A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable OGA Inhibitors
Bergeron-Brlek, Milan, Goodwin-Tindall, Jake, Cekic, Nevena, Roth, Christian, Zandberg, Wesley F., Shan, Xiaoyang, Varghese, Vimal, Chan, Sherry, Davies, Gideon J., Vocadlo, David J., Britton, Robert
Published in Angewandte Chemie (14.12.2015)
Published in Angewandte Chemie (14.12.2015)
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sp2-Iminosugar azobenzene O-glycosides: Light-sensitive glycosidase inhibitors with unprecedented tunability and switching factors
Rivero-Barbarroja, Gonzalo, Carmen Padilla-Pérez, M., Maisonneuve, Stéphane, Isabel García-Moreno, M., Tiet, Ben, Vocadlo, David J., Xie, Juan, García Fernández, José M., Ortiz Mellet, Carmen
Published in Bioorganic chemistry (01.09.2024)
Published in Bioorganic chemistry (01.09.2024)
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Rational design of cell active C2-modified DGJ analogues for the inhibition of human α-galactosidase A (GALA)
Ashmus, Roger A, Wang, Yang, González-Cuesta, Manuel, King, Dustin T, Tiet, Ben, Gilormini, Pierre-André, García Fernández, José M, Ortiz Mellet, Carmen, Britton, Robert, Vocadlo, David J
Published in Organic & biomolecular chemistry (29.09.2021)
Published in Organic & biomolecular chemistry (29.09.2021)
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O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors
Macauley, Matthew S, Whitworth, Garrett E, Debowski, Aleksandra W, Chin, Danielle, Vocadlo, David J
Published in The Journal of biological chemistry (08.07.2005)
Published in The Journal of biological chemistry (08.07.2005)
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Thiamme2-G, a Novel O-GlcNAcase Inhibitor, Reduces Tau Hyperphosphorylation and Rescues Cognitive Impairment in Mice
Pan, Danmin, Gu, Jin-Hua, Zhang, Jin, Hu, Yae, Liu, Fei, Iqbal, Khalid, Cekic, Nevena, Vocadlo, David J, Dai, Chun-Ling, Gong, Cheng-Xin
Published in Journal of Alzheimer's disease (01.01.2021)
Published in Journal of Alzheimer's disease (01.01.2021)
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Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β‐lactam antibiotic resistance
Vadlamani, Grishma, Stubbs, Keith A., Désiré, Jérôme, Blériot, Yves, Vocadlo, David J., Mark, Brian L.
Published in Protein science (01.06.2017)
Published in Protein science (01.06.2017)
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Molecular Basis for the Potent Inhibition of the Emerging Carbapenemase VCC-1 by Avibactam
Mangat, Chand S, Vadlamani, Grishma, Holicek, Viktor, Chu, Mitchell, Larmour, Veronica L C, Vocadlo, David J, Mulvey, Michael R, Mark, Brian L
Published in Antimicrobial agents and chemotherapy (01.04.2019)
Published in Antimicrobial agents and chemotherapy (01.04.2019)
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Structural Analysis of a Family 101 Glycoside Hydrolase in Complex with Carbohydrates Reveals Insights into Its Mechanism
Gregg, Katie J., Suits, Michael D.L., Deng, Lehua, Vocadlo, David J., Boraston, Alisdair B.
Published in The Journal of biological chemistry (16.10.2015)
Published in The Journal of biological chemistry (16.10.2015)
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Mechanism of Human Nucleocytoplasmic Hexosaminidase D
Alteen, Matthew G, Oehler, Verena, Nemčovičová, Ivana, Wilson, Iain B. H, Vocadlo, David J, Gloster, Tracey M
Published in Biochemistry (Easton) (17.05.2016)
Published in Biochemistry (Easton) (17.05.2016)
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Analysis of a New Family of Widely Distributed Metal-independent α-Mannosidases Provides Unique Insight into the Processing of N-Linked Glycans
Gregg, Katie J., Zandberg, Wesley F., Hehemann, Jan-Hendrik, Whitworth, Garrett E., Deng, Lehua, Vocadlo, David J., Boraston, Alisdair B.
Published in The Journal of biological chemistry (29.04.2011)
Published in The Journal of biological chemistry (29.04.2011)
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The Details of Glycolipid Glycan Hydrolysis by the Structural Analysis of a Family 123 Glycoside Hydrolase from Clostridium perfringens
Noach, Ilit, Pluvinage, Benjamin, Laurie, Cassandra, Abe, Kento T., Alteen, Matthew G., Vocadlo, David J., Boraston, Alisdair B.
Published in Journal of molecular biology (14.08.2016)
Published in Journal of molecular biology (14.08.2016)
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Analysis of PUGNAc and NAG-thiazoline as Transition State Analogues for Human O-GlcNAcase: Mechanistic and Structural Insights into Inhibitor Selectivity and Transition State Poise
Whitworth, Garrett E, Macauley, Matthew S, Stubbs, Keith A, Dennis, Rebecca J, Taylor, Edward J, Davies, Gideon J, Greig, Ian R, Vocadlo, David J
Published in Journal of the American Chemical Society (24.01.2007)
Published in Journal of the American Chemical Society (24.01.2007)
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A divergent synthesis to generate targeted libraries of inhibitors for endo-N-acetylglucosaminidases
Seo, Isaac K, Woo, Esther H, Cecioni, Samy, Vocadlo, David J
Published in Canadian journal of chemistry (01.02.2018)
Published in Canadian journal of chemistry (01.02.2018)
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Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate
Withers, Stephen G, Vocadlo, David J, Davies, Gideon J, Laine, Roger
Published in Nature (London) (23.08.2001)
Published in Nature (London) (23.08.2001)
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Synthesis and Use of Mechanism-Based Protein-Profiling Probes for Retaining β-d-Glucosaminidases Facilitate Identification of Pseudomonas aeruginosa NagZ
Stubbs, Keith A, Scaffidi, Adrian, Debowski, Aleksandra W, Mark, Brian L, Stick, Robert V, Vocadlo, David J
Published in Journal of the American Chemical Society (09.01.2008)
Published in Journal of the American Chemical Society (09.01.2008)
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