A Diverse Array of Large Capsules Transform in Response to Stimuli
Wu, Kai, Ronson, Tanya K., Goh, Leonard, Xue, Weichao, Heard, Andrew W., Su, Pingru, Li, Xiaopeng, Vinković, Mladen, Nitschke, Jonathan R.
Published in Journal of the American Chemical Society (24.05.2023)
Published in Journal of the American Chemical Society (24.05.2023)
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Journal Article
Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity
Howard, Steven, Berdini, Valerio, Boulstridge, John A, Carr, Maria G, Cross, David M, Curry, Jayne, Devine, Lindsay A, Early, Theresa R, Fazal, Lynsey, Gill, Adrian L, Heathcote, Michelle, Maman, Sarita, Matthews, Julia E, McMenamin, Rachel L, Navarro, Eva F, O’Brien, Michael A, O’Reilly, Marc, Rees, David C, Reule, Matthias, Tisi, Dominic, Williams, Glyn, Vinković, Mladen, Wyatt, Paul G
Published in Journal of medicinal chemistry (22.01.2009)
Published in Journal of medicinal chemistry (22.01.2009)
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Journal Article
Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design
Woodhead, Andrew J, Angove, Hayley, Carr, Maria G, Chessari, Gianni, Congreve, Miles, Coyle, Joseph E, Cosme, Jose, Graham, Brent, Day, Philip J, Downham, Robert, Fazal, Lynsey, Feltell, Ruth, Figueroa, Eva, Frederickson, Martyn, Lewis, Jonathan, McMenamin, Rachel, Murray, Christopher W, O’Brien, M. Alistair, Parra, Lina, Patel, Sahil, Phillips, Theresa, Rees, David C, Rich, Sharna, Smith, Donna-Michelle, Trewartha, Gary, Vinkovic, Mladen, Williams, Brian, Woolford, Alison J.-A
Published in Journal of medicinal chemistry (26.08.2010)
Published in Journal of medicinal chemistry (26.08.2010)
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Journal Article
Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator
Frederickson, Martyn, Callaghan, Owen, Chessari, Gianni, Congreve, Miles, Cowan, Suzanna R, Matthews, Julia E, McMenamin, Rachel, Smith, Donna-Michelle, Vinković, Mladen, Wallis, Nicola G
Published in Journal of medicinal chemistry (24.01.2008)
Published in Journal of medicinal chemistry (24.01.2008)
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Journal Article
High-throughput protein crystallography and drug discovery
Tickle, Ian, Sharff, Andrew, Vinkovic, Mladen, Yon, Jeff, Jhoti, Harren
Published in Chemical Society reviews (01.01.2004)
Published in Chemical Society reviews (01.01.2004)
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Journal Article
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction
Chessari, Gianni, Hardcastle, Ian R, Ahn, Jong Sook, Anil, Burcu, Anscombe, Elizabeth, Bawn, Ruth H, Bevan, Luke D, Blackburn, Timothy J, Buck, Ildiko, Cano, Celine, Carbain, Benoit, Castro, Juan, Cons, Ben, Cully, Sarah J, Endicott, Jane A, Fazal, Lynsey, Golding, Bernard T, Griffin, Roger J, Haggerty, Karen, Harnor, Suzannah J, Hearn, Keisha, Hobson, Stephen, Holvey, Rhian S, Howard, Steven, Jennings, Claire E, Johnson, Christopher N, Lunec, John, Miller, Duncan C, Newell, David R, Noble, Martin E. M, Reeks, Judith, Revill, Charlotte H, Riedinger, Christiane, St. Denis, Jeffrey D, Tamanini, Emiliano, Thomas, Huw, Thompson, Neil T, Vinković, Mladen, Wedge, Stephen R, Williams, Pamela A, Wilsher, Nicola E, Zhang, Bian, Zhao, Yan
Published in Journal of medicinal chemistry (08.04.2021)
Published in Journal of medicinal chemistry (08.04.2021)
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Journal Article
Abstract A143: Coupling fragment-based screening with targeted protein degradation and genetic rescue to identify and explore the function of a non-canonical pocket on eIF4E
Sharp, Swee Y, Martella, Marianna, Milton, Christopher I, Ward, George, Vinkovic, Mladen, Richardson, Caroline, Woodhead, Andrew, Clarke, Paul A
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
Abstract 7073: Integrating fragment-based crystallographic screening with dTAG-PROTAC degradation and genetic rescue to explore the function of eIF4E
Clarke, Paul A., Sharp, Swee Y., Martella, Marianna, Milton, Christopher I., East, Charlotte, Vinkovic, Mladen, Wallis, Nicola, Ward, George, Richardson, Caroline, Woodhead, Andrew
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Abstract 6588: Discovery of ASTX295, a potent, next-generation small molecule antagonist of MDM2 with differentiated pharmacokinetic profile
Ahn, Maria, Bevan, Luke, Buck, Ildiko, Cano, Celine, Castro, Juan, Cons, Ben, Endicott, Jane, Fazal, Lynsey, Ferrari, Nicola, Hardcastle, Ian, Hearn, Keisha, Holvey, Rhian, Howard, Steven, Johnson, Chris, Jennings, Claire, Kucia-Tran, Justyna, Kyle, Suzanne, Lunec, John, Lyons, John, Miller, Duncan, Rees, David, Noble, Martin, Newell, David R., Reeks, Judith, Saini, Harpreet, St. Denis, Jeffrey, Tamanini, Emiliano, Thomas, Huw, Thompson, Neil, Vinkovic, Mladen, Ward, George, Wallis, Nicola, Walton, Hugh, Wedge, Stephen, Williams, Pamela, Willmore, Elaine, Wilshire, Nicola, Zhao, Yan, Chessari, Gianni
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Crystal Structure of Human Soluble Adenylate Cyclase Reveals a Distinct, Highly Flexible Allosteric Bicarbonate Binding Pocket
Saalau-Bethell, Susanne M., Berdini, Valerio, Cleasby, Anne, Congreve, Miles, Coyle, Joseph E., Lock, Victoria, Murray, Christopher W., O'Brien, M. Alistair, Rich, Sharna J., Sambrook, Tracey, Vinkovic, Mladen, Yon, Jeff R., Jhoti, Harren
Published in ChemMedChem (01.04.2014)
Published in ChemMedChem (01.04.2014)
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Journal Article
Identification of novel allosteric inhibitors through fragment-based drug discovery and X-ray crystallography
Pathuri, Puja, Saalau-Bethell, Susanne M., Woodhead, Andrew J., Berdini, Valerio, Carr, Maria G., Chessari, Gianni, Cleasby, Anne, Congreve, Miles, Coyle, Joseph E., Graham, Brent, Hiscock, Steven D., Lock, Victoria, Murray, Christopher W., O'Brien, M. Alistair, Rich, Sharna J., Richardson, Caroline J., Sambrook, Tracey, Vinkovic, Mladen, Williams, Pamela A., Yon, Jeff R., Jhoti, Harren
Published in Acta crystallographica. Section A, Foundations and advances (23.08.2015)
Published in Acta crystallographica. Section A, Foundations and advances (23.08.2015)
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Journal Article
Abstract A1: The physiological form of MetAP2 can be inhibited through binding to either of the two active-site metals
Wallis, Nicola G., Berdini, Valerio, Besong, Gilbert, Chessari, Gianni, Coyle, Joe, Graham, Brent, Madin, Andrew, O'Brien, Alistair, Richardson, Caroline J., Smith, Kirsten, Thompson, Neil T., Vinkovic, Mladen, Williams, Pamela A.
Published in Molecular cancer therapeutics (10.12.2009)
Published in Molecular cancer therapeutics (10.12.2009)
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Journal Article
Structural constraints on protein self-processing in L-aspartate-α-decarboxylase
Schmitzberger, Florian, Kilkenny, Mairi L., Lobley, Carina M. C., Webb, Michael E., Vinkovic, Mladen, Matak-Vinkovic, Dijana, Witty, Michael, Chirgadze, Dimitri Y., Smith, Alison G., Abell, Chris, Blundell, Tom L.
Published in The EMBO journal (01.12.2003)
Published in The EMBO journal (01.12.2003)
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Journal Article
Farmasøytiske forbindelser
Wyatt, Paul Graham, Vinkovic, Mladen, Trewartha, Gary, Rees, David Charles
Year of Publication 06.06.2017
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Year of Publication 06.06.2017
Patent
HYDROBENZAMIDE DERIVATIVES AS INHIBITORS OF HSP90
Vinkovic, Mladen, Thompson, Neil, Woolford, Alison, Frederickson, Martyn, Williams, Brian, Woodhead, Andrew, Lyons, John
Year of Publication 28.08.2018
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Year of Publication 28.08.2018
Patent
HYDROBENZAMIDE DERIVATIVES AS INHIBITORS OF HSP90
Frederickson Martyn, Lyons John Francis, Woodhead Andrew James, Woolford Alison Jo-Anne, Williams Brian, Thompson Neil Thomas, Vinkovic Mladen
Year of Publication 30.04.2018
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Year of Publication 30.04.2018
Patent
HYDROBENZAMIDE DERIVATIVES AS INHIBITORS OF HSP90
Woolford, Alison Jo-Anne, Lyons, John Francis, Vinkovic, Mladen, Woodhead, Andrew James, Frederickson, Martyn, Thompson, Neil Thomas, Williams, Brian
Year of Publication 20.04.2018
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Year of Publication 20.04.2018
Patent
HYDROBENZAMIDE DERIVATIVES AS INHIBITORS OF HSP90
Woodhead, Andrew, James, Vinkovic, Mladen, Frederickson, Martyn, Williams, Brian, Lyons, John, Francis, Thompson, Neil, Thomas, Woolford, Alison, Jo-Anne
Year of Publication 26.03.2018
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Year of Publication 26.03.2018
Patent