Palladium-Catalyzed Direct Arylation of Azine and Azole N-Oxides: Reaction Development, Scope and Applications in Synthesis
Campeau, Louis-Charles, Stuart, David R., Leclerc, Jean-Philippe, Bertrand-Laperle, Mégan, Villemure, Elisia, Sun, Ho-Yan, Lasserre, Sandrine, Guimond, Nicolas, Lecavallier, Melanie, Fagnou, Keith
Published in Journal of the American Chemical Society (11.03.2009)
Published in Journal of the American Chemical Society (11.03.2009)
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Journal Article
Elements of Regiocontrol in Palladium-Catalyzed Oxidative Arene Cross-Coupling
Stuart, David R, Villemure, Elisia, Fagnou, Keith
Published in Journal of the American Chemical Society (10.10.2007)
Published in Journal of the American Chemical Society (10.10.2007)
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Journal Article
Medicinal Chemistry of Inhibiting RING-Type E3 Ubiquitin Ligases
Blaquiere, Nicole, Villemure, Elisia, Staben, Steven T
Published in Journal of medicinal chemistry (13.08.2020)
Published in Journal of medicinal chemistry (13.08.2020)
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Journal Article
Exploring Electrochemical C(sp3)–H Oxidation for the Late-Stage Methylation of Complex Molecules
Novaes, Luiz F. T, Ho, Justin S. K, Mao, Kaining, Liu, Kaida, Tanwar, Mayank, Neurock, Matthew, Villemure, Elisia, Terrett, Jack A, Lin, Song
Published in Journal of the American Chemical Society (26.01.2022)
Published in Journal of the American Chemical Society (26.01.2022)
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Journal Article
Regioselective aliphatic C–H functionalization using frustrated radical pairs
Lu, Zhipeng, Ju, Minsoo, Wang, Yi, Meinhardt, Jonathan M., Martinez Alvarado, Jesus I., Villemure, Elisia, Terrett, Jack A., Lin, Song
Published in Nature (London) (20.07.2023)
Published in Nature (London) (20.07.2023)
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Journal Article
α,β-Desaturation and Formal β‑C(sp3)–H Fluorination of N‑Substituted Amines: A Late-Stage Functionalization Strategy Enabled by Electrochemistry
Novaes, Luiz F. T., Ho, Justin S. K., Mao, Kaining, Villemure, Elisia, Terrett, Jack A., Lin, Song
Published in Journal of the American Chemical Society (21.08.2024)
Published in Journal of the American Chemical Society (21.08.2024)
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Journal Article
C2, C5, and C4 Azole N-Oxide Direct Arylation Including Room-Temperature Reactions
Campeau, Louis-Charles, Bertrand-Laperle, Mégan, Leclerc, Jean-Philippe, Villemure, Elisia, Gorelsky, Serge, Fagnou, Keith
Published in Journal of the American Chemical Society (19.03.2008)
Published in Journal of the American Chemical Society (19.03.2008)
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Journal Article
TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism
Chernov-Rogan, Tania, Gianti, Eleonora, Liu, Chang, Villemure, Elisia, Cridland, Andrew P., Hu, Xiaoyu, Ballini, Elisa, Lange, Wienke, Deisemann, Heike, Li, Tianbo, Ward, Stuart I., Hackos, David H., Magnuson, Steven, Safina, Brian, Klein, Michael L., Volgraf, Matthew, Carnevale, Vincenzo, Chena, Jun
Published in Proceedings of the National Academy of Sciences - PNAS (17.12.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (17.12.2019)
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Journal Article
치료 화합물 및 방법
AMARA NERI, GRANDNER JESSICA MARIE, GREEN SAMANTHA ALYSON, DIXIT VISHVA M, VILLEMURE ELISIA, STABEN STEVEN THOMAS
Year of Publication 20.03.2024
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Year of Publication 20.03.2024
Patent
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy
Terrett, Jack A, Chen, Huifen, Shore, Daniel G, Villemure, Elisia, Larouche-Gauthier, Robin, Déry, Martin, Beaumier, Francis, Constantineau-Forget, Léa, Grand-Maître, Chantal, Lépissier, Luce, Ciblat, Stéphane, Sturino, Claudio, Chen, Yong, Hu, Baihua, Lu, Aijun, Wang, Yunli, Cridland, Andrew P, Ward, Stuart I, Hackos, David H, Reese, Rebecca M, Shields, Shannon D, Chen, Jun, Balestrini, Alessia, Riol-Blanco, Lorena, Lee, Wyne P, Liu, John, Suto, Eric, Wu, Xiumin, Zhang, Juan, Ly, Justin Q, La, Hank, Johnson, Kevin, Baumgardner, Matt, Chou, Kang-Jye, Rohou, Alexis, Rougé, Lionel, Safina, Brian S, Magnuson, Steven, Volgraf, Matthew
Published in Journal of medicinal chemistry (08.04.2021)
Published in Journal of medicinal chemistry (08.04.2021)
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Journal Article
Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design
Volgraf, Matthew, Sellers, Benjamin D, Jiang, Yu, Wu, Guosheng, Ly, Cuong Q, Villemure, Elisia, Pastor, Richard M, Yuen, Po-wai, Lu, Aijun, Luo, Xifeng, Liu, Mingcui, Zhang, Shun, Sun, Liang, Fu, Yuhong, Lupardus, Patrick J, Wallweber, Heidi J.A, Liederer, Bianca M, Deshmukh, Gauri, Plise, Emile, Tay, Suzanne, Reynen, Paul, Herrington, James, Gustafson, Amy, Liu, Yichin, Dirksen, Akim, Dietz, Matthias G. A, Liu, Yanzhou, Wang, Tzu-Ming, Hanson, Jesse E, Hackos, David, Scearce-Levie, Kimberly, Schwarz, Jacob B
Published in Journal of medicinal chemistry (24.03.2016)
Published in Journal of medicinal chemistry (24.03.2016)
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Journal Article
A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists
Villemure, Elisia, Terrett, Jack A, Larouche-Gauthier, Robin, Déry, Martin, Chen, Huifen, Reese, Rebecca M, Shields, Shannon D, Chen, Jun, Magnuson, Steven, Volgraf, Matthew
Published in ACS medicinal chemistry letters (12.08.2021)
Published in ACS medicinal chemistry letters (12.08.2021)
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Journal Article
Discovery of a Potent (4R,5S)‑4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling
Chen, Huifen, Volgraf, Matthew, Do, Steven, Kolesnikov, Aleksandr, Shore, Daniel G, Verma, Vishal A, Villemure, Elisia, Wang, Lan, Chen, Yong, Hu, Baihua, Lu, Ai-Jun, Wu, Guosheng, Xu, Xiaofeng, Yuen, Po-wai, Zhang, Yamin, Erickson, Shawn D, Dahl, Martin, Brotherton-Pleiss, Christine, Tay, Suzanne, Ly, Justin Q, Murray, Lesley J, Chen, Jun, Amm, Desiree, Lange, Wienke, Hackos, David H, Reese, Rebecca M, Shields, Shannon D, Lyssikatos, Joseph P, Safina, Brian S, Estrada, Anthony A
Published in Journal of medicinal chemistry (26.04.2018)
Published in Journal of medicinal chemistry (26.04.2018)
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Journal Article
ATF6 promotes colorectal cancer growth and stemness by regulating the Wnt pathway
Rodvold, Jeffrey J, Grimmer, Matthew, Ruiz, Karen, Marsters, Scot A, Oikonomidi, Ioanna, Tan-Aristy, Eileen, Pham, Victoria C, Sarkar, Tamal, Harnoss, Jonathan M, Shatz-Binder, Whitney, Modrusan, Zora D, Wu, Thomas D, Lill, Jennie R, Villemure, Elisia, Rudolph, Joachim, de Sousa E Melo, Felipe, Ashkenazi, Avi
Published in Cancer research communications (26.09.2025)
Published in Cancer research communications (26.09.2025)
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Journal Article
OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS
LEPISSIER LUCE, DERY MARTIN, LAROUCHE GAUTHIER ROBIN, VOLGRAF MATTHEW, BEAUMIER FRANCIS, CHEN HUIFEN, CONSTANTINEAU FORGET LEA, GRAND MAITRE CHANTAL, STURINO CLAUDIO, TERRETT JACK ALEXANDER, VILLEMURE ELISIA
Year of Publication 22.05.2023
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Year of Publication 22.05.2023
Patent
Discovery of Hepatitis C Virus NS3-4A Protease Inhibitors with Improved Barrier to Resistance and Favorable Liver Distribution
Moreau, Benoît, O’Meara, Jeff A., Bordeleau, Josée, Garneau, Michel, Godbout, Cedrickx, Gorys, Vida, Leblanc, Mélissa, Villemure, Elisia, White, Peter W., Llinàs-Brunet, Montse
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
Preparation of 2-Azabicyclo[2.1.1]hexane Hydrochloride
Liao, Haili, Li, Aimin, Chen, Xingsong, Liang, Kun, Shen, Yang, Liang, Qingfeng, Xu, Kewei, Shore, Daniel G. M., Villemure, Elisia, Siu, Michael, Huestis, Malcolm P.
Published in Synlett (19.09.2016)
Published in Synlett (19.09.2016)
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Journal Article
GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile
Villemure, Elisia, Volgraf, Matthew, Jiang, Yu, Wu, Guosheng, Ly, Cuong Q, Yuen, Po-wai, Lu, Aijun, Luo, Xifeng, Liu, Mingcui, Zhang, Shun, Lupardus, Patrick J, Wallweber, Heidi J. A, Liederer, Bianca M, Deshmukh, Gauri, Plise, Emile, Tay, Suzanne, Wang, Tzu-Ming, Hanson, Jesse E, Hackos, David H, Scearce-Levie, Kimberly, Schwarz, Jacob B, Sellers, Benjamin D
Published in ACS medicinal chemistry letters (12.01.2017)
Published in ACS medicinal chemistry letters (12.01.2017)
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Journal Article
옥사디아졸 일시적 수용체 전위 채널 억제제
LEPISSIER LUCE, DERY MARTIN, LAROUCHE GAUTHIER ROBIN, VOLGRAF MATTHEW, BEAUMIER FRANCIS, CHEN HUIFEN, CONSTANTINEAU FORGET LEA, GRAND MAITRE CHANTAL, STURINO CLAUDIO, TERRETT JACK ALEXANDER, VILLEMURE ELISIA
Year of Publication 27.11.2020
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Year of Publication 27.11.2020
Patent