Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer
Lücking, Ulrich, Scholz, Arne, Lienau, Philip, Siemeister, Gerhard, Kosemund, Dirk, Bohlmann, Rolf, Briem, Hans, Terebesi, Ildiko, Meyer, Kirstin, Prelle, Katja, Denner, Karsten, Bömer, Ulf, Schäfer, Martina, Eis, Knut, Valencia, Ray, Ince, Stuart, von Nussbaum, Franz, Mumberg, Dominik, Ziegelbauer, Karl, Klebl, Bert, Choidas, Axel, Nussbaumer, Peter, Baumann, Matthias, Schultz‐Fademrecht, Carsten, Rühter, Gerd, Eickhoff, Jan, Brands, Michael
Published in ChemMedChem (08.11.2017)
Published in ChemMedChem (08.11.2017)
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Journal Article
Multiple Attack on Bacteria by the New Antibiotic Teixobactin
von Nussbaum, Franz, Süssmuth, Roderich D
Published in Angewandte Chemie International Edition (01.06.2015)
Published in Angewandte Chemie International Edition (01.06.2015)
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Journal Article
Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524
Baron, Anna P, von Schubert, Conrad, Cubizolles, Fabien, Siemeister, Gerhard, Hitchcock, Marion, Mengel, Anne, Schröder, Jens, Fernández-Montalván, Amaury, von Nussbaum, Franz, Mumberg, Dominik, Nigg, Erich A
Published in eLife (17.02.2016)
Published in eLife (17.02.2016)
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Journal Article
BAY 1024767 blocks androgen receptor mutants found in castration-resistant prostate cancer patients
Sugawara, Tatsuo, Lejeune, Pascale, Köhr, Silke, Neuhaus, Roland, Faus, Hortensia, Gelato, Kathy A, Busemann, Matthias, Cleve, Arwed, Lücking, Ulrich, von Nussbaum, Franz, Brands, Michael, Mumberg, Dominik, Jung, Klaus, Stephan, Carsten, Haendler, Bernard
Published in Oncotarget (02.02.2016)
Published in Oncotarget (02.02.2016)
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Journal Article
Antibacterial Natural Products in Medicinal Chemistry-Exodus or Revival?
von Nussbaum, Franz, Brands, Michael, Hinzen, Berthold, Weigand, Stefan, Häbich, Dieter
Published in Angewandte Chemie International Edition (04.08.2006)
Published in Angewandte Chemie International Edition (04.08.2006)
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Journal Article
Structure and Total Synthesis of Lysobactin (Katanosin B)
von Nussbaum, Franz, Anlauf, Sonja, Benet-Buchholz, Jordi, Häbich, Dieter, Köbberling, Johannes, Musza, László, Telser, Joachim, Rübsamen-Waigmann, Helga, Brunner, Nina A.
Published in Angewandte Chemie International Edition (01.01.2007)
Published in Angewandte Chemie International Edition (01.01.2007)
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Journal Article
Frontiers in Medicinal Chemistry 2022 Goes Virtual
Diamanti, Eleonora, Méndez, María, Ross, Tatjana, Kuttruff, Christian A., Lefranc, Julien, Klingler, Franca‐Maria, Nussbaum, Franz, Jung, Manfred, Gehringer, Matthias
Published in ChemMedChem (04.11.2022)
Published in ChemMedChem (04.11.2022)
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Journal Article
European Medicinal Chemistry Leaders in Industry (EMCL) – On the Status and Future of Medicinal Chemistry Research in Europe
Ali, Amjad, Bauser, Marcus, Bertrand, Sophie, Blackaby, Wesley, Boss, Christoph, Bossart, Martin, Hall, Adrian, Binch, Hayley, Czechtizky, Werngard, Gijsen, Harrie, Haning, Helmut, Hartung, Ingo V., Kilburn, Paul, Lassalle, Gilbert, Lücking, Ulrich, Mack, Jürgen, Missbach, Martin, Otsomaa, Leena, Torrens, Antoni, Wagner, Michael, Walter, Magnus, Weinstabl, Harald, Hijfte, Luc, Nussbaum, Franz
Published in ChemMedChem (03.07.2023)
Published in ChemMedChem (03.07.2023)
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Journal Article
Lost in Transcription--Inhibition of RNA Polymerase
Haebich, Dieter, von Nussbaum, Franz
Published in Angewandte Chemie (International ed.) (27.04.2009)
Published in Angewandte Chemie (International ed.) (27.04.2009)
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Journal Article
The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models
Lemos, Clara, Schulze, Volker K., Baumgart, Simon J., Nevedomskaya, Ekaterina, Heinrich, Tobias, Lefranc, Julien, Bader, Benjamin, Christ, Clara D., Briem, Hans, Kuhnke, Lara P., Holton, Simon J., Bömer, Ulf, Lienau, Philip, von Nussbaum, Franz, Nising, Carl F., Bauser, Marcus, Hägebarth, Andrea, Mumberg, Dominik, Haendler, Bernard
Published in Cellular oncology (Dordrecht) (01.06.2021)
Published in Cellular oncology (Dordrecht) (01.06.2021)
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Journal Article
Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine BAY-8040 in a Pulmonary Arterial Hypertension Rat Model
von Nussbaum, Franz, Li, Volkhart M., Meibom, Daniel, Anlauf, Sonja, Bechem, Martin, Delbeck, Martina, Gerisch, Michael, Harrenga, Axel, Karthaus, Dagmar, Lang, Dieter, Lustig, Klemens, Mittendorf, Joachim, Schäfer, Martina, Schäfer, Stefan, Schamberger, Jens
Published in ChemMedChem (19.01.2016)
Published in ChemMedChem (19.01.2016)
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Journal Article
Abstract 2718: Synthesis and characterization of novel benzylpyrazole-based BUB1 kinase inhibitors with anti-tumor activity
Hitchcock, Marion, Siemeister, Gerhard, Briem, Hans, Fernandez-Montalvan, Amaury Ernest, Holton, Simon, Mengel, Anne, Mönning, Ursula, Brands, Michael, Ziegelbauer, Karl, Mumberg, Dominik, Nussbaum, Franz von
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract 3022: BAY 1143572, a first-in-class, highly selective, potent and orally available inhibitor of PTEFb/CDK9 currently in Phase I, shows convincing anti-tumor activity in preclinical models of acute myeloid leukemia (AML)
Scholz, Arne, Oellerich, Thomas, Hussain, Akhtar, Lindner, Sarah, Luecking, Ulrich, Walter, Annette O., Ellinghaus, Peter, Valencia, Ray, von Nussbaum, Franz, Mumberg, Dominik, Brands, Michael, Ince, Stuart, Serve, Hubert, Ziegelbauer, Karl
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases
von Nussbaum, Franz, Li, Volkhart M.-J., Allerheiligen, Swen, Anlauf, Sonja, Bärfacker, Lars, Bechem, Martin, Delbeck, Martina, Fitzgerald, Mary F., Gerisch, Michael, Gielen-Haertwig, Heike, Haning, Helmut, Karthaus, Dagmar, Lang, Dieter, Lustig, Klemens, Meibom, Daniel, Mittendorf, Joachim, Rosentreter, Ulrich, Schäfer, Martina, Schäfer, Stefan, Schamberger, Jens, Telan, Leila A., Tersteegen, Adrian
Published in ChemMedChem (01.07.2015)
Published in ChemMedChem (01.07.2015)
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Journal Article