharia, Yousef, McWilliams, Robert R, Rixe, Olivier, Drabick, Joseph, Shaheen, Montaser F, Grossmann, Kenneth F, Kolhe, Ravindra, Pacholczyk, Rafal, Sadek, Ramses, Tennant, Lucinda L, Smith, Christopher M, Kennedy, Eugene P, Link Jr, Charles J, Vahanian, Nicholas N, Yu, Jiayi, Shen, Steven S, Brincks, Erik L, Rossi, Gabriela R, Munn, David, Milhem, Mohammed
Published in Journal for immunotherapy of cancer (01.06.2021)
Published in Journal for immunotherapy of cancer (01.06.2021)
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Addition of αGal HyperAcute™ technology to recombinant avian influenza vaccines induces strong low-dose antibody responses
Chen, Wenlan Alex, Zhang, Jinjin, Hall, Katie M, Martin, Carol B, Kisselev, Serguei, Dasen, Emily J, Vahanian, Nicholas N, Link, Charles J, Martin, Brian K
Published in PloS one (07.08.2017)
Published in PloS one (07.08.2017)
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514 Results of Phase 1b trial of the Indoleamine 2,3-dioxygenase (IDO) Pathway Inhibitor Indoximod plus Ipilimumab for the treatment of unresectable stage III or IV melanoma
Zakharia, Y, Drabick, J, Khleif, S, Munn, D, Link, C, Vahanian, N, Kennedy, E, Rixe, O, Milhem, M
Published in European journal of cancer (1990) (01.09.2015)
Published in European journal of cancer (1990) (01.09.2015)
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346 Phase 1a study of the safety, pharmacokinetics, and pharmacodynamics of GDC-0919 in patients with recurrent/advanced solid tumors
Nayak, A, Hao, Z, Sadek, R, Dobbins, R, Marshall, L, Vahanian, N, Ramsey, J, Kennedy, E, Mautino, M, Link, C, Lin, R, Royer-Joo, S, Morrissey, K, Mahrus, S, McCall, B, Pirzkall, A, Munn, D, Janik, J, Khleif, S
Published in European journal of cancer (1990) (01.09.2015)
Published in European journal of cancer (1990) (01.09.2015)
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Hematopoietic Mixed Chimerism Derived from Allogeneic Embryonic Stem Cells Prevents Autoimmune Diabetes Mellitus in NOD Mice
Verda, Larissa, Kim, Duck An, Ikehara, Susumu, Statkute, Laisvyde, Bronesky, Delphine, Petrenko, Yevgeniya, Oyama, Yu, He, Xiang, Link, Charles, Vahanian, Nicholas N., Burt, Richard K.
Published in Stem cells (Dayton, Ohio) (01.02.2008)
Published in Stem cells (Dayton, Ohio) (01.02.2008)
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Cellular immunotherapy study of prostate cancer patients and resulting IgG responses to peptide epitopes predicted from prostate tumor-associated autoantigens
Hemstreet, 3rd, George P, Rossi, Gabriela R, Pisarev, Vladimir M, Enke, Charles A, Helfner, Laura, Hauke, Ralph J, Tennant, Lucinda, Ramsey, William Jay, Vahanian, Nicholas N, Link, Charles J
Published in Journal of immunotherapy (1997) (01.01.2013)
Published in Journal of immunotherapy (1997) (01.01.2013)
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Abstract CT004: Front-line therapy of DIPG using the IDO pathway inhibitor indoximod in combination with radiation and chemotherapy
Johnson, Theodore S., Aguilera, Dolly, Al-Basheer, Ahmad, Castellino, Robert C., Eaton, Bree R., Esiashvili, Natia, Foreman, Nicholas, Heger, Ian M., Kennedy, Eugene P., Link, Charles J., Martin, William, Ring, Eric K., Sadek, Ramses F., Smith, Amy, Vahanian, Vahanian N., MacDonald, Tobey J., Munn, David H.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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A phase I study of indoximod in patients with advanced malignancies
Soliman, Hatem H, Minton, Susan E, Han, Hyo Sook, Ismail-Khan, Roohi, Neuger, Anthony, Khambati, Fatema, Noyes, David, Lush, Richard, Chiappori, Alberto A, Roberts, John D, Link, Charles, Vahanian, Nicholas N, Mautino, Mario, Streicher, Howard, Sullivan, Daniel M, Antonia, Scott J
Published in Oncotarget (19.04.2016)
Published in Oncotarget (19.04.2016)
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A first in man phase I trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors
Soliman, Hatem H, Jackson, Erica, Neuger, Tony, Dees, E Claire, Harvey, R Donald, Han, Hyo, Ismail-Khan, Roohi, Minton, Susan, Vahanian, Nicholas N, Link, Charles, Sullivan, Daniel M, Antonia, Scott
Published in Oncotarget (30.09.2014)
Published in Oncotarget (30.09.2014)
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αGal HyperAcute® Technology: Enhancing Immunogenicity of Antiviral Vaccines by Exploiting the Natural αGal-Mediated Zoonotic Blockade
Mandell, R.B, Flick, R, Staplin, W.R, Kaniewski, L.D, Carzoli, A.K, Manuszak, R.P, Wang, J, Rossi, G.R, Vahanian, N.N, Link, C.J
Published in Zoonoses and public health (01.08.2009)
Published in Zoonoses and public health (01.08.2009)
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Algenpantucel-L immunotherapy in pancreatic adenocarcinoma
Coveler, Andrew L, Rossi, Gabriela R, Vahanian, Nicholas N, Link, Charles, Chiorean, E Gabriela
Published in Immunotherapy (01.02.2016)
Published in Immunotherapy (01.02.2016)
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A replication-incompetent Rift Valley fever vaccine: Chimeric virus-like particles protect mice and rats against lethal challenge
Mandell, Robert B, Koukuntla, Ramesh, Mogler, Laura J.K, Carzoli, Andrea K, Freiberg, Alexander N, Holbrook, Michael R, Martin, Brian K, Staplin, William R, Vahanian, Nicholas N, Link, Charles J, Flick, Ramon
Published in Virology (New York, N.Y.) (05.02.2010)
Published in Virology (New York, N.Y.) (05.02.2010)
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Results of the NLG2105 Phase I Trial Using the IDO Pathway Inhibitor Indoximod, in Combination with Radiation and Chemotherapy, for Children with Newly Diagnosed DIPG
Johnson, T.S., Aguilera, D., Al-Basheer, A., Berrong, Z., Castellino, R.C., Eaton, B.R., Esiashvili, N., Foreman, N., Heger, I.M., Kennedy, E.P., Vahanian, N., Martin, W., Pacholczyk, R., Ring, E., Sadek, R.F., Smith, A., Shimoda, M., Macdonald, T.J., Munn, D.H.
Published in Annals of oncology (01.12.2019)
Published in Annals of oncology (01.12.2019)
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Abstract P2-11-09: A phase 2 randomized trial of the IDO pathway inhibitor indoximod in combination with taxane based chemotherapy for metastatic breast cancer: Preliminary data
Tang, S-C, Montero, A, Munn, D, Link, C, Vahanian, N, Kennedy, E, Soliman, H
Published in Cancer research (Chicago, Ill.) (15.02.2016)
Published in Cancer research (Chicago, Ill.) (15.02.2016)
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Combination immunotherapy for high-risk resected and metastatic melanoma patients
Riker, Adam I, Rossi, Gabriela R, Masih, Prerna, Alsfeld, L C, Denham, Fiona, Tennant, Lucinda, Ramsey, W Jay, Vahanian, Nicholas N, Link, Charles J
Published in The Ochsner journal (2014)
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Published in The Ochsner journal (2014)
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A Phase 2 Study of Docetaxel in Combination with Indoximod for Metastatic Breast Cancer
Kennedy, E.P., Soliman, H.H., Ismail-Khan, R., Han, H., Rossi, G., Vahanian, N., Link, C., Sullivan, D., Antonia, S.
Published in Annals of oncology (01.11.2014)
Published in Annals of oncology (01.11.2014)
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