The Immune Receptor NOD1 and Kinase RIP2 Interact with Bacterial Peptidoglycan on Early Endosomes to Promote Autophagy and Inflammatory Signaling
Irving, Aaron T., Mimuro, Hitomi, Kufer, Thomas A., Lo, Camden, Wheeler, Richard, Turner, Lorinda J., Thomas, Belinda J., Malosse, Christian, Gantier, Michael P., Casillas, Linda N., Votta, Bartholomew J., Bertin, John, Boneca, Ivo G., Sasakawa, Chihiro, Philpott, Dana J., Ferrero, Richard L., Kaparakis-Liaskos, Maria
Published in Cell host & microbe (14.05.2014)
Published in Cell host & microbe (14.05.2014)
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Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2
Mares, Alina, Miah, Afjal H., Smith, Ian E. D., Rackham, Mark, Thawani, Aditya R., Cryan, Jenni, Haile, Pamela A., Votta, Bartholomew J., Beal, Allison M., Capriotti, Carol, Reilly, Michael A., Fisher, Don T., Zinn, Nico, Bantscheff, Marcus, MacDonald, Thomas T., Vossenkamper, Anna, Dace, Phoebe, Churcher, Ian, Benowitz, Andrew B., Watt, Gillian, Denyer, Jane, Scott-Stevens, Paul, Harling, John D.
Published in Communications biology (20.03.2020)
Published in Communications biology (20.03.2020)
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Systemic Activation of the Transient Receptor Potential Vanilloid Subtype 4 Channel Causes Endothelial Failure and Circulatory Collapse: Part 2
Willette, Robert N, Bao, Weike, Nerurkar, Sandhya, Yue, Tian-Li, Doe, Chris P, Stankus, Gerald, Turner, Gregory H, Ju, Haisong, Thomas, Heath, Fishman, Cindy E, Sulpizio, Anthony, Behm, David J, Hoffman, Sandra, Lin, Zuojun, Lozinskaya, Irina, Casillas, Linda N, Lin, Min, Trout, Robert E Lee, Votta, Bartholomew J, Thorneloe, Kevin, Lashinger, Erin S R, Figueroa, David J, Marquis, Robert, Xu, Xiaoping
Published in The Journal of pharmacology and experimental therapeutics (01.08.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2008)
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Journal Article
Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers
Weisel, Kathleen, Scott, Nicola E., Tompson, Debra J., Votta, Bartholomew J., Madhavan, Sujith, Povey, Kat, Wolstenholme, Allen, Simeoni, Monica, Rudo, Todd, Richards‐Peterson, Lauren, Sahota, Tarjinder, Wang, J. Gene, Lich, John, Finger, Joshua, Verticelli, Adeline, Reilly, Michael, Gough, Peter J., Harris, Philip A., Bertin, John, Wang, Mei‐Lun
Published in Pharmacology research & perspectives (01.12.2017)
Published in Pharmacology research & perspectives (01.12.2017)
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Journal Article
Inhibition of Receptor-Interacting Protein Kinase 1 in Chronic Plaque Psoriasis: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study
Ludbrook, Valerie J., Budd, David C., Thorn, Katie, Tompson, Debra, Votta, Bartholomew J., Walker, Lucy, Lee, Amy, Chen, Xin, Peppercorn, Amanda, Loo, Wei Jing
Published in Dermatology and therapy (01.02.2024)
Published in Dermatology and therapy (01.02.2024)
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N-((1S)-1-{[4-((2S)-2-{[(2,4-Dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I
Thorneloe, Kevin S, Sulpizio, Anthony C, Lin, Zuojun, Figueroa, David J, Clouse, Angela K, McCafferty, Gerald P, Chendrimada, Tim P, Lashinger, Erin S R, Gordon, Earl, Evans, Louise, Misajet, Blake A, Demarini, Douglas J, Nation, Josephine H, Casillas, Linda N, Marquis, Robert W, Votta, Bartholomew J, Sheardown, Steven A, Xu, Xiaoping, Brooks, David P, Laping, Nicholas J, Westfall, Timothy D
Published in The Journal of pharmacology and experimental therapeutics (01.08.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2008)
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Journal Article
Catalytic in vivo protein knockdown by small-molecule PROTACs
Bondeson, Daniel P, Mares, Alina, Smith, Ian E D, Ko, Eunhwa, Campos, Sebastien, Miah, Afjal H, Mulholland, Katie E, Routly, Natasha, Buckley, Dennis L, Gustafson, Jeffrey L, Zinn, Nico, Grandi, Paola, Shimamura, Satoko, Bergamini, Giovanna, Faelth-Savitski, Maria, Bantscheff, Marcus, Cox, Carly, Gordon, Deborah A, Willard, Ryan R, Flanagan, John J, Casillas, Linda N, Votta, Bartholomew J, den Besten, Willem, Famm, Kristoffer, Kruidenier, Laurens, Carter, Paul S, Harling, John D, Churcher, Ian, Crews, Craig M
Published in Nature chemical biology (01.08.2015)
Published in Nature chemical biology (01.08.2015)
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Journal Article
Optimization of a Series of RIPK2 PROTACs
Miah, Afjal H, Smith, Ian E. D, Rackham, Mark, Mares, Alina, Thawani, Aditya R, Nagilla, Rakesh, Haile, Pamela A, Votta, Bartholomew J, Gordon, Laurie J, Watt, Gillian, Denyer, Jane, Fisher, Don T, Dace, Phoebe, Giffen, Paul, Goncalves, Andrea, Churcher, Ian, Scott-Stevens, Paul, Harling, John D
Published in Journal of medicinal chemistry (09.09.2021)
Published in Journal of medicinal chemistry (09.09.2021)
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Journal Article
Inhibition of p38 MAP kinase as a therapeutic strategy
Lee, John C, Kumar, Sanjay, Griswold, Don E, Underwood, David C, Votta, Bartholomew J, Adams, Jerry L
Published in Immunopharmacology (01.05.2000)
Published in Immunopharmacology (01.05.2000)
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Voltage-gated K+ currents in mouse articular chondrocytes regulate membrane potential
Clark, Robert B., Hatano, Noriyuki, Kondo, Colleen, Belke, Darrell D., Brown, Barry S., Kumar, Sanjay, Votta, Bartholomew J., Giles, Wayne R.
Published in Channels (Austin, Tex.) (01.05.2010)
Published in Channels (Austin, Tex.) (01.05.2010)
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Journal Article
Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2‑((4-(Benzo[d]thiazol-5-ylamino)-6‑(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases
Haile, Pamela A, Casillas, Linda N, Votta, Bartholomew J, Wang, Gren Z, Charnley, Adam K, Dong, Xiaoyang, Bury, Michael J, Romano, Joseph J, Mehlmann, John F, King, Bryan W, Erhard, Karl F, Hanning, Charles R, Lipshutz, David B, Desai, Biva M, Capriotti, Carol A, Schaeffer, Michelle C, Berger, Scott B, Mahajan, Mukesh K, Reilly, Michael A, Nagilla, Rakesh, Rivera, Elizabeth J, Sun, Helen H, Kenna, John K, Beal, Allison M, Ouellette, Michael T, Kelly, Mike, Stemp, Gillian, Convery, Máire A, Vossenkämper, Anna, MacDonald, Thomas T, Gough, Peter J, Bertin, John, Marquis, Robert W
Published in Journal of medicinal chemistry (25.07.2019)
Published in Journal of medicinal chemistry (25.07.2019)
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Journal Article
Understanding Pharmacokinetic Disconnect in Preclinical Species for 4-Aminoquinolines: Consequences of Low Permeability and High P-glycoprotein Efflux Ratio on Rat and Dog Oral Pharmacokinetics
Mahajan, Mukesh K., Rivera, Elizabeth J., Sun, Helen H., Nagilla, Rakesh, DeMartino, Michael P., Haile, Pamela A., Casillas, Linda N., Marquis, Robert W., Votta, Bartholomew J., Bertin, John, Reilly, Michael A.
Published in Journal of pharmaceutical sciences (01.10.2020)
Published in Journal of pharmaceutical sciences (01.10.2020)
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Journal Article
Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes
Phan, Mimi N., Leddy, Holly A., Votta, Bartholomew J., Kumar, Sanjay, Levy, Dana S., Lipshutz, David B., Lee, Suk Hee, Liedtke, Wolfgang, Guilak, Farshid
Published in Arthritis and rheumatism (01.10.2009)
Published in Arthritis and rheumatism (01.10.2009)
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Journal Article
A New Dimeric Dihydrochalcone and a New Prenylated Flavone from the Bud Covers of Artocarpus altilis: Potent Inhibitors of Cathepsin K
PATIL, Ashok D., FREYER, Alan J., KILLMER, Lew, OFFEN, Priscilla, TAYLOR, Paul B., VOTTA, Bartholomew J., JOHNSON, Randall K.
Published in Journal of natural products (Washington, D.C.) (01.04.2002)
Published in Journal of natural products (Washington, D.C.) (01.04.2002)
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Journal Article
Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: Age‐ and sex‐dependent progression of osteoarthritis in Trpv4‐deficient mice
Clark, Andrea L., Votta, Bartholomew J., Kumar, Sanjay, Liedtke, Wolfgang, Guilak, Farshid
Published in Arthritis and rheumatism (01.10.2010)
Published in Arthritis and rheumatism (01.10.2010)
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Journal Article
Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity
Charnley, Adam K., Convery, Máire A., Lakdawala Shah, Ami, Jones, Emma, Hardwicke, Philip, Bridges, Angela, Ouellette, Michael, Totoritis, Rachel, Schwartz, Benjamin, King, Bryan W., Wisnoski, David D., Kang, James, Eidam, Patrick M., Votta, Bartholomew J., Gough, Peter J., Marquis, Robert W., Bertin, John, Casillas, Linda
Published in Bioorganic & medicinal chemistry (01.11.2015)
Published in Bioorganic & medicinal chemistry (01.11.2015)
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Journal Article
Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors
Haffner, Curt D, Charnley, Adam K, Aquino, Christopher J, Casillas, Linda, Convery, Máire A, Cox, Julie A, Elban, Mark A, Goodwin, Nicole C, Gough, Peter J, Haile, Pamela A, Hughes, Terry V, Knapp-Reed, Beth, Kreatsoulas, Constantine, Lakdawala, Ami S, Li, Huijie, Lian, Yiqian, Lipshutz, David, Mehlmann, John F, Ouellette, Michael, Romano, Joseph, Shewchuk, Lisa, Shu, Arthur, Votta, Bartholomew J, Zhou, Huiqiang, Bertin, John, Marquis, Robert W
Published in ACS medicinal chemistry letters (14.11.2019)
Published in ACS medicinal chemistry letters (14.11.2019)
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Journal Article
Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel
Haile, Pamela A, Casillas, Linda N, Bury, Michael J, Mehlmann, John F, Singhaus, Robert, Charnley, Adam K, Hughes, Terry V, DeMartino, Michael P, Wang, Gren Z, Romano, Joseph J, Dong, Xiaoyang, Plotnikov, Nikolay V, Lakdawala, Ami S, Convery, Maire A, Votta, Bartholomew J, Lipshutz, David B, Desai, Biva M, Swift, Barbara, Capriotti, Carol A, Berger, Scott B, Mahajan, Mukesh K, Reilly, Michael A, Rivera, Elizabeth J, Sun, Helen H, Nagilla, Rakesh, LePage, Carol, Ouellette, Michael T, Totoritis, Rachel D, Donovan, Brian T, Brown, Barry S, Chaudhary, Khuram W, Gough, Peter J, Bertin, John, Marquis, Robert W
Published in ACS medicinal chemistry letters (11.10.2018)
Published in ACS medicinal chemistry letters (11.10.2018)
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Journal Article
Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel
Haile, Pamela A., Casillas, Linda N., Bury, Michael J., Mehlmann, John F., Singhaus, Robert, Charnley, Adam K., Hughes, Terry V., DeMartino, Michael P., Wang, Gren Z., Romano, Joseph J., Dong, Xiaoyang, Plotnikov, Nikolay V., Lakdawala, Ami S., Duraiswami, Chaya, Convery, Maire A., Votta, Bartholomew J., Lipshutz, David B., Desai, Biva M., Swift, Barbara, Capriotti, Carol A., Berger, Scott B., Mahajan, Mukesh K., Reilly, Michael A., Rivera, Elizabeth J., Sun, Helen H., Nagilla, Rakesh, LePage, Carol, Ouellette, Michael T., Totoritis, Rachel D., Donovan, Brian T., Brown, Barry S., Chaudhary, Khuram W., Gough, Peter J., Bertin, John, Marquis, Robert W.
Published in ACS medicinal chemistry letters (11.06.2020)
Published in ACS medicinal chemistry letters (11.06.2020)
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Journal Article
Identification of an antibody‐based immunoassay for measuring direct target binding of RIPK1 inhibitors in cells and tissues
Finger, Joshua N., Brusq, Jean‐Marie, Campobasso, Nino, Cook, Michael N., Deutsch, Jennifer, Haag, Heather, Harris, Philip A., Jenkins, Earl L., Joglekar, Devika, Lich, John D., Maguire, Sean, Nagilla, Rakesh, Rivera, Elizabeth J., Sun, Helen, Votta, Bartholomew J., Bertin, John, Gough, Peter J.
Published in Pharmacology research & perspectives (01.12.2017)
Published in Pharmacology research & perspectives (01.12.2017)
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Journal Article