Wnt addiction of genetically defined cancers reversed by PORCN inhibition
Madan, B, Ke, Z, Harmston, N, Ho, S Y, Frois, A O, Alam, J, Jeyaraj, D A, Pendharkar, V, Ghosh, K, Virshup, I H, Manoharan, V, Ong, E H Q, Sangthongpitag, K, Hill, J, Petretto, E, Keller, T H, Lee, M A, Matter, A, Virshup, D M
Published in Oncogene (28.04.2016)
Published in Oncogene (28.04.2016)
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IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ε and Wnt/β-catenin independent inhibition of mitotic spindle formation
CHEONG, J. K, NGUYEN, T. H, WANG, H, TAN, P, VOORHOEVE, P. M, LEE, S. H, VIRSHUP, D. M
Published in Oncogene (02.06.2011)
Published in Oncogene (02.06.2011)
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Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways
Somarelli, J A, Schaeffer, D, Marengo, M S, Bepler, T, Rouse, D, Ware, K E, Hish, A J, Zhao, Y, Buckley, A F, Epstein, J I, Armstrong, A J, Virshup, D M, Garcia-Blanco, M A
Published in Oncogene (18.08.2016)
Published in Oncogene (18.08.2016)
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FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway
Asad, M, Wong, M K, Tan, T Z, Choolani, M, Low, J, Mori, S, Virshup, D, Thiery, J P, Huang, R Y-J
Published in Cell death & disease (01.07.2014)
Published in Cell death & disease (01.07.2014)
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Modulation of Wnt β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer
Coombs, G S, Schmitt, A A, Canning, C A, Alok, A, Low, I C C, Banerjee, N, Kaur, S, Utomo, V, Jones, C M, Pervaiz, S, Toone, E J, Virshup, D M
Published in Oncogene (12.01.2012)
Published in Oncogene (12.01.2012)
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An hPer2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome
Toh, Kong L., Jones, Christopher R., He, Yan, Eide, Erik J., Hinz, William A., Virshup, David M., Ptáček, Louis J., Fu, Ying-Hui
Published in Science (American Association for the Advancement of Science) (09.02.2001)
Published in Science (American Association for the Advancement of Science) (09.02.2001)
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Phase I extension study of ETC-159 an oral PORCN inhibitor administered with bone protective treatment, in patients with advanced solid tumours
Tan, D., Ng, M., Subbiah, V., Messersmith, W., Teneggi, V., Diermayr, V., Ethirajulu, K., Yeo, P., Gan, B.H., Lee, L.H., Blanchard, S., Nellore, R., Yasin, M., Umrani, D., Lee, M.A., Hill, J., Madan, B., Virshup, D., Matter, A.
Published in Annals of oncology (01.11.2018)
Published in Annals of oncology (01.11.2018)
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Journal Article
172 Identification of Small Molecule Inhibitors of Wnt Secretion
Ke, Z, Lim, S, Wang, S, Fulwood, J, Proffitt, K, Madan, B, Choong, M, Flotow, H, Virshup, D, Lee, M
Published in European journal of cancer (1990) (01.11.2012)
Published in European journal of cancer (1990) (01.11.2012)
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Journal Article
Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle
Rivers, A, Gietzen, K F, Vielhaber, E, Virshup, D M
Published in The Journal of biological chemistry (26.06.1998)
Published in The Journal of biological chemistry (26.06.1998)
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PO-201 NF1 inhibits glioma cells invasion and reverts mesenchymal transition
Yeo, J, Fadhlullah, SF, Ho, R, Halim, N Abdul, Sandanaraj, E, Ang, BT, Tang, C, Ng, WH, Virshup, D, Ho, I
Published in ESMO open (01.07.2018)
Published in ESMO open (01.07.2018)
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A Conserved Docking Motif for CK1 Binding Controls the Nuclear Localization of NFAT1
Okamura, Heidi, Garcia-Rodriguez, Carmen, Martinson, Holly, Qin, Jun, Virshup, David M, Rao, Anjana
Published in Molecular and Cellular Biology (01.05.2004)
Published in Molecular and Cellular Biology (01.05.2004)
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Journal Article
Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon
Vielhaber, E, Eide, E, Rivers, A, Gao, Z H, Virshup, D M
Published in Molecular and cellular biology (01.07.2000)
Published in Molecular and cellular biology (01.07.2000)
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