Developability considerations for bispecific and multispecific antibodies
Amash, Alaa, Volkers, Gesa, Farber, Patrick, Griffin, Daniel, Davison, K Shawn, Goodman, Allison, Tonikian, Raffi, Yamniuk, Aaron, Barnhart, Bryan, Jacobs, Tim
Published in mAbs (31.12.2024)
Published in mAbs (31.12.2024)
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Journal Article
X-ray crystallographic structure of a bacterial polysialyltransferase provides insight into the biosynthesis of capsular polysialic acid
Lizak, Christian, Worrall, Liam J., Baumann, Lars, Pfleiderer, Moritz M., Volkers, Gesa, Sun, Tianjun, Sim, Lyann, Wakarchuk, Warren, Withers, Stephen G., Strynadka, Natalie C. J.
Published in Scientific reports (19.07.2017)
Published in Scientific reports (19.07.2017)
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Journal Article
1367 A rational approach to selecting CD3-binding antibodies for T-cell engager development
Mai, Juntao (Matt), Puyraimond, Valentine de, Pouliot, Philippe, Caldwell, Kate, Clifford, Lauren, Goodman, Allison, Farber, Patrick, Rowe, Patrick, Dhupar, Harveer, Reimer, Janice, Herve, Karine, Li, Vivian, Yu, Irene, Marwick, John, Blamey, Nathalie, Cid, Melissa, Crichlow, Cindy-Lee, Bolten, Lena M, Pinsky, Tova, Volkers, Gesa, Bodhankar, Girija, Jong, Caitlyn De, Cullen, Sophie, Xiang, Ping, Lee, Ahn, Conaghan, Gabrielle, Samiotakis, Antonios, Hannie, Stefan, Chappell, Rhys, Lathouwers, Emma, Chong, Lauren, Gibson, Kate, Masterman, Stephanie K, Brown, Kirstin, Fogg, Mark, Tonikian, Raffi, Jacobs, Tim, Yamniuk, Aaron, Barnhart, Bryan C
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity
Weisser, Nina E., Sanches, Mario, Escobar-Cabrera, Eric, O’Toole, Jason, Whalen, Elizabeth, Chan, Peter W. Y., Wickman, Grant, Abraham, Libin, Choi, Kate, Harbourne, Bryant, Samiotakis, Antonios, Rojas, Andrea Hernández, Volkers, Gesa, Wong, Jodi, Atkinson, Claire E., Baardsnes, Jason, Worrall, Liam J., Browman, Duncan, Smith, Emma E., Baichoo, Priya, Cheng, Chi Wing, Guedia, Joy, Kang, Sohyeong, Mukhopadhyay, Abhishek, Newhook, Lisa, Ohrn, Anders, Raghunatha, Prajwal, Zago-Schmitt, Matteo, Schrag, Joseph D., Smith, Joel, Zwierzchowski, Patricia, Scurll, Joshua M., Fung, Vincent, Black, Sonia, Strynadka, Natalie C. J., Gold, Michael R., Presta, Leonard G., Ng, Gordon, Dixit, Surjit
Published in Nature communications (13.03.2023)
Published in Nature communications (13.03.2023)
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Journal Article
Abstract 924: PROTECT, a novel antibody platform for integrating tumor-specific immune modulation and enhancing the therapeutic window of targeted multispecific biologics
Dixit, Surjit, Heinkel, Florian, Von Rossum, Anna, Pratap, Harsh, Arrafi, Sifa, Rahim, Javairia, Bhojane, Purva, Stangle, Liz, Stenberg, Leisa, Volkers, Gesa, Escobar-Cabrera, Eric, Spreter, Thomas
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation
Volkers, Gesa, Worrall, Liam J, Kwan, David H, Yu, Ching-Ching, Baumann, Lars, Lameignere, Emilie, Wasney, Gregory A, Scott, Nichollas E, Wakarchuk, Warren, Foster, Leonard J, Withers, Stephen G, Strynadka, Natalie C J
Published in Nature structural & molecular biology (01.08.2015)
Published in Nature structural & molecular biology (01.08.2015)
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Journal Article
Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase
Volkers, Gesa, Palm, Gottfried J., Weiss, Manfred S., Wright, Gerard D., Hinrichs, Winfried
Published in FEBS letters (06.04.2011)
Published in FEBS letters (06.04.2011)
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Journal Article
Abstract 1737: Understanding the geometry and valency of bispecific antibodies in the optimization of tumor-dependent activation of 4-1BB
von Rossum, Anna, Pratap, Harsh, Newhook, Lisa, Halvorsen, Elizabeth C., Freiburger, Lee, Duan, Renee, Stevens, Charles, Tcaciuc, Dimitri, Volkers, Gesa, Browman, Duncan, Clavette, Brandon, Mills, David, Spreter, Thomas, Patton, Daniel T.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Crystal structure of the Propionibacterium acnes surface sialidase, a drug target for P. acnes-associated diseases
Yu, Angel C Y, Volkers, Gesa, Jongkees, Seino A K, Worrall, Liam J, Withers, Stephen G, Strynadka, Natalie C J
Published in Glycobiology (Oxford) (19.03.2022)
Published in Glycobiology (Oxford) (19.03.2022)
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Journal Article
Abstract 1788: Increasing the therapeutic index of IL12 by engineering for tumor specific protease activation
Bishop, Jennifer Leah, Blackler, Ryan, Volkers, Gesa, Poffenberger, Maya, Yu, Irene, Smith, Joel, Khodabandehloo, Akram, Arrafi, Sifa, Lau, Desmond, Stangle, Liz, Stenberg, Leisa, Zwierzchowski, Patricia, Dude, Iulia, Douda, David, Wickman, Grant, Proctor, Jeff, Rowse, Gerry, Madera, Laurence, Desjardins, Genevieve, Afacan, Nicole, Barnscher, Stuart, Mills, David, Spreter, Thomas, Dixit, Surjit
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
차폐된 IL12 융합 단백질 및 이의 사용 방법
BLACKLER RYAN, AFACAN NICOLE, SPRETER VON KREUDENSTEIN THOMAS, DESJARDINS GENEVIEVE, DOUDA DAVID, VOLKERS GESA
Year of Publication 20.02.2023
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Year of Publication 20.02.2023
Patent
과립구 집락-자극 인자 수용체(G-CSFR)의 변형된 세포외 도메인 및 이에 결합하는 사이토카인
BOULANGER MARTIN J, DIXIT SURJIT BHIMARAO, LOVELESS BIANCA, SANCHES MARIO, FULLER MEGAN, NELSON BRAD, VOLKERS GESA
Year of Publication 01.08.2022
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Year of Publication 01.08.2022
Patent
리간드-수용체 쌍 및 생물학적 기능성 단백질을 포함하는 융합 단백질
VON ROSSUM ANNA, DIXIT SURJIT BHIMARAO, HEINKEL FLORIAN, SPRETER VON KREUDENSTEIN THOMAS, ESCOBAR CABRERA ERIC, VOLKERS GESA
Year of Publication 28.03.2023
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Year of Publication 28.03.2023
Patent
New Insights on Structure and Function of Sialyltransferases
Volkers, Gesa, Worrall, Liam, Lameignere, Emilie, Strynadka, Natalie
Published in Acta crystallographica. Section A, Foundations and advances (05.08.2014)
Published in Acta crystallographica. Section A, Foundations and advances (05.08.2014)
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Journal Article
Putative dioxygen-binding sites and recognition of tigecycline and minocycline in the tetracycline-degrading monooxygenase TetX
Volkers, Gesa, Damas, João M., Palm, Gottfried J., Panjikar, Santosh, Soares, Cláudio M., Hinrichs, Winfried
Published in Acta crystallographica. Section D, Biological crystallography. (01.09.2013)
Published in Acta crystallographica. Section D, Biological crystallography. (01.09.2013)
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Journal Article
Structural Basis for Binding of Fluorescent CMP-Neu5Ac Mimetics to Enzymes of the Human ST8Sia Family
Volkers, Gesa, Lizak, Christian, Niesser, Jürgen, Rosell, Frederico I, Preidl, Johannes, Gnanapragassam, Vinayaga S, Horstkorte, Ruediger, Rademann, Jörg, Strynadka, Natalie C. J
Published in ACS chemical biology (17.08.2018)
Published in ACS chemical biology (17.08.2018)
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Journal Article
4-1BB 및 종양-관련 항원에 결합하는 항체 작제물 및 이의 용도
DUAN ZHUANG, JANCOWSKI SYLWIA, CHAN PETER WING YIU, PATTON DANIEL T, BROWMAN DUNCAN, ZWIERZCHOWSKI PATRICIA, VOLKERS GESA, VON ROSSUM ANNA, GENE ROBERT WILLIAM, FREIBURGER LEE, CHUI DANNY, HALVORSEN ELIZABETH, SPRETER VON KREUDENSTEIN THOMAS, UROSEV DUNJA, KANG SUKHBIR SINGH, CLAVETTE BRANDON, MILLS DAVID M, PRATAP HARSH
Year of Publication 24.06.2021
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Year of Publication 24.06.2021
Patent
Crystallization and preliminary X-ray crystallographic analysis of the tetracycline-degrading monooxygenase TetX2 from Bacteroides thetaiotaomicron
Volkers, Gesa, Schuldt, Linda, Palm, Gottfried J., Wright, Gerard D., Hinrichs, Winfried
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.05.2010)
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.05.2010)
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Journal Article