Inhibitors in AKTion: ATP-competitive vs allosteric
Lazaro, Glorianne, Kostaras, Eleftherios, Vivanco, Igor
Published in Biochemical Society transactions (30.06.2020)
Published in Biochemical Society transactions (30.06.2020)
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Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death
Graham, Nicholas A, Tahmasian, Martik, Kohli, Bitika, Komisopoulou, Evangelia, Zhu, Maggie, Vivanco, Igor, Teitell, Michael A, Wu, Hong, Ribas, Antoni, Lo, Roger S, Mellinghoff, Ingo K, Mischel, Paul S, Graeber, Thomas G
Published in Molecular systems biology (26.06.2012)
Published in Molecular systems biology (26.06.2012)
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Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies
Solit, David B, Chan, Timothy A, Veeriah, Selvaraju, Taylor, Barry S, Meng, Shasha, Fang, Fang, Yilmaz, Emrullah, Vivanco, Igor, Janakiraman, Manickam, Schultz, Nikolaus, Hanrahan, Aphrothiti J, Pao, William, Ladanyi, Marc, Sander, Chris, Heguy, Adriana, Holland, Eric C, Paty, Philip B, Mischel, Paul S, Liau, Linda, Cloughesy, Timothy F, Mellinghoff, Ingo K
Published in Nature genetics (01.01.2010)
Published in Nature genetics (01.01.2010)
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Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma
Beroukhim, Rameen, Getz, Gad, Nghiemphu, Leia, Barretina, Jordi, Hsueh, Teli, Linhart, David, Vivanco, Igor, Lee, Jeffrey C, Huang, Julie H, Alexander, Sethu, Du, Jinyan, Kau, Tweeny, Thomas, Roman K, Shah, Kinjal, Soto, Horacio, Perner, Sven, Prensner, John, Debiasi, Ralph M, Demichelis, Francesca, Hatton, Charlie, Rubin, Mark A, Garraway, Levi A, Nelson, Stan F, Liau, Linda, Mischel, Paul S, Cloughesy, Tim F, Meyerson, Matthew, Golub, Todd A, Lander, Eric S, Mellinghoff, Ingo K, Sellers, William R
Published in Proceedings of the National Academy of Sciences - PNAS (11.12.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (11.12.2007)
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Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors
Vivanco, Igor, Robins, H Ian, Rohle, Daniel, Campos, Carl, Grommes, Christian, Nghiemphu, Phioanh Leia, Kubek, Sara, Oldrini, Barbara, Chheda, Milan G, Yannuzzi, Nicolas, Tao, Hui, Zhu, Shaojun, Iwanami, Akio, Kuga, Daisuke, Dang, Julie, Pedraza, Alicia, Brennan, Cameron W, Heguy, Adriana, Liau, Linda M, Lieberman, Frank, Yung, W K Alfred, Gilbert, Mark R, Reardon, David A, Drappatz, Jan, Wen, Patrick Y, Lamborn, Kathleen R, Chang, Susan M, Prados, Michael D, Fine, Howard A, Horvath, Steve, Wu, Nian, Lassman, Andrew B, DeAngelis, Lisa M, Yong, William H, Kuhn, John G, Mischel, Paul S, Mehta, Minesh P, Cloughesy, Timothy F, Mellinghoff, Ingo K
Published in Cancer discovery (01.05.2012)
Published in Cancer discovery (01.05.2012)
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Molecular Determinants of the Response of Glioblastomas to EGFR Kinase Inhibitors
Mellinghoff, Ingo K, Wang, Maria Y, Vivanco, Igor, Haas-Kogan, Daphne A, Zhu, Shaojun, Dia, Ederlyn Q, Lu, Kan V, Yoshimoto, Koji, Huang, Julie H.Y, Chute, Dennis J, Riggs, Bridget L, Horvath, Steve, Liau, Linda M, Cavenee, Webster K, Rao, P. Nagesh, Beroukhim, Rameen, Peck, Timothy C, Lee, Jeffrey C, Sellers, William R, Stokoe, David, Prados, Michael, Cloughesy, Timothy F, Sawyers, Charles L, Mischel, Paul S
Published in The New England journal of medicine (10.11.2005)
Published in The New England journal of medicine (10.11.2005)
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tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers
Veeriah, Selvaraju, Brennan, Cameron, Meng, Shasha, Singh, Bhuvanesh, Fagin, James A, Solit, David B, Paty, Philip B, Rohle, Dan, Vivanco, Igor, Chmielecki, Juliann, Pao, William, Ladanyi, Marc, Gerald, William L, Liau, Linda, Cloughesy, Timothy C, Mischel, Paul S, Sander, Chris, Taylor, Barry, Schultz, Nikolaus, Major, John, Heguy, Adriana, Fang, Fang, Mellinghoff, Ingo K, Chan, Timothy A
Published in Proceedings of the National Academy of Sciences - PNAS (09.06.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (09.06.2009)
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Murine cell lines derived from Pten null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development
JING JIAO, SHUNYOU WANG, RONG QIAO, VIVANCO, Igor, WATSON, Philip A, SAWYERS, Charles L, HONG WU
Published in Cancer research (Chicago, Ill.) (01.07.2007)
Published in Cancer research (Chicago, Ill.) (01.07.2007)
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A kinase-independent function of AKT promotes cancer cell survival
Vivanco, Igor, Chen, Zhi C, Tanos, Barbara, Oldrini, Barbara, Hsieh, Wan-Ying, Yannuzzi, Nicolas, Campos, Carl, Mellinghoff, Ingo K
Published in eLife (31.12.2014)
Published in eLife (31.12.2014)
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EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer
Oldrini, Barbara, Hsieh, Wan-Ying, Erdjument-Bromage, Hediye, Codega, Paolo, Carro, Maria Stella, Curiel-García, Alvaro, Campos, Carl, Pourmaleki, Maryam, Grommes, Christian, Vivanco, Igor, Rohle, Daniel, Bielski, Craig M., Taylor, Barry S., Hollmann, Travis J., Rosenblum, Marc, Tempst, Paul, Blenis, John, Squatrito, Massimo, Mellinghoff, Ingo K.
Published in Nature communications (11.12.2017)
Published in Nature communications (11.12.2017)
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Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells
WANG, Maria Y, LU, Kan V, MISCHEL, Paul S, SHAOJUN ZHU, DIA, Ederlyn Q, VIVANCO, Igor, SHACKLEFORD, Gregory M, CAVENEE, Webster K, MELLINGHOFF, Ingo K, CLOUGHESY, Timothy F, SAWYERS, Charles L
Published in Cancer research (Chicago, Ill.) (15.08.2006)
Published in Cancer research (Chicago, Ill.) (15.08.2006)
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phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation
Vivanco, Igor, Rohle, Daniel, Versele, Matthias, Iwanami, Akio, Kuga, Daisuke, Oldrini, Barbara, Tanaka, Kazuhiro, Dang, Julie, Kubek, Sara, Palaskas, Nicolaos, Hsueh, Teli, Evans, Michael, Mulholland, David, Wolle, Daniel, Rajasekaran, Sigrid, Rajasekaran, Ayyappan, Liau, Linda M, Cloughesy, Timothy F, Dikic, Ivan, Brennan, Cameron, Wu, Hong, Mischel, Paul S, Perera, Timothy, Mellinghoff, Ingo K
Published in Proceedings of the National Academy of Sciences - PNAS (06.04.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (06.04.2010)
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Identification of the JNK Signaling Pathway as a Functional Target of the Tumor Suppressor PTEN
Vivanco, Igor, Palaskas, Nicolaos, Tran, Chris, Finn, Stephen P., Getz, Gad, Kennedy, Norman J., Jiao, Jing, Rose, Joshua, Xie, Wanling, Loda, Massimo, Golub, Todd, Mellinghoff, Ingo K., Davis, Roger J., Wu, Hong, Sawyers, Charles L.
Published in Cancer cell (01.06.2007)
Published in Cancer cell (01.06.2007)
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IQGAP1 controls tight junction formation through differential regulation of claudin recruitment
Tanos, Barbara E, Perez Bay, Andres E, Salvarezza, Susana, Vivanco, Igor, Mellinghoff, Ingo, Osman, Mahasin, Sacks, David B, Rodriguez-Boulan, Enrique
Published in Journal of cell science (01.03.2015)
Published in Journal of cell science (01.03.2015)
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STEAP: A Prostate-Specific Cell-Surface Antigen Highly Expressed in Human Prostate Tumors
Hubert, Rene S., Vivanco, Igor, Chen, Emily, Rastegar, Shiva, Leong, Kahan, Mitchell, Steve C., Madraswala, Rashida, Zhou, Yanhong, Kuo, James, Raitano, Arthur B., Jakobovits, Aya, Saffran, Douglas C., Daniel E. H. Afar
Published in Proceedings of the National Academy of Sciences - PNAS (07.12.1999)
Published in Proceedings of the National Academy of Sciences - PNAS (07.12.1999)
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14-3-3σ and p21 synergize to determine DNA damage response following Chk2 inhibition
Meng, Shasha, Arbit, Tali, Veeriah, Selvaraju, Mellinghoff, Ingo K., Fang, Fang, Vivanco, Igor, Rohle, Dan, Chan, Timothy A.
Published in Cell cycle (Georgetown, Tex.) (15.07.2009)
Published in Cell cycle (Georgetown, Tex.) (15.07.2009)
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Targeting un-MET needs in advanced non-small cell lung cancer
Coleman, Niamh, Harbery, Alice, Heuss, Sara, Vivanco, Igor, Popat, Sanjay
Published in Lung cancer (Amsterdam, Netherlands) (01.02.2022)
Published in Lung cancer (Amsterdam, Netherlands) (01.02.2022)
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