Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants
Smith, Bryan D., Kaufman, Michael D., Lu, Wei-Ping, Gupta, Anu, Leary, Cynthia B., Wise, Scott C., Rutkoski, Thomas J., Ahn, Yu Mi, Al-Ani, Gada, Bulfer, Stacie L., Caldwell, Timothy M., Chun, Lawrence, Ensinger, Carol L., Hood, Molly M., McKinley, Arin, Patt, William C., Ruiz-Soto, Rodrigo, Su, Ying, Telikepalli, Hanumaiah, Town, Ajia, Turner, Benjamin A., Vogeti, Lakshminarayana, Vogeti, Subha, Yates, Karen, Janku, Filip, Abdul Razak, Albiruni Ryan, Rosen, Oliver, Heinrich, Michael C., Flynn, Daniel L.
Published in Cancer cell (13.05.2019)
Published in Cancer cell (13.05.2019)
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Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by Macrophages
Smith, Bryan D, Kaufman, Michael D, Wise, Scott C, Ahn, Yu Mi, Caldwell, Timothy M, Leary, Cynthia B, Lu, Wei-Ping, Tan, Gege, Vogeti, Lakshminarayana, Vogeti, Subha, Wilky, Breelyn A, Davis, Lara E, Sharma, Maitreyi, Ruiz-Soto, Rodrigo, Flynn, Daniel L
Published in Molecular cancer therapeutics (01.11.2021)
Published in Molecular cancer therapeutics (01.11.2021)
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Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors
Zhang, Weihe, Wu, Minwan, Vadlakonda, Satish, Juarez, Luis, Cheng, Xiaogang, Muppa, Saritha, Chintareddy, Venkat, Vogeti, Lakshminarayana, Kellogg-Yelder, Debra, Williams, Jason, Polach, Kevin, Chen, Xilin, Raman, Krishnan, Babu, Y.S., Kotian, Pravin
Published in Bioorganic & medicinal chemistry (15.11.2022)
Published in Bioorganic & medicinal chemistry (15.11.2022)
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Journal Article
Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of Tenosynovial Giant Cell Tumor (TGCT)
Caldwell, Timothy M., Ahn, Yu Mi, Bulfer, Stacie L., Leary, Cynthia B., Hood, Molly M., Lu, Wei-Ping, Vogeti, Lakshminarayana, Vogeti, Subha, Kaufman, Michael D., Wise, Scott C., Le Bourdonnec, Bertrand, Smith, Bryan D., Flynn, Daniel L.
Published in Bioorganic & medicinal chemistry letters (15.10.2022)
Published in Bioorganic & medicinal chemistry letters (15.10.2022)
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Journal Article
Discovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors
Caldwell, Timothy M., Kaufman, Michael D., Wise, Scott C., Mi Ahn, Yu, Hood, Molly M., Lu, Wei-Ping, Patt, William C., Samarakoon, Thiwanka, Vogeti, Lakshminarayana, Vogeti, Subha, Yates, Karen M., Bulfer, Stacie L., Le Bourdonnec, Bertrand, Smith, Bryan D., Flynn, Daniel L.
Published in Bioorganic & medicinal chemistry letters (15.10.2022)
Published in Bioorganic & medicinal chemistry letters (15.10.2022)
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Journal Article
RAF 키나아제 억제제 및 그 사용 방법
LE BOURDONNEC BERTRAND, FLYNN DANIEL L, AHN YU MI, VOGETI LAKSHMINARAYANA
Year of Publication 04.09.2024
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Year of Publication 04.09.2024
Patent
Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036
Chan, Wayne W., Wise, Scott C., Kaufman, Michael D., Ahn, Yu Mi, Ensinger, Carol L., Haack, Torsten, Hood, Molly M., Jones, Jennifer, Lord, John W., Lu, Wei Ping, Miller, David, Patt, William C., Smith, Bryan D., Petillo, Peter A., Rutkoski, Thomas J., Telikepalli, Hanumaiah, Vogeti, Lakshminarayana, Yao, Tony, Chun, Lawrence, Clark, Robin, Evangelista, Peter, Gavrilescu, L. Cristina, Lazarides, Katherine, Zaleskas, Virginia M., Stewart, Lance J., Van Etten, Richard A., Flynn, Daniel L.
Published in Cancer cell (12.04.2011)
Published in Cancer cell (12.04.2011)
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Discovery of 1‑(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3‑d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a Pan-RAF Inhibitor with Minimal Paradoxical Activation and Activity against BRAF or RAS Mutant Tumor Cells
Henry, James R, Kaufman, Michael D, Peng, Sheng-Bin, Ahn, Yu Mi, Caldwell, Timothy M, Vogeti, Lakshminarayana, Telikepalli, Hanumaiah, Lu, Wei-Ping, Hood, Molly M, Rutkoski, Thomas J, Smith, Bryan D, Vogeti, Subha, Miller, David, Wise, Scott C, Chun, Lawrence, Zhang, Xiaoyi, Zhang, Youyan, Kays, Lisa, Hipskind, Philip A, Wrobleski, Aaron D, Lobb, Karen L, Clay, Julia M, Cohen, Jeffrey D, Walgren, Jennie L, McCann, Denis, Patel, Phenil, Clawson, David K, Guo, Sherry, Manglicmot, Danalyn, Groshong, Chris, Logan, Cheyenne, Starling, James J, Flynn, Daniel L
Published in Journal of medicinal chemistry (28.05.2015)
Published in Journal of medicinal chemistry (28.05.2015)
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Journal Article
Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2
Smith, Bryan D, Kaufman, Michael D, Leary, Cynthia B, Turner, Benjamin A, Wise, Scott C, Ahn, Yu Mi, Booth, R John, Caldwell, Timothy M, Ensinger, Carol L, Hood, Molly M, Lu, Wei-Ping, Patt, Tristan W, Patt, William C, Rutkoski, Thomas J, Samarakoon, Thiwanka, Telikepalli, Hanumaiah, Vogeti, Lakshminarayana, Vogeti, Subha, Yates, Karen M, Chun, Lawrence, Stewart, Lance J, Clare, Michael, Flynn, Daniel L
Published in Molecular cancer therapeutics (01.09.2015)
Published in Molecular cancer therapeutics (01.09.2015)
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Journal Article
Abstract B129: Preclinical studies with DCC-3116, an ULK kinase inhibitor designed to inhibit autophagy as a potential strategy to address mutant RAS cancers
Smith, Bryan D, Vogeti, Lakshminarayana, Gupta, Anu, Singh, Jarnail, Al-Ani, Gada, Bulfer, Stacie L, Caldwell, Timothy M, Timson, Mary J, Vogeti, Subha, Ahn, Yu Mi, Al-Hashimi, Hikmat, Crawley, Chase K, Heiniger, Cale L, Leary, Cynthia B, Proto, Justin T, Shen, Quanrong, Telikepalli, Hanumaiah, Yates, Karen, Lu, Wei-Ping, Flynn, Daniel L
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Journal Article
Abstract 4045: DCC-3084, a RAF dimer inhibitor, broadly inhibits BRAF class I, II, III, BRAF fusions, and RAS-driven solid tumors leading to tumor regression in preclinical models
Bulfer, Stacie L., Bourdonnec, Bertrand Le, Zwicker, Jeffery D., Ahn, Yu Mi, Al-Ani, Gada, Al-Hashimi, Hikmat, Crawley, Chase, Elliott, Kristin M., Faisal, Saqib, Harned, Andrew M., Heiniger, Cale L., Hood, Molly M., Javed, Salim, Kennedy, Michael, Large, Joshua W., Leary, Cynthia B., Lu, Wei-Ping, Luther, Kylie, Petty, Max D., Picard, Hunter R., Proto, Justin T., Romero, Yeni K., Stanley, Forrest A., Stoltz, Kristen L., Tanner, Daniel C., Telikepalli, Hanumaiah, Timson, Mary J., Vogeti, Lakshminarayana, Vogeti, Subha, Yang, Sihyung, Zhong, Lexy H., Smith, Bryan D., Flynn, Daniel L.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
인간 혈장 칼리크레인 저해제
KUMAR V. SATISH, ZHANG WEIHE, KOTIAN PRAVIN L, BABU YARLAGADDA S, VOGETI LAKSHMINARAYANA
Year of Publication 01.06.2018
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Year of Publication 01.06.2018
Patent
벤조피라졸 화합물 및 이의 유사체
WU MINWAN, ZHANG WEIHE, KOTIAN PRAVIN L, RAMAN KRISHNAN, BABU YARLAGADDA S, CHINTAREDDY VENKAT R, VOGETI LAKSHMINARAYANA
Year of Publication 29.10.2018
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Year of Publication 29.10.2018
Patent
Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region
Ahn, Yu Mi, Clare, Michael, Ensinger, Carol L., Hood, Molly M., Lord, John W., Lu, Wei-Ping, Miller, David F., Patt, William C., Smith, Bryan D., Vogeti, Lakshminarayana, Kaufman, Michael D., Petillo, Peter A., Wise, Scott C., Abendroth, Jan, Chun, Lawrence, Clark, Robin, Feese, Michael, Kim, Hidong, Stewart, Lance, Flynn, Daniel L.
Published in Bioorganic & medicinal chemistry letters (01.10.2010)
Published in Bioorganic & medicinal chemistry letters (01.10.2010)
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