Pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1)
Purandare, Ashok V., Chen, Zhong, Huynh, Tram, Pang, Suhong, Geng, Jieping, Vaccaro, Wayne, Poss, Michael A., Oconnell, Jonathan, Nowak, Kimberly, Jayaraman, Lata
Published in Bioorganic & medicinal chemistry (01.08.2008)
Published in Bioorganic & medicinal chemistry (01.08.2008)
Get full text
Journal Article
Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)
Huynh, Tram, Chen, Zhong, Pang, Suhong, Geng, Jieping, Bandiera, Tiziano, Bindi, Simona, Vianello, Paola, Roletto, Fulvia, Thieffine, Sandrine, Galvani, Arturo, Vaccaro, Wayne, Poss, Michael A., Trainor, George L., Lorenzi, Matthew V., Gottardis, Marco, Jayaraman, Lata, Purandare, Ashok V.
Published in Bioorganic & medicinal chemistry letters (01.06.2009)
Published in Bioorganic & medicinal chemistry letters (01.06.2009)
Get full text
Journal Article
Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13)
Kim, Soong-Hoon, Pudzianowski, Andrew T., Leavitt, Kenneth J., Barbosa, Joseph, McDonnell, Patricia A., Metzler, William J., Rankin, Bruce M., Liu, Richard, Vaccaro, Wayne, Pitts, William
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
Get full text
Journal Article
Core exploration in optimization of chemokine receptor CCR4 antagonists
Purandare, Ashok V., Wan, Honghe, Somerville, John E., Burke, Christine, Vaccaro, Wayne, Yang, XiaoXia, McIntyre, Kim W., Poss, Michael A.
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
Get full text
Journal Article
Inhibitors of human mitotic kinesin Eg5: Characterization of the 4-phenyl-tetrahydroisoquinoline lead series
Tarby, Christine M., Kaltenbach, Robert F., Huynh, Tram, Pudzianowski, Andrew, Shen, Henry, Ortega-Nanos, Marie, Sheriff, Steven, Newitt, John A., McDonnell, Patricia A., Burford, Neil, Fairchild, Craig R., Vaccaro, Wayne, Chen, Zhong, Borzilleri, Robert M., Naglich, Joseph, Lombardo, Louis J., Gottardis, Marco, Trainor, George L., Roussell, Deborah L.
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Get full text
Journal Article
Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists
BERLIN, Michael, TING, Pauline C, DUGUMA, Luli, SOLOMON, Daniel M, WEI ZHOU, SHER, Rosy, FAVREAU, Leonard, BRYANT, Matthew, KORFMACHER, Walter A, NARDO, Cymbelene, WEST, Robert E, ANTHES, John C, VACCARO, Wayne D, WILLIAMS, Shirley M, WU, Ren-Long, SHE, H. Susan, RIVELLI, Maria A, CORBOZ, Michel R, HEY, John A, ASLANIAN, Robert, MCCORMICK, Kevin D, LEE, Joe F, ALBANESE, Margaret M, MUTAHI, Mwangi W, PIWINSKI, John J, SHIH, Neng-Yang
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
Get full text
Journal Article
Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffold
VACCARO, Wayne D, SHER, Rosy, WILLIAMS, Shirley M, WU, Ren-Long, SHE, H. Susan, RIVELLI, Maria A, MUTTER, Jennifer C, CORBOZ, Michel R, HEY, John A, FAVREAU, Leonard, BERLIN, Michael, SHIH, Neng-Yang, ASLANIAN, Robert, SCHWERDT, John H, MCCORMICK, Kevin D, PIWINSKI, John J, WEST, Robert E, ANTHES, John C
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Get full text
Journal Article
Dihydropyrazolopyrimidines containing benzimidazoles as KV1.5 potassium channel antagonists
Lloyd, John, Finlay, Heather J., Atwal, Karnail, Kover, Alexander, Prol, Joseph, Yan, Lin, Bhandaru, Rao, Vaccaro, Wayne, Huynh, Tram, Huang, Christine S., Conder, MaryLee, Jenkins-West, Tonya, Sun, Huabin, Li, Danshi, Levesque, Paul
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Get full text
Journal Article
Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design
Gavai, Ashvinikumar V, Norris, Derek, Delucca, George, Tortolani, David, Tokarski, John S, Dodd, Dharmpal, O’Malley, Daniel, Zhao, Yufen, Quesnelle, Claude, Gill, Patrice, Vaccaro, Wayne, Huynh, Tram, Ahuja, Vijay, Han, Wen-Ching, Mussari, Christopher, Harikrishnan, Lalgudi, Kamau, Muthoni, Poss, Michael, Sheriff, Steven, Yan, Chunhong, Marsilio, Frank, Menard, Krista, Wen, Mei-Li, Rampulla, Richard, Wu, Dauh-Rurng, Li, Jianqing, Zhang, Huiping, Li, Peng, Sun, Dawn, Yip, Henry, Traeger, Sarah C, Zhang, Yingru, Mathur, Arvind, Zhang, Haiying, Huang, Christine, Yang, Zheng, Ranasinghe, Asoka, Everlof, Gerry, Raghavan, Nirmala, Tye, Ching Kim, Wee, Susan, Hunt, John T, Vite, Gregory, Westhouse, Richard, Lee, Francis Y
Published in Journal of medicinal chemistry (14.10.2021)
Published in Journal of medicinal chemistry (14.10.2021)
Get full text
Journal Article
KRAS 억제제
VACCARO WAYNE DAVID, RUAN ZHEMING, CHERNEY ROBERT JOSEPH, SHIRUDE PRAVIN S, RAHAMAN HASIBUR, NGU KHEHYONG, QIN LAN YING, VELAPARTHI UPENDER, FINK BRIAN EDWARD
Year of Publication 18.12.2023
Get full text
Year of Publication 18.12.2023
Patent
KRAS G12D 억제제
VACCARO WAYNE DAVID, RUAN ZHEMING, CHERNEY ROBERT JOSEPH, SHIRUDE PRAVIN S, RAHAMAN HASIBUR, NGU KHEHYONG, QIN LAN YING, VELAPARTHI UPENDER, FINK BRIAN EDWARD
Year of Publication 18.12.2023
Get full text
Year of Publication 18.12.2023
Patent
Trends in Kinase Selectivity: Insights for Target Class-Focused Library Screening
Posy, Shana L, Hermsmeier, Mark A, Vaccaro, Wayne, Ott, Karl-Heinz, Todderud, Gordon, Lippy, Jonathan S, Trainor, George L, Loughney, Deborah A, Johnson, Stephen R
Published in Journal of medicinal chemistry (13.01.2011)
Published in Journal of medicinal chemistry (13.01.2011)
Get full text
Journal Article
Abstract 5789: Discovery of clinical candidate BMS-986158, an oral BET inhibitor, for the treatment of cancer
Gavai, Ashvinikumar V., Norris, Derek, Tortolani, David, O'Malley, Daniel, Zhao, Yufen, Quesnelle, Claude, Gill, Patrice, Vaccaro, Wayne, Huynh, Tram, Ahuja, Vijay, Dodd, Dharmpal, Mussari, Christopher, Harikrishnan, Lalgudi, Kamau, Muthoni, Tokarski, John S., Sheriff, Steven, Rampulla, Richard, Wu, Dauh-Rurng, Li, Jianqing, Zhang, Huiping, Li, Peng, Sun, Dawn, Yip, Henry, Zhang, Yingru, Mathur, Arvind, Zhang, Haiying, Huang, Christine, Yang, Zheng, Ranasinghe, Asoka, D'Arienzo, Celia, Su, Ching, Everlof, Gerry, Zhang, Lisa, Raghavan, Nirmala, Hunt, John T., Poss, Michael, Vite, Gregory D., Westhouse, Richard A., Wee, Susan
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
Discovery of ((S)-5-(Methoxymethyl)-7-(1-methyl-1H-indol-2-yl)-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)((S)-2-(3-methylisoxazol-5-yl)pyrrolidin-1-yl)methanone As a Potent and Selective I-Kur Inhibitor
Finlay, Heather J., Lloyd, John, Vaccaro, Wayne, Kover, Alexander, Yan, Lin, Bhave, Gauri, Prol, Joseph, Tram Huynh, Bhandaru, Rao, Caringal, Yolanda, DiMarco, John, Gan, Jinping, Harper, Tim, Huang, Christine, Conder, Mary Lee, Sun, Huabin, Levesque, Paul, Blanar, Michael, Atwal, Karnail, Wexler, Ruth
Published in Journal of medicinal chemistry (12.04.2012)
Published in Journal of medicinal chemistry (12.04.2012)
Get full text
Journal Article
Dihydropyrazolopyrimidines containing benzimidazoles as K(V)1.5 potassium channel antagonists
Lloyd, John, Finlay, Heather J, Atwal, Karnail, Kover, Alexander, Prol, Joseph, Yan, Lin, Bhandaru, Rao, Vaccaro, Wayne, Huynh, Tram, Huang, Christine S, Conder, Marylee, Jenkins-West, Tonya, Sun, Huabin, Li, Danshi, Levesque, Paul
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
Get full text
Journal Article
Benzo[ d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)—Hit to Lead studies
Wan, Honghe, Huynh, Tram, Pang, Suhong, Geng, Jieping, Vaccaro, Wayne, Poss, Michael A., Trainor, George L., Lorenzi, Matthew V., Gottardis, Marco, Jayaraman, Lata, Purandare, Ashok V.
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Get full text
Journal Article
Dimethyl-diphenyl-propanamide Derivatives As Nonsteroidal Dissociated Glucocorticoid Receptor Agonists
Yang, Bingwei V, Weinstein, David S, Doweyko, Lidia M, Gong, Hua, Vaccaro, Wayne, Huynh, Tram, Xiao, Hai-yun, Doweyko, Arthur M, Mckay, Lorraine, Holloway, Deborah A, Somerville, John E, Habte, Sium, Cunningham, Mark, McMahon, Michele, Townsend, Robert, Shuster, David, Dodd, John H, Nadler, Steven G, Barrish, Joel C
Published in Journal of medicinal chemistry (09.12.2010)
Published in Journal of medicinal chemistry (09.12.2010)
Get full text
Journal Article
Modulation of cofilin phosphorylation by inhibition of the Lim family kinases
He, Liqi, Seitz, Steven P., Trainor, George L., Tortolani, David, Vaccaro, Wayne, Poss, Michael, Tarby, Christine M., Tokarski, John S., Penhallow, Becky, Hung, Chen-Yi, Attar, Ricardo, Lin, Tai-An
Published in Bioorganic & medicinal chemistry letters (15.09.2012)
Published in Bioorganic & medicinal chemistry letters (15.09.2012)
Get full text
Journal Article
Dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I(Kur))
Vaccaro, Wayne, Huynh, Tram, Lloyd, John, Atwal, Karnail, Finlay, Heather J, Levesque, Paul, Conder, Mary Lee, Jenkins-West, Tonya, Shi, Hong, Sun, Lucy
Published in Bioorganic & medicinal chemistry letters (15.12.2008)
Published in Bioorganic & medicinal chemistry letters (15.12.2008)
Get full text
Journal Article
Small Molecule Antagonist of Leukocyte Function Associated Antigen-1 (LFA-1): Structure−Activity Relationships Leading to the Identification of 6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic Acid (BMS-688521)
Watterson, Scott H, Xiao, Zili, Dodd, Dharmpal S, Tortolani, David R, Vaccaro, Wayne, Potin, Dominique, Launay, Michele, Stetsko, Dawn K, Skala, Stacey, Davis, Patric M, Lee, Deborah, Yang, Xiaoxia, McIntyre, Kim W, Balimane, Praveen, Patel, Karishma, Yang, Zheng, Marathe, Punit, Kadiyala, Pathanjali, Tebben, Andrew J, Sheriff, Steven, Chang, ChiehYing Y, Ziemba, Theresa, Zhang, Huiping, Chen, Bang-Chi, DelMonte, Albert J, Aranibar, Nelly, McKinnon, Murray, Barrish, Joel C, Suchard, Suzanne J, Murali Dhar, T. G
Published in Journal of medicinal chemistry (13.05.2010)
Published in Journal of medicinal chemistry (13.05.2010)
Get full text
Journal Article